Duration of SARS-CoV-2 RNA detection in COVID-19 patients in home isolation, Rhineland-Palatinate, Germany, 2020 - an interval-censored survival analysis.
Identifieur interne : 000897 ( Main/Corpus ); précédent : 000896; suivant : 000898Duration of SARS-CoV-2 RNA detection in COVID-19 patients in home isolation, Rhineland-Palatinate, Germany, 2020 - an interval-censored survival analysis.
Auteurs : Sarah Omar ; Christoph Bartz ; Sabine Becker ; Silke Basenach ; Sandra Pfeifer ; Corinna Trapp ; Hildegard Hamm ; Hans Christoph Schlichting ; Magdalena Friederichs ; Ulrich Koch ; Christian Jestrabek ; Ernst Hilger ; Manfred Vogt ; Klaus Jahn ; Simiao Chen ; Till B Rnighausen ; Philipp ZangerSource :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [ 1560-7917 ] ; 2020.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Coronavirus (genetics), Coronavirus (isolation & purification), Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Germany (epidemiology), Humans (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Patient Isolation (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Pneumonia, Viral (virology), Quarantine (MeSH), RNA Replicase (genetics), Real-Time Polymerase Chain Reaction (methods), Survival Analysis (MeSH), Time Factors (MeSH), Viral Nonstructural Proteins (genetics).
- MESH :
- chemical , genetics : RNA Replicase, Viral Nonstructural Proteins.
- geographic , epidemiology : Germany.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- genetics : Betacoronavirus, Coronavirus.
- isolation & purification : Betacoronavirus, Coronavirus.
- methods : Real-Time Polymerase Chain Reaction.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Aged, 80 and over, Humans, Middle Aged, Pandemics, Patient Isolation, Quarantine, Survival Analysis, Time Factors.
Abstract
We analysed consecutive RT-qPCR results of 537 symptomatic coronavirus disease (COVID-19) patients in home quarantine. Respectively 2, 3, and 4 weeks after symptom onset, 50%, 25% and 10% of patients had detectable RNA from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In patients with mild COVID-19, RNA detection is likely to outlast currently known periods of infectiousness by far and fixed time periods seem more appropriate in determining the length of home isolation than laboratory-based approaches.
DOI: 10.2807/1560-7917.ES.2020.25.30.2001292
PubMed: 32734855
PubMed Central: PMC7393848
Links to Exploration step
pubmed:32734855Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Duration of SARS-CoV-2 RNA detection in COVID-19 patients in home isolation, Rhineland-Palatinate, Germany, 2020 - an interval-censored survival analysis.</title><author><name sortKey="Omar, Sarah" sort="Omar, Sarah" uniqKey="Omar S" first="Sarah" last="Omar">Sarah Omar</name><affiliation><nlm:affiliation>District Public Health Authority, Montabaur, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bartz, Christoph" sort="Bartz, Christoph" uniqKey="Bartz C" first="Christoph" last="Bartz">Christoph Bartz</name><affiliation><nlm:affiliation>District Public Health Authority, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, Sabine" sort="Becker, Sabine" uniqKey="Becker S" first="Sabine" last="Becker">Sabine Becker</name><affiliation><nlm:affiliation>District Public Health Authority, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Basenach, Silke" sort="Basenach, Silke" uniqKey="Basenach S" first="Silke" last="Basenach">Silke Basenach</name><affiliation><nlm:affiliation>District Public Health Authority, Neustadt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pfeifer, Sandra" sort="Pfeifer, Sandra" uniqKey="Pfeifer S" first="Sandra" last="Pfeifer">Sandra Pfeifer</name><affiliation><nlm:affiliation>District Public Health Authority, Neustadt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Trapp, Corinna" sort="Trapp, Corinna" uniqKey="Trapp C" first="Corinna" last="Trapp">Corinna Trapp</name><affiliation><nlm:affiliation>District Health Authority, Neuwied, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hamm, Hildegard" sort="Hamm, Hildegard" uniqKey="Hamm H" first="Hildegard" last="Hamm">Hildegard Hamm</name><affiliation><nlm:affiliation>District Public Health Authority, Bad Ems, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schlichting, Hans Christoph" sort="Schlichting, Hans Christoph" uniqKey="Schlichting H" first="Hans Christoph" last="Schlichting">Hans Christoph Schlichting</name><affiliation><nlm:affiliation>District Public Health Authority, Wittlich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Friederichs, Magdalena" sort="Friederichs, Magdalena" uniqKey="Friederichs M" first="Magdalena" last="Friederichs">Magdalena Friederichs</name><affiliation><nlm:affiliation>District Public Health Authority, Kirchheimbolanden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Koch, Ulrich" sort="Koch, Ulrich" uniqKey="Koch U" first="Ulrich" last="Koch">Ulrich Koch</name><affiliation><nlm:affiliation>District Public Health Authority, Pirmasens, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jestrabek, Christian" sort="Jestrabek, Christian" uniqKey="Jestrabek C" first="Christian" last="Jestrabek">Christian Jestrabek</name><affiliation><nlm:affiliation>District Public Health