A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report.
Identifieur interne : 000054 ( Main/Corpus ); précédent : 000053; suivant : 000055A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report.
Auteurs : Taojiang Chen ; Qin Yang ; Hongyu DuanSource :
- BMC gastroenterology [ 1471-230X ] ; 2020.
English descriptors
- KwdEn :
- Aged, 80 and over (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (complications), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Fatal Outcome (MeSH), Gastrointestinal Hemorrhage (diagnosis), Gastrointestinal Hemorrhage (therapy), Gastrointestinal Hemorrhage (virology), Humans (MeSH), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), Risk Factors (MeSH).
- MESH :
- complications : Coronavirus Infections, Pneumonia, Viral.
- diagnosis : Gastrointestinal Hemorrhage.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- therapy : Coronavirus Infections, Gastrointestinal Hemorrhage, Pneumonia, Viral.
- virology : Gastrointestinal Hemorrhage.
- Aged, 80 and over, Betacoronavirus, Fatal Outcome, Humans, Male, Pandemics, Risk Factors.
Abstract
BACKGROUND
SARS-CoV-2 is highly infectious and has been a significant public health threat. Despite typical manifestations of illness are dominated by respiratory symptom, some patients have concurrent gastrointestinal manifestations, including nausea, diarrhea, and vomiting. Massive gastrointestinal bleeding, however, has rarely been reported.
CASE PRESENTATION
We herein described a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Although aggressive resuscitation was administered, hematochezia was uncontrolled. The patient rapidly deteriorated, suffered from cardiac arrest, and expired.
CONCLUSIONS
Digestive symptoms could be severe in SARS-CoV-2 infected patients, especially for the high-risk individuals with predisposing conditions. A more thorough protocol for preventing cross-infection through faecal-oral transmission should be implemented in the process of patient care and infection control.
DOI: 10.1186/s12876-020-01458-x
PubMed: 32993509
PubMed Central: PMC7522923
Links to Exploration step
pubmed:32993509Le document en format XML
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<author><name sortKey="Chen, Taojiang" sort="Chen, Taojiang" uniqKey="Chen T" first="Taojiang" last="Chen">Taojiang Chen</name>
<affiliation><nlm:affiliation>Department of Critical Care Medicine, Chengdu Fifth People's Hospital, Chengdu, Sichuan, China.</nlm:affiliation>
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<author><name sortKey="Yang, Qin" sort="Yang, Qin" uniqKey="Yang Q" first="Qin" last="Yang">Qin Yang</name>
<affiliation><nlm:affiliation>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation>
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<author><name sortKey="Duan, Hongyu" sort="Duan, Hongyu" uniqKey="Duan H" first="Hongyu" last="Duan">Hongyu Duan</name>
<affiliation><nlm:affiliation>Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. 495429978@qq.com.</nlm:affiliation>
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<affiliation><nlm:affiliation>Department of Pediatric Cardiovascular Disease, West China Second University Hospital, Sichuan University, No. 20, Section 3, RenminNanLu Road, Chengdu, Sichuan, 610041, China. 495429978@qq.com.</nlm:affiliation>
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<author><name sortKey="Yang, Qin" sort="Yang, Qin" uniqKey="Yang Q" first="Qin" last="Yang">Qin Yang</name>
<affiliation><nlm:affiliation>Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.</nlm:affiliation>
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<author><name sortKey="Duan, Hongyu" sort="Duan, Hongyu" uniqKey="Duan H" first="Hongyu" last="Duan">Hongyu Duan</name>
<affiliation><nlm:affiliation>Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. 495429978@qq.com.</nlm:affiliation>
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<affiliation><nlm:affiliation>Department of Pediatric Cardiovascular Disease, West China Second University Hospital, Sichuan University, No. 20, Section 3, RenminNanLu Road, Chengdu, Sichuan, 610041, China. 495429978@qq.com.</nlm:affiliation>
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<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Fatal Outcome (MeSH)</term>
<term>Gastrointestinal Hemorrhage (diagnosis)</term>
<term>Gastrointestinal Hemorrhage (therapy)</term>
<term>Gastrointestinal Hemorrhage (virology)</term>
<term>Humans (MeSH)</term>
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<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Risk Factors (MeSH)</term>
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<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>SARS-CoV-2 is highly infectious and has been a significant public health threat. Despite typical manifestations of illness are dominated by respiratory symptom, some patients have concurrent gastrointestinal manifestations, including nausea, diarrhea, and vomiting. Massive gastrointestinal bleeding, however, has rarely been reported.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CASE PRESENTATION</b>
</p>
<p>We herein described a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Although aggressive resuscitation was administered, hematochezia was uncontrolled. The patient rapidly deteriorated, suffered from cardiac arrest, and expired.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Digestive symptoms could be severe in SARS-CoV-2 infected patients, especially for the high-risk individuals with predisposing conditions. A more thorough protocol for preventing cross-infection through faecal-oral transmission should be implemented in the process of patient care and infection control.</p>
</div>
</front>
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<AbstractText Label="CASE PRESENTATION" NlmCategory="METHODS">We herein described a case of severe SARS-CoV-2 infected patient with several risk factors for poor prognosis, including male, hypertension, old age, mixed bacterial infection and multilobular infiltration on radiological imaging. After improvement of respiratory status, the onset of gastrointestinal bleeding occurred, probably resulting from direct viral invasion as evidenced by the positive findings for SARS-CoV-2 in the repeat stool specimens. Although aggressive resuscitation was administered, hematochezia was uncontrolled. The patient rapidly deteriorated, suffered from cardiac arrest, and expired.</AbstractText>
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