COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.
Identifieur interne : 000463 ( Main/Corpus ); précédent : 000462; suivant : 000464COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.
Auteurs : Lennard Y W. Lee ; Jean-Baptiste Cazier ; Thomas Starkey ; Sarah E W. Briggs ; Roland Arnold ; Vartika Bisht ; Stephen Booth ; Naomi A. Campton ; Vinton W T. Cheng ; Graham Collins ; Helen M. Curley ; Philip Earwaker ; Matthew W. Fittall ; Spyridon Gennatas ; Anshita Goel ; Simon Hartley ; Daniel J. Hughes ; David Kerr ; Alvin J X. Lee ; Rebecca J. Lee ; Siow Ming Lee ; Hayley Mckenzie ; Chris P. Middleton ; Nirupa Murugaesu ; Tom Newsom-Davis ; Anna C. Olsson-Brown ; Claire Palles ; Thomas Powles ; Emily A. Protheroe ; Karin Purshouse ; Archana Sharma-Oates ; Shivan Sivakumar ; Ashley J. Smith ; Oliver Topping ; Chris D. Turnbull ; Csilla Várnai ; Adam D M. Briggs ; Gary Middleton ; Rachel KerrSource :
- The Lancet. Oncology [ 1474-5488 ] ; 2020.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Betacoronavirus (pathogenicity), Coronavirus Infections (complications), Coronavirus Infections (mortality), Coronavirus Infections (pathology), Coronavirus Infections (virology), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Neoplasms (mortality), Neoplasms (pathology), Neoplasms (virology), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (mortality), Pneumonia, Viral (pathology), Pneumonia, Viral (virology), Prospective Studies (MeSH), Risk Assessment (MeSH), Risk Factors (MeSH).
- MESH :
- complications : Coronavirus Infections, Pneumonia, Viral.
- mortality : Coronavirus Infections, Neoplasms, Pneumonia, Viral.
- pathogenicity : Betacoronavirus.
- pathology : Coronavirus Infections, Neoplasms, Pneumonia, Viral.
- virology : Coronavirus Infections, Neoplasms, Pneumonia, Viral.
- Adult, Aged, Aged, 80 and over, Female, Hospitalization, Humans, Male, Middle Aged, Pandemics, Prospective Studies, Risk Assessment, Risk Factors.
Abstract
BACKGROUND
Patients with cancer are purported to have poor COVID-19 outcomes. However, cancer is a heterogeneous group of diseases, encompassing a spectrum of tumour subtypes. The aim of this study was to investigate COVID-19 risk according to tumour subtype and patient demographics in patients with cancer in the UK.
METHODS
We compared adult patients with cancer enrolled in the UK Coronavirus Cancer Monitoring Project (UKCCMP) cohort between March 18 and May 8, 2020, with a parallel non-COVID-19 UK cancer control population from the UK Office for National Statistics (2017 data). The primary outcome of the study was the effect of primary tumour subtype, age, and sex and on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevalence and the case-fatality rate during hospital admission. We analysed the effect of tumour subtype and patient demographics (age and sex) on prevalence and mortality from COVID-19 using univariable and multivariable models.
FINDINGS
319 (30·6%) of 1044 patients in the UKCCMP cohort died, 295 (92·5%) of whom had a cause of death recorded as due to COVID-19. The all-cause case-fatality rate in patients with cancer after SARS-CoV-2 infection was significantly associated with increasing age, rising from 0·10 in patients aged 40-49 years to 0·48 in those aged 80 years and older. Patients with haematological malignancies (leukaemia, lymphoma, and myeloma) had a more severe COVID-19 trajectory compared with patients with solid organ tumours (odds ratio [OR] 1·57, 95% CI 1·15-2·15; p<0·0043). Compared with the rest of the UKCCMP cohort, patients with leukaemia showed a significantly increased case-fatality rate (2·25, 1·13-4·57; p=0·023). After correction for age and sex, patients with haematological malignancies who had recent chemotherapy had an increased risk of death during COVID-19-associated hospital admission (OR 2·09, 95% CI 1·09-4·08; p=0·028).
