A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.
Identifieur interne : 000705 ( Main/Corpus ); précédent : 000704; suivant : 000706A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.
Auteurs : Mats I. Nilsson ; Andrew Mikhail ; Lucy Lan ; Alessia Di Carlo ; Bethanie Hamilton ; Kristin Barnard ; Bart P. Hettinga ; Erin Hatcher ; Milla G. Tarnopolsky ; Joshua P. Nederveen ; Adam L. Bujak ; Linda May ; Mark A. TarnopolskySource :
- Nutrients [ 2072-6643 ] ; 2020.
English descriptors
- KwdEn :
- Aged (MeSH), Anabolic Agents (therapeutic use), Body Composition (MeSH), Body Fluid Compartments (MeSH), Caseins (therapeutic use), Combined Modality Therapy (MeSH), Creatine (therapeutic use), Dietary Supplements (MeSH), Double-Blind Method (MeSH), Exercise (MeSH), Fatty Acids, Omega-3 (therapeutic use), Humans (MeSH), Male (MeSH), Muscle Fibers, Fast-Twitch (MeSH), Muscle Proteins (MeSH), Muscle Strength (MeSH), Muscle, Skeletal (drug effects), Muscle, Skeletal (metabolism), Muscle, Skeletal (physiology), Quadriceps Muscle (MeSH), Resistance Training (MeSH), Sarcopenia (physiopathology), Sarcopenia (therapy), Self Care (MeSH), Vitamin D (therapeutic use), Vitamins (MeSH), Whey Proteins (therapeutic use).
- MESH :
- chemical , therapeutic use : Anabolic Agents, Caseins, Creatine, Fatty Acids, Omega-3, Vitamin D, Whey Proteins.
- drug effects : Muscle, Skeletal.
- metabolism : Muscle, Skeletal.
- physiology : Muscle, Skeletal.
- physiopathology : Sarcopenia.
- therapy : Sarcopenia.
- Aged, Body Composition, Body Fluid Compartments, Combined Modality Therapy, Dietary Supplements, Double-Blind Method, Exercise, Humans, Male, Muscle Fibers, Fast-Twitch, Muscle Proteins, Muscle Strength, Quadriceps Muscle, Resistance Training, Self Care, Vitamins.
Abstract
Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) and protein supplementation partially protect against sarcopenia under controlled conditions, the efficacy of home-based, unsupervised RE (HBRE) and multi-ingredient supplementation (MIS) is largely unknown. In this randomized, placebo-controlled and double-blind trial, we examined the effects of HBRE/MIS on muscle mass, strength, and function in free-living, older men. Thirty-two sedentary men underwent twelve weeks of home-based resistance band training (3 d/week), in combination with daily intake of a novel five-nutrient supplement ('Muscle5'; M5, n = 16, 77.4 ± 2.8 y) containing whey, micellar casein, creatine, vitamin D, and omega-3 fatty acids, or an isocaloric/isonitrogenous placebo (PLA; n = 16, 74.4 ± 1.3 y), containing collagen and sunflower oil. Appendicular and total lean mass (ASM; +3%, TLM; +2%), lean mass to fat ratios (ASM/% body fat; +6%, TLM/% body fat; +5%), maximal strength (grip; +8%, leg press; +17%), and function (5-Times Sit-to-Stand time; -9%) were significantly improved in the M5 group following HBRE/MIS therapy (pre vs. post tests; p < 0.05). Fast-twitch muscle fiber cross-sectional areas of the quadriceps muscle were also significantly increased in the M5 group post intervention (Type IIa; +30.9%, Type IIx, +28.5%, p < 0.05). Sub-group analysis indicated even greater gains in total lean mass in sarcopenic individuals following HBRE/MIS therapy (TLM; +1.65 kg/+3.4%, p < 0.05). We conclude that the Muscle5 supplement is a safe, well-tolerated, and effective complement to low-intensity, home-based resistance exercise and improves lean mass, strength, and overall muscle quality in old age.