Authority, Germersheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hilger, Ernst" sort="Hilger, Ernst" uniqKey="Hilger E" first="Ernst" last="Hilger">Ernst Hilger</name><affiliation><nlm:affiliation>District Public Health Authority, Cochem, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Vogt, Manfred" sort="Vogt, Manfred" uniqKey="Vogt M" first="Manfred" last="Vogt">Manfred Vogt</name><affiliation><nlm:affiliation>Federal State Agency for Consumer and Health Protection Rhineland-Palatinate, Koblenz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jahn, Klaus" sort="Jahn, Klaus" uniqKey="Jahn K" first="Klaus" last="Jahn">Klaus Jahn</name><affiliation><nlm:affiliation>Ministry of Health, Federal State of Rhineland-Palatinate, Mainz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Simiao" sort="Chen, Simiao" uniqKey="Chen S" first="Simiao" last="Chen">Simiao Chen</name><affiliation><nlm:affiliation>Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Heidelberg Institute of Global Heath, University Hospitals, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="B Rnighausen, Till" sort="B Rnighausen, Till" uniqKey="B Rnighausen T" first="Till" last="B Rnighausen">Till B Rnighausen</name><affiliation><nlm:affiliation>Department of Global Health and Population, Harvard School of Public Health, Boston, United States.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Harvard Center for Population and Development Studies, Harvard University, Cambridge, United States.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Heidelberg Institute of Global Heath, University Hospitals, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Zanger, Philipp" sort="Zanger, Philipp" uniqKey="Zanger P" first="Philipp" last="Zanger">Philipp Zanger</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Medical Microbiology and Hygiene, University Hospitals, Heidelberg, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Federal State Agency for Consumer and Health Protection Rhineland-Palatinate, Koblenz, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Heidelberg Institute of Global Heath, University Hospitals, Heidelberg, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Ministry of Health, Federal State of Rhineland-Palatinate, Mainz, Germany.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32734855</idno><idno type="pmid">32734855</idno><idno type="doi">10.2807/1560-7917.ES.2020.25.30.2001292</idno><idno type="pmc">PMC7393848</idno><idno type="wicri:Area/Main/Corpus">000897</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000897</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Duration of SARS-CoV-2 RNA detection in COVID-19 patients in home isolation, Rhineland-Palatinate, Germany, 2020 - an interval-censored survival analysis.</title><author><name sortKey="Omar, Sarah" sort="Omar, Sarah" uniqKey="Omar S" first="Sarah" last="Omar">Sarah Omar</name><affiliation><nlm:affiliation>District Public Health Authority, Montabaur, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bartz, Christoph" sort="Bartz, Christoph" uniqKey="Bartz C" first="Christoph" last="Bartz">Christoph Bartz</name><affiliation><nlm:affiliation>District Public Health Authority, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, Sabine" sort="Becker, Sabine" uniqKey="Becker S" first="Sabine" last="Becker">Sabine Becker</name><affiliation><nlm:affiliation>District Public Health Authority, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Basenach, Silke" sort="Basenach, Silke" uniqKey="Basenach S" first="Silke" last="Basenach">Silke Basenach</name><affiliation><nlm:affiliation>District Public Health Authority, Neustadt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pfeifer, Sandra" sort="Pfeifer, Sandra" uniqKey="Pfeifer S" first="Sandra" last="Pfeifer">Sandra Pfeifer</name><affiliation><nlm:affiliation>District Public Health Authority, Neustadt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Trapp, Corinna" sort="Trapp, Corinna" uniqKey="Trapp C" first="Corinna" last="Trapp">Corinna Trapp</name><affiliation><nlm:affiliation>District Health Authority, Neuwied, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hamm, Hildegard" sort="Hamm, Hildegard" uniqKey="Hamm H" first="Hildegard" last="Hamm">Hildegard Hamm</name><affiliation><nlm:affiliation>District Public Health Authority, Bad Ems, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schlichting, Hans Christoph" sort="Schlichting, Hans Christoph" uniqKey="Schlichting H" first="Hans Christoph" last="Schlichting">Hans Christoph Schlichting</name><affiliation><nlm:affiliation>District Public Health Authority, Wittlich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Friederichs, Magdalena" sort="Friederichs, Magdalena" uniqKey="Friederichs M" first="Magdalena" last="Friederichs">Magdalena Friederichs</name><affiliation><nlm:affiliation>District Public Health Authority, Kirchheimbolanden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Koch, Ulrich" sort="Koch, Ulrich" uniqKey="Koch U" first="Ulrich" last="Koch">Ulrich Koch</name><affiliation><nlm:affiliation>District Public Health Authority, Pirmasens, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jestrabek, Christian" sort="Jestrabek, Christian" uniqKey="Jestrabek C" first="Christian" last="Jestrabek">Christian Jestrabek</name><affiliation><nlm:affiliation>District