CovidSeniorV1, Main, Corpus, bibRecord, 000705

A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.

Identifieur interne : 000705 ( Main/Corpus ); précédent : 000704; suivant : 000706

A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.

Auteurs : Mats I. Nilsson ; Andrew Mikhail ; Lucy Lan ; Alessia Di Carlo ; Bethanie Hamilton ; Kristin Barnard ; Bart P. Hettinga ; Erin Hatcher ; Milla G. Tarnopolsky ; Joshua P. Nederveen ; Adam L. Bujak ; Linda May ; Mark A. Tarnopolsky

Source :

Nutrients [ 2072-6643 ] ; 2020.

RBID : pubmed:32785021

English descriptors

KwdEn :
- Aged (MeSH), Anabolic Agents (therapeutic use), Body Composition (MeSH), Body Fluid Compartments (MeSH), Caseins (therapeutic use), Combined Modality Therapy (MeSH), Creatine (therapeutic use), Dietary Supplements (MeSH), Double-Blind Method (MeSH), Exercise (MeSH), Fatty Acids, Omega-3 (therapeutic use), Humans (MeSH), Male (MeSH), Muscle Fibers, Fast-Twitch (MeSH), Muscle Proteins (MeSH), Muscle Strength (MeSH), Muscle, Skeletal (drug effects), Muscle, Skeletal (metabolism), Muscle, Skeletal (physiology), Quadriceps Muscle (MeSH), Resistance Training (MeSH), Sarcopenia (physiopathology), Sarcopenia (therapy), Self Care (MeSH), Vitamin D (therapeutic use), Vitamins (MeSH), Whey Proteins (therapeutic use).
MESH :
- chemical , therapeutic use : Anabolic Agents, Caseins, Creatine, Fatty Acids, Omega-3, Vitamin D, Whey Proteins.
- drug effects : Muscle, Skeletal.
- metabolism : Muscle, Skeletal.
- physiology : Muscle, Skeletal.
- physiopathology : Sarcopenia.
- therapy : Sarcopenia.
- Aged, Body Composition, Body Fluid Compartments, Combined Modality Therapy, Dietary Supplements, Double-Blind Method, Exercise, Humans, Male, Muscle Fibers, Fast-Twitch, Muscle Proteins, Muscle Strength, Quadriceps Muscle, Resistance Training, Self Care, Vitamins.

Abstract

Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) and protein supplementation partially protect against sarcopenia under controlled conditions, the efficacy of home-based, unsupervised RE (HBRE) and multi-ingredient supplementation (MIS) is largely unknown. In this randomized, placebo-controlled and double-blind trial, we examined the effects of HBRE/MIS on muscle mass, strength, and function in free-living, older men. Thirty-two sedentary men underwent twelve weeks of home-based resistance band training (3 d/week), in combination with daily intake of a novel five-nutrient supplement ('Muscle5'; M5, n = 16, 77.4 ± 2.8 y) containing whey, micellar casein, creatine, vitamin D, and omega-3 fatty acids, or an isocaloric/isonitrogenous placebo (PLA; n = 16, 74.4 ± 1.3 y), containing collagen and sunflower oil. Appendicular and total lean mass (ASM; +3%, TLM; +2%), lean mass to fat ratios (ASM/% body fat; +6%, TLM/% body fat; +5%), maximal strength (grip; +8%, leg press; +17%), and function (5-Times Sit-to-Stand time; -9%) were significantly improved in the M5 group following HBRE/MIS therapy (pre vs. post tests; p < 0.05). Fast-twitch muscle fiber cross-sectional areas of the quadriceps muscle were also significantly increased in the M5 group post intervention (Type IIa; +30.9%, Type IIx, +28.5%, p < 0.05). Sub-group analysis indicated even greater gains in total lean mass in sarcopenic individuals following HBRE/MIS therapy (TLM; +1.65 kg/+3.4%, p < 0.05). We conclude that the Muscle5 supplement is a safe, well-tolerated, and effective complement to low-intensity, home-based resistance exercise and improves lean mass, strength, and overall muscle quality in old age.