DOI: 10.3390/nu12082391
PubMed: 32785021
PubMed Central: PMC7468764
Links to Exploration step
pubmed:32785021Le document en format XML
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<author><name sortKey="Tarnopolsky, Milla G" sort="Tarnopolsky, Milla G" uniqKey="Tarnopolsky M" first="Milla G" last="Tarnopolsky">Milla G. Tarnopolsky</name>
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<author><name sortKey="Nederveen, Joshua P" sort="Nederveen, Joshua P" uniqKey="Nederveen J" first="Joshua P" last="Nederveen">Joshua P. Nederveen</name>
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</affiliation>
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<author><name sortKey="Bujak, Adam L" sort="Bujak, Adam L" uniqKey="Bujak A" first="Adam L" last="Bujak">Adam L. Bujak</name>
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</affiliation>
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<author><name sortKey="May, Linda" sort="May, Linda" uniqKey="May L" first="Linda" last="May">Linda May</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Tarnopolsky, Mark A" sort="Tarnopolsky, Mark A" uniqKey="Tarnopolsky M" first="Mark A" last="Tarnopolsky">Mark A. Tarnopolsky</name>
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<affiliation><nlm:affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.</title>
<author><name sortKey="Nilsson, Mats I" sort="Nilsson, Mats I" uniqKey="Nilsson M" first="Mats I" last="Nilsson">Mats I. Nilsson</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
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<author><name sortKey="Mikhail, Andrew" sort="Mikhail, Andrew" uniqKey="Mikhail A" first="Andrew" last="Mikhail">Andrew Mikhail</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Department of Kinesiology, McMaster University, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Lan, Lucy" sort="Lan, Lucy" uniqKey="Lan L" first="Lucy" last="Lan">Lucy Lan</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Di Carlo, Alessia" sort="Di Carlo, Alessia" uniqKey="Di Carlo A" first="Alessia" last="Di Carlo">Alessia Di Carlo</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hamilton, Bethanie" sort="Hamilton, Bethanie" uniqKey="Hamilton B" first="Bethanie" last="Hamilton">Bethanie Hamilton</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Barnard, Kristin" sort="Barnard, Kristin" uniqKey="Barnard K" first="Kristin" last="Barnard">Kristin Barnard</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Hettinga, Bart P" sort="Hettinga, Bart P" uniqKey="Hettinga B" first="Bart P" last="Hettinga">Bart P. Hettinga</name>
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</affiliation>
</author>
<author><name sortKey="Hatcher, Erin" sort="Hatcher, Erin" uniqKey="Hatcher E" first="Erin" last="Hatcher">Erin Hatcher</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Tarnopolsky, Milla G" sort="Tarnopolsky, Milla G" uniqKey="Tarnopolsky M" first="Milla G" last="Tarnopolsky">Milla G. Tarnopolsky</name>
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</affiliation>
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<author><name sortKey="Nederveen, Joshua P" sort="Nederveen, Joshua P" uniqKey="Nederveen J" first="Joshua P" last="Nederveen">Joshua P. Nederveen</name>
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</affiliation>
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<author><name sortKey="Bujak, Adam L" sort="Bujak, Adam L" uniqKey="Bujak A" first="Adam L" last="Bujak">Adam L. Bujak</name>
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</affiliation>
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<author><name sortKey="May, Linda" sort="May, Linda" uniqKey="May L" first="Linda" last="May">Linda May</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tarnopolsky, Mark A" sort="Tarnopolsky, Mark A" uniqKey="Tarnopolsky M" first="Mark A" last="Tarnopolsky">Mark A. Tarnopolsky</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
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<series><title level="j">Nutrients</title>
<idno type="eISSN">2072-6643</idno>
<imprint><date when="2020" type="published">2020</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Anabolic Agents (therapeutic use)</term>
<term>Body Composition (MeSH)</term>
<term>Body Fluid Compartments (MeSH)</term>
<term>Caseins (therapeutic use)</term>
<term>Combined Modality Therapy (MeSH)</term>
<term>Creatine (therapeutic use)</term>
<term>Dietary Supplements (MeSH)</term>
<term>Double-Blind Method (MeSH)</term>
<term>Exercise (MeSH)</term>
<term>Fatty Acids, Omega-3 (therapeutic use)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Muscle Fibers, Fast-Twitch (MeSH)</term>
<term>Muscle Proteins (MeSH)</term>
<term>Muscle Strength (MeSH)</term>
<term>Muscle, Skeletal (drug effects)</term>
<term>Muscle, Skeletal (metabolism)</term>
<term>Muscle, Skeletal (physiology)</term>
<term>Quadriceps Muscle (MeSH)</term>
<term>Resistance Training (MeSH)</term>
<term>Sarcopenia (physiopathology)</term>
<term>Sarcopenia (therapy)</term>
<term>Self Care (MeSH)</term>
<term>Vitamin D (therapeutic use)</term>
<term>Vitamins (MeSH)</term>
<term>Whey Proteins (therapeutic use)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anabolic Agents</term>
<term>Caseins</term>
<term>Creatine</term>
<term>Fatty Acids, Omega-3</term>
<term>Vitamin D</term>
<term>Whey Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Sarcopenia</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Sarcopenia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Body Composition</term>
<term>Body Fluid Compartments</term>
<term>Combined Modality Therapy</term>
<term>Dietary Supplements</term>
<term>Double-Blind Method</term>
<term>Exercise</term>
<term>Humans</term>
<term>Male</term>
<term>Muscle Fibers, Fast-Twitch</term>
<term>Muscle Proteins</term>
<term>Muscle Strength</term>
