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Fangcang Shelter Hospital in Wuhan: A radiographic report on a cohort of 98 COVID-19 patients.

Identifieur interne : 000235 ( Main/Curation ); précédent : 000234; suivant : 000236

Fangcang Shelter Hospital in Wuhan: A radiographic report on a cohort of 98 COVID-19 patients.

Auteurs : Tingting Guo [République populaire de Chine] ; Xiaoming Liu [République populaire de Chine] ; Cihao Xu [République populaire de Chine] ; Jiazheng Wang [République populaire de Chine] ; Lian Yang [République populaire de Chine] ; Heshui Shi [République populaire de Chine] ; Meng Dai [République populaire de Chine]

Source :

RBID : pubmed:32922173

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Abstract

Objectives: To present the temporal changes of CT manifestations in COVID-19 patients from a single fangcang shelter hospital and to facilitate the understanding of the disease course. Materials and Methods: This retrospective study included 98 patients (males: females, 43:55, mean year, 49±12 years) with confirmed COVID-19 at Jianghan fangcang shelter hospital admitted between Feb 05, 2020, and Feb 09, 2020, who had initial chest CTs at our hospital. Radiographic features and CT scores were analyzed. Results: A total of 267 CT scans of 98 patients were evaluated. Our study showed a high median total CT score of 7 within the first week from symptom onset, peaked in the 2nd week at 10, followed by persistently high levels of CT score with 9.5, 7 and 7 for the week 3, 4, and >4, respectively, and a prolonged median disease course (30 days, the median interval between the onset of initial symptoms and discharge). Ground-glass opacity (GGO) (58%, 41/71) was the earliest and most frequent finding in week 1. Consolidation (26%, 14/53) and mixed pattern (40%, 21/53) were predominant patterns in 2nd week. GGO and reticular were the main patterns of later phase CT scans in patients with relatively advanced diseases who had longer illness duration (≥4 weeks). Among the 94 CT abnormalities obtained within 3 days from the twice RT-PCR test turned negative, the mixed pattern was mainly presented in patients with disease duration of 2-3 weeks, for GGO and reticular were common during the whole course. Conclusion: Discharged patients from fangcang shelter hospital demonstrated a high extent of lung abnormalities on CT within the first week from symptom onset, peaked at 2nd week, followed by persistence of high levels and a prolonged median disease course. GGO was the predominant pattern in week 1, consolidation and mixed pattern in 2nd week, whereas GGO and reticular patterns in later stages (≥4 weeks).

