Using psychoneuroimmunity against COVID-19.
Identifieur interne : 000090 ( Main/Exploration ); précédent : 000089; suivant : 000091Using psychoneuroimmunity against COVID-19.
Auteurs : Sung-Wan Kim [Corée du Sud] ; Kuan-Pin Su [Taïwan]Source :
- Brain, behavior, and immunity [ 1090-2139 ] ; 2020.
Descripteurs français
- KwdFr :
- Comportement social, Exercice physique, Humains, Infections à coronavirus (prévention et contrôle), Infections à coronavirus (psychologie), Infections à coronavirus (épidémiologie), Masques, Mode de vie sain, Pandémies (prévention et contrôle), Pneumopathie virale (prévention et contrôle), Pneumopathie virale (psychologie), Pneumopathie virale (épidémiologie), Psycho-neuro-immunologie, Résilience psychologique, Sommeil, Soutien social, Stress psychologique (psychologie), Stress psychologique (épidémiologie), Troubles mentaux (psychologie), Troubles mentaux (épidémiologie).
- MESH :
- prévention et contrôle : Infections à coronavirus, Pandémies, Pneumopathie virale.
- psychologie : Infections à coronavirus, Pneumopathie virale, Stress psychologique, Troubles mentaux.
- épidémiologie : Infections à coronavirus, Pneumopathie virale, Stress psychologique, Troubles mentaux.
- Comportement social, Exercice physique, Humains, Masques, Mode de vie sain, Psycho-neuro-immunologie, Résilience psychologique, Sommeil, Soutien social.
English descriptors
- KwdEn :
- Betacoronavirus, Coronavirus Infections (epidemiology), Coronavirus Infections (prevention & control), Coronavirus Infections (psychology), Diet, Healthy, Exercise, Healthy Lifestyle, Humans, Masks, Mental Disorders (epidemiology), Mental Disorders (psychology), Pandemics (prevention & control), Pneumonia, Viral (epidemiology), Pneumonia, Viral (prevention & control), Pneumonia, Viral (psychology), Psychoneuroimmunology, Resilience, Psychological, Sleep, Social Behavior, Social Support, Stress, Psychological (epidemiology), Stress, Psychological (psychology).
- MESH :
- epidemiology : Coronavirus Infections, Mental Disorders, Pneumonia, Viral, Stress, Psychological.
- prevention & control : Coronavirus Infections, Pandemics, Pneumonia, Viral.
- psychology : Coronavirus Infections, Mental Disorders, Pneumonia, Viral, Stress, Psychological.
- Betacoronavirus, Diet, Healthy, Exercise, Healthy Lifestyle, Humans, Masks, Psychoneuroimmunology, Resilience, Psychological, Sleep, Social Behavior, Social Support.
Abstract
The worldwide outbreak of coronavirus disease 2019 (COVID-19) raises concerns of widespread panic and anxiety in individuals subjected to the real or perceived threat of the virus. Compared to general populations, patients who are institutionalized in a closed unit are also very vulnerable to COVID-19 infection and complications. This crisis touched on difficult issues of not only psychiatric care and ethics, but also psychological impacts to psychiatric care givers. In this Viewpoint, we address both physical and biopsychosocial aspects of this infection, as well as the psychoneuroimmunity of preventive strategies of healthy lifestyle, regular exercise, balanced nutrition, quality sleep and a strong connection with people. Social distancing and wearing masks might help us from pathogen exposure, yet such these measures also prevent us from expressing compassion and friendliness. Therefore, all forms of psychological support should be routinely implemented not only to consider psychological resilience but also to enhance psychoneuroimmunity against COVID-19.
DOI: 10.1016/j.bbi.2020.03.025
PubMed: 32234338
PubMed Central: PMC7194899
Affiliations:
Links toward previous steps (curation, corpus...)
