Immune response to SARS-CoV-2 in health care workers following a COVID-19 outbreak: A prospective longitudinal study.
Identifieur interne : 000614 ( Main/Corpus ); précédent : 000613; suivant : 000615Immune response to SARS-CoV-2 in health care workers following a COVID-19 outbreak: A prospective longitudinal study.
Auteurs : Sara Fill Malfertheiner ; Susanne Brandstetter ; Samra Roth ; Susanne Harner ; Heike Buntrock-Döpke ; Antoaneta A. Toncheva ; Natascha Borchers ; Rudolf Gruber ; Andreas Ambrosch ; Michael Kabesch ; Sebastian H UslerSource :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2020.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Antibodies, Viral (blood), Betacoronavirus (MeSH), Coronavirus Infections (diagnosis), Coronavirus Infections (immunology), Cross-Sectional Studies (MeSH), Female (MeSH), Germany (MeSH), Health Personnel (statistics & numerical data), Humans (MeSH), Immunoglobulin G (blood), Longitudinal Studies (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (immunology), Prospective Studies (MeSH), Seroconversion (MeSH), Young Adult (MeSH).
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- geographic : Germany.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- immunology : Coronavirus Infections, Pneumonia, Viral.
- statistics & numerical data : Health Personnel.
- Adolescent, Adult, Aged, Betacoronavirus, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Pandemics, Prospective Studies, Seroconversion, Young Adult.
Abstract
OBJECTIVE
Currently, little is known about the progression of an immune response against SARSCoV- 2 upon infection or sub-infection-exposure over time. We examined the serologic response in healthcare workers up to 12 weeks after a well-documented and contained outbreak and compared results with findings from earlier serologic testing in the same population.
METHODS
This study followed 166 health care workers of the University Perinatal Care Center, Regensburg, Germany, for up to 12 weeks. 27 of the subjects had previously tested positive for the presence of SARS-CoV-2 by PCR testing and developed COVID-19. Serologic responses were tested with two independent commercially available test kits.
RESULTS
77.8 % of COVID-19 study subjects developed a specific IgG-response over the course of the 12-week study, while none of the COVID-19 contact groups had a detectable IgG response. Amongst most COVID-19 patients the values of detectable IgG-responses significantly increased over time as confirmed with both tests, while that of positive IgA responses decreased. Between the number of reported symptoms and antibody responses in COVID-19 patients no correlation was found and no new cases of seroconversion were identified in asymptomatic coworkers with negative PCR during the outbreak.
CONCLUSIONS
Immune response after COVID-19 increases significantly over time but still approximately 22 % of COVID-19 patients did not mount a measurable serologic immune response within 60 days. Exposed co-workers did not develop any relevant antibody levels at all. We conclude that immunity after infection increases over time, but the antibody response does not develop reliably in all infected people.
DOI: 10.1016/j.jcv.2020.104575
PubMed: 32805631
PubMed Central: PMC7406471
Links to Exploration step
pubmed:32805631Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immune response to SARS-CoV-2 in health care workers following a COVID-19 outbreak: A prospective longitudinal study.</title><author><name sortKey="Fill Malfertheiner, Sara" sort="Fill Malfertheiner, Sara" uniqKey="Fill Malfertheiner S" first="Sara" last="Fill Malfertheiner">Sara Fill Malfertheiner</name><affiliation><nlm:affiliation>University Department of Obstetrics and Gynecology at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany. Electronic address: sara.fillmalfertheiner@barmherzige-regensburg.de.</nlm:affiliation></affiliation></author><author><name sortKey="Brandstetter, Susanne" sort="Brandstetter, Susanne" uniqKey="Brandstetter S" first="Susanne" last="Brandstetter">Susanne Brandstetter</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Roth, Samra" sort="Roth, Samra" uniqKey="Roth S" first="Samra" last="Roth">Samra Roth</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Harner, Susanne" sort="Harner, Susanne" uniqKey="Harner S" first="Susanne" last="Harner">Susanne Harner</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Buntrock Dopke, Heike" sort="Buntrock Dopke, Heike" uniqKey="Buntrock Dopke H" first="Heike" last="Buntrock-Döpke">Heike Buntrock-Döpke</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Toncheva, Antoaneta A" sort="Toncheva, Antoaneta A" uniqKey="Toncheva A" first="Antoaneta A" last="Toncheva">Antoaneta A. Toncheva</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Borchers, Natascha" sort="Borchers, Natascha" uniqKey="Borchers N" first="Natascha" last="Borchers">Natascha Borchers</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gruber, Rudolf" sort="Gruber, Rudolf" uniqKey="Gruber R" first="Rudolf" last="Gruber">Rudolf Gruber</name><affiliation><nlm:affiliation>Institute of Laboratory Medicine, Microbiology and Hygiene, Hospital of the Order of St. John, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ambrosch, Andreas" sort="Ambrosch, Andreas" uniqKey="Ambrosch A" first="Andreas" last="Ambrosch">Andreas Ambrosch</name><affiliation><nlm:affiliation>Institute of Laboratory Medicine, Microbiology and Hygiene, Hospital of the Order of St. John, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kabesch, Michael" sort="Kabesch, Michael" uniqKey="Kabesch M" first="Michael" last="Kabesch">Michael Kabesch</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="H Usler, Sebastian" sort="H Usler, Sebastian" uniqKey="H Usler S" first="Sebastian" last="H Usler">Sebastian H Usler</name><affiliation><nlm:affiliation>University Department of Obstetrics and Gynecology at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32805631</idno><idno type="pmid">32805631</idno><idno type="doi">10.1016/j.jcv.2020.104575</idno><idno type="pmc">PMC7406471</idno><idno type="wicri:Area/Main/Corpus">000614</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000614</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Immune response to SARS-CoV-2 in health care workers following a COVID-19 outbreak: A prospective longitudinal study.