INTERPRETATION
Patients with cancer with different tumour types have differing susceptibility to SARS-CoV-2 infection and COVID-19 phenotypes. We generated individualised risk tables for patients with cancer, considering age, sex, and tumour subtype. Our results could be useful to assist physicians in informed risk-benefit discussions to explain COVID-19 risk and enable an evidenced-based approach to national social isolation policies.
FUNDING
University of Birmingham and University of Oxford.
DOI: 10.1016/S1470-2045(20)30442-3
PubMed: 32853557
PubMed Central: PMC7444972
Links to Exploration step
pubmed:32853557Le document en format XML
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Lee</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Department of Oncology, University of Oxford, Oxford, UK; University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cazier, Jean Baptiste" sort="Cazier, Jean Baptiste" uniqKey="Cazier J" first="Jean-Baptiste" last="Cazier">Jean-Baptiste Cazier</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Starkey, Thomas" sort="Starkey, Thomas" uniqKey="Starkey T" first="Thomas" last="Starkey">Thomas Starkey</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Briggs, Sarah E W" sort="Briggs, Sarah E W" uniqKey="Briggs S" first="Sarah E W" last="Briggs">Sarah E W. Briggs</name><affiliation><nlm:affiliation>Nuffield Department of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Arnold, Roland" sort="Arnold, Roland" uniqKey="Arnold R" first="Roland" last="Arnold">Roland Arnold</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bisht, Vartika" sort="Bisht, Vartika" uniqKey="Bisht V" first="Vartika" last="Bisht">Vartika Bisht</name><affiliation><nlm:affiliation>Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Booth, Stephen" sort="Booth, Stephen" uniqKey="Booth S" first="Stephen" last="Booth">Stephen Booth</name><affiliation><nlm:affiliation>Department of Haematology, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Campton, Naomi A" sort="Campton, Naomi A" uniqKey="Campton N" first="Naomi A" last="Campton">Naomi A. Campton</name><affiliation><nlm:affiliation>Institute of Translational Medicine, Birmingham Health Partners, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Vinton W T" sort="Cheng, Vinton W T" uniqKey="Cheng V" first="Vinton W T" last="Cheng">Vinton W T. Cheng</name><affiliation><nlm:affiliation>Leeds Institute of Medical Research, University of Leeds, Leeds, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Collins, Graham" sort="Collins, Graham" uniqKey="Collins G" first="Graham" last="Collins">Graham Collins</name><affiliation><nlm:affiliation>Department of Haematology, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Curley, Helen M" sort="Curley, Helen M" uniqKey="Curley H" first="Helen M" last="Curley">Helen M. Curley</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Earwaker, Philip" sort="Earwaker, Philip" uniqKey="Earwaker P" first="Philip" last="Earwaker">Philip Earwaker</name><affiliation><nlm:affiliation>University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fittall, Matthew W" sort="Fittall, Matthew W" uniqKey="Fittall M" first="Matthew W" last="Fittall">Matthew W. Fittall</name><affiliation><nlm:affiliation>The Royal Marsden Hospital NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gennatas, Spyridon" sort="Gennatas, Spyridon" uniqKey="Gennatas S" first="Spyridon" last="Gennatas">Spyridon Gennatas</name><affiliation><nlm:affiliation>The Royal Marsden Hospital NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Goel, Anshita" sort="Goel, Anshita" uniqKey="Goel A" first="Anshita" last="Goel">Anshita Goel</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hartley, Simon" sort="Hartley, Simon" uniqKey="Hartley S" first="Simon" last="Hartley">Simon Hartley</name><affiliation><nlm:affiliation>Centre for Computational Biology, University of Birmingham, Birmingham, UK; Advanced Research Computing, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hughes, Daniel J" sort="Hughes, Daniel J" uniqKey="Hughes D" first="Daniel J" last="Hughes">Daniel J. Hughes</name><affiliation><nlm:affiliation>Department of Cancer Imaging, King's College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kerr, David" sort="Kerr, David" uniqKey="Kerr D" first="David" last="Kerr">David Kerr</name><affiliation><nlm:affiliation>Nuffield Division of Clinical and Laboratory Services, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Alvin J X" sort="Lee, Alvin J X" uniqKey="Lee A" first="Alvin J X" last="Lee">Alvin J X. Lee</name><affiliation><nlm:affiliation>UCL Cancer Institute, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Rebecca J" sort="Lee, Rebecca J" uniqKey="Lee R" first="Rebecca