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Universal laboratory testing for SARS-CoV-2 in hyperacute stroke during the COVID-19 pandemic.

Identifieur interne : 000607 ( Main/Corpus ); précédent : 000606; suivant : 000608

Universal laboratory testing for SARS-CoV-2 in hyperacute stroke during the COVID-19 pandemic.

Auteurs : Kristian Barlinn ; Timo Siepmann ; Lars-Peder Pallesen ; Simon Winzer ; Annahita Sedghi ; Percy Schroettner ; Kristina Hochauf-Stange ; Alexandra Prakapenia ; Haidar Moustafa ; Katja De With ; Jennifer Linn ; Heinz Reichmann ; Jessica Barlinn ; Volker Puetz

Source :

RBID : pubmed:32807466

English descriptors

Abstract

OBJECTIVE

Stroke patients are thought to be at increased risk of Coronavirus Disease 2019 (COVID-19). To evaluate yield of universal laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in acute stroke patients and its impact on hyperacute stroke care.

METHODS

Between weeks 14 and 18 in 2020, a protected code stroke protocol including infection control screening and laboratory testing for SARS-CoV-2 was prospectively implemented for all code stroke patients upon arrival to the emergency department. If infection control screen was positive, patients received protective hygienic measures and laboratory test results were available within four hours from testing. In patients with negative screen, laboratory results were available no later than the next working day. Door-to-imaging times of patients treated with thrombolysis or thrombectomy were compared with those of patients treated during the preceding weeks 1 to 13 in 2020.

RESULTS

During the 4-weeks study period, 116 consecutive code stroke patients underwent infection control screen and laboratory testing for SARS-CoV-2. Among 5 (4.3%) patients whose infection control screen was positive, no patient was tested positive for SARS-CoV-2. All patients with negative infection control screens had negative test results. Door-to-imaging times of patients treated with thrombolysis and/or thrombectomy were not different to those treated during the preceding weeks (12 [9-15] min versus 13 [11-17] min, p = 0.24).

CONCLUSIONS

Universal laboratory testing for SARS-CoV-2 provided useful information on patients' infection status and its implementation into a protected code stroke protocol did not adversely affect hyperacute stroke care.


DOI: 10.1016/j.jstrokecerebrovasdis.2020.105061
PubMed: 32807466
PubMed Central: PMC7305910

Links to Exploration step

pubmed:32807466

Le document en format XML

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<name sortKey="Linn, Jennifer" sort="Linn, Jennifer" uniqKey="Linn J" first="Jennifer" last="Linn">Jennifer Linn</name>
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<name sortKey="Linn, Jennifer" sort="Linn, Jennifer" uniqKey="Linn J" first="Jennifer" last="Linn">Jennifer Linn</name>
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<name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name>
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<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Betacoronavirus (isolation & purification)</term>
<term>Clinical Decision-Making (MeSH)</term>
<term>Clinical Laboratory Techniques (MeSH)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Coronavirus Infections (virology)</term>
<term>Emergency Service, Hospital (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Infection Control (MeSH)</term>
<term>Male (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Patient Safety (MeSH)</term>
<term>Patient Selection (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Predictive Value of Tests (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Stroke (complications)</term>
<term>Stroke (diagnosis)</term>
<term>Stroke (therapy)</term>
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<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Stroke</term>
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<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Stroke</term>
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<term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Stroke</term>
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<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
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<term>Aged, 80 and over</term>
<term>Clinical Decision-Making</term>
<term>Clinical Laboratory Techniques</term>
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<term>Humans</term>
<term>Infection Control</term>
<term>Male</term>
<term>Pandemics</term>
<term>Patient Safety</term>
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<p>
<b>OBJECTIVE</b>
</p>
<p>Stroke patients are thought to be at increased risk of Coronavirus Disease 2019 (COVID-19). To evaluate yield of universal laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in acute stroke patients and its impact on hyperacute stroke care.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>Between weeks 14 and 18 in 2020, a protected code stroke protocol including infection control screening and laboratory testing for SARS-CoV-2 was prospectively implemented for all code stroke patients upon arrival to the emergency department. If infection control screen was positive, patients received protective hygienic measures and laboratory test results were available within four hours from testing. In patients with negative screen, laboratory results were available no later than the next working day. Door-to-imaging times of patients treated with thrombolysis or thrombectomy were compared with those of patients treated during the preceding weeks 1 to 13 in 2020.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>During the 4-weeks study period, 116 consecutive code stroke patients underwent infection control screen and laboratory testing for SARS-CoV-2. Among 5 (4.3%) patients whose infection control screen was positive, no patient was tested positive for SARS-CoV-2. All patients with negative infection control screens had negative test results. Door-to-imaging times of patients treated with thrombolysis and/or thrombectomy were not different to those treated during the preceding weeks (12 [9-15] min versus 13 [11-17] min, p = 0.24).</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>Universal laboratory testing for SARS-CoV-2 provided useful information on patients' infection status and its implementation into a protected code stroke protocol did not adversely affect hyperacute stroke care.</p>
</div>
</front>
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<Day>24</Day>
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<Day>03</Day>
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<Title>Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association</Title>
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<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Stroke patients are thought to be at increased risk of Coronavirus Disease 2019 (COVID-19). To evaluate yield of universal laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in acute stroke patients and its impact on hyperacute stroke care.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Between weeks 14 and 18 in 2020, a protected code stroke protocol including infection control screening and laboratory testing for SARS-CoV-2 was prospectively implemented for all code stroke patients upon arrival to the emergency department. If infection control screen was positive, patients received protective hygienic measures and laboratory test results were available within four hours from testing. In patients with negative screen, laboratory results were available no later than the next working day. Door-to-imaging times of patients treated with thrombolysis or thrombectomy were compared with those of patients treated during the preceding weeks 1 to 13 in 2020.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">During the 4-weeks study period, 116 consecutive code stroke patients underwent infection control screen and laboratory testing for SARS-CoV-2. Among 5 (4.3%) patients whose infection control screen was positive, no patient was tested positive for SARS-CoV-2. All patients with negative infection control screens had negative test results. Door-to-imaging times of patients treated with thrombolysis and/or thrombectomy were not different to those treated during the preceding weeks (12 [9-15] min versus 13 [11-17] min, p = 0.24).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Universal laboratory testing for SARS-CoV-2 provided useful information on patients' infection status and its implementation into a protected code stroke protocol did not adversely affect hyperacute stroke care.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation>
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<LastName>Barlinn</LastName>
<ForeName>Kristian</ForeName>
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<Affiliation>Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany. Electronic address: kristian.barlinn@ukdd.de.</Affiliation>
</AffiliationInfo>
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<Affiliation>Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany. Electronic address: timo.siepmann@ukdd.de.</Affiliation>
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<Initials>LP</Initials>
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<Affiliation>Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany. Electronic address: lars.peder-pallesen@ukdd.de.</Affiliation>
</AffiliationInfo>
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<AffiliationInfo>
<Affiliation>Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany. Electronic address: simon.winzer@ukdd.de.</Affiliation>
</AffiliationInfo>
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<Affiliation>Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany. Electronic address: annahita.sedghi@ukdd.de.</Affiliation>
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<Keyword MajorTopicYN="N">Acute Stroke</Keyword>
<Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Patient safety</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">Stroke protocol</Keyword>
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<CoiStatement>Declaration of Competing Interests The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.</CoiStatement>
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<Year>2020</Year>
<Month>05</Month>
<Day>26</Day>
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<Year>2020</Year>
<Month>06</Month>
<Day>07</Day>
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<Year>2020</Year>
<Month>06</Month>
<Day>12</Day>
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