Cerebral Microbleeds and Leukoencephalopathy in Critically Ill Patients With COVID-19.
Identifieur interne : 000819 ( Main/Corpus ); précédent : 000818; suivant : 000820Cerebral Microbleeds and Leukoencephalopathy in Critically Ill Patients With COVID-19.
Auteurs : Shashank Agarwal ; Rajan Jain ; Siddhant Dogra ; Penina Krieger ; Ariane Lewis ; Vinh Nguyen ; Kara Melmed ; Steven GalettaSource :
- Stroke [ 1524-4628 ] ; 2020.
English descriptors
- KwdEn :
- Aged (MeSH), Cerebral Hemorrhage (complications), Cerebral Hemorrhage (diagnostic imaging), Cerebral Hemorrhage (epidemiology), Coronavirus Infections (complications), Coronavirus Infections (diagnostic imaging), Coronavirus Infections (epidemiology), Critical Illness (MeSH), Female (MeSH), Fibrin Fibrinogen Degradation Products (analysis), Hospitalization (MeSH), Humans (MeSH), International Normalized Ratio (MeSH), Length of Stay (MeSH), Leukoencephalopathies (complications), Leukoencephalopathies (diagnostic imaging), Leukoencephalopathies (epidemiology), Magnetic Resonance Imaging (MeSH), Male (MeSH), Middle Aged (MeSH), New York City (epidemiology), Pandemics (MeSH), Platelet Count (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (diagnostic imaging), Pneumonia, Viral (epidemiology), Prevalence (MeSH), Pulmonary Disease, Chronic Obstructive (complications), Pulmonary Disease, Chronic Obstructive (epidemiology), Respiration, Artificial (statistics & numerical data), Retrospective Studies (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical , analysis : Fibrin Fibrinogen Degradation Products.
- geographic , epidemiology : New York City.
- complications : Cerebral Hemorrhage, Coronavirus Infections, Leukoencephalopathies, Pneumonia, Viral, Pulmonary Disease, Chronic Obstructive.
- diagnostic imaging : Cerebral Hemorrhage, Coronavirus Infections, Leukoencephalopathies, Pneumonia, Viral.
- epidemiology : Cerebral Hemorrhage, Coronavirus Infections, Leukoencephalopathies, Pneumonia, Viral, Pulmonary Disease, Chronic Obstructive.
- statistics & numerical data : Respiration, Artificial.
- Aged, Critical Illness, Female, Hospitalization, Humans, International Normalized Ratio, Length of Stay, Magnetic Resonance Imaging, Male, Middle Aged, Pandemics, Platelet Count, Prevalence, Retrospective Studies, Treatment Outcome.
Abstract
BACKGROUND AND PURPOSE
We conducted this study to investigate the prevalence and distribution of cerebral microbleeds and leukoencephalopathy in hospitalized patients with coronavirus disease 2019 (COVID-19) and correlate with clinical, laboratory, and functional outcomes.
METHODS
We performed a retrospective chart review of 4131 COVID-19 positive adult patients who were admitted to 3 tertiary care hospitals of an academic medical center at the epicenter of the COVID-19 pandemic in New York City from March 1, 2020, to May 10, 2020, to identify patients who had magnetic resonance imaging (MRI) of the brain. We evaluated the MRIs in detail, and identified a subset of patients with leukoencephalopathy and/or cerebral microbleeds. We compared clinical, laboratory, and functional outcomes for these patients to patients who had a brain MRI that did not show these findings.
RESULTS
Of 115 patients who had an MRI of the brain performed, 35 (30.4%) patients had leukoencephalopathy and/or cerebral microbleeds. Patients with leukoencephalopathy and/or cerebral microbleeds had neuroimaging performed later during the hospitalization course (27 versus 10.6 days;
CONCLUSIONS
The presence of leukoencephalopathy and/or cerebral microbleeds is associated with a critical illness, increased mortality, and worse functional outcome in patients with COVID-19.