J" last="Lee">Rebecca J. Lee</name><affiliation><nlm:affiliation>The University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Siow Ming" sort="Lee, Siow Ming" uniqKey="Lee S" first="Siow Ming" last="Lee">Siow Ming Lee</name><affiliation><nlm:affiliation>University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mckenzie, Hayley" sort="Mckenzie, Hayley" uniqKey="Mckenzie H" first="Hayley" last="Mckenzie">Hayley Mckenzie</name><affiliation><nlm:affiliation>University Hospital Southampton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Middleton, Chris P" sort="Middleton, Chris P" uniqKey="Middleton C" first="Chris P" last="Middleton">Chris P. Middleton</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Murugaesu, Nirupa" sort="Murugaesu, Nirupa" uniqKey="Murugaesu N" first="Nirupa" last="Murugaesu">Nirupa Murugaesu</name><affiliation><nlm:affiliation>St George's University Hospitals NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Newsom Davis, Tom" sort="Newsom Davis, Tom" uniqKey="Newsom Davis T" first="Tom" last="Newsom-Davis">Tom Newsom-Davis</name><affiliation><nlm:affiliation>Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Olsson Brown, Anna C" sort="Olsson Brown, Anna C" uniqKey="Olsson Brown A" first="Anna C" last="Olsson-Brown">Anna C. Olsson-Brown</name><affiliation><nlm:affiliation>The Clatterbridge Cancer Centre, Birkenhead, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Palles, Claire" sort="Palles, Claire" uniqKey="Palles C" first="Claire" last="Palles">Claire Palles</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Powles, Thomas" sort="Powles, Thomas" uniqKey="Powles T" first="Thomas" last="Powles">Thomas Powles</name><affiliation><nlm:affiliation>Bart's Cancer Institute, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Protheroe, Emily A" sort="Protheroe, Emily A" uniqKey="Protheroe E" first="Emily A" last="Protheroe">Emily A. Protheroe</name><affiliation><nlm:affiliation>University of Birmingham Medical School, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Purshouse, Karin" sort="Purshouse, Karin" uniqKey="Purshouse K" first="Karin" last="Purshouse">Karin Purshouse</name><affiliation><nlm:affiliation>Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma Oates, Archana" sort="Sharma Oates, Archana" uniqKey="Sharma Oates A" first="Archana" last="Sharma-Oates">Archana Sharma-Oates</name><affiliation><nlm:affiliation>Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sivakumar, Shivan" sort="Sivakumar, Shivan" uniqKey="Sivakumar S" first="Shivan" last="Sivakumar">Shivan Sivakumar</name><affiliation><nlm:affiliation>Department of Oncology, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Ashley J" sort="Smith, Ashley J" uniqKey="Smith A" first="Ashley J" last="Smith">Ashley J. Smith</name><affiliation><nlm:affiliation>Consultancy Support, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Topping, Oliver" sort="Topping, Oliver" uniqKey="Topping O" first="Oliver" last="Topping">Oliver Topping</name><affiliation><nlm:affiliation>University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Turnbull, Chris D" sort="Turnbull, Chris D" uniqKey="Turnbull C" first="Chris D" last="Turnbull">Chris D. Turnbull</name><affiliation><nlm:affiliation>Nuffield Department of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Varnai, Csilla" sort="Varnai, Csilla" uniqKey="Varnai C" first="Csilla" last="Várnai">Csilla Várnai</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Briggs, Adam D M" sort="Briggs, Adam D M" uniqKey="Briggs A" first="Adam D M" last="Briggs">Adam D M. Briggs</name><affiliation><nlm:affiliation>Warwick Medical School, University of Warwick, Coventry, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Middleton, Gary" sort="Middleton, Gary" uniqKey="Middleton G" first="Gary" last="Middleton">Gary Middleton</name><affiliation><nlm:affiliation>Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; University Hospitals Birmingham, Birmingham, UK. Electronic address: g.middleton@bham.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Kerr, Rachel" sort="Kerr, Rachel" uniqKey="Kerr R" first="Rachel" last="Kerr">Rachel Kerr</name><affiliation><nlm:affiliation>Department of Oncology, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32853557</idno><idno type="pmid">32853557</idno><idno type="doi">10.1016/S1470-2045(20)30442-3</idno><idno type="pmc">PMC7444972</idno><idno type="wicri:Area/Main/Corpus">000463</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000463</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.