Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019.
Identifieur interne : 000826 ( Main/Corpus ); précédent : 000825; suivant : 000827Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019.
Auteurs : Jiaoyue Zhang ; Wen Kong ; Pengfei Xia ; Ying Xu ; Li Li ; Qin Li ; Li Yang ; Qi Wei ; Hanyu Wang ; Huiqing Li ; Juan Zheng ; Hui Sun ; Wenfang Xia ; Geng Liu ; Xueyu Zhong ; Kangli Qiu ; Yan Li ; Han Wang ; Yuxiu Wang ; Xiaoli Song ; Hua Liu ; Si Xiong ; Yumei Liu ; Zhenhai Cui ; Yu Hu ; Lulu Chen ; An Pan ; Tianshu ZengSource :
- Frontiers in endocrinology [ 1664-2392 ] ; 2020.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Betacoronavirus (isolation & purification), Blood Glucose (metabolism), China (epidemiology), Coronavirus Infections (complications), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (virology), Diabetes Complications (epidemiology), Diabetes Complications (mortality), Diabetes Complications (virology), Diabetes Mellitus (physiopathology), Diabetes Mellitus (virology), Fasting (MeSH), Female (MeSH), Follow-Up Studies (MeSH), Glucose Intolerance (complications), Glucose Intolerance (virology), Hospital Mortality (MeSH), Hospitalization (MeSH), Humans (MeSH), Hyperglycemia (complications), Hyperglycemia (virology), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (epidemiology), Pneumonia, Viral (mortality), Pneumonia, Viral (virology), Prognosis (MeSH), Retrospective Studies (MeSH), Risk Factors (MeSH), Severity of Illness Index (MeSH), Survival Rate (MeSH).
- MESH :
- chemical , metabolism : Blood Glucose.
- geographic , epidemiology : China.
- complications : Coronavirus Infections, Glucose Intolerance, Hyperglycemia, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Diabetes Complications, Pneumonia, Viral.
- isolation & purification : Betacoronavirus.
- mortality : Coronavirus Infections, Diabetes Complications, Pneumonia, Viral.
- physiopathology : Diabetes Mellitus.
- virology : Coronavirus Infections, Diabetes Complications, Diabetes Mellitus, Glucose Intolerance, Hyperglycemia, Pneumonia, Viral.
- Adult, Aged, Fasting, Female, Follow-Up Studies, Hospital Mortality, Hospitalization, Humans, Male, Middle Aged, Pandemics, Prognosis, Retrospective Studies, Risk Factors, Severity of Illness Index, Survival Rate.
Abstract
Background: Diabetes correlates with poor prognosis in patients with COVID-19, but very few studies have evaluated whether impaired fasting glucose (IFG) is also a risk factor for the poor outcomes of patients with COVID-19. Here we aimed to examine the associations between IFG and diabetes at admission with risks of complications and mortality among patients with COVID-19. Methods: In this multicenter retrospective cohort study, we enrolled 312 hospitalized patients with COVID-19 from 5 hospitals in Wuhan from Jan 1 to Mar 17, 2020. Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. The associations between hyperglycemia and diabetes status at admission with primary composite end-point events (including mechanical ventilation, admission to intensive care unit, or death) were analyzed by Cox proportional hazards regression models. Results: The median age of the patients was 57 years (interquartile range 38-66), and 172 (55%) were women. At the time of hospital admission, 84 (27%) had diabetes (and 36 were new-diagnosed), 62 (20%) had IFG, and 166 (53%) had normal fasting glucose (NFG) levels. Compared to patients with NFG, patients with IFG and diabetes developed more primary composite end-point events (9 [5%], 11 [18%], 26 [31%]), including receiving mechanical ventilation (5 [3%], 6 [10%], 21 [25%]), and death (4 [2%], 9 [15%], 20 [24%]). Multivariable Cox regression analyses showed diabetes was associated increased risks of primary composite end-point events (hazard ratio 3.53; 95% confidence interval 1.48-8.40) and mortality (6.25; 1.91-20.45), and IFG was associated with an increased risk of mortality (4.11; 1.15-14.74), after adjusting for age, sex, hospitals and comorbidities. Conclusion: IFG and diabetes at admission were associated with higher risks of adverse outcomes among patients with COVID-19.
