A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report.
Identifieur interne : 000054 ( Main/Corpus ); précédent : 000053; suivant : 000055A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report.
Auteurs : Taojiang Chen ; Qin Yang ; Hongyu DuanSource :
- BMC gastroenterology [ 1471-230X ] ; 2020.
English descriptors
- KwdEn :
- Aged, 80 and over (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (complications), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Fatal Outcome (MeSH), Gastrointestinal Hemorrhage (diagnosis), Gastrointestinal Hemorrhage (therapy), Gastrointestinal Hemorrhage (virology), Humans (MeSH), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), Risk Factors (MeSH).
- MESH :
- complications : Coronavirus Infections, Pneumonia, Viral.
- diagnosis : Gastrointestinal Hemorrhage.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- therapy : Coronavirus Infections, Gastrointestinal Hemorrhage, Pneumonia, Viral.
- virology : Gastrointestinal Hemorrhage.
- Aged, 80 and over, Betacoronavirus, Fatal Outcome, Humans, Male, Pandemics, Risk Factors.
Abstract
BACKGROUND
SARS-CoV-2 is highly infectious and has been a significant public health threat. Despite typical manifestations of illness are dominated by respiratory symptom, some patients have concurrent gastrointestinal manifestations, including nausea, diarrhea, and vomiting. Massive gastrointestinal bleeding, however, has rarely been reported.
CASE PRESENTATION
We herein described a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Although aggressive resuscitation was administered, hematochezia was uncontrolled. The patient rapidly deteriorated, suffered from cardiac arrest, and expired.
CONCLUSIONS
Digestive symptoms could be severe in SARS-CoV-2 infected patients, especially for the high-risk individuals with predisposing conditions. A more thorough protocol for preventing cross-infection through faecal-oral transmission should be implemented in the process of patient care and infection control.
DOI: 10.1186/s12876-020-01458-x
PubMed: 32993509
PubMed Central: PMC7522923
Links to Exploration step
pubmed:32993509Le document en format XML
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Second University Hospital, Sichuan University, Chengdu, Sichuan, China. 495429978@qq.com.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Chengdu, Sichuan, China. 495429978@qq.com.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Pediatric Cardiovascular Disease, West China Second University Hospital, Sichuan University, No. 20, Section 3, RenminNanLu Road, Chengdu, Sichuan, 610041, China. 495429978@qq.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32993509</idno><idno type="pmid">32993509</idno><idno type="doi">10.1186/s12876-020-01458-x</idno><idno type="pmc">PMC7522923</idno><idno type="wicri:Area/Main/Corpus">000054</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000054</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report.</title><author><name sortKey="Chen, Taojiang" sort="Chen, Taojiang" uniqKey="Chen T" first="Taojiang" last="Chen">Taojiang Chen</name><affiliation><nlm:affiliation>Department of Critical Care Medicine, Chengdu Fifth People's Hospital, Chengdu, Sichuan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Qin" sort="Yang, Qin" uniqKey="Yang Q" first="Qin" last="Yang">Qin Yang</name><affiliation><nlm:affiliation>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation></affiliation></author><author><name sortKey="Duan, Hongyu" sort="Duan, Hongyu" uniqKey="Duan H" first="Hongyu" last="Duan">Hongyu Duan</name><affiliation><nlm:affiliation>Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. 495429978@qq.com.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Chengdu, Sichuan, China. 495429978@qq.com.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Pediatric Cardiovascular Disease, West China Second University Hospital, Sichuan University, No. 20, Section 3, RenminNanLu Road, Chengdu, Sichuan, 610041, China. 495429978@qq.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">BMC gastroenterology</title><idno type="eISSN">1471-230X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged, 80 and over (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (therapy)</term><term>Fatal Outcome (MeSH)</term><term>Gastrointestinal Hemorrhage (diagnosis)</term><term>Gastrointestinal Hemorrhage (therapy)</term><term>Gastrointestinal Hemorrhage (virology)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (therapy)</term><term>Risk Factors (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Gastrointestinal Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Gastrointestinal Hemorrhage</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Gastrointestinal Hemorrhage</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged, 80 and over</term><term>Betacoronavirus</term><term>Fatal Outcome</term><term>Humans</term><term>Male</term><term>Pandemics</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>SARS-CoV-2 is highly infectious and has been a significant public health threat. Despite typical manifestations of illness are dominated by respiratory symptom, some patients have concurrent gastrointestinal manifestations, including nausea, diarrhea, and vomiting. Massive gastrointestinal bleeding, however, has rarely been reported.</p></div><div type="abstract" xml:lang="en"><p><b>CASE PRESENTATION</b></p><p>We herein described a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Although aggressive resuscitation was administered, hematochezia was uncontrolled. The patient rapidly deteriorated, suffered from cardiac arrest, and expired.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Digestive symptoms could be severe in SARS-CoV-2 infected patients, especially for the high-risk individuals with predisposing conditions. A more thorough protocol for preventing cross-infection through faecal-oral transmission should be implemented in the process of patient care and infection control.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32993509</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>08</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>08</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-230X</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Sep</Month><Day>29</Day></PubDate></JournalIssue><Title>BMC gastroenterology</Title><ISOAbbreviation>BMC Gastroenterol</ISOAbbreviation></Journal><ArticleTitle>A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report.</ArticleTitle><Pagination><MedlinePgn>318</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12876-020-01458-x</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">SARS-CoV-2 is highly infectious and has been a significant public health threat. Despite typical manifestations of illness are dominated by respiratory symptom, some patients have concurrent gastrointestinal manifestations, including nausea, diarrhea, and vomiting. Massive gastrointestinal bleeding, however, has rarely been reported.</AbstractText><AbstractText Label="CASE PRESENTATION" NlmCategory="METHODS">We herein described a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Although aggressive resuscitation was administered, hematochezia was uncontrolled. The patient rapidly deteriorated, suffered from cardiac arrest, and expired.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Digestive symptoms could be severe in SARS-CoV-2 infected patients, especially for the high-risk individuals with predisposing conditions. A more thorough protocol for preventing cross-infection through faecal-oral transmission should be implemented in the process of patient care and infection control.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Taojiang</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine, Chengdu Fifth People's Hospital, Chengdu, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Qin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duan</LastName><ForeName>Hongyu</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. 495429978@qq.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Chengdu, Sichuan, China. 495429978@qq.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pediatric Cardiovascular Disease, West China Second University Hospital, Sichuan University, No. 20, Section 3, RenminNanLu Road, Chengdu, Sichuan, 610041, China. 495429978@qq.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>81971457</GrantID><Agency>National Natural Science Foundation of China</Agency><Country></Country></Grant><Grant><GrantID>81800288</GrantID><Agency>National Natural Science Foundation of China</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal 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UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017809" MajorTopicYN="N">Fatal Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006471" MajorTopicYN="N">Gastrointestinal Hemorrhage</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" 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