Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study.
Identifieur interne : 000984 ( Main/Corpus ); précédent : 000983; suivant : 000985Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study.
Auteurs : Lisa Cariani ; Beatrice Silvia Orena ; Federico Ambrogi ; Simone Gambazza ; Anna Maraschini ; Antonella Dodaro ; Massimo Oggioni ; Annarosa Orlandi ; Alessia Pirrone ; Sara Uceda Renteria ; Mara Bernazzani ; Anna Paola Cantù ; Ferruccio Ceriotti ; Giovanna LunghiSource :
- International journal of environmental research and public health [ 1660-4601 ] ; 2020.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Betacoronavirus (isolation & purification), Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Female (MeSH), Health Personnel (MeSH), Humans (MeSH), Italy (epidemiology), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Pneumonia, Viral (virology), Retrospective Studies (MeSH), Young Adult (MeSH).
- MESH :
- geographic , epidemiology : Italy.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- isolation & purification : Betacoronavirus.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Female, Health Personnel, Humans, Male, Middle Aged, Pandemics, Retrospective Studies, Young Adult.
Abstract
Background: Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide, becoming an unprecedented public health emergency. Rapid detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) suspected cases is crucial to control the spread of infection. We aimed to evaluate the time length of negativization from the onset of symptoms in healthcare workers (HCWs) with COVID-19, and to evaluate significant variations in cycle threshold (CT) values and gene positivity (E, RdRP, and N genes) among positive individuals who returned to work. Methods: We retrospectively analyzed a consecutive cohort of 182 SARS-CoV-2-positive HCWs in Milan, from 16 March to 30 April 2020. Nasopharyngeal swabs were tested by RT-PCR. Results: Asymptomatic HCWs were 17.6% (32/182), and 58 healed at 30 April 2020. The median time length of negativization was 4 weeks (35% of symptomatic versus 40% of asymptomatic HCWs). Four HCWs, healed at 30 April, turned positive within three weeks during controls set up in the work unit. Three-gene positivity had the greatest variability, and increasing CT values from single- to three-gene positivity among all age groups were observed. Conclusions: Self-isolation longer than two weeks and prolonged follow-up periods for the staff returning to work after COVID-19 could be the most suitable choices to counter the SARS-CoV-2 spread. Further studies are needed to investigate infectiousness profiles among positive individuals.
DOI: 10.3390/ijerph17155313
PubMed: 32718008
PubMed Central: PMC7432921
Links to Exploration step
pubmed:32718008Le document en format XML
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<author><name sortKey="Orlandi, Annarosa" sort="Orlandi, Annarosa" uniqKey="Orlandi A" first="Annarosa" last="Orlandi">Annarosa Orlandi</name>
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<author><name sortKey="Pirrone, Alessia" sort="Pirrone, Alessia" uniqKey="Pirrone A" first="Alessia" last="Pirrone">Alessia Pirrone</name>
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<author><name sortKey="Uceda Renteria, Sara" sort="Uceda Renteria, Sara" uniqKey="Uceda Renteria S" first="Sara" last="Uceda Renteria">Sara Uceda Renteria</name>
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<author><name sortKey="Bernazzani, Mara" sort="Bernazzani, Mara" uniqKey="Bernazzani M" first="Mara" last="Bernazzani">Mara Bernazzani</name>
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<author><name sortKey="Cantu, Anna Paola" sort="Cantu, Anna Paola" uniqKey="Cantu A" first="Anna Paola" last="Cantù">Anna Paola Cantù</name>
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</affiliation>
<affiliation><nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Romeo ed Enrica Invernizzi Paediatric Research Centre, Department of Biosciences, University of Milan, 20122 Milan, Italy.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Ceriotti, Ferruccio" sort="Ceriotti, Ferruccio" uniqKey="Ceriotti F" first="Ferruccio" last="Ceriotti">Ferruccio Ceriotti</name>
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<author><name sortKey="Oggioni, Massimo" sort="Oggioni, Massimo" uniqKey="Oggioni M" first="Massimo" last="Oggioni">Massimo Oggioni</name>
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<author><name sortKey="Orlandi, Annarosa" sort="Orlandi, Annarosa" uniqKey="Orlandi A" first="Annarosa" last="Orlandi">Annarosa Orlandi</name>
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</affiliation>
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<author><name sortKey="Pirrone, Alessia" sort="Pirrone, Alessia" uniqKey="Pirrone A" first="Alessia" last="Pirrone">Alessia Pirrone</name>