DOI: 10.3389/fendo.2020.00525
PubMed: 32754119
PubMed Central: PMC7365851
Links to Exploration step
pubmed:32754119Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019.</title><author><name sortKey="Zhang, Jiaoyue" sort="Zhang, Jiaoyue" uniqKey="Zhang J" first="Jiaoyue" last="Zhang">Jiaoyue Zhang</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kong, Wen" sort="Kong, Wen" uniqKey="Kong W" first="Wen" last="Kong">Wen Kong</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xia, Pengfei" sort="Xia, Pengfei" uniqKey="Xia P" first="Pengfei" last="Xia">Pengfei Xia</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Ying" sort="Xu, Ying" uniqKey="Xu Y" first="Ying" last="Xu">Ying Xu</name><affiliation><nlm:affiliation>Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation><nlm:affiliation>Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><affiliation><nlm:affiliation>Department of Endocrinology, General Hospital of the Yangtze River Shipping, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Li" sort="Yang, Li" uniqKey="Yang L" first="Li" last="Yang">Li Yang</name><affiliation><nlm:affiliation>Department of Endocrinology, Hankou Hospital of Wuhan City, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Qi" sort="Wei, Qi" uniqKey="Wei Q" first="Qi" last="Wei">Qi Wei</name><affiliation><nlm:affiliation>Department of Endocrinology, Red Cross Hospital of Wuhan City, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hanyu" sort="Wang, Hanyu" uniqKey="Wang H" first="Hanyu" last="Wang">Hanyu Wang</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Huiqing" sort="Li, Huiqing" uniqKey="Li H" first="Huiqing" last="Li">Huiqing Li</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Juan" sort="Zheng, Juan" uniqKey="Zheng J" first="Juan" last="Zheng">Juan Zheng</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Hui" sort="Sun, Hui" uniqKey="Sun H" first="Hui" last="Sun">Hui Sun</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xia, Wenfang" sort="Xia, Wenfang" uniqKey="Xia W" first="Wenfang" last="Xia">Wenfang Xia</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Geng" sort="Liu, Geng" uniqKey="Liu G" first="Geng" last="Liu">Geng Liu</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Xueyu" sort="Zhong, Xueyu" uniqKey="Zhong X" first="Xueyu" last="Zhong">Xueyu Zhong</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qiu, Kangli" sort="Qiu, Kangli" uniqKey="Qiu K" first="Kangli" last="Qiu">Kangli Qiu</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><affiliation><nlm:affiliation>Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Han" sort="Wang, Han" uniqKey="Wang H" first="Han" last="Wang">Han Wang</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yuxiu" sort="Wang, Yuxiu" uniqKey="Wang Y" first="Yuxiu" last="Wang">Yuxiu Wang</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Xiaoli" sort="Song, Xiaoli" uniqKey="Song X" first="Xiaoli" last="Song">Xiaoli Song</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Hua" sort="Liu, Hua" uniqKey="Liu H" first="Hua" last="Liu">Hua Liu</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiong, Si" sort="Xiong, Si" uniqKey="Xiong S" first="Si" last="Xiong">Si Xiong</name><affiliation><nlm:affiliation>Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Yumei" sort="Liu, Yumei" uniqKey="Liu Y" first="Yumei" last="Liu">Yumei Liu</name><affiliation><nlm:affiliation>Department of Endocrinology, Hankou Hospital of Wuhan City, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cui, Zhenhai" sort="Cui, Zhenhai" uniqKey="Cui Z" first="Zhenhai" last="Cui">Zhenhai Cui</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Yu" sort="Hu, Yu" uniqKey="Hu Y" first="Yu" last="Hu">Yu Hu</name><affiliation><nlm:affiliation>Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Clinical and Research Centre of Thrombosis and Haemostasis, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Lulu" sort="Chen, Lulu" uniqKey="Chen L" first="Lulu" last="Chen">Lulu Chen</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Pan, An" sort="Pan, An" uniqKey="Pan A" first="An" last="Pan">An Pan</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zeng, Tianshu" sort="Zeng, Tianshu" uniqKey="Zeng T" first="Tianshu" last="Zeng">Tianshu Zeng</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32754119</idno><idno type="pmid">32754119</idno><idno type="doi">10.3389/fendo.2020.00525</idno><idno type="pmc">PMC7365851</idno><idno type="wicri:Area/Main/Corpus">000826</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000826</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019.