Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019.
Identifieur interne : 001337 ( Main/Exploration ); précédent : 001336; suivant : 001338Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019.
Auteurs : Jerome R. Lechien [France, Belgique] ; Carlos M. Chiesa-Estomba [France, Espagne] ; Sammy Place [France, Belgique] ; Yves Van Laethem [Belgique] ; Pierre Cabaraux [France, Belgique] ; Quentin Mat [France, Belgique] ; Kathy Huet [France, Belgique] ; Jan Plzak [République tchèque, Autriche] ; Mihaela Horoi [France, Belgique] ; Stéphane Hans [France] ; Maria Rosaria Barillari [France, Italie] ; Giovanni Cammaroto [France, Italie] ; Nicolas Fakhry [France] ; Delphine Martiny [Belgique] ; Tareck Ayad [France, Canada] ; Lionel Jouffe [France] ; Claire Hopkins [Royaume-Uni] ; Sven Saussez [Belgique]Source :
- Journal of internal medicine [ 1365-2796 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Céphalée (épidémiologie), Europe (MeSH), Facteurs sexuels (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (complications), Infections à coronavirus (diagnostic), Infections à coronavirus (enzymologie), Myalgie (épidémiologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (diagnostic), Pneumopathie virale (enzymologie), Prévalence (MeSH), Théorème de Bayes (MeSH), Troubles de l'olfaction (épidémiologie), Troubles du goût (épidémiologie), Évaluation des symptômes (MeSH).
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- enzymologie : Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Céphalée, Myalgie, Troubles de l'olfaction, Troubles du goût.
- Adulte, Adulte d'âge moyen, Betacoronavirus, Europe, Facteurs sexuels, Facteurs âges, Femelle, Humains, Infections à coronavirus, Mâle, Pandémies, Pneumopathie virale, Prévalence, Théorème de Bayes, Évaluation des symptômes.
English descriptors
- KwdEn :
- Adult (MeSH), Age Factors (MeSH), Bayes Theorem (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (complications), Coronavirus Infections (diagnosis), Coronavirus Infections (enzymology), Europe (MeSH), Female (MeSH), Headache (epidemiology), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Myalgia (epidemiology), Olfaction Disorders (epidemiology), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (diagnosis), Pneumonia, Viral (enzymology), Prevalence (MeSH), Sex Factors (MeSH), Symptom Assessment (MeSH), Taste Disorders (epidemiology).
- MESH :
- geographic : Europe.
- complications : Coronavirus Infections, Pneumonia, Viral.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- enzymology : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Headache, Myalgia, Olfaction Disorders, Taste Disorders.
- Adult, Age Factors, Bayes Theorem, Betacoronavirus, Female, Humans, Male, Middle Aged, Pandemics, Prevalence, Sex Factors, Symptom Assessment.
Abstract
BACKGROUND
The clinical presentation of European patients with mild-to-moderate COVID-19 infection is still unknown.
OBJECTIVE
To study the clinical presentation of COVID-19 in Europe.
METHODS
Patients with positive diagnosis of COVID-19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analysing the relationship between outcomes.
RESULTS
A total of 1,420 patients completed the study (962 females, 30.7% of healthcare workers). The mean age of patients was 39.17 ± 12.09 years. The most common symptoms were headache (70.3%), loss of smell (70.2%), nasal obstruction (67.8%), cough (63.2%), asthenia (63.3%), myalgia (62.5%), rhinorrhea (60.1%), gustatory dysfunction (54.2%) and sore throat (52.9%). Fever was reported by 45.4%. The mean duration of COVID-19 symptoms of mild-to-moderate cured patients was 11.5 ± 5.7 days. The prevalence of symptoms significantly varied according to age and sex. Young patients more frequently had ear, nose and throat complaints, whereas elderly individuals often presented fever, fatigue and loss of appetite. Loss of smell, headache, nasal obstruction and fatigue were more prevalent in female patients. The loss of smell was a key symptom of mild-to-moderate COVID-19 patients and was not associated with nasal obstruction and rhinorrhea. Loss of smell persisted at least 7 days after the disease in 37.5% of cured patients.