<affiliation><nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Uceda Renteria, Sara" sort="Uceda Renteria, Sara" uniqKey="Uceda Renteria S" first="Sara" last="Uceda Renteria">Sara Uceda Renteria</name>
<affiliation><nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Bernazzani, Mara" sort="Bernazzani, Mara" uniqKey="Bernazzani M" first="Mara" last="Bernazzani">Mara Bernazzani</name>
<affiliation><nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Responsabile Infermieristico area Direzione Medica di Presidio, Coordinamento dipartimenti clinici, Servizio Prevenzione Igiene Ospedaliera, 20122 Milan, Italy.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Cantu, Anna Paola" sort="Cantu, Anna Paola" uniqKey="Cantu A" first="Anna Paola" last="Cantù">Anna Paola Cantù</name>
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</affiliation>
<affiliation><nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Romeo ed Enrica Invernizzi Paediatric Research Centre, Department of Biosciences, University of Milan, 20122 Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ceriotti, Ferruccio" sort="Ceriotti, Ferruccio" uniqKey="Ceriotti F" first="Ferruccio" last="Ceriotti">Ferruccio Ceriotti</name>
<affiliation><nlm:affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore, Clinical Laboratory, 20122 Milan, Italy.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Lunghi, Giovanna" sort="Lunghi, Giovanna" uniqKey="Lunghi G" first="Giovanna" last="Lunghi">Giovanna Lunghi</name>
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<term>Aged (MeSH)</term>
<term>Betacoronavirus (isolation & purification)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female (MeSH)</term>
<term>Health Personnel (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Italy (epidemiology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Young Adult (MeSH)</term>
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<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Italy</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
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<term>Aged</term>
<term>Female</term>
<term>Health Personnel</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en"><i>Background</i>
: Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide, becoming an unprecedented public health emergency. Rapid detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) suspected cases is crucial to control the spread of infection. We aimed to evaluate the time length of negativization from the onset of symptoms in healthcare workers (HCWs) with COVID-19, and to evaluate significant variations in cycle threshold (CT) values and gene positivity (E, RdRP, and N genes) among positive individuals who returned to work. <i>Methods</i>
: We retrospectively analyzed a consecutive cohort of 182 SARS-CoV-2-positive HCWs in Milan, from 16 March to 30 April 2020. Nasopharyngeal swabs were tested by RT-PCR. <i>Results</i>
: Asymptomatic HCWs were 17.6% (32/182), and 58 healed at 30 April 2020. The median time length of negativization was 4 weeks (35% of symptomatic versus 40% of asymptomatic HCWs). Four HCWs, healed at 30 April, turned positive within three weeks during controls set up in the work unit. Three-gene positivity had the greatest variability, and increasing CT values from single- to three-gene positivity among all age groups were observed. <i>Conclusions</i>
: Self-isolation longer than two weeks and prolonged follow-up periods for the staff returning to work after COVID-19 could be the most suitable choices to counter the SARS-CoV-2 spread. Further studies are needed to investigate infectiousness profiles among positive individuals.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32718008</PMID>
<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>08</Month>
<Day>29</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1660-4601</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>15</Issue>
<PubDate><Year>2020</Year>
<Month>07</Month>
<Day>23</Day>
</PubDate>
</JournalIssue>
<Title>International journal of environmental research and public health</Title>
<ISOAbbreviation>Int J Environ Res Public Health</ISOAbbreviation>
</Journal>
<ArticleTitle>Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E5313</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/ijerph17155313</ELocationID>
<Abstract><AbstractText><i>Background</i>
: Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide, becoming an unprecedented public health emergency. Rapid detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) suspected cases is crucial to control the spread of infection. We aimed to evaluate the time length of negativization from the onset of symptoms in healthcare workers (HCWs) with COVID-19, and to evaluate significant variations in cycle threshold (CT) values and gene positivity (E, RdRP, and N genes) among positive individuals who returned to work. <i>Methods</i>
: We retrospectively analyzed a consecutive cohort of 182 SARS-CoV-2-positive HCWs in Milan, from 16 March to 30 April 2020. Nasopharyngeal swabs were tested by RT-PCR. <i>Results</i>