DOI: 10.7150/ijms.48074
PubMed: 32922173
PubMed Central: PMC7484669

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<term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Betacoronavirus (genetics)</term>
<term>Betacoronavirus (isolation & purification)</term>
<term>China (epidemiology)</term>
<term>Clinical Laboratory Techniques (methods)</term>
<term>Clinical Laboratory Techniques (statistics & numerical data)</term>
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<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (virology)</term>
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<term>Humans (MeSH)</term>
<term>Lung (diagnostic imaging)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Mobile Health Units (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>RNA, Viral (isolation & purification)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
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<term>Young Adult (MeSH)</term>
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<term>Betacoronavirus (isolement et purification)</term>
<term>Chine (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
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<term>Mâle (MeSH)</term>
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<term>Techniques de laboratoire clinique</term>
<term>Tomodensitométrie</term>
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<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
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<term>Chine</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
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<term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mobile Health Units</term>
<term>Pandemics</term>
<term>Retrospective Studies</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Jeune adulte</term>
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<term>Pandémies</term>
<term>RT-PCR</term>
<term>Sujet âgé</term>
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<term>Évolution de la maladie</term>
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<div type="abstract" xml:lang="en">
<b>Objectives:</b>
To present the temporal changes of CT manifestations in COVID-19 patients from a single fangcang shelter hospital and to facilitate the understanding of the disease course.
<b>Materials and Methods:</b>
This retrospective study included 98 patients (males: females, 43:55, mean year, 49±12 years) with confirmed COVID-19 at Jianghan fangcang shelter hospital admitted between Feb 05, 2020, and Feb 09, 2020, who had initial chest CTs at our hospital. Radiographic features and CT scores were analyzed.
<b>Results:</b>
A total of 267 CT scans of 98 patients were evaluated. Our study showed a high median total CT score of 7 within the first week from symptom onset, peaked in the 2
<sup>nd</sup>
week at 10, followed by persistently high levels of CT score with 9.5, 7 and 7 for the week 3, 4, and >4, respectively, and a prolonged median disease course (30 days, the median interval between the onset of initial symptoms and discharge). Ground-glass opacity (GGO) (58%, 41/71) was the earliest and most frequent finding in week 1. Consolidation (26%, 14/53) and mixed pattern (40%, 21/53) were predominant patterns in 2
<sup>nd</sup>
week. GGO and reticular were the main patterns of later phase CT scans in patients with relatively advanced diseases who had longer illness duration (≥4 weeks). Among the 94 CT abnormalities obtained within 3 days from the twice RT-PCR test turned negative, the mixed pattern was mainly presented in patients with disease duration of 2-3 weeks, for GGO and reticular were common during the whole course.
<b>Conclusion:</b>
Discharged patients from fangcang shelter hospital demonstrated a high extent of lung abnormalities on CT within the first week from symptom onset, peaked at 2
<sup>nd</sup>
week, followed by persistence of high levels and a prolonged median disease course. GGO was the predominant pattern in week 1, consolidation and mixed pattern in 2
<sup>nd</sup>
week, whereas GGO and reticular patterns in later stages (≥4 weeks).</div>
</front>
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<ELocationID EIdType="doi" ValidYN="Y">10.7150/ijms.48074</ELocationID>
<Abstract>
<AbstractText>
<b>Objectives:</b>
To present the temporal changes of CT manifestations in COVID-19 patients from a single fangcang shelter hospital and to facilitate the understanding of the disease course.
<b>Materials and Methods:</b>
This retrospective study included 98 patients (males: females, 43:55, mean year, 49±12 years) with confirmed COVID-19 at Jianghan fangcang shelter hospital admitted between Feb 05, 2020, and Feb 09, 2020, who had initial chest CTs at our hospital. Radiographic features and CT scores were analyzed.
<b>Results:</b>
A total of 267 CT scans of 98 patients were evaluated. Our study showed a high median total CT score of 7 within the first week from symptom onset, peaked in the 2
<sup>nd</sup>
week at 10, followed by persistently high levels of CT score with 9.5, 7 and 7 for the week 3, 4, and >4, respectively, and a prolonged median disease course (30 days, the median interval between the onset of initial symptoms and discharge). Ground-glass opacity (GGO) (58%, 41/71) was the earliest and most frequent finding in week 1. Consolidation (26%, 14/53) and mixed pattern (40%, 21/53) were predominant patterns in 2
<sup>nd</sup>
week. GGO and reticular were the main patterns of later phase CT scans in patients with relatively advanced diseases who had longer illness duration (≥4 weeks). Among the 94 CT abnormalities obtained within 3 days from the twice RT-PCR test turned negative, the mixed pattern was mainly presented in patients with disease duration of 2-3 weeks, for GGO and reticular were common during the whole course.
<b>Conclusion:</b>
Discharged patients from fangcang shelter hospital demonstrated a high extent of lung abnormalities on CT within the first week from symptom onset, peaked at 2
<sup>nd</sup>
week, followed by persistence of high levels and a prolonged median disease course. GGO was the predominant pattern in week 1, consolidation and mixed pattern in 2
<sup>nd</sup>
week, whereas GGO and reticular patterns in later stages (≥4 weeks).</AbstractText>
<CopyrightInformation>© The author(s).</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Guo</LastName>
<ForeName>Tingting</ForeName>
<Initials>T</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Liu</LastName>
<ForeName>Xiaoming</ForeName>
<Initials>X</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Xu</LastName>
<ForeName>Cihao</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Wang</LastName>
<ForeName>Jiazheng</ForeName>
<Initials>J</Initials>
<AffiliationInfo>
<Affiliation>MSC Clinical & Technical Solutions, Philips Healthcare, Beijing, 100000, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Yang</LastName>
<ForeName>Lian</ForeName>
<Initials>L</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y">
<LastName>Shi</LastName>
<ForeName>Heshui</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Dai</LastName>
<ForeName>Meng</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
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</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2020</Year>
<Month>07</Month>
<Day>30</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>Australia</Country>
<MedlineTA>Int J Med Sci</MedlineTA>
<NlmUniqueID>101213954</NlmUniqueID>
<ISSNLinking>1449-1907</ISSNLinking>
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<MeshHeading>
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<MeshHeading>
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</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading>
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<DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
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<CoiStatement>Competing Interests: The authors have declared that no competing interest exists. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</CoiStatement>
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