DOI: 10.1161/STROKEAHA.120.030940
PubMed: 32755456
PubMed Central: PMC7434006
Links to Exploration step
pubmed:32755456Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebral Microbleeds and Leukoencephalopathy in Critically Ill Patients With COVID-19.</title><author><name sortKey="Agarwal, Shashank" sort="Agarwal, Shashank" uniqKey="Agarwal S" first="Shashank" last="Agarwal">Shashank Agarwal</name><affiliation><nlm:affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Jain, Rajan" sort="Jain, Rajan" uniqKey="Jain R" first="Rajan" last="Jain">Rajan Jain</name><affiliation><nlm:affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Neurosurgery (R.J., A.L., K.M.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Dogra, Siddhant" sort="Dogra, Siddhant" uniqKey="Dogra S" first="Siddhant" last="Dogra">Siddhant Dogra</name><affiliation><nlm:affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Krieger, Penina" sort="Krieger, Penina" uniqKey="Krieger P" first="Penina" last="Krieger">Penina Krieger</name><affiliation><nlm:affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Lewis, Ariane" sort="Lewis, Ariane" uniqKey="Lewis A" first="Ariane" last="Lewis">Ariane Lewis</name><affiliation><nlm:affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Neurosurgery (R.J., A.L., K.M.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen, Vinh" sort="Nguyen, Vinh" uniqKey="Nguyen V" first="Vinh" last="Nguyen">Vinh Nguyen</name><affiliation><nlm:affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Melmed, Kara" sort="Melmed, Kara" uniqKey="Melmed K" first="Kara" last="Melmed">Kara Melmed</name><affiliation><nlm:affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Neurosurgery (R.J., A.L., K.M.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Galetta, Steven" sort="Galetta, Steven" uniqKey="Galetta S" first="Steven" last="Galetta">Steven Galetta</name><affiliation><nlm:affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32755456</idno><idno type="pmid">32755456</idno><idno type="doi">10.1161/STROKEAHA.120.030940</idno><idno type="pmc">PMC7434006</idno><idno type="wicri:Area/Main/Corpus">000819</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000819</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cerebral Microbleeds and Leukoencephalopathy in Critically Ill Patients With COVID-19.</title><author><name sortKey="Agarwal, Shashank" sort="Agarwal, Shashank" uniqKey="Agarwal S" first="Shashank" last="Agarwal">Shashank Agarwal</name><affiliation><nlm:affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Jain, Rajan" sort="Jain, Rajan" uniqKey="Jain R" first="Rajan" last="Jain">Rajan Jain</name><affiliation><nlm:affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Neurosurgery (R.J., A.L., K.M.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Dogra, Siddhant" sort="Dogra, Siddhant" uniqKey="Dogra S" first="Siddhant" last="Dogra">Siddhant Dogra</name><affiliation><nlm:affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Krieger, Penina" sort="Krieger, Penina" uniqKey="Krieger P" first="Penina" last="Krieger">Penina Krieger</name><affiliation><nlm:affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Lewis, Ariane" sort="Lewis, Ariane" uniqKey="Lewis A" first="Ariane" last="Lewis">Ariane Lewis</name><affiliation><nlm:affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Neurosurgery (R.J., A.L., K.M.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Nguyen, Vinh" sort="Nguyen, Vinh" uniqKey="Nguyen V" first="Vinh" last="Nguyen">Vinh Nguyen</name><affiliation><nlm:affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Melmed, Kara" sort="Melmed, Kara" uniqKey="Melmed K" first="Kara" last="Melmed">Kara Melmed</name><affiliation><nlm:affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Neurosurgery (R.J., A.L., K.M.