Does incubation period of COVID-19 vary with age? A study of epidemiologically linked cases in Singapore.
Identifieur interne : 000395 ( Main/Corpus ); précédent : 000394; suivant : 000396Does incubation period of COVID-19 vary with age? A study of epidemiologically linked cases in Singapore.
Auteurs : W Y T. Tan ; L Y Wong ; Y S Leo ; M P H S. TohSource :
- Epidemiology and infection [ 1469-4409 ] ; 2020.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aging (MeSH), Betacoronavirus (MeSH), Child (MeSH), Child, Preschool (MeSH), Coronavirus Infections (epidemiology), Coronavirus Infections (pathology), Female (MeSH), Humans (MeSH), Infectious Disease Incubation Period (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Pneumonia, Viral (pathology), Singapore (epidemiology), Young Adult (MeSH).
- MESH :
- geographic , epidemiology : Singapore.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- pathology : Coronavirus Infections, Pneumonia, Viral.
- Adolescent, Adult, Aged, Aging, Betacoronavirus, Child, Child, Preschool, Female, Humans, Infectious Disease Incubation Period, Male, Middle Aged, Pandemics, Young Adult.
Abstract
This study estimates the incubation period of COVID-19 among locally transmitted cases, and its association with age to better inform public health measures in containing COVID-19. Epidemiological data of all PCR-confirmed COVID-19 cases from all restructured hospitals in Singapore were collected between 23 January 2020 and 2 April 2020. Activity mapping and detailed epidemiological investigation were conducted by trained personnel. Positive cases without clear exposure to another positive case were excluded from the analysis. One hundred and sixty-four cases (15.6% of patients) met the inclusion criteria during the defined period. The crude median incubation period was 5 days (range 1-12 days) and median age was 42 years (range 5-79 years). The median incubation period among those 70 years and older was significantly longer than those younger than 70 years (8 vis-à-vis 5 days, P = 0.040). Incubation period was negatively correlated with day of illness in both groups. These findings support current policies of 14-day quarantine periods for close contacts of confirmed cases and 28 days for monitoring infections in known clusters. An elderly person who may have a longer incubation period than a younger counterpart may benefit from earlier and proactive testing, especially after exposure to a positive case.
DOI: 10.1017/S0950268820001995
PubMed: 32873357
PubMed Central: PMC7484300
Links to Exploration step
pubmed:32873357Le document en format XML
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Tan</name><affiliation><nlm:affiliation>Tan Tock Seng Hospital, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, L Y" sort="Wong, L Y" uniqKey="Wong L" first="L Y" last="Wong">L Y Wong</name><affiliation><nlm:affiliation>National Healthcare Group, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Leo, Y S" sort="Leo, Y S" uniqKey="Leo Y" first="Y S" last="Leo">Y S Leo</name><affiliation><nlm:affiliation>Tan Tock Seng Hospital, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>National Centre for Infectious Diseases, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Lee Kong Chian School of Medicine, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Yong Loo Lin School of Medicine, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Toh, M P H S" sort="Toh, M P H S" uniqKey="Toh M" first="M P H S" last="Toh">M P H S. Toh</name><affiliation><nlm:affiliation>Tan Tock Seng Hospital, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>National Centre for Infectious Diseases, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, Singapore.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32873357</idno><idno type="pmid">32873357</idno><idno type="doi">10.1017/S0950268820001995</idno><idno type="pmc">PMC7484300</idno><idno type="wicri:Area/Main/Corpus">000395</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000395</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Does incubation period of COVID-19 vary with age? A study of epidemiologically linked cases in Singapore.</title><author><name sortKey="Tan, W Y T" sort="Tan, W Y T" uniqKey="Tan W" first="W Y T" last="Tan">W Y T. Tan</name><affiliation><nlm:affiliation>Tan Tock Seng Hospital, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, L Y" sort="Wong, L Y" uniqKey="Wong L" first="L Y" last="Wong">L Y Wong</name><affiliation><nlm:affiliation>National Healthcare Group, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Leo, Y S" sort="Leo, Y S" uniqKey="Leo Y" first="Y S" last="Leo">Y S Leo</name><affiliation><nlm:affiliation>Tan Tock Seng Hospital, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>National Centre for Infectious Diseases, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Lee Kong Chian School of Medicine, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Yong Loo Lin School of Medicine, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Toh, M P H S" sort="Toh, M P H S" uniqKey="Toh M" first="M P H S" last="Toh">M P H S. Toh</name><affiliation><nlm:affiliation>Tan Tock Seng Hospital, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>National Centre for Infectious Diseases, Singapore.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, Singapore.