</title><author><name sortKey="Lee, Lennard Y W" sort="Lee, Lennard Y W" uniqKey="Lee L" first="Lennard Y W" last="Lee">Lennard Y W. Lee</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Department of Oncology, University of Oxford, Oxford, UK; University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cazier, Jean Baptiste" sort="Cazier, Jean Baptiste" uniqKey="Cazier J" first="Jean-Baptiste" last="Cazier">Jean-Baptiste Cazier</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Starkey, Thomas" sort="Starkey, Thomas" uniqKey="Starkey T" first="Thomas" last="Starkey">Thomas Starkey</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Briggs, Sarah E W" sort="Briggs, Sarah E W" uniqKey="Briggs S" first="Sarah E W" last="Briggs">Sarah E W. Briggs</name><affiliation><nlm:affiliation>Nuffield Department of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Arnold, Roland" sort="Arnold, Roland" uniqKey="Arnold R" first="Roland" last="Arnold">Roland Arnold</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bisht, Vartika" sort="Bisht, Vartika" uniqKey="Bisht V" first="Vartika" last="Bisht">Vartika Bisht</name><affiliation><nlm:affiliation>Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Booth, Stephen" sort="Booth, Stephen" uniqKey="Booth S" first="Stephen" last="Booth">Stephen Booth</name><affiliation><nlm:affiliation>Department of Haematology, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Campton, Naomi A" sort="Campton, Naomi A" uniqKey="Campton N" first="Naomi A" last="Campton">Naomi A. Campton</name><affiliation><nlm:affiliation>Institute of Translational Medicine, Birmingham Health Partners, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Vinton W T" sort="Cheng, Vinton W T" uniqKey="Cheng V" first="Vinton W T" last="Cheng">Vinton W T. Cheng</name><affiliation><nlm:affiliation>Leeds Institute of Medical Research, University of Leeds, Leeds, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Collins, Graham" sort="Collins, Graham" uniqKey="Collins G" first="Graham" last="Collins">Graham Collins</name><affiliation><nlm:affiliation>Department of Haematology, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Curley, Helen M" sort="Curley, Helen M" uniqKey="Curley H" first="Helen M" last="Curley">Helen M. Curley</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Earwaker, Philip" sort="Earwaker, Philip" uniqKey="Earwaker P" first="Philip" last="Earwaker">Philip Earwaker</name><affiliation><nlm:affiliation>University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fittall, Matthew W" sort="Fittall, Matthew W" uniqKey="Fittall M" first="Matthew W" last="Fittall">Matthew W. Fittall</name><affiliation><nlm:affiliation>The Royal Marsden Hospital NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gennatas, Spyridon" sort="Gennatas, Spyridon" uniqKey="Gennatas S" first="Spyridon" last="Gennatas">Spyridon Gennatas</name><affiliation><nlm:affiliation>The Royal Marsden Hospital NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Goel, Anshita" sort="Goel, Anshita" uniqKey="Goel A" first="Anshita" last="Goel">Anshita Goel</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hartley, Simon" sort="Hartley, Simon" uniqKey="Hartley S" first="Simon" last="Hartley">Simon Hartley</name><affiliation><nlm:affiliation>Centre for Computational Biology, University of Birmingham, Birmingham, UK; Advanced Research Computing, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hughes, Daniel J" sort="Hughes, Daniel J" uniqKey="Hughes D" first="Daniel J" last="Hughes">Daniel J. Hughes</name><affiliation><nlm:affiliation>Department of Cancer Imaging, King's College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kerr, David" sort="Kerr, David" uniqKey="Kerr D" first="David" last="Kerr">David Kerr</name><affiliation><nlm:affiliation>Nuffield Division of Clinical and Laboratory Services, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Alvin J X" sort="Lee, Alvin J X" uniqKey="Lee A" first="Alvin J X" last="Lee">Alvin J X. Lee</name><affiliation><nlm:affiliation>UCL Cancer Institute, University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Rebecca J" sort="Lee, Rebecca J" uniqKey="Lee R" first="Rebecca J" last="Lee">Rebecca J. Lee</name><affiliation><nlm:affiliation>The University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Siow Ming" sort="Lee, Siow Ming" uniqKey="Lee S" first="Siow Ming" last="Lee">Siow Ming Lee</name><affiliation><nlm:affiliation>University College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mckenzie, Hayley" sort="Mckenzie, Hayley" uniqKey="Mckenzie H" first="Hayley" last="Mckenzie">Hayley Mckenzie</name><affiliation><nlm:affiliation>University Hospital Southampton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Middleton, Chris P" sort="Middleton, Chris P" uniqKey="Middleton C" first="Chris P" last="Middleton">Chris P. Middleton</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Murugaesu, Nirupa" sort="Murugaesu, Nirupa" uniqKey="Murugaesu