DOI: 10.3390/nu12082391
PubMed: 32785021
PubMed Central: PMC7468764

Links to Exploration step

pubmed:32785021

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.</title>
<author><name sortKey="Nilsson, Mats I" sort="Nilsson, Mats I" uniqKey="Nilsson M" first="Mats I" last="Nilsson">Mats I. Nilsson</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mikhail, Andrew" sort="Mikhail, Andrew" uniqKey="Mikhail A" first="Andrew" last="Mikhail">Andrew Mikhail</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Department of Kinesiology, McMaster University, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lan, Lucy" sort="Lan, Lucy" uniqKey="Lan L" first="Lucy" last="Lan">Lucy Lan</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Di Carlo, Alessia" sort="Di Carlo, Alessia" uniqKey="Di Carlo A" first="Alessia" last="Di Carlo">Alessia Di Carlo</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hamilton, Bethanie" sort="Hamilton, Bethanie" uniqKey="Hamilton B" first="Bethanie" last="Hamilton">Bethanie Hamilton</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Barnard, Kristin" sort="Barnard, Kristin" uniqKey="Barnard K" first="Kristin" last="Barnard">Kristin Barnard</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hettinga, Bart P" sort="Hettinga, Bart P" uniqKey="Hettinga B" first="Bart P" last="Hettinga">Bart P. Hettinga</name>
<affiliation><nlm:affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hatcher, Erin" sort="Hatcher, Erin" uniqKey="Hatcher E" first="Erin" last="Hatcher">Erin Hatcher</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tarnopolsky, Milla G" sort="Tarnopolsky, Milla G" uniqKey="Tarnopolsky M" first="Milla G" last="Tarnopolsky">Milla G. Tarnopolsky</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nederveen, Joshua P" sort="Nederveen, Joshua P" uniqKey="Nederveen J" first="Joshua P" last="Nederveen">Joshua P. Nederveen</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bujak, Adam L" sort="Bujak, Adam L" uniqKey="Bujak A" first="Adam L" last="Bujak">Adam L. Bujak</name>
<affiliation><nlm:affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="May, Linda" sort="May, Linda" uniqKey="May L" first="Linda" last="May">Linda May</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tarnopolsky, Mark A" sort="Tarnopolsky, Mark A" uniqKey="Tarnopolsky M" first="Mark A" last="Tarnopolsky">Mark A. Tarnopolsky</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32785021</idno>
<idno type="pmid">32785021</idno>
<idno type="doi">10.3390/nu12082391</idno>
<idno type="pmc">PMC7468764</idno>
<idno type="wicri:Area/Main/Corpus">000705</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000705</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.</title>
<author><name sortKey="Nilsson, Mats I" sort="Nilsson, Mats I" uniqKey="Nilsson M" first="Mats I" last="Nilsson">Mats I. Nilsson</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mikhail, Andrew" sort="Mikhail, Andrew" uniqKey="Mikhail A" first="Andrew" last="Mikhail">Andrew Mikhail</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Department of Kinesiology, McMaster University, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lan, Lucy" sort="Lan, Lucy" uniqKey="Lan L" first="Lucy" last="Lan">Lucy Lan</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Di Carlo, Alessia" sort="Di Carlo, Alessia" uniqKey="Di Carlo A" first="Alessia" last="Di Carlo">Alessia Di Carlo</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hamilton, Bethanie" sort="Hamilton, Bethanie" uniqKey="Hamilton B" first="Bethanie" last="Hamilton">Bethanie Hamilton</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Barnard, Kristin" sort="Barnard, Kristin" uniqKey="Barnard K" first="Kristin" last="Barnard">Kristin Barnard</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hettinga, Bart P" sort="Hettinga, Bart P" uniqKey="Hettinga B" first="Bart P" last="Hettinga">Bart P. Hettinga</name>
<affiliation><nlm:affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hatcher, Erin" sort="Hatcher, Erin" uniqKey="Hatcher E" first="Erin" last="Hatcher">Erin Hatcher</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tarnopolsky, Milla G" sort="Tarnopolsky, Milla G" uniqKey="Tarnopolsky M" first="Milla G" last="Tarnopolsky">Milla G. Tarnopolsky</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nederveen, Joshua P" sort="Nederveen, Joshua P" uniqKey="Nederveen J" first="Joshua P" last="Nederveen">Joshua P. Nederveen</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bujak, Adam L" sort="Bujak, Adam L" uniqKey="Bujak A" first="Adam L" last="Bujak">Adam L. Bujak</name>
<affiliation><nlm:affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="May, Linda" sort="May, Linda" uniqKey="May L" first="Linda" last="May">Linda May</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tarnopolsky, Mark A" sort="Tarnopolsky, Mark A" uniqKey="Tarnopolsky M" first="Mark A" last="Tarnopolsky">Mark A. Tarnopolsky</name>
<affiliation><nlm:affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Nutrients</title>
<idno type="eISSN">2072-6643</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Anabolic Agents (therapeutic use)</term>
<term>Body Composition (MeSH)</term>
<term>Body Fluid Compartments (MeSH)</term>
<term>Caseins (therapeutic use)</term>
<term>Combined Modality Therapy (MeSH)</term>
<term>Creatine (therapeutic use)</term>
<term>Dietary Supplements (MeSH)</term>
<term>Double-Blind Method (MeSH)</term>
<term>Exercise (MeSH)</term>
<term>Fatty Acids, Omega-3 (therapeutic use)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Muscle Fibers, Fast-Twitch (MeSH)</term>
<term>Muscle Proteins (MeSH)</term>
<term>Muscle Strength (MeSH)</term>
<term>Muscle, Skeletal (drug effects)</term>
<term>Muscle, Skeletal (metabolism)</term>
<term>Muscle, Skeletal (physiology)</term>
<term>Quadriceps Muscle (MeSH)</term>
<term>Resistance Training (MeSH)</term>
<term>Sarcopenia (physiopathology)</term>