CONCLUSION
The clinical presentation of mild-to-moderate COVID-19 substantially varies according to the age and the sex characteristics of patients. Olfactory dysfunction seems to be an important underestimated symptom of mild-to-moderate COVID-19 that needs to be recognized as such by the WHO.
DOI: 10.1111/joim.13089
PubMed: 32352202
PubMed Central: PMC7267446
Affiliations:
- Autriche, Belgique, Canada, Espagne, France, Italie, Royaume-Uni, République tchèque
- Angleterre, Bohême centrale, Grand Londres, Provence-Alpes-Côte d'Azur, Province de Hainaut, Région de Bruxelles-Capitale, Région wallonne, Vienne (Autriche), Île-de-France
- Bruxelles, Liège, Londres, Marseille, Paris, Prague, Vienne (Autriche)
- Université de Mons, Université libre de Bruxelles
Links toward previous steps (curation, corpus...)
Le document en format XML
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Lechien</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea><orgName type="university">Université de Mons</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Hainaut</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Chiesa Estomba, Carlos M" sort="Chiesa Estomba, Carlos M" uniqKey="Chiesa Estomba C" first="Carlos M" last="Chiesa-Estomba">Carlos M. Chiesa-Estomba</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian</wicri:regionArea><wicri:noRegion>San Sebastian</wicri:noRegion></affiliation></author><author><name sortKey="Place, Sammy" sort="Place, Sammy" uniqKey="Place S" first="Sammy" last="Place">Sammy Place</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Infectiology, EpiCURA Hospital, Baudour, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Internal Medicine, Infectiology, EpiCURA Hospital, Baudour</wicri:regionArea><wicri:noRegion>Baudour</wicri:noRegion></affiliation></author><author><name sortKey="Van Laethem, Yves" sort="Van Laethem, Yves" uniqKey="Van Laethem Y" first="Yves" last="Van Laethem">Yves Van Laethem</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Infectiology, CHU Saint-Pierre, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Internal Medicine, Infectiology, CHU Saint-Pierre, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Cabaraux, Pierre" sort="Cabaraux, Pierre" uniqKey="Cabaraux P" first="Pierre" last="Cabaraux">Pierre Cabaraux</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Neurology, CHU de Charleroi, Charleroi, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Medicine, Neurology, CHU de Charleroi, Charleroi</wicri:regionArea><wicri:noRegion>Charleroi</wicri:noRegion></affiliation></author><author><name sortKey="Mat, Quentin" sort="Mat, Quentin" uniqKey="Mat Q" first="Quentin" last="Mat">Quentin Mat</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Neurology, CHU de Charleroi, Charleroi, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Medicine, Neurology, CHU de Charleroi, Charleroi</wicri:regionArea><wicri:noRegion>Charleroi</wicri:noRegion></affiliation></author><author><name sortKey="Huet, Kathy" sort="Huet, Kathy" uniqKey="Huet K" first="Kathy" last="Huet">Kathy Huet</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, Language Sciences, University of Mons, Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Statistics, Language Sciences, University of Mons, Mons</wicri:regionArea><orgName type="university">Université de Mons</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Hainaut</region></placeName></affiliation></author><author><name sortKey="Plzak, Jan" sort="Plzak, Jan" uniqKey="Plzak J" first="Jan" last="Plzak">Jan Plzak</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otolaryngology - Head & Neck Surgery, 1st Faculty of Medicine, University Hospital Motol, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Otolaryngology - Head & Neck Surgery, 1st Faculty of Medicine, University Hospital Motol, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Confederation of European Otorhinolaryngology-Head & Neck Surgery, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Confederation of European Otorhinolaryngology-Head & Neck Surgery, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Horoi, Mihaela" sort="Horoi, Mihaela" uniqKey="Horoi M" first="Mihaela" last="Horoi">Mihaela Horoi</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Hans, Stephane" sort="Hans, Stephane" uniqKey="Hans S" first="Stéphane" last="Hans">Stéphane Hans</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rosaria Barillari, Maria" sort="Rosaria Barillari, Maria" uniqKey="Rosaria Barillari M" first="Maria" last="Rosaria Barillari">Maria Rosaria Barillari</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Cammaroto, Giovanni" sort="Cammaroto, Giovanni" uniqKey="Cammaroto G" first="Giovanni" last="Cammaroto">Giovanni