</title><author><name sortKey="Fill Malfertheiner, Sara" sort="Fill Malfertheiner, Sara" uniqKey="Fill Malfertheiner S" first="Sara" last="Fill Malfertheiner">Sara Fill Malfertheiner</name><affiliation><nlm:affiliation>University Department of Obstetrics and Gynecology at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany. Electronic address: sara.fillmalfertheiner@barmherzige-regensburg.de.</nlm:affiliation></affiliation></author><author><name sortKey="Brandstetter, Susanne" sort="Brandstetter, Susanne" uniqKey="Brandstetter S" first="Susanne" last="Brandstetter">Susanne Brandstetter</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Roth, Samra" sort="Roth, Samra" uniqKey="Roth S" first="Samra" last="Roth">Samra Roth</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Harner, Susanne" sort="Harner, Susanne" uniqKey="Harner S" first="Susanne" last="Harner">Susanne Harner</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Buntrock Dopke, Heike" sort="Buntrock Dopke, Heike" uniqKey="Buntrock Dopke H" first="Heike" last="Buntrock-Döpke">Heike Buntrock-Döpke</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Toncheva, Antoaneta A" sort="Toncheva, Antoaneta A" uniqKey="Toncheva A" first="Antoaneta A" last="Toncheva">Antoaneta A. Toncheva</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Borchers, Natascha" sort="Borchers, Natascha" uniqKey="Borchers N" first="Natascha" last="Borchers">Natascha Borchers</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gruber, Rudolf" sort="Gruber, Rudolf" uniqKey="Gruber R" first="Rudolf" last="Gruber">Rudolf Gruber</name><affiliation><nlm:affiliation>Institute of Laboratory Medicine, Microbiology and Hygiene, Hospital of the Order of St. John, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ambrosch, Andreas" sort="Ambrosch, Andreas" uniqKey="Ambrosch A" first="Andreas" last="Ambrosch">Andreas Ambrosch</name><affiliation><nlm:affiliation>Institute of Laboratory Medicine, Microbiology and Hygiene, Hospital of the Order of St. John, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kabesch, Michael" sort="Kabesch, Michael" uniqKey="Kabesch M" first="Michael" last="Kabesch">Michael Kabesch</name><affiliation><nlm:affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="H Usler, Sebastian" sort="H Usler, Sebastian" uniqKey="H Usler S" first="Sebastian" last="H Usler">Sebastian H Usler</name><affiliation><nlm:affiliation>University Department of Obstetrics and Gynecology at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</title><idno type="eISSN">1873-5967</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Antibodies, Viral (blood)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (immunology)</term><term>Cross-Sectional Studies (MeSH)</term><term>Female (MeSH)</term><term>Germany (MeSH)</term><term>Health Personnel (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Immunoglobulin G (blood)</term><term>Longitudinal Studies (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (immunology)</term><term>Prospective Studies (MeSH)</term><term>Seroconversion (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Health Personnel</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Betacoronavirus</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prospective Studies</term><term>Seroconversion</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>Currently, little is known about the progression of an immune response against SARSCoV- 2 upon infection or sub-infection-exposure over time. We examined the serologic response in healthcare workers up to 12 weeks after a well-documented and contained outbreak and compared results with findings from earlier serologic testing in the same population.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>This study followed 166 health care workers of the University Perinatal Care Center, Regensburg, Germany, for up to 12 weeks. 27 of the subjects had previously tested positive for the presence of SARS-CoV-2 by PCR testing and developed COVID-19. Serologic responses were tested with two independent commercially available test kits.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>77.8 % of COVID-19 study subjects developed a specific IgG-response over the course of the 12-week study, while none of the COVID-19 contact groups had a detectable IgG response. Amongst most COVID-19 patients the values of detectable IgG-responses significantly increased over time as confirmed with both tests, while that of positive IgA responses decreased. Between the number of reported symptoms and antibody responses in COVID-19 patients no correlation was found and no new cases of seroconversion were identified in asymptomatic coworkers with negative PCR during the outbreak.