<term>Sarcopenia (therapy)</term>
<term>Self Care (MeSH)</term>
<term>Vitamin D (therapeutic use)</term>
<term>Vitamins (MeSH)</term>
<term>Whey Proteins (therapeutic use)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anabolic Agents</term>
<term>Caseins</term>
<term>Creatine</term>
<term>Fatty Acids, Omega-3</term>
<term>Vitamin D</term>
<term>Whey Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Sarcopenia</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Sarcopenia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Body Composition</term>
<term>Body Fluid Compartments</term>
<term>Combined Modality Therapy</term>
<term>Dietary Supplements</term>
<term>Double-Blind Method</term>
<term>Exercise</term>
<term>Humans</term>
<term>Male</term>
<term>Muscle Fibers, Fast-Twitch</term>
<term>Muscle Proteins</term>
<term>Muscle Strength</term>
<term>Quadriceps Muscle</term>
<term>Resistance Training</term>
<term>Self Care</term>
<term>Vitamins</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) and protein supplementation partially protect against sarcopenia under controlled conditions, the efficacy of home-based, unsupervised RE (HBRE) and multi-ingredient supplementation (MIS) is largely unknown. In this randomized, placebo-controlled and double-blind trial, we examined the effects of HBRE/MIS on muscle mass, strength, and function in free-living, older men. Thirty-two sedentary men underwent twelve weeks of home-based resistance band training (3 d/week), in combination with daily intake of a novel five-nutrient supplement ('Muscle5'; M5, <i>n</i>
 = 16, 77.4 ± 2.8 y) containing whey, micellar casein, creatine, vitamin D, and omega-3 fatty acids, or an isocaloric/isonitrogenous placebo (PLA; <i>n</i>
 = 16, 74.4 ± 1.3 y), containing collagen and sunflower oil. Appendicular and total lean mass (ASM; +3%, TLM; +2%), lean mass to fat ratios (ASM/% body fat; +6%, TLM/% body fat; +5%), maximal strength (grip; +8%, leg press; +17%), and function (5-Times Sit-to-Stand time; -9%) were significantly improved in the M5 group following HBRE/MIS therapy (pre vs. post tests; <i>p</i>
 < 0.05). Fast-twitch muscle fiber cross-sectional areas of the quadriceps muscle were also significantly increased in the M5 group post intervention (Type IIa; +30.9%, Type IIx, +28.5%, <i>p</i>
 < 0.05). Sub-group analysis indicated even greater gains in total lean mass in sarcopenic individuals following HBRE/MIS therapy (TLM; +1.65 kg/+3.4%, <i>p</i>
 < 0.05). We conclude that the Muscle5 supplement is a safe, well-tolerated, and effective complement to low-intensity, home-based resistance exercise and improves lean mass, strength, and overall muscle quality in old age.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32785021</PMID>
<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>05</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2072-6643</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>12</Volume>
<Issue>8</Issue>
<PubDate><Year>2020</Year>
<Month>Aug</Month>
<Day>10</Day>
</PubDate>
</JournalIssue>
<Title>Nutrients</Title>
<ISOAbbreviation>Nutrients</ISOAbbreviation>
</Journal>
<ArticleTitle>A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E2391</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/nu12082391</ELocationID>
<Abstract><AbstractText>Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) and protein supplementation partially protect against sarcopenia under controlled conditions, the efficacy of home-based, unsupervised RE (HBRE) and multi-ingredient supplementation (MIS) is largely unknown. In this randomized, placebo-controlled and double-blind trial, we examined the effects of HBRE/MIS on muscle mass, strength, and function in free-living, older men. Thirty-two sedentary men underwent twelve weeks of home-based resistance band training (3 d/week), in combination with daily intake of a novel five-nutrient supplement ('Muscle5'; M5, <i>n</i>
 = 16, 77.4 ± 2.8 y) containing whey, micellar casein, creatine, vitamin D, and omega-3 fatty acids, or an isocaloric/isonitrogenous placebo (PLA; <i>n</i>
 = 16, 74.4 ± 1.3 y), containing collagen and sunflower oil. Appendicular and total lean mass (ASM; +3%, TLM; +2%), lean mass to fat ratios (ASM/% body fat; +6%, TLM/% body fat; +5%), maximal strength (grip; +8%, leg press; +17%), and function (5-Times Sit-to-Stand time; -9%) were significantly improved in the M5 group following HBRE/MIS therapy (pre vs. post tests; <i>p</i>
 < 0.05). Fast-twitch muscle fiber cross-sectional areas of the quadriceps muscle were also significantly increased in the M5 group post intervention (Type IIa; +30.9%, Type IIx, +28.5%, <i>p</i>
 < 0.05). Sub-group analysis indicated even greater gains in total lean mass in sarcopenic individuals following HBRE/MIS therapy (TLM; +1.65 kg/+3.4%, <i>p</i>
 < 0.05). We conclude that the Muscle5 supplement is a safe, well-tolerated, and effective complement to low-intensity, home-based resistance exercise and improves lean mass, strength, and overall muscle quality in old age.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nilsson</LastName>
<ForeName>Mats I</ForeName>
<Initials>MI</Initials>
<Identifier Source="ORCID">0000-0001-5656-5578</Identifier>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mikhail</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Kinesiology, McMaster University, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lan</LastName>
<ForeName>Lucy</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Di Carlo</LastName>
<ForeName>Alessia</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hamilton</LastName>
<ForeName>Bethanie</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barnard</LastName>
<ForeName>Kristin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hettinga</LastName>
<ForeName>Bart P</ForeName>
<Initials>BP</Initials>
<AffiliationInfo><Affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hatcher</LastName>