Public Health Authority, Germersheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hilger, Ernst" sort="Hilger, Ernst" uniqKey="Hilger E" first="Ernst" last="Hilger">Ernst Hilger</name><affiliation><nlm:affiliation>District Public Health Authority, Cochem, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Vogt, Manfred" sort="Vogt, Manfred" uniqKey="Vogt M" first="Manfred" last="Vogt">Manfred Vogt</name><affiliation><nlm:affiliation>Federal State Agency for Consumer and Health Protection Rhineland-Palatinate, Koblenz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jahn, Klaus" sort="Jahn, Klaus" uniqKey="Jahn K" first="Klaus" last="Jahn">Klaus Jahn</name><affiliation><nlm:affiliation>Ministry of Health, Federal State of Rhineland-Palatinate, Mainz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Simiao" sort="Chen, Simiao" uniqKey="Chen S" first="Simiao" last="Chen">Simiao Chen</name><affiliation><nlm:affiliation>Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Heidelberg Institute of Global Heath, University Hospitals, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="B Rnighausen, Till" sort="B Rnighausen, Till" uniqKey="B Rnighausen T" first="Till" last="B Rnighausen">Till B Rnighausen</name><affiliation><nlm:affiliation>Department of Global Health and Population, Harvard School of Public Health, Boston, United States.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Harvard Center for Population and Development Studies, Harvard University, Cambridge, United States.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Heidelberg Institute of Global Heath, University Hospitals, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Zanger, Philipp" sort="Zanger, Philipp" uniqKey="Zanger P" first="Philipp" last="Zanger">Philipp Zanger</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Medical Microbiology and Hygiene, University Hospitals, Heidelberg, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Federal State Agency for Consumer and Health Protection Rhineland-Palatinate, Koblenz, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Heidelberg Institute of Global Heath, University Hospitals, Heidelberg, Germany.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Ministry of Health, Federal State of Rhineland-Palatinate, Mainz, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</title><idno type="eISSN">1560-7917</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Betacoronavirus (genetics)</term><term>Betacoronavirus (isolation & purification)</term><term>Coronavirus (genetics)</term><term>Coronavirus (isolation & purification)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (virology)</term><term>Germany (epidemiology)</term><term>Humans (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Patient Isolation (MeSH)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (virology)</term><term>Quarantine (MeSH)</term><term>RNA Replicase (genetics)</term><term>Real-Time Polymerase Chain Reaction (methods)</term><term>Survival Analysis (MeSH)</term><term>Time Factors (MeSH)</term><term>Viral Nonstructural Proteins (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA Replicase</term><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Real-Time Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Humans</term><term>Middle Aged</term><term>Pandemics</term><term>Patient Isolation</term><term>Quarantine</term><term>Survival Analysis</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We analysed consecutive RT-qPCR results of 537 symptomatic coronavirus disease (COVID-19) patients in home quarantine. Respectively 2, 3, and 4 weeks after symptom onset, 50%, 25% and 10% of patients had detectable RNA from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In patients with mild COVID-19, RNA detection is likely to outlast currently known periods of infectiousness by far and fixed time periods seem more appropriate in determining the length of home isolation than laboratory-based approaches.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32734855</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>05</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1560-7917</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>30</Issue><PubDate><Year>2020</Year><Month>07</Month></PubDate></JournalIssue><Title>Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</Title><ISOAbbreviation>Euro Surveill</ISOAbbreviation></Journal><ArticleTitle>Duration of SARS-CoV-2 RNA detection in COVID-19 patients in home isolation, Rhineland-Palatinate, Germany, 2020 - an interval-censored survival analysis.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.2807/1560-7917.ES.2020.25.30.2001292</ELocationID><Abstract><AbstractText>We analysed consecutive RT-qPCR results of 537 symptomatic coronavirus disease (COVID-19) patients in home quarantine. Respectively 2, 3, and 4 weeks after symptom onset, 50%, 25% and 10% of patients had detectable RNA from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In patients with mild COVID-19, RNA detection is likely to outlast currently known periods of infectiousness by far and fixed time periods seem more appropriate in determining the length of home isolation than laboratory-based approaches.