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Galetta, Steven" sort="Galetta, Steven" uniqKey="Galetta S" first="Steven" last="Galetta">Steven Galetta</name><affiliation><nlm:affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Stroke</title><idno type="eISSN">1524-4628</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Cerebral Hemorrhage (complications)</term><term>Cerebral Hemorrhage (diagnostic imaging)</term><term>Cerebral Hemorrhage (epidemiology)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (diagnostic imaging)</term><term>Coronavirus Infections (epidemiology)</term><term>Critical Illness (MeSH)</term><term>Female (MeSH)</term><term>Fibrin Fibrinogen Degradation Products (analysis)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>International Normalized Ratio (MeSH)</term><term>Length of Stay (MeSH)</term><term>Leukoencephalopathies (complications)</term><term>Leukoencephalopathies (diagnostic imaging)</term><term>Leukoencephalopathies (epidemiology)</term><term>Magnetic Resonance Imaging (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>New York City (epidemiology)</term><term>Pandemics (MeSH)</term><term>Platelet Count (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (diagnostic imaging)</term><term>Pneumonia, Viral (epidemiology)</term><term>Prevalence (MeSH)</term><term>Pulmonary Disease, Chronic Obstructive (complications)</term><term>Pulmonary Disease, Chronic Obstructive (epidemiology)</term><term>Respiration, Artificial (statistics & numerical data)</term><term>Retrospective Studies (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fibrin Fibrinogen Degradation Products</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>New York City</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cerebral Hemorrhage</term><term>Coronavirus Infections</term><term>Leukoencephalopathies</term><term>Pneumonia, Viral</term><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Cerebral Hemorrhage</term><term>Coronavirus Infections</term><term>Leukoencephalopathies</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cerebral Hemorrhage</term><term>Coronavirus Infections</term><term>Leukoencephalopathies</term><term>Pneumonia, Viral</term><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Critical Illness</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>International Normalized Ratio</term><term>Length of Stay</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Platelet Count</term><term>Prevalence</term><term>Retrospective Studies</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND AND PURPOSE</b></p><p>We conducted this study to investigate the prevalence and distribution of cerebral microbleeds and leukoencephalopathy in hospitalized patients with coronavirus disease 2019 (COVID-19) and correlate with clinical, laboratory, and functional outcomes.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We performed a retrospective chart review of 4131 COVID-19 positive adult patients who were admitted to 3 tertiary care hospitals of an academic medical center at the epicenter of the COVID-19 pandemic in New York City from March 1, 2020, to May 10, 2020, to identify patients who had magnetic resonance imaging (MRI) of the brain. We evaluated the MRIs in detail, and identified a subset of patients with leukoencephalopathy and/or cerebral microbleeds. We compared clinical, laboratory, and functional outcomes for these patients to patients who had a brain MRI that did not show these findings.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Of 115 patients who had an MRI of the brain performed, 35 (30.4%) patients had leukoencephalopathy and/or cerebral microbleeds. Patients with leukoencephalopathy and/or cerebral microbleeds had neuroimaging performed later during the hospitalization course (27 versus 10.6 days; </p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The presence of leukoencephalopathy and/or cerebral microbleeds is associated with a critical illness, increased mortality, and worse functional outcome in patients with COVID-19.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32755456</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>09</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4628</ISSN><JournalIssue CitedMedium="Internet"><Volume>51</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>09</Month></PubDate></JournalIssue><Title>Stroke</Title><ISOAbbreviation>Stroke</ISOAbbreviation></Journal><ArticleTitle>Cerebral Microbleeds and Leukoencephalopathy in Critically Ill Patients With COVID-19.</ArticleTitle><Pagination><MedlinePgn>2649-2655</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1161/STROKEAHA.120.030940</ELocationID><Abstract><AbstractText Label="BACKGROUND AND PURPOSE">We conducted this study to investigate the prevalence and distribution of cerebral microbleeds and leukoencephalopathy in hospitalized patients with coronavirus disease 2019 (COVID-19) and correlate with clinical, laboratory, and functional outcomes.