<ForeName>Erin</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tarnopolsky</LastName>
<ForeName>Milla G</ForeName>
<Initials>MG</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nederveen</LastName>
<ForeName>Joshua P</ForeName>
<Initials>JP</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bujak</LastName>
<ForeName>Adam L</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>May</LastName>
<ForeName>Linda</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tarnopolsky</LastName>
<ForeName>Mark A</ForeName>
<Initials>MA</Initials>
<Identifier Source="ORCID">0000-0003-0312-3746</Identifier>
<AffiliationInfo><Affiliation>Department of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Exerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>143325</GrantID>
<Acronym>CAPMC</Acronym>
<Agency> CIHR</Agency>
<Country>Canada</Country>
</Grant>
<Grant><GrantID>1</GrantID>
<Acronym>CX</Acronym>
<Agency>CSRD VA</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>10</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Nutrients</MedlineTA>
<NlmUniqueID>101521595</NlmUniqueID>
<ISSNLinking>2072-6643</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D045930">Anabolic Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D002364">Caseins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015525">Fatty Acids, Omega-3</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009124">Muscle Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014815">Vitamins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000067816">Whey Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>1406-16-2</RegistryNumber>
<NameOfSubstance UI="D014807">Vitamin D</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>MU72812GK0</RegistryNumber>
<NameOfSubstance UI="D003401">Creatine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045930" MajorTopicYN="N">Anabolic Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001823" MajorTopicYN="Y">Body Composition</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001825" MajorTopicYN="N">Body Fluid Compartments</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002364" MajorTopicYN="N">Caseins</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003401" MajorTopicYN="N">Creatine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019587" MajorTopicYN="Y">Dietary Supplements</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015444" MajorTopicYN="N">Exercise</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015525" MajorTopicYN="N">Fatty Acids, Omega-3</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018656" MajorTopicYN="N">Muscle Fibers, Fast-Twitch</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009124" MajorTopicYN="N">Muscle Proteins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053580" MajorTopicYN="Y">Muscle Strength</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018482" MajorTopicYN="N">Muscle, Skeletal</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D052097" MajorTopicYN="N">Quadriceps Muscle</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055070" MajorTopicYN="Y">Resistance Training</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055948" MajorTopicYN="N">Sarcopenia</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012648" MajorTopicYN="N">Self Care</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014807" MajorTopicYN="N">Vitamin D</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014815" MajorTopicYN="N">Vitamins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000067816" MajorTopicYN="N">Whey Proteins</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">creatine</Keyword>
<Keyword MajorTopicYN="N">multi-ingredient supplement</Keyword>
<Keyword MajorTopicYN="N">omega-3</Keyword>
<Keyword MajorTopicYN="N">randomized clinical trial</Keyword>
<Keyword MajorTopicYN="N">resistance exercise</Keyword>
<Keyword MajorTopicYN="N">sarcopenia</Keyword>
<Keyword MajorTopicYN="N">vitamin D</Keyword>
<Keyword MajorTopicYN="N">whey</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>07</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>08</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>08</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>8</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>8</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>8</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32785021</ArticleId>
<ArticleId IdType="pii">nu12082391</ArticleId>
<ArticleId IdType="doi">10.3390/nu12082391</ArticleId>
<ArticleId IdType="pmc">PMC7468764</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Front Nutr. 2019 Aug 09;6:124</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31448281</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Nutr. 2020 Jun;39(6):1631-1638</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32305181</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gerontol A Biol Sci Med Sci. 2000 Apr;55(4):M221-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10811152</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ageing Res Rev. 2012 Jul;11(3):404-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22465452</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Age Ageing. 2011 Jul;40(4):423-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21624928</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Med. 2007 Apr;120(4):337-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17398228</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biogerontology. 2013 Jun;14(3):303-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23686362</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Phys Ther Sci. 2016 Nov;28(11):3183-3188</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27942146</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Medicine (Baltimore). 