Cammaroto</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head & Neck Surgery, Morgagni Pierantoni Hospital, Forli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Otolaryngology-Head & Neck Surgery, Morgagni Pierantoni Hospital, Forli</wicri:regionArea><wicri:noRegion>Forli</wicri:noRegion></affiliation></author><author><name sortKey="Fakhry, Nicolas" sort="Fakhry, Nicolas" uniqKey="Fakhry N" first="Nicolas" last="Fakhry">Nicolas Fakhry</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology- Head & Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Otorhinolaryngology- Head & Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Martiny, Delphine" sort="Martiny, Delphine" uniqKey="Martiny D" first="Delphine" last="Martiny">Delphine Martiny</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles, Universitair Laboratorium Brussel (LHUB-ULB), Brussels, Faculté de Médecine et Pharmacie, Université de Mons (UMONS), Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles, Universitair Laboratorium Brussel (LHUB-ULB), Brussels, Faculté de Médecine et Pharmacie, Université de Mons (UMONS), Mons</wicri:regionArea><wicri:noRegion>Mons</wicri:noRegion></affiliation></author><author><name sortKey="Ayad, Tareck" sort="Ayad, Tareck" uniqKey="Ayad T" first="Tareck" last="Ayad">Tareck Ayad</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Otolaryngology-Head & Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Otolaryngology-Head & Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Jouffe, Lionel" sort="Jouffe, Lionel" uniqKey="Jouffe L" first="Lionel" last="Jouffe">Lionel Jouffe</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>BayesiaLab, Changé, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>BayesiaLab, Changé</wicri:regionArea><wicri:noRegion>Changé</wicri:noRegion><wicri:noRegion>Changé</wicri:noRegion></affiliation></author><author><name sortKey="Hopkins, Claire" sort="Hopkins, Claire" uniqKey="Hopkins C" first="Claire" last="Hopkins">Claire Hopkins</name><affiliation wicri:level="3"><nlm:affiliation>Guy's and St Thomas NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy's and St Thomas NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>British Rhinological Society (President), London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>British Rhinological Society (President), London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Saussez, Sven" sort="Saussez, Sven" uniqKey="Saussez S" first="Sven" last="Saussez">Sven Saussez</name><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea><orgName type="university">Université de Mons</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Hainaut</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head & Neck Surgery, EpiCURA Hospital, Hornu, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Otolaryngology-Head & Neck Surgery, EpiCURA Hospital, Hornu</wicri:regionArea><wicri:noRegion>Hornu</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32352202</idno><idno type="pmid">32352202</idno><idno type="doi">10.1111/joim.13089</idno><idno type="pmc">PMC7267446</idno><idno type="wicri:Area/Main/Corpus">001525</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001525</idno><idno type="wicri:Area/Main/Curation">001525</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001525</idno><idno type="wicri:Area/Main/Exploration">001525</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019.</title><author><name sortKey="Lechien, Jerome R" sort="Lechien, Jerome R" uniqKey="Lechien J" first="Jerome R" last="Lechien">Jerome R. Lechien</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea><orgName type="university">Université de Mons</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Hainaut</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Chiesa Estomba, Carlos M" sort="Chiesa Estomba, Carlos M" uniqKey="Chiesa Estomba C" first="Carlos M" last="Chiesa-Estomba">Carlos M. Chiesa-Estomba</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian</wicri:regionArea><wicri:noRegion>San Sebastian</wicri:noRegion></affiliation></author><author><name sortKey="Place, Sammy" sort="Place, Sammy" uniqKey="Place S" first="Sammy" last="Place">Sammy Place</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Infectiology, EpiCURA Hospital, Baudour, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Internal Medicine, Infectiology, EpiCURA Hospital, Baudour</wicri:regionArea><wicri:noRegion>Baudour</wicri:noRegion></affiliation></author><author><name sortKey="Van Laethem, Yves" sort="Van Laethem, Yves" uniqKey="Van Laethem Y" first="Yves" last="Van Laethem">Yves Van Laethem</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Infectiology, CHU