Hyperbaric oxygen therapy for COVID-19 patients with respiratory distress: treated cases versus propensity-matched controls.
Identifieur interne : 000209 ( Main/Corpus ); précédent : 000208; suivant : 000210Hyperbaric oxygen therapy for COVID-19 patients with respiratory distress: treated cases versus propensity-matched controls.
Auteurs : Scott A. Gorenstein ; Michael L. Castellano ; Eric S. Slone ; Brian Gillette ; Helen Liu ; Cindy Alsamarraie ; Alan M. Jacobson ; Stephen P. Wall ; Samrachana Adhikari ; Jordan L. Swartz ; Jenica J S. Mcmullen ; Marcela Osorio ; Christian A. Koziatek ; David C. LeeSource :
- Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc [ 1066-2936 ]
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Atmospheric Pressure (MeSH), Betacoronavirus (MeSH), Case-Control Studies (MeSH), Coronavirus Infections (complications), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Female (MeSH), Humans (MeSH), Hyperbaric Oxygenation (adverse effects), Hyperbaric Oxygenation (methods), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), Propensity Score (MeSH), Respiration, Artificial (mortality), Respiratory Distress Syndrome, Adult (etiology), Respiratory Distress Syndrome, Adult (mortality), Respiratory Distress Syndrome, Adult (therapy), Risk Factors (MeSH), Safety (MeSH), Survival Analysis (MeSH), Time Factors (MeSH), Treatment Outcome (MeSH).
- MESH :
- adverse effects : Hyperbaric Oxygenation.
- complications : Coronavirus Infections, Pneumonia, Viral.
- etiology : Respiratory Distress Syndrome, Adult.
- methods : Hyperbaric Oxygenation.
- mortality : Coronavirus Infections, Pneumonia, Viral, Respiration, Artificial, Respiratory Distress Syndrome, Adult.
- therapy : Coronavirus Infections, Pneumonia, Viral, Respiratory Distress Syndrome, Adult.
- Adult, Aged, Atmospheric Pressure, Betacoronavirus, Case-Control Studies, Female, Humans, Male, Middle Aged, Pandemics, Propensity Score, Risk Factors, Safety, Survival Analysis, Time Factors, Treatment Outcome.
Abstract
Objective
Given the high mortality and prolonged duration of mechanical ventilation of COVID-19 patients, we evaluated the safety and efficacy of hyperbaric oxygen for COVID-19 patients with respiratory distress.
Methods
This is a single-center clinical trial of COVID-19 patients at NYU Winthrop Hospital from March 31 to April 28, 2020. Patients in this trial received hyperbaric oxygen therapy at 2.0 atmospheres of pressure in monoplace hyperbaric chambers for 90 minutes daily for a maximum of five total treatments. Controls were identified using propensity score matching among COVID-19 patients admitted during the same time period. Using competing-risks survival regression, we analyzed our primary outcome of inpatient mortality and secondary outcome of mechanical ventilation.
Results
We treated 20 COVID-19 patients with hyperbaric oxygen. Ages ranged from 30 to 79 years with an oxygen requirement ranging from 2 to 15 liters on hospital days 0 to 14. Of these 20 patients, two (10%) were intubated and died, and none remain hospitalized. Among 60 propensity-matched controls based on age, sex, body mass index, coronary artery disease, troponin, D-dimer, hospital day, and oxygen requirement, 18 (30%) were intubated, 13 (22%) have died, and three (5%) remain hospitalized (with one still requiring mechanical ventilation). Assuming no further deaths among controls, we estimate that the adjusted subdistribution hazard ratios were 0.37 for inpatient mortality (p=0.14) and 0.26 for mechanical ventilation (p=0.046).
Conclusion
Though limited by its study design, our results demonstrate the safety of hyperbaric oxygen among COVID-19 patients and strongly suggests the need for a well-designed, multicenter randomized control trial.
PubMed: 32931666
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pubmed:32931666Le document en format XML
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Castellano</name><affiliation><nlm:affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Slone, Eric S" sort="Slone, Eric S" uniqKey="Slone E" first="Eric S" last="Slone">Eric S. 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Jacobson</name><affiliation><nlm:affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Foundations of Medicine Department, NYU Winthrop Hospital, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Wall, Stephen P" sort="Wall, Stephen P" uniqKey="Wall S" first="Stephen P" last="Wall">Stephen P. Wall</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Population Health, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Adhikari, Samrachana" sort="Adhikari, Samrachana" uniqKey="Adhikari S" first="Samrachana" last="Adhikari">Samrachana Adhikari</name><affiliation><nlm:affiliation>Department of Population Health, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Swartz, Jordan L" sort="Swartz, Jordan L" uniqKey="Swartz J" first="Jordan L" last="Swartz">Jordan L. Swartz</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmullen, Jenica J S" sort="Mcmullen, Jenica J S" uniqKey="Mcmullen J" first="Jenica J S" last="Mcmullen">Jenica J S. Mcmullen</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Osorio, Marcela" sort="Osorio, Marcela" uniqKey="Osorio M" first="Marcela" last="Osorio">Marcela Osorio</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Koziatek, Christian A" sort="Koziatek, Christian A" uniqKey="Koziatek C" first="Christian A" last="Koziatek">Christian A. Koziatek</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, David C" sort="Lee, David C" uniqKey="Lee D" first="David C" last="Lee">David C. Lee</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Population Health, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020 Third Quarter</date><idno type="RBID">pubmed:32931666</idno><idno type="pmid">32931666</idno><idno type="wicri:Area/Main/Corpus">000209</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000209</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hyperbaric oxygen therapy for COVID-19 patients with respiratory distress: treated cases versus propensity-matched controls.</title><author><name sortKey="Gorenstein, Scott A" sort="Gorenstein, Scott A" uniqKey="Gorenstein S" first="Scott A" last="Gorenstein">Scott A. Gorenstein</name><affiliation><nlm:affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Castellano, Michael L" sort="Castellano, Michael L" uniqKey="Castellano M" first="Michael L" last="Castellano">Michael L. Castellano</name><affiliation><nlm:affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Slone, Eric S" sort="Slone, Eric S" uniqKey="Slone E" first="Eric S" last="Slone">Eric S. Slone</name><affiliation><nlm:affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Gillette, Brian" sort="Gillette, Brian" uniqKey="Gillette B" first="Brian" last="Gillette">Brian Gillette</name><affiliation><nlm:affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Helen" sort="Liu, Helen" uniqKey="Liu H" first="Helen" last="Liu">Helen Liu</name><affiliation><nlm:affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Alsamarraie, Cindy" sort="Alsamarraie, Cindy" uniqKey="Alsamarraie C" first="Cindy" last="Alsamarraie">Cindy Alsamarraie</name><affiliation><nlm:affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Jacobson, Alan M" sort="Jacobson, Alan M" uniqKey="Jacobson A" first="Alan M" last="Jacobson">Alan M. Jacobson</name><affiliation><nlm:affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Foundations of Medicine Department, NYU Winthrop Hospital, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Wall, Stephen P" sort="Wall, Stephen P" uniqKey="Wall S" first="Stephen P" last="Wall">Stephen P. Wall</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Population Health, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Adhikari, Samrachana" sort="Adhikari, Samrachana" uniqKey="Adhikari S" first="Samrachana" last="Adhikari">Samrachana Adhikari</name><affiliation><nlm:affiliation>Department of Population Health, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Swartz, Jordan L" sort="Swartz, Jordan L" uniqKey="Swartz J" first="Jordan L" last="Swartz">Jordan L. Swartz</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmullen, Jenica J S" sort="Mcmullen, Jenica J S" uniqKey="Mcmullen J" first="Jenica J S" last="Mcmullen">Jenica J S. Mcmullen</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Osorio, Marcela" sort="Osorio, Marcela" uniqKey="Osorio M" first="Marcela" last="Osorio">Marcela Osorio</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Koziatek, Christian A" sort="Koziatek, Christian A" uniqKey="Koziatek C" first="Christian A" last="Koziatek">Christian A. Koziatek</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, David C" sort="Lee, David C" uniqKey="Lee D" first="David C" last="Lee">David C. Lee</name><affiliation><nlm:affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Population Health, NYU Grossman School of Medicine, New York, NY, U.S.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc</title><idno type="ISSN">1066-2936</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Atmospheric Pressure (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (therapy)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Hyperbaric Oxygenation (adverse effects)</term><term>Hyperbaric Oxygenation (methods)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (therapy)</term><term>Propensity Score (MeSH)</term><term>Respiration, Artificial (mortality)</term><term>Respiratory Distress Syndrome, Adult (etiology)</term><term>Respiratory Distress Syndrome, Adult (mortality)</term><term>Respiratory Distress Syndrome, Adult (therapy)</term><term>Risk Factors (MeSH)</term><term>Safety (MeSH)</term><term>Survival Analysis (MeSH)</term><term>Time Factors (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Hyperbaric Oxygenation</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hyperbaric Oxygenation</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Respiration, Artificial</term><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Atmospheric Pressure</term><term>Betacoronavirus</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Propensity Score</term><term>Risk Factors</term><term>Safety</term><term>Survival Analysis</term><term>Time Factors</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Objective</b></p><p>Given the high mortality and prolonged duration of mechanical ventilation of COVID-19 patients, we evaluated the safety and efficacy of hyperbaric oxygen for COVID-19 patients with respiratory distress.</p></div><div type="abstract" xml:lang="en"><p><b>Methods</b></p><p>This is a single-center clinical trial of COVID-19 patients at NYU Winthrop Hospital from March 31 to April 28, 2020. Patients in this trial received hyperbaric oxygen therapy at 2.0 atmospheres of pressure in monoplace hyperbaric chambers for 90 minutes daily for a maximum of five total treatments. Controls were identified using propensity score matching among COVID-19 patients admitted during the same time period. Using competing-risks survival regression, we analyzed our primary outcome of inpatient mortality and secondary outcome of mechanical ventilation.</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>We treated 20 COVID-19 patients with hyperbaric oxygen. Ages ranged from 30 to 79 years with an oxygen requirement ranging from 2 to 15 liters on hospital days 0 to 14. Of these 20 patients, two (10%) were intubated and died, and none remain hospitalized. Among 60 propensity-matched controls based on age, sex, body mass index, coronary artery disease, troponin, D-dimer, hospital day, and oxygen requirement, 18 (30%) were intubated, 13 (22%) have died, and three (5%) remain hospitalized (with one still requiring mechanical ventilation). Assuming no further deaths among controls, we estimate that the adjusted subdistribution hazard ratios were 0.37 for inpatient mortality (p=0.14) and 0.26 for mechanical ventilation (p=0.046).</p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>Though limited by its study design, our results demonstrate the safety of hyperbaric oxygen among COVID-19 patients and strongly suggests the need for a well-designed, multicenter randomized control trial.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32931666</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>24</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1066-2936</ISSN><JournalIssue CitedMedium="Internet"><Volume>47</Volume><Issue>3</Issue><PubDate><MedlineDate>2020 Third Quarter</MedlineDate></PubDate></JournalIssue><Title>Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc</Title><ISOAbbreviation>Undersea Hyperb Med</ISOAbbreviation></Journal><ArticleTitle>Hyperbaric oxygen therapy for COVID-19 patients with respiratory distress: treated cases versus propensity-matched controls.</ArticleTitle><Pagination><MedlinePgn>405-413</MedlinePgn></Pagination><Abstract><AbstractText Label="Objective" NlmCategory="UNASSIGNED">Given the high mortality and prolonged duration of mechanical ventilation of COVID-19 patients, we evaluated the safety and efficacy of hyperbaric oxygen for COVID-19 patients with respiratory distress.</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">This is a single-center clinical trial of COVID-19 patients at NYU Winthrop Hospital from March 31 to April 28, 2020. Patients in this trial received hyperbaric oxygen therapy at 2.0 atmospheres of pressure in monoplace hyperbaric chambers for 90 minutes daily for a maximum of five total treatments. Controls were identified using propensity score matching among COVID-19 patients admitted during the same time period. Using competing-risks survival regression, we analyzed our primary outcome of inpatient mortality and secondary outcome of mechanical ventilation.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">We treated 20 COVID-19 patients with hyperbaric oxygen. Ages ranged from 30 to 79 years with an oxygen requirement ranging from 2 to 15 liters on hospital days 0 to 14. Of these 20 patients, two (10%) were intubated and died, and none remain hospitalized. Among 60 propensity-matched controls based on age, sex, body mass index, coronary artery disease, troponin, D-dimer, hospital day, and oxygen requirement, 18 (30%) were intubated, 13 (22%) have died, and three (5%) remain hospitalized (with one still requiring mechanical ventilation). Assuming no further deaths among controls, we estimate that the adjusted subdistribution hazard ratios were 0.37 for inpatient mortality (p=0.14) and 0.26 for mechanical ventilation (p=0.046).</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">Though limited by its study design, our results demonstrate the safety of hyperbaric oxygen among COVID-19 patients and strongly suggests the need for a well-designed, multicenter randomized control trial.</AbstractText><CopyrightInformation>Copyright© Undersea and Hyperbaric Medical Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gorenstein</LastName><ForeName>Scott A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castellano</LastName><ForeName>Michael L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slone</LastName><ForeName>Eric S</ForeName><Initials>ES</Initials><AffiliationInfo><Affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gillette</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Helen</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alsamarraie</LastName><ForeName>Cindy</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Wound Care, Department of Surgery, NYU Winthrop Hospital, New York, NY, U.S.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jacobson</LastName><ForeName>Alan M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>NYU Long Island School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Foundations of Medicine Department, NYU Winthrop Hospital, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wall</LastName><ForeName>Stephen P</ForeName><Initials>SP</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Population Health, NYU Grossman School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adhikari</LastName><ForeName>Samrachana</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Population Health, NYU Grossman School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Swartz</LastName><ForeName>Jordan L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMullen</LastName><ForeName>Jenica J S</ForeName><Initials>JJS</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Osorio</LastName><ForeName>Marcela</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koziatek</LastName><ForeName>Christian A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>David C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Population Health, NYU Grossman School of Medicine, New York, NY, U.S.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Undersea Hyperb Med</MedlineTA><NlmUniqueID>9312954</NlmUniqueID><ISSNLinking>1066-2936</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CitationSubset>S</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001274" MajorTopicYN="N">Atmospheric Pressure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006931" MajorTopicYN="N">Hyperbaric Oxygenation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057216" MajorTopicYN="Y">Propensity Score</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012449" MajorTopicYN="N">Safety</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N"> COVID-19 </Keyword><Keyword MajorTopicYN="N"> hyperbaric oxygen therapy </Keyword><Keyword MajorTopicYN="N"> infectious diseases </Keyword></KeywordList><CoiStatement>The authors of this paper declare no conflicts of interest exist with this submission.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>15</Day><Hour>17</Hour><Minute>15</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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