2017 Jun;96(23):e7115</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28591061</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cochrane Database Syst Rev. 2009 Jul 08;(3):CD002759</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19588334</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Endocrinol Metab. 2014 Nov;99(11):4336-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25033068</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biofactors. 2009 Jan-Feb;35(1):28-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19319843</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exerc Sport Sci Rev. 2013 Oct;41(4):216-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23873131</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Sports Med. 2020 May;54(10):573-581</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30824459</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sports Med. 2013 Jul;43(7):627-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23568373</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Can J Appl Physiol. 2001 Feb;26(1):78-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11291626</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gerontol A Biol Sci Med Sci. 2003 Jan;58(1):11-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12560406</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Perspect Clin Res. 2011 Jul;2(3):109-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21897887</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Sci Sports Exerc. 2002 May;34(5):740-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11984288</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurol Sci. 1988 Apr;84(2-3):275-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3379447</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Brain Behav Immun. 2020 Jul;87:184-187</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32454138</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oxid Med Cell Longev. 2017;2017:4234765</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28751932</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Appl Physiol. 2016 May;116(5):885-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26931422</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Clin Nutr. 2011 Feb;93(2):402-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21159787</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Aging Neurosci. 2019 May 09;11:107</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31143111</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Health Promot Chronic Dis Prev Can. 2015 Aug;35(6):87-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26302227</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nutr Metab (Lond). 2011 Oct 05;8:68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21975196</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Prog Mol Biol Transl Sci. 2015;135:355-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26477922</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2012;7(4):e35273</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22530000</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Nutr Health Aging. 2012 Jan;16(1):67-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22238004</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Med Dir Assoc. 2011 May;12(4):249-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21527165</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Wien Med Wochenschr. 2011 Sep;161(17-18):402-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21792531</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Geriatr Soc. 2004 Jan;52(1):80-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14687319</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cochrane Database Syst Rev. 2011 Nov 09;(11):CD004963</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22071817</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Nutr. 2015 Sep;145(9):1981-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26224750</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Environ Res Public Health. 2020 Jun 10;17(11):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32532013</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Pain. 2018 Feb;22(2):333-345</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29235193</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Nutr Health Aging. 2014;18(6):561-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24950145</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Geriatr Soc. 2005 Oct;53(10):1675-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16181165</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Nutr. 2013 Apr;143(4):410-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23343671</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Nutr Metab. 2009;54(4):291-300</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19729890</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Muscle Nerve. 2011 May;43(5):717-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21462204</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Appl Physiol (1985). 1992 Dec;73(6):2517-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1490965</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ageing Res Rev. 2010 Jul;9(3):226-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20385254</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Appl Physiol Nutr Metab. 2016 May;41(5):565-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26960445</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nutrients. 2020 May 19;12(5):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32438620</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Age Ageing. 2019 Jul 1;48(4):601</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31081853</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Appl Physiol (1985). 2003 Oct;95(4):1717-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12970377</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Sci Sports Exerc. 