Saint-Pierre, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Internal Medicine, Infectiology, CHU Saint-Pierre, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Cabaraux, Pierre" sort="Cabaraux, Pierre" uniqKey="Cabaraux P" first="Pierre" last="Cabaraux">Pierre Cabaraux</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Neurology, CHU de Charleroi, Charleroi, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Medicine, Neurology, CHU de Charleroi, Charleroi</wicri:regionArea><wicri:noRegion>Charleroi</wicri:noRegion></affiliation></author><author><name sortKey="Mat, Quentin" sort="Mat, Quentin" uniqKey="Mat Q" first="Quentin" last="Mat">Quentin Mat</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Neurology, CHU de Charleroi, Charleroi, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Medicine, Neurology, CHU de Charleroi, Charleroi</wicri:regionArea><wicri:noRegion>Charleroi</wicri:noRegion></affiliation></author><author><name sortKey="Huet, Kathy" sort="Huet, Kathy" uniqKey="Huet K" first="Kathy" last="Huet">Kathy Huet</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Statistics, Language Sciences, University of Mons, Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Statistics, Language Sciences, University of Mons, Mons</wicri:regionArea><orgName type="university">Université de Mons</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Hainaut</region></placeName></affiliation></author><author><name sortKey="Plzak, Jan" sort="Plzak, Jan" uniqKey="Plzak J" first="Jan" last="Plzak">Jan Plzak</name><affiliation wicri:level="3"><nlm:affiliation>Department of Otolaryngology - Head & Neck Surgery, 1st Faculty of Medicine, University Hospital Motol, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Otolaryngology - Head & Neck Surgery, 1st Faculty of Medicine, University Hospital Motol, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Confederation of European Otorhinolaryngology-Head & Neck Surgery, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Confederation of European Otorhinolaryngology-Head & Neck Surgery, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Horoi, Mihaela" sort="Horoi, Mihaela" uniqKey="Horoi M" first="Mihaela" last="Horoi">Mihaela Horoi</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Hans, Stephane" sort="Hans, Stephane" uniqKey="Hans S" first="Stéphane" last="Hans">Stéphane Hans</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rosaria Barillari, Maria" sort="Rosaria Barillari, Maria" uniqKey="Rosaria Barillari M" first="Maria" last="Rosaria Barillari">Maria Rosaria Barillari</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Cammaroto, Giovanni" sort="Cammaroto, Giovanni" uniqKey="Cammaroto G" first="Giovanni" last="Cammaroto">Giovanni Cammaroto</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head & Neck Surgery, Morgagni Pierantoni Hospital, Forli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Otolaryngology-Head & Neck Surgery, Morgagni Pierantoni Hospital, Forli</wicri:regionArea><wicri:noRegion>Forli</wicri:noRegion></affiliation></author><author><name sortKey="Fakhry, Nicolas" sort="Fakhry, Nicolas" uniqKey="Fakhry N" first="Nicolas" last="Fakhry">Nicolas Fakhry</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology- Head & Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Otorhinolaryngology- Head & Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Martiny, Delphine" sort="Martiny, Delphine" uniqKey="Martiny D" first="Delphine" last="Martiny">Delphine Martiny</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles, Universitair Laboratorium Brussel (LHUB-ULB), Brussels, Faculté de Médecine et Pharmacie, Université de Mons (UMONS), Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles, Universitair Laboratorium Brussel (LHUB-ULB), Brussels, Faculté de Médecine et Pharmacie, Université de Mons (UMONS), Mons</wicri:regionArea><wicri:noRegion>Mons</wicri:noRegion></affiliation></author><author><name sortKey="Ayad, Tareck" sort="Ayad, Tareck" uniqKey="Ayad T" first="Tareck" last="Ayad">Tareck Ayad</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Otolaryngology-Head & Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Otolaryngology-Head & Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Jouffe, Lionel" sort="Jouffe, Lionel" uniqKey="Jouffe L" first="Lionel" last="Jouffe">Lionel Jouffe</name><affiliation wicri:level="3"><nlm:affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>BayesiaLab, Changé, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>BayesiaLab, Changé</wicri:regionArea><wicri:noRegion>Changé</wicri:noRegion><wicri:noRegion>Changé</wicri:noRegion></affiliation></author><author><name sortKey="Hopkins, Claire" sort="Hopkins, Claire" uniqKey="Hopkins