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Compared to general populations, patients who are institutionalized in a closed unit are also very vulnerable to COVID-19 infection and complications. This crisis touched on difficult issues of not only psychiatric care and ethics, but also psychological impacts to psychiatric care givers. In this Viewpoint, we address both physical and biopsychosocial aspects of this infection, as well as the psychoneuroimmunity of preventive strategies of healthy lifestyle, regular exercise, balanced nutrition, quality sleep and a strong connection with people. Social distancing and wearing masks might help us from pathogen exposure, yet such these measures also prevent us from expressing compassion and friendliness. Therefore, all forms of psychological support should be routinely implemented not only to consider psychological resilience but also to enhance psychoneuroimmunity against COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32234338</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>02</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2139</ISSN><JournalIssue CitedMedium="Internet"><Volume>87</Volume><PubDate><Year>2020</Year><Month>07</Month></PubDate></JournalIssue><Title>Brain, behavior, and immunity</Title><ISOAbbreviation>Brain Behav. Immun.</ISOAbbreviation></Journal><ArticleTitle>Using psychoneuroimmunity against COVID-19.</ArticleTitle><Pagination><MedlinePgn>4-5</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0889-1591(20)30391-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbi.2020.03.025</ELocationID><Abstract><AbstractText>The worldwide outbreak of coronavirus disease 2019 (COVID-19) raises concerns of widespread panic and anxiety in individuals subjected to the real or perceived threat of the virus. Compared to general populations, patients who are institutionalized in a closed unit are also very vulnerable to COVID-19 infection and complications. This crisis touched on difficult issues of not only psychiatric care and ethics, but also psychological impacts to psychiatric care givers. In this Viewpoint, we address both physical and biopsychosocial aspects of this infection, as well as the psychoneuroimmunity of preventive strategies of healthy lifestyle, regular exercise, balanced nutrition, quality sleep and a strong connection with people. Social distancing and wearing masks might help us from pathogen exposure, yet such these measures also prevent us from expressing compassion and friendliness. Therefore, all forms of psychological support should be routinely implemented not only to consider psychological resilience but also to enhance psychoneuroimmunity against COVID-19.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Sung-Wan</ForeName><Initials>SW</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Chonnam National University Medical School; Mindlink, Gwangju Bukgu Community Mental Health Center, Gwangju, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Kuan-Pin</ForeName><Initials>KP</Initials><AffiliationInfo><Affiliation>Department of Psychiatry & Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan; An-Nan Hospital, China Medical University, Tainan, Taiwan. Electronic address: cobolsu@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Behav Immun</MedlineTA><NlmUniqueID>8800478</NlmUniqueID><ISSNLinking>0889-1591</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Brain Behav Immun. 2020 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IdType="pubmed">32093458</ArticleId></ArticleIdList></Reference><Reference><Citation>Gen Hosp Psychiatry. 2009 Jul-Aug;31(4):318-26</Citation><ArticleIdList><ArticleId IdType="pubmed">19555791</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Mar 3;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32125371</ArticleId></ArticleIdList></Reference><Reference><Citation>Psychiatry Investig. 2018 Apr;15(4):355-360</Citation><ArticleIdList><ArticleId IdType="pubmed">29593206</ArticleId></ArticleIdList></Reference><Reference><Citation>Compr Psychiatry. 2018 Nov;87:123-127</Citation><ArticleIdList><ArticleId IdType="pubmed">30343247</ArticleId></ArticleIdList></Reference><Reference><Citation>Infection. 2015 Aug;43(4):495-501</Citation><ArticleIdList><ArticleId IdType="pubmed">25600929</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Psychopharmacol Neurosci. 2019 May 31;17(2):279-287</Citation><ArticleIdList><ArticleId IdType="pubmed">30905128</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Mar 14;395(10227):912-920</Citation><ArticleIdList><ArticleId IdType="pubmed">32112714</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Regul Homeost Agents. 2020 Mar 14;34(2):</Citation><ArticleIdList><ArticleId IdType="pubmed">32171193</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li><li>Taïwan</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Sung Wan" sort="Kim, Sung Wan" uniqKey="Kim S" first="Sung-Wan" last="Kim">Sung-Wan Kim</name></noRegion></country><country name="Taïwan"><noRegion><name sortKey="Su, Kuan Pin" sort="Su, Kuan Pin" uniqKey="Su K" first="Kuan-Pin" last="Su">Kuan-Pin Su</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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