2016 Mar;48(3):543-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26891166</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Cases Miner Bone Metab. 2014 Sep;11(3):177-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25568649</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Diabetes Care. 1981 Jul-Aug;4(4):493-501</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7049632</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Geriatr. 2017 Oct 16;17(1):238</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29037155</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Age Ageing. 2013 Mar;42(2):203-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23321202</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Geriatr Soc. 2009 Feb;57(2):251-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19207142</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Gerontol. 2006 Dec;41(12):1234-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17052879</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Geriatr Soc. 2004 May;52(5):657-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15086643</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Appl Physiol Nutr Metab. 2008 Feb;33(1):213-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18347674</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Geriatr Soc. 2009 Dec;57(12):2183-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20121985</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Nutr Soc. 2018 Feb;77(1):20-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28847314</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Public Health. 2013 Dec 10;13:1161</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24325303</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Age Ageing. 2010 Jul;39(4):412-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20392703</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Physiol. 2009 Jan 15;587(1):211-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19001042</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Geriatr. 2018 May 16;18(1):116</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29769029</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Med. 2018 Nov 26;7(12):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30486262</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Sport Health Sci. 2019 May;8(3):201-217</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31193280</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exerc Sport Sci Rev. 2008 Apr;36(2):51-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18362685</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biogerontology. 2013 Jun;14(3):273-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23666344</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Endocrinol Metab. 2002 Feb;87(2):589-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11836290</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biofactors. 2014 Mar-Apr;40(2):199-205</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24105883</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Gerontol. 2015 Dec;72:99-108</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26341720</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Med Dir Assoc. 2015 Jul 1;16(7):607-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25820131</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Environ Res Public Health. 2020 Apr 13;17(8):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32294922</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 1999 Feb 10;281(6):558-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10022113</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Clin Nutr. 2009 Nov;90(5):1343-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19740975</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Sports Med. 2011 Sep;45(12):987-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21041243</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Sci Sports Exerc. 2000 Jun;32(6):1175-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10862549</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Nutr. 2005 Mar;135(3):376-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15735066</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 1990 Jun 13;263(22):3029-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2342214</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Nutr Rep. 2016 Jun;5(2):99-105</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27398264</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):677-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23183903</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Int Soc Sports Nutr. 2017 Jun 13;14:18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28615996</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Geriatr Soc. 2002 Apr;50(4):655-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11982665</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Scand J Med Sci Sports. 2007 Aug;17(4):422-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17490465</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2007 Oct 03;2(10):e991</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17912368</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Behav Nutr Phys Act. 2011 Jul 28;8:80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21798044</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biology (Basel). 2019 May 11;8(2):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31083586</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2019 Jan 25;14(1):e0210863</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30682077</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Redox Biol. 2020 May;32:101508</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32220789</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exerc Sport Sci Rev. 2009 Oct;37(4):157-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19955864</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Endocrinol Metab. 