</title><author><name sortKey="Zhang, Jiaoyue" sort="Zhang, Jiaoyue" uniqKey="Zhang J" first="Jiaoyue" last="Zhang">Jiaoyue Zhang</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kong, Wen" sort="Kong, Wen" uniqKey="Kong W" first="Wen" last="Kong">Wen Kong</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xia, Pengfei" sort="Xia, Pengfei" uniqKey="Xia P" first="Pengfei" last="Xia">Pengfei Xia</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Ying" sort="Xu, Ying" uniqKey="Xu Y" first="Ying" last="Xu">Ying Xu</name><affiliation><nlm:affiliation>Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation><nlm:affiliation>Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><affiliation><nlm:affiliation>Department of Endocrinology, General Hospital of the Yangtze River Shipping, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Li" sort="Yang, Li" uniqKey="Yang L" first="Li" last="Yang">Li Yang</name><affiliation><nlm:affiliation>Department of Endocrinology, Hankou Hospital of Wuhan City, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Qi" sort="Wei, Qi" uniqKey="Wei Q" first="Qi" last="Wei">Qi Wei</name><affiliation><nlm:affiliation>Department of Endocrinology, Red Cross Hospital of Wuhan City, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Hanyu" sort="Wang, Hanyu" uniqKey="Wang H" first="Hanyu" last="Wang">Hanyu Wang</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Huiqing" sort="Li, Huiqing" uniqKey="Li H" first="Huiqing" last="Li">Huiqing Li</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Juan" sort="Zheng, Juan" uniqKey="Zheng J" first="Juan" last="Zheng">Juan Zheng</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Hui" sort="Sun, Hui" uniqKey="Sun H" first="Hui" last="Sun">Hui Sun</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xia, Wenfang" sort="Xia, Wenfang" uniqKey="Xia W" first="Wenfang" last="Xia">Wenfang Xia</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Geng" sort="Liu, Geng" uniqKey="Liu G" first="Geng" last="Liu">Geng Liu</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Xueyu" sort="Zhong, Xueyu" uniqKey="Zhong X" first="Xueyu" last="Zhong">Xueyu Zhong</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qiu, Kangli" sort="Qiu, Kangli" uniqKey="Qiu K" first="Kangli" last="Qiu">Kangli Qiu</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><affiliation><nlm:affiliation>Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Han" sort="Wang, Han" uniqKey="Wang H" first="Han" last="Wang">Han Wang</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yuxiu" sort="Wang, Yuxiu" uniqKey="Wang Y" first="Yuxiu" last="Wang">Yuxiu Wang</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Xiaoli" sort="Song, Xiaoli" uniqKey="Song X" first="Xiaoli" last="Song">Xiaoli Song</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Hua" sort="Liu, Hua" uniqKey="Liu H" first="Hua" last="Liu">Hua Liu</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiong, Si" sort="Xiong, Si" uniqKey="Xiong S" first="Si" last="Xiong">Si Xiong</name><affiliation><nlm:affiliation>Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Yumei" sort="Liu, Yumei" uniqKey="Liu Y" first="Yumei" last="Liu">Yumei Liu</name><affiliation><nlm:affiliation>Department of Endocrinology, Hankou Hospital of Wuhan City, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cui, Zhenhai" sort="Cui, Zhenhai" uniqKey="Cui Z" first="Zhenhai" last="Cui">Zhenhai Cui</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Yu" sort="Hu, Yu" uniqKey="Hu Y" first="Yu" last="Hu">Yu Hu</name><affiliation><nlm:affiliation>Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Clinical and Research Centre of Thrombosis and Haemostasis, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Lulu" sort="Chen, Lulu" uniqKey="Chen L" first="Lulu" last="Chen">Lulu Chen</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Pan, An" sort="Pan, An" uniqKey="Pan A" first="An" last="Pan">An Pan</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zeng, Tianshu" sort="Zeng, Tianshu" uniqKey="Zeng T" first="Tianshu" last="Zeng">Tianshu Zeng</name><affiliation><nlm:affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Frontiers in endocrinology</title><idno type="ISSN">1664-2392</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Betacoronavirus (isolation & purification)</term><term>Blood Glucose (metabolism)</term><term>China (epidemiology)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (virology)</term><term>Diabetes Complications (epidemiology)</term><term>Diabetes Complications (mortality)</term><term>Diabetes Complications (virology)</term><term>Diabetes