: Asymptomatic HCWs were 17.6% (32/182), and 58 healed at 30 April 2020. The median time length of negativization was 4 weeks (35% of symptomatic versus 40% of asymptomatic HCWs). Four HCWs, healed at 30 April, turned positive within three weeks during controls set up in the work unit. Three-gene positivity had the greatest variability, and increasing CT values from single- to three-gene positivity among all age groups were observed. <i>Conclusions</i>
: Self-isolation longer than two weeks and prolonged follow-up periods for the staff returning to work after COVID-19 could be the most suitable choices to counter the SARS-CoV-2 spread. Further studies are needed to investigate infectiousness profiles among positive individuals.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cariani</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Orena</LastName>
<ForeName>Beatrice Silvia</ForeName>
<Initials>BS</Initials>
<Identifier Source="ORCID">0000-0003-4921-0757</Identifier>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Specialization School in Microbiology and Virology, University of Milan, 20142 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ambrogi</LastName>
<ForeName>Federico</ForeName>
<Initials>F</Initials>
<Identifier Source="ORCID">0000-0001-9358-011X</Identifier>
<AffiliationInfo><Affiliation>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gambazza</LastName>
<ForeName>Simone</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">0000-0002-6225-2989</Identifier>
<AffiliationInfo><Affiliation>Laboratory of Medical Statistics and Biometry, Giulio A. Maccacaro, Department of Clinical Sciences and Community Health, Campus Cascina Rosa, University of Milan, 20133 Milan, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>UOC Direzione Professioni Sanitarie, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maraschini</LastName>
<ForeName>Anna</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dodaro</LastName>
<ForeName>Antonella</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oggioni</LastName>
<ForeName>Massimo</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0003-2709-6965</Identifier>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Orlandi</LastName>
<ForeName>Annarosa</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pirrone</LastName>
<ForeName>Alessia</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Microbiology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Uceda Renteria</LastName>
<ForeName>Sara</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bernazzani</LastName>
<ForeName>Mara</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Responsabile Infermieristico area Direzione Medica di Presidio, Coordinamento dipartimenti clinici, Servizio Prevenzione Igiene Ospedaliera, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cantù</LastName>
<ForeName>Anna Paola</ForeName>
<Initials>AP</Initials>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Direzione Medica di Presidio, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Romeo ed Enrica Invernizzi Paediatric Research Centre, Department of Biosciences, University of Milan, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ceriotti</LastName>
<ForeName>Ferruccio</ForeName>
<Initials>F</Initials>
<Identifier Source="ORCID">0000-0002-0958-5354</Identifier>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore, Clinical Laboratory, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lunghi</LastName>
<ForeName>Giovanna</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Virology Unit, 20122 Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>07</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Int J Environ Res Public Health</MedlineTA>
<NlmUniqueID>101238455</NlmUniqueID>
<ISSNLinking>1660-4601</ISSNLinking>
</MedlineJournalInfo>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
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<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006282" MajorTopicYN="Y">Health Personnel</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Coronavirus Disease 2019</Keyword>
<Keyword MajorTopicYN="Y">Cycle Threshold values</Keyword>
<Keyword MajorTopicYN="Y">Reverse Transcription PCR</Keyword>
<Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="Y">health care workers</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>06</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>07</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>7</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>7</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>8</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32718008</ArticleId>
<ArticleId IdType="pii">ijerph17155313</ArticleId>
<ArticleId IdType="doi">10.3390/ijerph17155313</ArticleId>
<ArticleId IdType="pmc">PMC7432921</ArticleId>
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