2020 Aug 1;105(8):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32474598</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2007 May 23;2(5):e465</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17520024</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Geriatr Soc. 2020 Jan;68(1):163-169</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31647585</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Nutr. 2012 Oct;31(5):652-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22414775</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Geriatr. 2016 Oct 5;16(1):170</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27716195</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2017 Jul 18;12(7):e0181387</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28719669</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Physiol. 2013 Jun 1;591(11):2911-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23551944</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sports Med. 2017 Nov;47(11):2341-2361</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28573401</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Heart Circ Physiol. 2000 Mar;278(3):H829-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10710351</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2005 Feb 17;433(7027):760-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15716955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sports Med. 2016 Jan;46(1):125-137</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26403469</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Clin Nutr. 1982 Nov;36(5):936-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7137077</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Skelet Muscle. 2011 Mar 02;1(1):11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21798089</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Aging Neurosci. 2014 Sep 22;6:246</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25295003</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gerontol A Biol Sci Med Sci. 2002 Oct;57(10):B359-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12242311</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Nutr Health Aging. 2011 May;15(5):376-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21528164</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Int Soc Sports Nutr. 2013 May 16;10(1):26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23680457</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Physiol Rev. 2000 Jul;80(3):1107-213</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10893433</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Clin Nutr. 2012 Dec;96(6):1454-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23134885</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>West J Med. 1984 Nov;141(5):691-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6516349</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Appl Physiol Nutr Metab. 2018 Mar;43(3):299-302</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29106814</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gerontol A Biol Sci Med Sci. 2006 Jan;61(1):78-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16456197</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Sports Med. 2018 Mar;52(6):376-384</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28698222</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sports Med. 2004;34(5):329-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15107011</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cochrane Database Syst Rev. 2011 Jul 06;(7):CD000333</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21735380</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Muscle Nerve. 1983 Oct;6(8):588-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6646161</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2020 May;92(5):479-490</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32052466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 May 29;369:m1996</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32471884</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Amino Acids. 2010 May;38(5):1533-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19882215</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 1994 Jun 23;330(25):1769-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8190152</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Nutr. 2018 May 1;9(3):171-182</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29635313</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Geriatr Med. 2011 Aug;27(3):423-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21824556</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Sci Sports Exerc. 2011 Feb;43(2):249-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20543750</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidSeniorV1/Data/Main/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000705 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000705 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    CovidSeniorV1
   |flux=    Main
   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:32785021
   |texte=   A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i   -Sk "pubmed:32785021" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidSeniorV1

This area was generated with Dilib version V0.6.37.
Data generation: Thu Oct 15 09:49:45 2020. Site generation: Wed Jan 27 17:10:23 2021

	Serveur d'exploration sur la COVID chez les séniors
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la COVID chez les séniors

A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.

A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki