Determination of risk factors for predicting the onset of symptoms in asymptomatic COVID-19 infected patients.
Identifieur interne : 000234 ( Main/Corpus ); précédent : 000233; suivant : 000235Determination of risk factors for predicting the onset of symptoms in asymptomatic COVID-19 infected patients.
Auteurs : Pei-Yao Tao ; Ling Leng ; Kun Liu ; Ri-Hua Zhou ; Yue-Chun Hu ; Shang-Jie Wu ; Yu-Dong Xiao ; Jun LiuSource :
- International journal of medical sciences [ 1449-1907 ] ; 2020.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Antiviral Agents (therapeutic use), Asymptomatic Infections (epidemiology), Child (MeSH), Child, Preschool (MeSH), China (epidemiology), Coronavirus Infections (diagnosis), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Female (MeSH), Humans (MeSH), Infant (MeSH), Lung (diagnostic imaging), Lung Diseases (complications), Lung Diseases (epidemiology), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (drug therapy), Pneumonia, Viral (epidemiology), Pneumonia, Viral (virology), Pregnancy (MeSH), Prognosis (MeSH), Retrospective Studies (MeSH), Risk Assessment (MeSH), Risk Factors (MeSH), Severity of Illness Index (MeSH), Smoking (adverse effects), Smoking (epidemiology), Symptom Flare Up (MeSH), Tomography, X-Ray Computed (MeSH), Treatment Outcome (MeSH), Young Adult (MeSH).
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- geographic , epidemiology : China.
- adverse effects : Smoking.
- complications : Lung Diseases.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- diagnostic imaging : Lung.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Asymptomatic Infections, Coronavirus Infections, Lung Diseases, Pneumonia, Viral, Smoking.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Pandemics, Pregnancy, Prognosis, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Symptom Flare Up, Tomography, X-Ray Computed, Treatment Outcome, Young Adult.
Abstract
Background: The number of asymptomatic infected patients with coronavirus disease 2019 (COVID-2019) is rampaging around the world but limited information aimed on risk factors of asymptomatic infections. The purpose of this study is to investigate the risk factors of symptoms onset and clinical features in asymptomatic COVID-19 infected patients. Methods: A retrospective study was performed in 70 asymptomatic COVID-2019 infected patients confirmed by nucleic acid tests in Hunan province, China between 28 January 2020 and 18 February, 2020. The epidemiological, clinical features and laboratory data were reviewed and analyzed. Presence or absence at the onset of symptoms was taken as the outcome. A Cox regression model was performed to evaluate the potential predictors of the onset of symptoms. Results: The study included 36 males and 34 females with a mean age of 33.24±20.40 years (range, 0.5-84 years). There were 22 asymptomatic carriers developed symptoms during hospitalization isolated observation, and diagnosed as confirmed cases, while 48 cases remained asymptomatic throughout the course of disease. Of 70 asymptomatic patients, 14 (14/70, 20%) had underlying diseases, 3 (3/70, 4.3%) had drinking history, and 11 (11/70, 15.7%) had smoking history. 22 patients developed symptoms onset of fever (4/22, 18.2%), cough (13/22, 59.1%), chest discomfort (2/22, 9.1%), fatigue (1/22, 4.5%), pharyngalgia (1/22, 4.5%) during hospitalization; only one (1/22, 4.5%) patient developed signs of both cough and pharyngalgia. Abnormalities on chest CT were detected among 35 of the 69 patients (50.7%) after admission, except for one pregnant woman had not been examined. 4 (4/70, 5.7%) and 8 (8/70, 11.4%) cases showed leucopenia and lymphopenia. With the effective antiviral treatment, all the 70 asymptomatic infections had been discharged, none cases developed severe pneumonia, admission to intensive care unit, or died. The mean time from nucleic acid positive to negative was 13.2±6.84 days. Cox regression analysis showed that smoking history (P=0.028, hazard ratio=4.49, 95% CI 1.18-17.08) and existence of pulmonary disease (P=0.038, hazard ratio=7.09, 95% CI 1.12-44.90) were risk factors of the onset of symptoms in asymptomatic carries. Conclusion: The initially asymptomatic patients can develop mild symptoms and have a good prognosis. History of smoking and pulmonary disease was prone to illness onset in asymptomatic patients, and it is necessary to be highly vigilant to those patients.
DOI: 10.7150/ijms.47576
PubMed: 32922180
PubMed Central: PMC7484673
Links to Exploration step
pubmed:32922180Le document en format XML
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<author><name sortKey="Xiao, Yu Dong" sort="Xiao, Yu Dong" uniqKey="Xiao Y" first="Yu-Dong" last="Xiao">Yu-Dong Xiao</name>
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<term>Antiviral Agents (therapeutic use)</term>
<term>Asymptomatic Infections (epidemiology)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>China (epidemiology)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Infant (MeSH)</term>
<term>Lung (diagnostic imaging)</term>
<term>Lung Diseases (complications)</term>
<term>Lung Diseases (epidemiology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Pregnancy (MeSH)</term>
<term>Prognosis (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Risk Assessment (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Smoking (adverse effects)</term>
<term>Smoking (epidemiology)</term>
<term>Symptom Flare Up (MeSH)</term>
<term>Tomography, X-Ray Computed (MeSH)</term>
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<front><div type="abstract" xml:lang="en"><b>Background:</b>
The number of asymptomatic infected patients with coronavirus disease 2019 (COVID-2019) is rampaging around the world but limited information aimed on risk factors of asymptomatic infections. The purpose of this study is to investigate the risk factors of symptoms onset and clinical features in asymptomatic COVID-19 infected patients. <b>Methods:</b>
A retrospective study was performed in 70 asymptomatic COVID-2019 infected patients confirmed by nucleic acid tests in Hunan province, China between 28 January 2020 and 18 February, 2020. The epidemiological, clinical features and laboratory data were reviewed and analyzed. Presence or absence at the onset of symptoms was taken as the outcome. A Cox regression model was performed to evaluate the potential predictors of the onset of symptoms. <b>Results:</b>
The study included 36 males and 34 females with a mean age of 33.24±20.40 years (range, 0.5-84 years). There were 22 asymptomatic carriers developed symptoms during hospitalization isolated observation, and diagnosed as confirmed cases, while 48 cases remained asymptomatic throughout the course of disease. Of 70 asymptomatic patients, 14 (14/70, 20%) had underlying diseases, 3 (3/70, 4.3%) had drinking history, and 11 (11/70, 15.7%) had smoking history. 22 patients developed symptoms onset of fever (4/22, 18.2%), cough (13/22, 59.1%), chest discomfort (2/22, 9.1%), fatigue (1/22, 4.5%), pharyngalgia (1/22, 4.5%) during hospitalization; only one (1/22, 4.5%) patient developed signs of both cough and pharyngalgia. Abnormalities on chest CT were detected among 35 of the 69 patients (50.7%) after admission, except for one pregnant woman had not been examined. 4 (4/70, 5.7%) and 8 (8/70, 11.4%) cases showed leucopenia and lymphopenia. With the effective antiviral treatment, all the 70 asymptomatic infections had been discharged, none cases developed severe pneumonia, admission to intensive care unit, or died. The mean time from nucleic acid positive to negative was 13.2±6.84 days. Cox regression analysis showed that smoking history (P=0.028, hazard ratio=4.49, 95% CI 1.18-17.08) and existence of pulmonary disease (P=0.038, hazard ratio=7.09, 95% CI 1.12-44.90) were risk factors of the onset of symptoms in asymptomatic carries. <b>Conclusion:</b>
The initially asymptomatic patients can develop mild symptoms and have a good prognosis. History of smoking and pulmonary disease was prone to illness onset in asymptomatic patients, and it is necessary to be highly vigilant to those patients.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32922180</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>22</Day>
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<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1449-1907</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>14</Issue>
<PubDate><Year>2020</Year>
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</JournalIssue>
<Title>International journal of medical sciences</Title>
<ISOAbbreviation>Int J Med Sci</ISOAbbreviation>
</Journal>
<ArticleTitle>Determination of risk factors for predicting the onset of symptoms in asymptomatic COVID-19 infected patients.</ArticleTitle>
<Pagination><MedlinePgn>2187-2193</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.7150/ijms.47576</ELocationID>
<Abstract><AbstractText><b>Background:</b>
The number of asymptomatic infected patients with coronavirus disease 2019 (COVID-2019) is rampaging around the world but limited information aimed on risk factors of asymptomatic infections. The purpose of this study is to investigate the risk factors of symptoms onset and clinical features in asymptomatic COVID-19 infected patients. <b>Methods:</b>
A retrospective study was performed in 70 asymptomatic COVID-2019 infected patients confirmed by nucleic acid tests in Hunan province, China between 28 January 2020 and 18 February, 2020. The epidemiological, clinical features and laboratory data were reviewed and analyzed. Presence or absence at the onset of symptoms was taken as the outcome. A Cox regression model was performed to evaluate the potential predictors of the onset of symptoms. <b>Results:</b>
The study included 36 males and 34 females with a mean age of 33.24±20.40 years (range, 0.5-84 years). There were 22 asymptomatic carriers developed symptoms during hospitalization isolated observation, and diagnosed as confirmed cases, while 48 cases remained asymptomatic throughout the course of disease. Of 70 asymptomatic patients, 14 (14/70, 20%) had underlying diseases, 3 (3/70, 4.3%) had drinking history, and 11 (11/70, 15.7%) had smoking history. 22 patients developed symptoms onset of fever (4/22, 18.2%), cough (13/22, 59.1%), chest discomfort (2/22, 9.1%), fatigue (1/22, 4.5%), pharyngalgia (1/22, 4.5%) during hospitalization; only one (1/22, 4.5%) patient developed signs of both cough and pharyngalgia. Abnormalities on chest CT were detected among 35 of the 69 patients (50.7%) after admission, except for one pregnant woman had not been examined. 4 (4/70, 5.7%) and 8 (8/70, 11.4%) cases showed leucopenia and lymphopenia. With the effective antiviral treatment, all the 70 asymptomatic infections had been discharged, none cases developed severe pneumonia, admission to intensive care unit, or died. The mean time from nucleic acid positive to negative was 13.2±6.84 days. Cox regression analysis showed that smoking history (P=0.028, hazard ratio=4.49, 95% CI 1.18-17.08) and existence of pulmonary disease (P=0.038, hazard ratio=7.09, 95% CI 1.12-44.90) were risk factors of the onset of symptoms in asymptomatic carries. <b>Conclusion:</b>
The initially asymptomatic patients can develop mild symptoms and have a good prognosis. History of smoking and pulmonary disease was prone to illness onset in asymptomatic patients, and it is necessary to be highly vigilant to those patients.</AbstractText>
<CopyrightInformation>© The author(s).</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tao</LastName>
<ForeName>Pei-Yao</ForeName>
<Initials>PY</Initials>
<AffiliationInfo><Affiliation>Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China, 410011.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leng</LastName>
<ForeName>Ling</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology, School of Basic Medical Science, Tianjin Medical University, Tianjing, China, 300070.</Affiliation>
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<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Kun</ForeName>
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<AffiliationInfo><Affiliation>Department of Infection and rehabilitation, Yiyang The Fourth People's Hospital, Yiyang, China, 413000.</Affiliation>
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<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Ri-Hua</ForeName>
<Initials>RH</Initials>
<AffiliationInfo><Affiliation>Medical Department, Chenzhou The Second People's Hospital, Chenzhou, China, 423000.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Yue-Chun</ForeName>
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<AffiliationInfo><Affiliation>Department of Radiology, Loudi Central Hospital, Nanhua University, Loudi, China, 417000.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Shang-Jie</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China, 410011.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xiao</LastName>
<ForeName>Yu-Dong</ForeName>
<Initials>YD</Initials>
<AffiliationInfo><Affiliation>Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China, 410011.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Jun</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China, 410011.</Affiliation>
</AffiliationInfo>
</Author>
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