Mellitus (physiopathology)</term><term>Diabetes Mellitus (virology)</term><term>Fasting (MeSH)</term><term>Female (MeSH)</term><term>Follow-Up Studies (MeSH)</term><term>Glucose Intolerance (complications)</term><term>Glucose Intolerance (virology)</term><term>Hospital Mortality (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Hyperglycemia (complications)</term><term>Hyperglycemia (virology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (virology)</term><term>Prognosis (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Risk Factors (MeSH)</term><term>Severity of Illness Index (MeSH)</term><term>Survival Rate (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Glucose Intolerance</term><term>Hyperglycemia</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Diabetes Complications</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Diabetes Complications</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Diabetes Mellitus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Diabetes Complications</term><term>Diabetes Mellitus</term><term>Glucose Intolerance</term><term>Hyperglycemia</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Fasting</term><term>Female</term><term>Follow-Up Studies</term><term>Hospital Mortality</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prognosis</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Survival Rate</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><b>Background:</b> Diabetes correlates with poor prognosis in patients with COVID-19, but very few studies have evaluated whether impaired fasting glucose (IFG) is also a risk factor for the poor outcomes of patients with COVID-19. Here we aimed to examine the associations between IFG and diabetes at admission with risks of complications and mortality among patients with COVID-19. <b>Methods:</b> In this multicenter retrospective cohort study, we enrolled 312 hospitalized patients with COVID-19 from 5 hospitals in Wuhan from Jan 1 to Mar 17, 2020. Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. The associations between hyperglycemia and diabetes status at admission with primary composite end-point events (including mechanical ventilation, admission to intensive care unit, or death) were analyzed by Cox proportional hazards regression models. <b>Results:</b> The median age of the patients was 57 years (interquartile range 38-66), and 172 (55%) were women. At the time of hospital admission, 84 (27%) had diabetes (and 36 were new-diagnosed), 62 (20%) had IFG, and 166 (53%) had normal fasting glucose (NFG) levels. Compared to patients with NFG, patients with IFG and diabetes developed more primary composite end-point events (9 [5%], 11 [18%], 26 [31%]), including receiving mechanical ventilation (5 [3%], 6 [10%], 21 [25%]), and death (4 [2%], 9 [15%], 20 [24%]). Multivariable Cox regression analyses showed diabetes was associated increased risks of primary composite end-point events (hazard ratio 3.53; 95% confidence interval 1.48-8.40) and mortality (6.25; 1.91-20.45), and IFG was associated with an increased risk of mortality (4.11; 1.15-14.74), after adjusting for age, sex, hospitals and comorbidities. <b>Conclusion:</b> IFG and diabetes at admission were associated with higher risks of adverse outcomes among patients with COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32754119</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>21</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>21</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-2392</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Frontiers in endocrinology</Title><ISOAbbreviation>Front Endocrinol (Lausanne)</ISOAbbreviation></Journal><ArticleTitle>Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019.</ArticleTitle><Pagination><MedlinePgn>525</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fendo.2020.00525</ELocationID><Abstract><AbstractText><b>Background:</b> Diabetes correlates with poor prognosis in patients with COVID-19, but very few studies have evaluated whether impaired fasting glucose (IFG) is also a risk factor for the poor outcomes of patients with COVID-19. Here we aimed to examine the associations between IFG and diabetes at admission with risks of complications and mortality among patients with COVID-19. <b>Methods:</b> In this multicenter retrospective cohort study, we enrolled 312 hospitalized patients with COVID-19 from 5 hospitals in Wuhan from Jan 1 to Mar 17, 2020. Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. The associations between hyperglycemia and diabetes status at admission with primary composite end-point events (including mechanical ventilation, admission to intensive care unit, or death) were analyzed by Cox proportional hazards regression models. <b>Results:</b> The median age of the patients was 57 years (interquartile range 38-66), and 172 (55%) were women. At the time of hospital admission, 84 (27%) had diabetes (and 36 were new-diagnosed), 62 (20%) had IFG, and 166 (53%) had normal fasting glucose (NFG) levels. Compared to patients with NFG, patients with IFG and diabetes developed more primary composite end-point events (9 [5%], 11 [18%], 26 [31%]), including receiving mechanical ventilation (5 [3%], 6 [10%], 21 [25%]), and death (4 [2%], 9 [15%], 20 [24%]). Multivariable Cox regression analyses showed diabetes was associated increased risks of primary composite end-point events (hazard ratio 3.53; 95% confidence interval 1.48-8.40) and mortality (6.25; 1.91-20.45), and IFG was associated with an increased risk of mortality (4.11; 1.15-14.74), after adjusting for age, sex, hospitals and comorbidities. <b>Conclusion:</b> IFG and diabetes at admission were associated with higher risks of adverse outcomes among patients with COVID-19.</AbstractText><CopyrightInformation>Copyright © 2020 Zhang, Kong, Xia, Xu, Li, Li, Yang, Wei, Wang, Li, Zheng, Sun, Xia, Liu, Zhong, Qiu, Li, Wang, Wang, Song, Liu, Xiong, Liu, Cui, Hu, Chen, Pan and Zeng.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jiaoyue</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kong</LastName><ForeName>Wen</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xia</LastName><ForeName>Pengfei</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Qin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, General Hospital of the Yangtze River Shipping, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Hankou Hospital of Wuhan City, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Qi</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Red Cross Hospital of Wuhan City, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hanyu</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Huiqing</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Hui</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xia</LastName><ForeName>Wenfang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Geng</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhong</LastName><ForeName>Xueyu</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qiu</LastName><ForeName>Kangli</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Han</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yuxiu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Xiaoli</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hua</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>Si</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yumei</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Hankou Hospital of Wuhan City, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cui</LastName><ForeName>Zhenhai</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Clinical and Research Centre of Thrombosis and Haemostasis, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Lulu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pan</LastName><ForeName>An</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeng</LastName><ForeName>Tianshu</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Endocrinol (Lausanne)</MedlineTA><NlmUniqueID>101555782</NlmUniqueID><ISSNLinking>1664-2392</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001786">Blood Glucose</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001786" MajorTopicYN="N">Blood Glucose</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D048909" MajorTopicYN="N">Diabetes Complications</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003920" MajorTopicYN="N">Diabetes Mellitus</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005215" MajorTopicYN="N">Fasting</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018149" MajorTopicYN="N">Glucose Intolerance</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006943" MajorTopicYN="N">Hyperglycemia</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">cohort study</Keyword><Keyword MajorTopicYN="Y">coronavirus</Keyword><Keyword MajorTopicYN="Y">diabetes</Keyword><Keyword MajorTopicYN="Y">hyperglycemia</Keyword><Keyword MajorTopicYN="Y">impaired fasting glucose</Keyword><Keyword MajorTopicYN="Y">severe acute respiratory coronavirus 2 (SARS-CoV-2)</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId 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