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Epidemiology and infection</title><idno type="eISSN">1469-4409</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aging (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (pathology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Infectious Disease Incubation Period (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (pathology)</term><term>Singapore (epidemiology)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Singapore</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aging</term><term>Betacoronavirus</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infectious Disease Incubation Period</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study estimates the incubation period of COVID-19 among locally transmitted cases, and its association with age to better inform public health measures in containing COVID-19. Epidemiological data of all PCR-confirmed COVID-19 cases from all restructured hospitals in Singapore were collected between 23 January 2020 and 2 April 2020. Activity mapping and detailed epidemiological investigation were conducted by trained personnel. Positive cases without clear exposure to another positive case were excluded from the analysis. One hundred and sixty-four cases (15.6% of patients) met the inclusion criteria during the defined period. The crude median incubation period was 5 days (range 1-12 days) and median age was 42 years (range 5-79 years). The median incubation period among those 70 years and older was significantly longer than those younger than 70 years (8 vis-à-vis 5 days, P = 0.040). Incubation period was negatively correlated with day of illness in both groups. These findings support current policies of 14-day quarantine periods for close contacts of confirmed cases and 28 days for monitoring infections in known clusters. An elderly person who may have a longer incubation period than a younger counterpart may benefit from earlier and proactive testing, especially after exposure to a positive case.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32873357</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>24</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1469-4409</ISSN><JournalIssue CitedMedium="Internet"><Volume>148</Volume><PubDate><Year>2020</Year><Month>09</Month><Day>02</Day></PubDate></JournalIssue><Title>Epidemiology and infection</Title><ISOAbbreviation>Epidemiol Infect</ISOAbbreviation></Journal><ArticleTitle>Does incubation period of COVID-19 vary with age? A study of epidemiologically linked cases in Singapore.</ArticleTitle><Pagination><MedlinePgn>e197</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1017/S0950268820001995</ELocationID><Abstract><AbstractText>This study estimates the incubation period of COVID-19 among locally transmitted cases, and its association with age to better inform public health measures in containing COVID-19. Epidemiological data of all PCR-confirmed COVID-19 cases from all restructured hospitals in Singapore were collected between 23 January 2020 and 2 April 2020. Activity mapping and detailed epidemiological investigation were conducted by trained personnel. Positive cases without clear exposure to another positive case were excluded from the analysis. One hundred and sixty-four cases (15.6% of patients) met the inclusion criteria during the defined period. The crude median incubation period was 5 days (range 1-12 days) and median age was 42 years (range 5-79 years). The median incubation period among those 70 years and older was significantly longer than those younger than 70 years (8 vis-à-vis 5 days, P = 0.040). Incubation period was negatively correlated with day of illness in both groups. These findings support current policies of 14-day quarantine periods for close contacts of confirmed cases and 28 days for monitoring infections in known clusters. An elderly person who may have a longer incubation period than a younger counterpart may benefit from earlier and proactive testing, especially after exposure to a positive case.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>W Y T</ForeName><Initials>WYT</Initials><Identifier Source="ORCID">0000-0002-4348-7926</Identifier><AffiliationInfo><Affiliation>Tan Tock Seng Hospital, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>L Y</ForeName><Initials>LY</Initials><AffiliationInfo><Affiliation>National Healthcare Group, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leo</LastName><ForeName>Y S</ForeName><Initials>YS</Initials><AffiliationInfo><Affiliation>Tan Tock Seng Hospital, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Centre for Infectious Diseases, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Lee Kong Chian School of Medicine, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Yong Loo Lin School of Medicine, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toh</LastName><ForeName>M P H S</ForeName><Initials>MPHS</Initials><AffiliationInfo><Affiliation>Tan Tock Seng Hospital, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Centre for Infectious Diseases, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, Singapore.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Epidemiol Infect</MedlineTA><NlmUniqueID>8703737</NlmUniqueID><ISSNLinking>0950-2688</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="Y">Aging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" 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PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32873357</ArticleId><ArticleId IdType="doi">10.1017/S0950268820001995</ArticleId><ArticleId IdType="pii">S0950268820001995</ArticleId><ArticleId IdType="pmc">PMC7484300</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Virol. 2020 Jun 1;94(12):</Citation><ArticleIdList><ArticleId IdType="pubmed">32269121</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2020 Aug;20(8):920-928</Citation><ArticleIdList><ArticleId 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