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Immune response after COVID-19 increases significantly over time but still approximately 22 % of COVID-19 patients did not mount a measurable serologic immune response within 60 days. Exposed co-workers did not develop any relevant antibody levels at all. We conclude that immunity after infection increases over time, but the antibody response does not develop reliably in all infected people.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32805631</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>05</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>05</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5967</ISSN><JournalIssue CitedMedium="Internet"><Volume>130</Volume><PubDate><Year>2020</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title><ISOAbbreviation>J Clin Virol</ISOAbbreviation></Journal><ArticleTitle>Immune response to SARS-CoV-2 in health care workers following a COVID-19 outbreak: A prospective longitudinal study.</ArticleTitle><Pagination><MedlinePgn>104575</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1386-6532(20)30317-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcv.2020.104575</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Currently, little is known about the progression of an immune response against SARSCoV- 2 upon infection or sub-infection-exposure over time. We examined the serologic response in healthcare workers up to 12 weeks after a well-documented and contained outbreak and compared results with findings from earlier serologic testing in the same population.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This study followed 166 health care workers of the University Perinatal Care Center, Regensburg, Germany, for up to 12 weeks. 27 of the subjects had previously tested positive for the presence of SARS-CoV-2 by PCR testing and developed COVID-19. Serologic responses were tested with two independent commercially available test kits.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">77.8 % of COVID-19 study subjects developed a specific IgG-response over the course of the 12-week study, while none of the COVID-19 contact groups had a detectable IgG response. Amongst most COVID-19 patients the values of detectable IgG-responses significantly increased over time as confirmed with both tests, while that of positive IgA responses decreased. Between the number of reported symptoms and antibody responses in COVID-19 patients no correlation was found and no new cases of seroconversion were identified in asymptomatic coworkers with negative PCR during the outbreak.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Immune response after COVID-19 increases significantly over time but still approximately 22 % of COVID-19 patients did not mount a measurable serologic immune response within 60 days. Exposed co-workers did not develop any relevant antibody levels at all. We conclude that immunity after infection increases over time, but the antibody response does not develop reliably in all infected people.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fill Malfertheiner</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University Department of Obstetrics and Gynecology at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany. Electronic address: sara.fillmalfertheiner@barmherzige-regensburg.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brandstetter</LastName><ForeName>Susanne</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roth</LastName><ForeName>Samra</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harner</LastName><ForeName>Susanne</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buntrock-Döpke</LastName><ForeName>Heike</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toncheva</LastName><ForeName>Antoaneta A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borchers</LastName><ForeName>Natascha</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gruber</LastName><ForeName>Rudolf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Medicine, Microbiology and Hygiene, Hospital of the Order of St. John, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ambrosch</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Medicine, Microbiology and Hygiene, Hospital of the Order of St. John, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kabesch</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University Children's Hospital Regensburg (KUNO) at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; WECARE Research and Development Campus Regensburg at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Häusler</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University Department of Obstetrics and Gynecology at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Clin Virol</MedlineTA><NlmUniqueID>9815671</NlmUniqueID><ISSNLinking>1386-6532</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006282" MajorTopicYN="N">Health Personnel</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000069078" MajorTopicYN="N">Seroconversion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Corona virus</Keyword><Keyword MajorTopicYN="N">Health care workers</Keyword><Keyword MajorTopicYN="N">Immune response</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2 antibodies</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32805631</ArticleId><ArticleId IdType="pii">S1386-6532(20)30317-6</ArticleId><ArticleId IdType="doi">10.1016/j.jcv.2020.104575</ArticleId><ArticleId IdType="pmc">PMC7406471</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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