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Omar</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>District Public Health Authority, Montabaur, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bartz</LastName><ForeName>Christoph</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>District Public Health Authority, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Becker</LastName><ForeName>Sabine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>District Public Health Authority, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Basenach</LastName><ForeName>Silke</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>District Public Health Authority, Neustadt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfeifer</LastName><ForeName>Sandra</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>District Public Health Authority, Neustadt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trapp</LastName><ForeName>Corinna</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>District Health Authority, Neuwied, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamm</LastName><ForeName>Hildegard</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>District Public Health Authority, Bad Ems, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schlichting</LastName><ForeName>Hans Christoph</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>District Public Health Authority, Wittlich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Friederichs</LastName><ForeName>Magdalena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>District Public Health Authority, Kirchheimbolanden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koch</LastName><ForeName>Ulrich</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>District Public Health Authority, Pirmasens, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jestrabek</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>District Public Health Authority, Germersheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hilger</LastName><ForeName>Ernst</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>District Public Health Authority, Cochem, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vogt</LastName><ForeName>Manfred</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Federal State Agency for Consumer and Health Protection Rhineland-Palatinate, Koblenz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jahn</LastName><ForeName>Klaus</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Ministry of Health, Federal State of Rhineland-Palatinate, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Simiao</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Heidelberg Institute of Global Heath, University Hospitals, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bärnighausen</LastName><ForeName>Till</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Global Health and Population, Harvard School of Public Health, Boston, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Harvard Center for Population and Development Studies, Harvard University, Cambridge, United States.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Heidelberg Institute of Global Heath, University Hospitals, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zanger</LastName><ForeName>Philipp</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Medical Microbiology and Hygiene, University Hospitals, Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Federal State Agency for Consumer and Health Protection Rhineland-Palatinate, Koblenz, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Heidelberg Institute of Global Heath, University Hospitals, Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Ministry of Health, Federal State of Rhineland-Palatinate, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Palatina Public Health Study Group</CollectiveName><AffiliationInfo><Affiliation>The participating members of the Palatina Public Health Study Group are acknowledged at the end of the article.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Sweden</Country><MedlineTA>Euro Surveill</MedlineTA><NlmUniqueID>100887452</NlmUniqueID><ISSNLinking>1025-496X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017361">Viral Nonstructural Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.7.48</RegistryNumber><NameOfSubstance UI="D012324">RNA Replicase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.7.48</RegistryNumber><NameOfSubstance UI="C000657944">RNA-dependent RNA polymerase, coronavirus</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017934" MajorTopicYN="N">Coronavirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000821" 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Total Environ. 2020 Aug 1;728:138812</Citation><ArticleIdList><ArticleId IdType="pubmed">32335406</ArticleId></ArticleIdList></Reference><Reference><Citation>Stat Med. 1998 Jan 30;17(2):219-38</Citation><ArticleIdList><ArticleId IdType="pubmed">9483730</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Respir J. 2020 Jul 16;56(1):</Citation><ArticleIdList><ArticleId IdType="pubmed">32430428</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2020 May;26(5):672-675</Citation><ArticleIdList><ArticleId IdType="pubmed">32296168</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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