</AbstractText><AbstractText Label="METHODS">We performed a retrospective chart review of 4131 COVID-19 positive adult patients who were admitted to 3 tertiary care hospitals of an academic medical center at the epicenter of the COVID-19 pandemic in New York City from March 1, 2020, to May 10, 2020, to identify patients who had magnetic resonance imaging (MRI) of the brain. We evaluated the MRIs in detail, and identified a subset of patients with leukoencephalopathy and/or cerebral microbleeds. We compared clinical, laboratory, and functional outcomes for these patients to patients who had a brain MRI that did not show these findings.</AbstractText><AbstractText Label="RESULTS">Of 115 patients who had an MRI of the brain performed, 35 (30.4%) patients had leukoencephalopathy and/or cerebral microbleeds. Patients with leukoencephalopathy and/or cerebral microbleeds had neuroimaging performed later during the hospitalization course (27 versus 10.6 days; <i>P</i><0.001), were clinically sicker at the time of brain MRI (median GCS 6 versus 14; <i>P</i><0.001), and had higher peak D-dimer levels (8018±6677 versus 3183±3482; <i>P</i><0.001), lower nadir platelet count (116.9±62.2 versus 158.3±76.2; <i>P</i>=0.03), higher peak international normalized ratio (2.2 versus 1.57; <i>P</i><0.001) values when compared with patients who had a brain MRI that did not show these findings. They required longer ventilator support (34.6 versus 9.1 days; <i>P</i><0.001) and were more likely to have moderate and severe acute respiratory distress syndrome score (88.6% versus 23.8%, <i>P</i><0.001). These patients had longer hospitalizations (42.1 versus 20.9 days; <i>P</i><0.001), overall worse functional status on discharge (mRS 5 versus 4; <i>P</i>=0.001), and higher mortality (20% versus 9%; <i>P</i>=0.144).</AbstractText><AbstractText Label="CONCLUSIONS">The presence of leukoencephalopathy and/or cerebral microbleeds is associated with a critical illness, increased mortality, and worse functional outcome in patients with COVID-19.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Agarwal</LastName><ForeName>Shashank</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jain</LastName><ForeName>Rajan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurosurgery (R.J., A.L., K.M.), NYU Langone Health, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dogra</LastName><ForeName>Siddhant</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krieger</LastName><ForeName>Penina</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewis</LastName><ForeName>Ariane</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurosurgery (R.J., A.L., K.M.), NYU Langone Health, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Vinh</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Radiology (R.J., S.D., P.K., V.N.), NYU Langone Health, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melmed</LastName><ForeName>Kara</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurosurgery (R.J., A.L., K.M.), NYU Langone Health, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galetta</LastName><ForeName>Steven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology (S.A., A.L., K.M., S.G.), NYU Langone Health, New York, NY.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Stroke</MedlineTA><NlmUniqueID>0235266</NlmUniqueID><ISSNLinking>0039-2499</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005338">Fibrin Fibrinogen Degradation Products</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C036309">fibrin fragment D</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002543" MajorTopicYN="N">Cerebral Hemorrhage</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005338" MajorTopicYN="N">Fibrin Fibrinogen Degradation Products</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019934" MajorTopicYN="N">International Normalized Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007902" MajorTopicYN="N">Length of Stay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056784" MajorTopicYN="N">Leukoencephalopathies</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009519" MajorTopicYN="N" Type="Geographic">New York City</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010976" MajorTopicYN="N">Platelet Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D029424" MajorTopicYN="N">Pulmonary Disease, Chronic Obstructive</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">coronavirus</Keyword><Keyword MajorTopicYN="Y">critical illness</Keyword><Keyword MajorTopicYN="Y">leukoencephalopathy</Keyword><Keyword MajorTopicYN="Y">microbleeds</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32755456</ArticleId><ArticleId IdType="doi">10.1161/STROKEAHA.120.030940</ArticleId><ArticleId IdType="pmc">PMC7434006</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Front Med. 2020 May 4;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32367431</ArticleId></ArticleIdList></Reference><Reference><Citation>Stroke. 