Description of 3 patients with myasthenia gravis and COVID-19.
Identifieur interne : 000917 ( Main/Corpus ); précédent : 000916; suivant : 000918Description of 3 patients with myasthenia gravis and COVID-19.
Auteurs : Netaniel Rein ; Nitzan Haham ; Efrat Orenbuch-Harroch ; Marc Romain ; Zohar Argov ; Adi Vaknin-Dembinsky ; Marc GotkineSource :
- Journal of the neurological sciences [ 1878-5883 ] ; 2020.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Azithromycin (therapeutic use), Betacoronavirus (MeSH), Coronavirus Infections (complications), Coronavirus Infections (drug therapy), Diabetes Mellitus, Type 2 (complications), Female (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Hypertension (complications), Hypothyroidism (complications), Immunocompromised Host (MeSH), Immunoglobulins, Intravenous (therapeutic use), Immunosuppressive Agents (adverse effects), Immunosuppressive Agents (therapeutic use), Lopinavir (therapeutic use), Male (MeSH), Myasthenia Gravis (complications), Myasthenia Gravis (drug therapy), Myasthenia Gravis (therapy), Pandemics (MeSH), Plasmapheresis (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (drug therapy), Ritonavir (therapeutic use), Treatment Outcome (MeSH).
- MESH :
- chemical , adverse effects : Immunosuppressive Agents.
- chemical , therapeutic use : Azithromycin, Hydroxychloroquine, Immunoglobulins, Intravenous, Immunosuppressive Agents, Lopinavir, Ritonavir.
- complications : Coronavirus Infections, Diabetes Mellitus, Type 2, Hypertension, Hypothyroidism, Myasthenia Gravis, Pneumonia, Viral.
- drug therapy : Coronavirus Infections, Myasthenia Gravis, Pneumonia, Viral.
- therapy : Myasthenia Gravis.
- Adult, Aged, Betacoronavirus, Female, Humans, Immunocompromised Host, Male, Pandemics, Plasmapheresis, Treatment Outcome.
Abstract
BACKGROUND
The COVID-19 pandemic presents two main concerns for patients with myasthenia gravis (MG); chronic immunosuppression may put them at greater risk, and some proposed treatments for COVID-19 could cause MG exacerbation.
CASE DESCRIPTION
We present three patients with generalized seropositive MG who developed COVID-19. All patients had a favorable outcome, with only one patient experiencing exacerbation. In this case, exacerbation began before COVID-19; she required ICU admission, non-invasive ventilatory support, and received hydroxychloroquine, lopinavir and ritonavir which were well tolerated. One patient received IVIG in place of scheduled plasma exchange.
CONCLUSION
Outcome was favorable in all cases despite immunosuppressive therapy, use of experimental COVID-19 medication and switching of plasma exchange for IVIG.
DOI: 10.1016/j.jns.2020.117053
PubMed: 32731059
Links to Exploration step
pubmed:32731059Le document en format XML
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<term>Immunosuppressive Agents (therapeutic use)</term>
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<term>Myasthenia Gravis (therapy)</term>
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<term>Myasthenia Gravis</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>The COVID-19 pandemic presents two main concerns for patients with myasthenia gravis (MG); chronic immunosuppression may put them at greater risk, and some proposed treatments for COVID-19 could cause MG exacerbation.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CASE DESCRIPTION</b>
</p>
<p>We present three patients with generalized seropositive MG who developed COVID-19. All patients had a favorable outcome, with only one patient experiencing exacerbation. In this case, exacerbation began before COVID-19; she required ICU admission, non-invasive ventilatory support, and received hydroxychloroquine, lopinavir and ritonavir which were well tolerated. One patient received IVIG in place of scheduled plasma exchange.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Outcome was favorable in all cases despite immunosuppressive therapy, use of experimental COVID-19 medication and switching of plasma exchange for IVIG.</p>
</div>
</front>
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<AbstractText Label="CASE DESCRIPTION">We present three patients with generalized seropositive MG who developed COVID-19. All patients had a favorable outcome, with only one patient experiencing exacerbation. In this case, exacerbation began before COVID-19; she required ICU admission, non-invasive ventilatory support, and received hydroxychloroquine, lopinavir and ritonavir which were well tolerated. One patient received IVIG in place of scheduled plasma exchange.</AbstractText>
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