<term>Quadriceps Muscle</term>
<term>Resistance Training</term>
<term>Self Care</term>
<term>Vitamins</term>
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<front><div type="abstract" xml:lang="en">Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) and protein supplementation partially protect against sarcopenia under controlled conditions, the efficacy of home-based, unsupervised RE (HBRE) and multi-ingredient supplementation (MIS) is largely unknown. In this randomized, placebo-controlled and double-blind trial, we examined the effects of HBRE/MIS on muscle mass, strength, and function in free-living, older men. Thirty-two sedentary men underwent twelve weeks of home-based resistance band training (3 d/week), in combination with daily intake of a novel five-nutrient supplement ('Muscle5'; M5, <i>n</i>
= 16, 77.4 ± 2.8 y) containing whey, micellar casein, creatine, vitamin D, and omega-3 fatty acids, or an isocaloric/isonitrogenous placebo (PLA; <i>n</i>
= 16, 74.4 ± 1.3 y), containing collagen and sunflower oil. Appendicular and total lean mass (ASM; +3%, TLM; +2%), lean mass to fat ratios (ASM/% body fat; +6%, TLM/% body fat; +5%), maximal strength (grip; +8%, leg press; +17%), and function (5-Times Sit-to-Stand time; -9%) were significantly improved in the M5 group following HBRE/MIS therapy (pre vs. post tests; <i>p</i>
< 0.05). Fast-twitch muscle fiber cross-sectional areas of the quadriceps muscle were also significantly increased in the M5 group post intervention (Type IIa; +30.9%, Type IIx, +28.5%, <i>p</i>
< 0.05). Sub-group analysis indicated even greater gains in total lean mass in sarcopenic individuals following HBRE/MIS therapy (TLM; +1.65 kg/+3.4%, <i>p</i>
< 0.05). We conclude that the Muscle5 supplement is a safe, well-tolerated, and effective complement to low-intensity, home-based resistance exercise and improves lean mass, strength, and overall muscle quality in old age.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32785021</PMID>
<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>05</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2072-6643</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>12</Volume>
<Issue>8</Issue>
<PubDate><Year>2020</Year>
<Month>Aug</Month>
<Day>10</Day>
</PubDate>
</JournalIssue>
<Title>Nutrients</Title>
<ISOAbbreviation>Nutrients</ISOAbbreviation>
</Journal>
<ArticleTitle>A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E2391</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/nu12082391</ELocationID>
<Abstract><AbstractText>Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) and protein supplementation partially protect against sarcopenia under controlled conditions, the efficacy of home-based, unsupervised RE (HBRE) and multi-ingredient supplementation (MIS) is largely unknown. In this randomized, placebo-controlled and double-blind trial, we examined the effects of HBRE/MIS on muscle mass, strength, and function in free-living, older men. Thirty-two sedentary men underwent twelve weeks of home-based resistance band training (3 d/week), in combination with daily intake of a novel five-nutrient supplement ('Muscle5'; M5, <i>n</i>
= 16, 77.4 ± 2.8 y) containing whey, micellar casein, creatine, vitamin D, and omega-3 fatty acids, or an isocaloric/isonitrogenous placebo (PLA; <i>n</i>
= 16, 74.4 ± 1.3 y), containing collagen and sunflower oil. Appendicular and total lean mass (ASM; +3%, TLM; +2%), lean mass to fat ratios (ASM/% body fat; +6%, TLM/% body fat; +5%), maximal strength (grip; +8%, leg press; +17%), and function (5-Times Sit-to-Stand time; -9%) were significantly improved in the M5 group following HBRE/MIS therapy (pre vs. post tests; <i>p</i>
< 0.05). Fast-twitch muscle fiber cross-sectional areas of the quadriceps muscle were also significantly increased in the M5 group post intervention (Type IIa; +30.9%, Type IIx, +28.5%, <i>p</i>
< 0.05). Sub-group analysis indicated even greater gains in total lean mass in sarcopenic individuals following HBRE/MIS therapy (TLM; +1.65 kg/+3.4%, <i>p</i>
< 0.05). We conclude that the Muscle5 supplement is a safe, well-tolerated, and effective complement to low-intensity, home-based resistance exercise and improves lean mass, strength, and overall muscle quality in old age.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nilsson</LastName>
<ForeName>Mats I</ForeName>
<Initials>MI</Initials>
<Identifier Source="ORCID">0000-0001-5656-5578</Identifier>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mikhail</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Kinesiology, McMaster University, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lan</LastName>
<ForeName>Lucy</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Di Carlo</LastName>
<ForeName>Alessia</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hamilton</LastName>
<ForeName>Bethanie</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barnard</LastName>
<ForeName>Kristin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hettinga</LastName>
<ForeName>Bart P</ForeName>
<Initials>BP</Initials>
<AffiliationInfo><Affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hatcher</LastName>
<ForeName>Erin</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tarnopolsky</LastName>
<ForeName>Milla G</ForeName>
<Initials>MG</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nederveen</LastName>
<ForeName>Joshua P</ForeName>
<Initials>JP</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bujak</LastName>
<ForeName>Adam L</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>May</LastName>
<ForeName>Linda</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tarnopolsky</LastName>
<ForeName>Mark A</ForeName>
<Initials>MA</Initials>
<Identifier Source="ORCID">0000-0003-0312-3746</Identifier>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
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