2017 Apr;48(4):1085-1087</Citation><ArticleIdList><ArticleId IdType="pubmed">28235962</ArticleId></ArticleIdList></Reference><Reference><Citation>Radiology. 2020 May 8;:201697</Citation><ArticleIdList><ArticleId IdType="pubmed">32384020</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurol Sci. 2020 Jun 15;413:116832</Citation><ArticleIdList><ArticleId IdType="pubmed">32299017</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2013 Sep 18;17(5):R204</Citation><ArticleIdList><ArticleId IdType="pubmed">24047502</ArticleId></ArticleIdList></Reference><Reference><Citation>Intensive Care Med. 2007 May;33(5):798-806</Citation><ArticleIdList><ArticleId IdType="pubmed">17377766</ArticleId></ArticleIdList></Reference><Reference><Citation>AJNR Am J Neuroradiol. 2020 Aug;41(8):1380-1383</Citation><ArticleIdList><ArticleId IdType="pubmed">32527843</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Regul Homeost Agents. 2020 Mar 14;34(2):327-331</Citation><ArticleIdList><ArticleId IdType="pubmed">32171193</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2015 Sep;43(9):e386-9</Citation><ArticleIdList><ArticleId IdType="pubmed">26110491</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Neurol. 2014 Apr;71(4):510-1</Citation><ArticleIdList><ArticleId IdType="pubmed">24566732</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neuroimaging. 2015 Jul-Aug;25(4):660-1</Citation><ArticleIdList><ArticleId IdType="pubmed">25655097</ArticleId></ArticleIdList></Reference><Reference><Citation>CNS Neurosci Ther. 2020 May;26(5):499-501</Citation><ArticleIdList><ArticleId IdType="pubmed">32266761</ArticleId></ArticleIdList></Reference><Reference><Citation>AJNR Am J Neuroradiol. 2009 Feb;30(2):338-43</Citation><ArticleIdList><ArticleId IdType="pubmed">19001544</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 May 2;395(10234):1417-1418</Citation><ArticleIdList><ArticleId IdType="pubmed">32325026</ArticleId></ArticleIdList></Reference><Reference><Citation>Radiology. 2020 Sep;296(3):E184-E185</Citation><ArticleIdList><ArticleId IdType="pubmed">32407258</ArticleId></ArticleIdList></Reference><Reference><Citation>Radiology. 2020 Aug;296(2):E119-E120</Citation><ArticleIdList><ArticleId IdType="pubmed">32228363</ArticleId></ArticleIdList></Reference><Reference><Citation>AJNR Am J Neuroradiol. 2019 Mar;40(3):464-469</Citation><ArticleIdList><ArticleId IdType="pubmed">30679208</ArticleId></ArticleIdList></Reference><Reference><Citation>AJNR Am J Neuroradiol. 1994 Apr;15(4):763-5</Citation><ArticleIdList><ArticleId IdType="pubmed">8010280</ArticleId></ArticleIdList></Reference><Reference><Citation>AJNR Am J Neuroradiol. 2009 Apr;30(4):825-30</Citation><ArticleIdList><ArticleId IdType="pubmed">19131408</ArticleId></ArticleIdList></Reference><Reference><Citation>Radiology. 2020 May 21;:202040</Citation><ArticleIdList><ArticleId IdType="pubmed">32437314</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Neurol. 2020 Jun 1;77(6):683-690</Citation><ArticleIdList><ArticleId IdType="pubmed">32275288</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurol Sci. 2020 Jul 15;414:116923</Citation><ArticleIdList><ArticleId IdType="pubmed">32447193</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidSeniorV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000819 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000819 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidSeniorV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:32755456
|texte= Cerebral Microbleeds and Leukoencephalopathy in Critically Ill Patients With COVID-19.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:32755456" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a CovidSeniorV1
| This area was generated with Dilib version V0.6.37. |  |