N" first="Nirupa" last="Murugaesu">Nirupa Murugaesu</name><affiliation><nlm:affiliation>St George's University Hospitals NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Newsom Davis, Tom" sort="Newsom Davis, Tom" uniqKey="Newsom Davis T" first="Tom" last="Newsom-Davis">Tom Newsom-Davis</name><affiliation><nlm:affiliation>Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Olsson Brown, Anna C" sort="Olsson Brown, Anna C" uniqKey="Olsson Brown A" first="Anna C" last="Olsson-Brown">Anna C. Olsson-Brown</name><affiliation><nlm:affiliation>The Clatterbridge Cancer Centre, Birkenhead, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Palles, Claire" sort="Palles, Claire" uniqKey="Palles C" first="Claire" last="Palles">Claire Palles</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Powles, Thomas" sort="Powles, Thomas" uniqKey="Powles T" first="Thomas" last="Powles">Thomas Powles</name><affiliation><nlm:affiliation>Bart's Cancer Institute, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Protheroe, Emily A" sort="Protheroe, Emily A" uniqKey="Protheroe E" first="Emily A" last="Protheroe">Emily A. Protheroe</name><affiliation><nlm:affiliation>University of Birmingham Medical School, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Purshouse, Karin" sort="Purshouse, Karin" uniqKey="Purshouse K" first="Karin" last="Purshouse">Karin Purshouse</name><affiliation><nlm:affiliation>Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma Oates, Archana" sort="Sharma Oates, Archana" uniqKey="Sharma Oates A" first="Archana" last="Sharma-Oates">Archana Sharma-Oates</name><affiliation><nlm:affiliation>Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sivakumar, Shivan" sort="Sivakumar, Shivan" uniqKey="Sivakumar S" first="Shivan" last="Sivakumar">Shivan Sivakumar</name><affiliation><nlm:affiliation>Department of Oncology, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Ashley J" sort="Smith, Ashley J" uniqKey="Smith A" first="Ashley J" last="Smith">Ashley J. Smith</name><affiliation><nlm:affiliation>Consultancy Support, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Topping, Oliver" sort="Topping, Oliver" uniqKey="Topping O" first="Oliver" last="Topping">Oliver Topping</name><affiliation><nlm:affiliation>University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Turnbull, Chris D" sort="Turnbull, Chris D" uniqKey="Turnbull C" first="Chris D" last="Turnbull">Chris D. Turnbull</name><affiliation><nlm:affiliation>Nuffield Department of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Varnai, Csilla" sort="Varnai, Csilla" uniqKey="Varnai C" first="Csilla" last="Várnai">Csilla Várnai</name><affiliation><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Briggs, Adam D M" sort="Briggs, Adam D M" uniqKey="Briggs A" first="Adam D M" last="Briggs">Adam D M. Briggs</name><affiliation><nlm:affiliation>Warwick Medical School, University of Warwick, Coventry, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Middleton, Gary" sort="Middleton, Gary" uniqKey="Middleton G" first="Gary" last="Middleton">Gary Middleton</name><affiliation><nlm:affiliation>Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; University Hospitals Birmingham, Birmingham, UK. Electronic address: g.middleton@bham.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Kerr, Rachel" sort="Kerr, Rachel" uniqKey="Kerr R" first="Rachel" last="Kerr">Rachel Kerr</name><affiliation><nlm:affiliation>Department of Oncology, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Betacoronavirus (pathogenicity)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Female (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Neoplasms (mortality)</term><term>Neoplasms (pathology)</term><term>Neoplasms (virology)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (pathology)</term><term>Pneumonia, Viral (virology)</term><term>Prospective Studies (MeSH)</term><term>Risk Assessment (MeSH)</term><term>Risk Factors (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Neoplasms</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Neoplasms</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Neoplasms</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prospective Studies</term><term>Risk Assessment</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Patients with cancer are purported to have poor COVID-19 outcomes. However, cancer is a heterogeneous group of diseases, encompassing a spectrum of tumour subtypes. The aim of this study was to investigate COVID-19 risk according to tumour subtype and patient demographics in patients with cancer in the UK.