Dynamic changes of throat swabs RNA and serum antibodies for SARS-CoV-2 and their diagnostic performances in patients with COVID-19.
Identifieur interne : 000697 ( Main/Corpus ); précédent : 000696; suivant : 000698Dynamic changes of throat swabs RNA and serum antibodies for SARS-CoV-2 and their diagnostic performances in patients with COVID-19.
Auteurs : Xueping Qiu ; Yang Xiang ; Jianbin Sun ; Xinrui Wang ; Guoqiang Chen ; Xianqun Xu ; Shengjun Liao ; Na Yang ; Siwei Li ; Gang Yang ; Yueting Tang ; Junli Fan ; Wen Xie ; Hanning Hu ; Yirong Li ; Fang ZhengSource :
- Emerging microbes & infections [ 2222-1751 ] ; 2020.
English descriptors
- KwdEn :
- Aged (MeSH), Antibodies, Viral (blood), Betacoronavirus (genetics), Betacoronavirus (immunology), Clinical Laboratory Techniques (methods), Coronavirus Infections (diagnosis), Female (MeSH), Humans (MeSH), Immunoglobulin G (blood), Immunoglobulin M (blood), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pharynx (virology), Pneumonia, Viral (diagnosis), RNA, Viral (genetics), RNA, Viral (isolation & purification), Retrospective Studies (MeSH), Reverse Transcriptase Polymerase Chain Reaction (MeSH), Sensitivity and Specificity (MeSH), Seroconversion (MeSH).
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G, Immunoglobulin M.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- genetics : Betacoronavirus, RNA, Viral.
- immunology : Betacoronavirus.
- chemical , isolation & purification : RNA, Viral.
- methods : Clinical Laboratory Techniques.
- virology : Pharynx.
- Aged, Female, Humans, Male, Middle Aged, Pandemics, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Sensitivity and Specificity, Seroconversion.
Abstract
Dynamic changes of RNA and antibodies in SARS-CoV-2 infected patients remain largely unknown, and influence factors for antibody production have not been fully clarified. In this study, consecutive throat swabs specimens (n = 1875) from 187 patients were collected to analyse the dynamic changes of RNA. Moreover, 162 serial serum samples from 31 patients were tested for seroconversion of IgM and IgG. Meanwhile, IgM and IgG were also detected in 409 COVID-19 patients and 389 controls. Additionally, the logistic regression analysis was executed to identify the possible influence factors for antibody production. The median positive conversion time for RNA was day 7 (IQR, 3-11), and the positive rate was highest in day 1-5 (74.59 %) and then gradually decreased. The median time of seroconversion for IgM and IgG were both day 12 (IQR, 10-15). The sensitivity and specificity for IgM (or IgG) was 87.04% and 96.92%, respectively. Multivariate logistic regression indicated that reduced lymphocytes and short positive conversion time for SARS-CoV-2 RNA were independent factors for negative results of IgM and IgG. In conclusion, RNA and antibodies should be combined for COVID-19 diagnosis, and delayed seroconversion was influenced by the decreased lymphocytes and short positive conversion time for RNA.