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We compared adult patients with cancer enrolled in the UK Coronavirus Cancer Monitoring Project (UKCCMP) cohort between March 18 and May 8, 2020, with a parallel non-COVID-19 UK cancer control population from the UK Office for National Statistics (2017 data). The primary outcome of the study was the effect of primary tumour subtype, age, and sex and on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevalence and the case-fatality rate during hospital admission. We analysed the effect of tumour subtype and patient demographics (age and sex) on prevalence and mortality from COVID-19 using univariable and multivariable models.</p></div><div type="abstract" xml:lang="en"><p><b>FINDINGS</b></p><p>319 (30·6%) of 1044 patients in the UKCCMP cohort died, 295 (92·5%) of whom had a cause of death recorded as due to COVID-19. The all-cause case-fatality rate in patients with cancer after SARS-CoV-2 infection was significantly associated with increasing age, rising from 0·10 in patients aged 40-49 years to 0·48 in those aged 80 years and older. Patients with haematological malignancies (leukaemia, lymphoma, and myeloma) had a more severe COVID-19 trajectory compared with patients with solid organ tumours (odds ratio [OR] 1·57, 95% CI 1·15-2·15; p<0·0043). Compared with the rest of the UKCCMP cohort, patients with leukaemia showed a significantly increased case-fatality rate (2·25, 1·13-4·57; p=0·023). After correction for age and sex, patients with haematological malignancies who had recent chemotherapy had an increased risk of death during COVID-19-associated hospital admission (OR 2·09, 95% CI 1·09-4·08; p=0·028).</p></div><div type="abstract" xml:lang="en"><p><b>INTERPRETATION</b></p><p>Patients with cancer with different tumour types have differing susceptibility to SARS-CoV-2 infection and COVID-19 phenotypes. We generated individualised risk tables for patients with cancer, considering age, sex, and tumour subtype. Our results could be useful to assist physicians in informed risk-benefit discussions to explain COVID-19 risk and enable an evidenced-based approach to national social isolation policies.</p></div><div type="abstract" xml:lang="en"><p><b>FUNDING</b></p><p>University of Birmingham and University of Oxford.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32853557</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>13</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-5488</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>10</Issue><PubDate><Year>2020</Year><Month>10</Month></PubDate></JournalIssue><Title>The Lancet. Oncology</Title><ISOAbbreviation>Lancet Oncol</ISOAbbreviation></Journal><ArticleTitle>COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.</ArticleTitle><Pagination><MedlinePgn>1309-1316</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1470-2045(20)30442-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S1470-2045(20)30442-3</ELocationID><Abstract><AbstractText Label="BACKGROUND">Patients with cancer are purported to have poor COVID-19 outcomes. However, cancer is a heterogeneous group of diseases, encompassing a spectrum of tumour subtypes. The aim of this study was to investigate COVID-19 risk according to tumour subtype and patient demographics in patients with cancer in the UK.</AbstractText><AbstractText Label="METHODS">We compared adult patients with cancer enrolled in the UK Coronavirus Cancer Monitoring Project (UKCCMP) cohort between March 18 and May 8, 2020, with a parallel non-COVID-19 UK cancer control population from the UK Office for National Statistics (2017 data). The primary outcome of the study was the effect of primary tumour subtype, age, and sex and on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevalence and the case-fatality rate during hospital admission. We analysed the effect of tumour subtype and patient demographics (age and sex) on prevalence and mortality from COVID-19 using univariable and multivariable models.</AbstractText><AbstractText Label="FINDINGS">319 (30·6%) of 1044 patients in the UKCCMP cohort died, 295 (92·5%) of whom had a cause of death recorded as due to COVID-19. The all-cause case-fatality rate in patients with cancer after SARS-CoV-2 infection was significantly associated with increasing age, rising from 0·10 in patients aged 40-49 years to 0·48 in those aged 80 years and older. Patients with haematological malignancies (leukaemia, lymphoma, and myeloma) had a more severe COVID-19 trajectory compared with patients with solid organ tumours (odds ratio [OR] 1·57, 95% CI 1·15-2·15; p<0·0043). Compared with the rest of the UKCCMP cohort, patients with leukaemia showed a significantly increased case-fatality rate (2·25, 1·13-4·57; p=0·023). After correction for age and sex, patients with haematological malignancies who had recent chemotherapy had an increased risk of death during COVID-19-associated hospital admission (OR 2·09, 95% CI 1·09-4·08; p=0·028).