DOI: 10.1080/22221751.2020.1810133
PubMed: 32787527
Links to Exploration step
pubmed:32787527Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dynamic changes of throat swabs RNA and serum antibodies for SARS-CoV-2 and their diagnostic performances in patients with COVID-19.</title><author><name sortKey="Qiu, Xueping" sort="Qiu, Xueping" uniqKey="Qiu X" first="Xueping" last="Qiu">Xueping Qiu</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiang, Yang" sort="Xiang, Yang" uniqKey="Xiang Y" first="Yang" last="Xiang">Yang Xiang</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Jianbin" sort="Sun, Jianbin" uniqKey="Sun J" first="Jianbin" last="Sun">Jianbin Sun</name><affiliation><nlm:affiliation>Wuhan Third Hospital-Tongren Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xinrui" sort="Wang, Xinrui" uniqKey="Wang X" first="Xinrui" last="Wang">Xinrui Wang</name><affiliation><nlm:affiliation>Hebi City Center for Disease Control and Prevention, Hebi, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Guoqiang" sort="Chen, Guoqiang" uniqKey="Chen G" first="Guoqiang" last="Chen">Guoqiang Chen</name><affiliation><nlm:affiliation>Huang Gang Central Hospital, Huang Gang, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Xianqun" sort="Xu, Xianqun" uniqKey="Xu X" first="Xianqun" last="Xu">Xianqun Xu</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liao, Shengjun" sort="Liao, Shengjun" uniqKey="Liao S" first="Shengjun" last="Liao">Shengjun Liao</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Na" sort="Yang, Na" uniqKey="Yang N" first="Na" last="Yang">Na Yang</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Siwei" sort="Li, Siwei" uniqKey="Li S" first="Siwei" last="Li">Siwei Li</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Gang" sort="Yang, Gang" uniqKey="Yang G" first="Gang" last="Yang">Gang Yang</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Yueting" sort="Tang, Yueting" uniqKey="Tang Y" first="Yueting" last="Tang">Yueting Tang</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Fan, Junli" sort="Fan, Junli" uniqKey="Fan J" first="Junli" last="Fan">Junli Fan</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Wen" sort="Xie, Wen" uniqKey="Xie W" first="Wen" last="Xie">Wen Xie</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Hanning" sort="Hu, Hanning" uniqKey="Hu H" first="Hanning" last="Hu">Hanning Hu</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yirong" sort="Li, Yirong" uniqKey="Li Y" first="Yirong" last="Li">Yirong Li</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Fang" sort="Zheng, Fang" uniqKey="Zheng F" first="Fang" last="Zheng">Fang Zheng</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32787527</idno><idno type="pmid">32787527</idno><idno type="doi">10.1080/22221751.2020.1810133</idno><idno type="wicri:Area/Main/Corpus">000697</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000697</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dynamic changes of throat swabs RNA and serum antibodies for SARS-CoV-2 and their diagnostic performances in patients with COVID-19.</title><author><name sortKey="Qiu, Xueping" sort="Qiu, Xueping" uniqKey="Qiu X" first="Xueping" last="Qiu">Xueping Qiu</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiang, Yang" sort="Xiang, Yang" uniqKey="Xiang Y" first="Yang" last="Xiang">Yang Xiang</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Jianbin" sort="Sun, Jianbin" uniqKey="Sun J" first="Jianbin" last="Sun">Jianbin Sun</name><affiliation><nlm:affiliation>Wuhan Third Hospital-Tongren Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xinrui" sort="Wang, Xinrui" uniqKey="Wang X" first="Xinrui" last="Wang">Xinrui Wang</name><affiliation><nlm:affiliation>Hebi City Center for Disease Control and Prevention, Hebi, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Guoqiang" sort="Chen, Guoqiang" uniqKey="Chen G" first="Guoqiang" last="Chen">Guoqiang Chen</name><affiliation><nlm:affiliation>Huang Gang Central Hospital, Huang Gang, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Xianqun" sort="Xu, Xianqun" uniqKey="Xu X" first="Xianqun" last="Xu">Xianqun Xu</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liao, Shengjun" sort="Liao, Shengjun" uniqKey="Liao S" first="Shengjun" last="Liao">Shengjun Liao</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Na" sort="Yang, Na" uniqKey="Yang N" first="Na" last="Yang">Na Yang</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Siwei" sort="Li, Siwei" uniqKey="Li S" first="Siwei" last="Li">Siwei Li</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Gang" sort="Yang, Gang" uniqKey="Yang G" first="Gang" last="Yang">Gang Yang</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Yueting" sort="Tang, Yueting" uniqKey="Tang Y" first="Yueting" last="Tang">Yueting Tang</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Fan, Junli" sort="Fan, Junli" uniqKey="Fan J" first="Junli" last="Fan">Junli Fan</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Wen" sort="Xie, Wen" uniqKey="Xie W" first="Wen" last="Xie">Wen Xie</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Hanning" sort="Hu, Hanning" uniqKey="Hu H" first="Hanning" last="Hu">Hanning Hu</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yirong" sort="Li, Yirong" uniqKey="Li Y" first="Yirong" last="Li">Yirong Li</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Fang" sort="Zheng, Fang" uniqKey="Zheng F" first="Fang" last="Zheng">Fang Zheng</name><affiliation><nlm:affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Emerging microbes & infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Antibodies, Viral (blood)</term><term>Betacoronavirus (genetics)</term><term>Betacoronavirus (immunology)</term><term>Clinical Laboratory Techniques (methods)</term><term>Coronavirus Infections (diagnosis)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin M (blood)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pharynx (virology)</term><term>Pneumonia, Viral (diagnosis)</term><term>RNA, Viral (genetics)</term><term>RNA, Viral (isolation & purification)</term><term>Retrospective Studies (MeSH)</term><term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term><term>Sensitivity and Specificity (MeSH)</term><term>Seroconversion (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Clinical Laboratory Techniques</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pharynx</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Retrospective Studies</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Sensitivity and Specificity</term><term>Seroconversion</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dynamic changes of RNA and antibodies in SARS-CoV-2 infected patients remain largely unknown, and influence factors for antibody production have not been fully clarified. In this study, consecutive throat swabs specimens (<i>n</i> = 1875) from 187 patients were collected to analyse the dynamic changes of RNA. Moreover, 162 serial serum samples from 31 patients were tested for seroconversion of IgM and IgG. Meanwhile, IgM and IgG were also detected in 409 COVID-19 patients and 389 controls. Additionally, the logistic regression analysis was executed to identify the possible influence factors for antibody production. The median positive conversion time for RNA was day 7 (IQR, 3-11), and the positive rate was highest in day 1-5 (74.59 %) and then gradually decreased. The median time of seroconversion for IgM and IgG were both day 12 (IQR, 10-15). The sensitivity and specificity for IgM (or IgG) was 87.04% and 96.92%, respectively. Multivariate logistic regression indicated that reduced lymphocytes and short positive conversion time for SARS-CoV-2 RNA were independent factors for negative results of IgM and IgG. In conclusion, RNA and antibodies should be combined for COVID-19 diagnosis, and delayed seroconversion was influenced by the decreased lymphocytes and short positive conversion time for RNA.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32787527</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>28</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2222-1751</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Emerging microbes & infections</Title><ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation></Journal><ArticleTitle>Dynamic changes of throat swabs RNA and serum antibodies for SARS-CoV-2 and their diagnostic performances in patients with COVID-19.</ArticleTitle><Pagination><MedlinePgn>1974-1983</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/22221751.2020.1810133</ELocationID><Abstract><AbstractText>Dynamic changes of RNA and antibodies in SARS-CoV-2 infected patients remain largely unknown, and influence factors for antibody production have not been fully clarified. In this study, consecutive throat swabs specimens (<i>n</i> = 1875) from 187 patients were collected to analyse the dynamic changes of RNA. Moreover, 162 serial serum samples from 31 patients were tested for seroconversion of IgM and IgG. Meanwhile, IgM and IgG were also detected in 409 COVID-19 patients and 389 controls. Additionally, the logistic regression analysis was executed to identify the possible influence factors for antibody production. The median positive conversion time for RNA was day 7 (IQR, 3-11), and the positive rate was highest in day 1-5 (74.59 %) and then gradually decreased. The median time of seroconversion for IgM and IgG were both day 12 (IQR, 10-15). The sensitivity and specificity for IgM (or IgG) was 87.04% and 96.92%, respectively. Multivariate logistic regression indicated that reduced lymphocytes and short positive conversion time for SARS-CoV-2 RNA were independent factors for negative results of IgM and IgG. In conclusion, RNA and antibodies should be combined for COVID-19 diagnosis, and delayed seroconversion was influenced by the decreased lymphocytes and short positive conversion time for RNA.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Qiu</LastName><ForeName>Xueping</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiang</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Jianbin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Wuhan Third Hospital-Tongren Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xinrui</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Hebi City Center for Disease Control and Prevention, Hebi, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Guoqiang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Huang Gang Central Hospital, Huang Gang, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Xianqun</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liao</LastName><ForeName>Shengjun</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Na</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Siwei</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Gang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Yueting</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Junli</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Wen</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Hanning</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yirong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Fang</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Center for Gene Diagnosis & Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Emerg Microbes Infect</MedlineTA><NlmUniqueID>101594885</NlmUniqueID><ISSNLinking>2222-1751</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007075">Immunoglobulin 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PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32787527</ArticleId><ArticleId IdType="doi">10.1080/22221751.2020.1810133</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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