</AbstractText><AbstractText Label="INTERPRETATION">Patients with cancer with different tumour types have differing susceptibility to SARS-CoV-2 infection and COVID-19 phenotypes. We generated individualised risk tables for patients with cancer, considering age, sex, and tumour subtype. Our results could be useful to assist physicians in informed risk-benefit discussions to explain COVID-19 risk and enable an evidenced-based approach to national social isolation policies.</AbstractText><AbstractText Label="FUNDING">University of Birmingham and University of Oxford.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Lennard Y W</ForeName><Initials>LYW</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Department of Oncology, University of Oxford, Oxford, UK; University Hospitals Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cazier</LastName><ForeName>Jean-Baptiste</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Starkey</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Briggs</LastName><ForeName>Sarah E W</ForeName><Initials>SEW</Initials><AffiliationInfo><Affiliation>Nuffield Department of Medicine, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arnold</LastName><ForeName>Roland</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bisht</LastName><ForeName>Vartika</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Centre for Computational Biology, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Booth</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Haematology, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campton</LastName><ForeName>Naomi A</ForeName><Initials>NA</Initials><AffiliationInfo><Affiliation>Institute of Translational Medicine, Birmingham Health Partners, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Vinton W T</ForeName><Initials>VWT</Initials><AffiliationInfo><Affiliation>Leeds Institute of Medical Research, University of Leeds, Leeds, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Collins</LastName><ForeName>Graham</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Haematology, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curley</LastName><ForeName>Helen M</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Earwaker</LastName><ForeName>Philip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>University Hospitals Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fittall</LastName><ForeName>Matthew W</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>The Royal Marsden Hospital NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gennatas</LastName><ForeName>Spyridon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The Royal Marsden Hospital NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goel</LastName><ForeName>Anshita</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartley</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for Computational Biology, University of Birmingham, Birmingham, UK; Advanced Research Computing, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hughes</LastName><ForeName>Daniel J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Department of Cancer Imaging, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kerr</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Nuffield Division of Clinical and Laboratory Services, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Alvin J X</ForeName><Initials>AJX</Initials><AffiliationInfo><Affiliation>UCL Cancer Institute, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Rebecca J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>The University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Siow Ming</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mckenzie</LastName><ForeName>Hayley</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University Hospital Southampton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Middleton</LastName><ForeName>Chris P</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murugaesu</LastName><ForeName>Nirupa</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>St George's University Hospitals NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Newsom-Davis</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsson-Brown</LastName><ForeName>Anna C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>The Clatterbridge Cancer Centre, Birkenhead, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palles</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Powles</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Bart's Cancer Institute, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Protheroe</LastName><ForeName>Emily A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>University of Birmingham Medical School, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Purshouse</LastName><ForeName>Karin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma-Oates</LastName><ForeName>Archana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sivakumar</LastName><ForeName>Shivan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Oncology, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Ashley J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Consultancy Support, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Topping</LastName><ForeName>Oliver</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>University Hospitals Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turnbull</LastName><ForeName>Chris D</ForeName><Initials>CD</Initials><AffiliationInfo><Affiliation>Nuffield Department of Medicine, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Várnai</LastName><ForeName>Csilla</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Briggs</LastName><ForeName>Adam D M</ForeName><Initials>ADM</Initials><AffiliationInfo><Affiliation>Warwick Medical School, University of Warwick, Coventry, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Middleton</LastName><ForeName>Gary</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; University Hospitals Birmingham, Birmingham, UK. Electronic address: g.middleton@bham.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kerr</LastName><ForeName>Rachel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Oncology, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>UK Coronavirus Cancer Monitoring Project Team</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MR/P001106/1</GrantID><Acronym>MRC_</Acronym><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet Oncol</MedlineTA><NlmUniqueID>100957246</NlmUniqueID><ISSNLinking>1470-2045</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Lancet Oncol. 2020 Sep 3;:</RefSource><PMID Version="1">32891190</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList><InvestigatorList><Investigator ValidYN="Y"><LastName>Gault</LastName><ForeName>Abigails</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Agnieszka</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bedair</LastName><ForeName>Ahmed</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ghaus</LastName><ForeName>Aisha</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Akingboye</LastName><ForeName>Akinfemi</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Maynard</LastName><ForeName>Alec</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pawsey</LastName><ForeName>Alexander</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mohamed</LastName><ForeName>Ali Abdulnabi</ForeName><Initials>AA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Okines</LastName><ForeName>Alicia</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Massey</LastName><ForeName>Alison</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kwan</LastName><ForeName>Amy</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ferreira</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Angelakas</LastName><ForeName>Angelos</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wu</LastName><ForeName>Anjui</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tivey</LastName><ForeName>Ann</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Armstrong</LastName><ForeName>Anne</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Madhan</LastName><ForeName>Annet</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pillai</LastName><ForeName>Annet</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Poon-King</LastName><ForeName>Ashley</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kurec</LastName><ForeName>Bartlomiej</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Usborne</LastName><ForeName>Caroline</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dobeson</LastName><ForeName>Caroline</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Thirlwell</LastName><ForeName>Christina</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sng</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Scrase</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jingree</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brunner</LastName><ForeName>Clair</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fuller</LastName><ForeName>Claire</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Griffin</LastName><ForeName>Clare</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Barrington</LastName><ForeName>Craig</ForeName><Initials>C</Initials></Investigator><Investigator 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