C" first="Claire" last="Hopkins">Claire Hopkins</name><affiliation wicri:level="3"><nlm:affiliation>Guy's and St Thomas NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Guy's and St Thomas NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>British Rhinological Society (President), London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>British Rhinological Society (President), London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Saussez, Sven" sort="Saussez, Sven" uniqKey="Saussez S" first="Sven" last="Saussez">Sven Saussez</name><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea><orgName type="university">Université de Mons</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Hainaut</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head & Neck Surgery, EpiCURA Hospital, Hornu, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Otolaryngology-Head & Neck Surgery, EpiCURA Hospital, Hornu</wicri:regionArea><wicri:noRegion>Hornu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of internal medicine</title><idno type="eISSN">1365-2796</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Age Factors (MeSH)</term><term>Bayes Theorem (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (enzymology)</term><term>Europe (MeSH)</term><term>Female (MeSH)</term><term>Headache (epidemiology)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Myalgia (epidemiology)</term><term>Olfaction Disorders (epidemiology)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (enzymology)</term><term>Prevalence (MeSH)</term><term>Sex Factors (MeSH)</term><term>Symptom Assessment (MeSH)</term><term>Taste Disorders (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Céphalée (épidémiologie)</term><term>Europe (MeSH)</term><term>Facteurs sexuels (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (complications)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (enzymologie)</term><term>Myalgie (épidémiologie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (complications)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (enzymologie)</term><term>Prévalence (MeSH)</term><term>Théorème de Bayes (MeSH)</term><term>Troubles de l'olfaction (épidémiologie)</term><term>Troubles du goût (épidémiologie)</term><term>Évaluation des symptômes (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Headache</term><term>Myalgia</term><term>Olfaction Disorders</term><term>Taste Disorders</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Céphalée</term><term>Myalgie</term><term>Troubles de l'olfaction</term><term>Troubles du goût</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Bayes Theorem</term><term>Betacoronavirus</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prevalence</term><term>Sex Factors</term><term>Symptom Assessment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Europe</term><term>Facteurs sexuels</term><term>Facteurs âges</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus</term><term>Mâle</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Prévalence</term><term>Théorème de Bayes</term><term>Évaluation des symptômes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>The clinical presentation of European patients with mild-to-moderate COVID-19 infection is still unknown.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To study the clinical presentation of COVID-19 in Europe.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Patients with positive diagnosis of COVID-19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analysing the relationship between outcomes.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>A total of 1,420 patients completed the study (962 females, 30.7% of healthcare workers). The mean age of patients was 39.17 ± 12.09 years. The most common symptoms were headache (70.3%), loss of smell (70.2%), nasal obstruction (67.8%), cough (63.2%), asthenia (63.3%), myalgia (62.5%), rhinorrhea (60.1%), gustatory dysfunction (54.2%) and sore throat (52.9%). Fever was reported by 45.4%. The mean duration of COVID-19 symptoms of mild-to-moderate cured patients was 11.5 ± 5.7 days. The prevalence of symptoms significantly varied according to age and sex. Young patients more frequently had ear, nose and throat complaints, whereas elderly individuals often presented fever, fatigue and loss of appetite. Loss of smell, headache, nasal obstruction and fatigue were more prevalent in female patients. The loss of smell was a key symptom of mild-to-moderate COVID-19 patients and was not associated with nasal obstruction and rhinorrhea. Loss of smell persisted at least 7 days after the disease in 37.5% of cured patients.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>The clinical presentation of mild-to-moderate COVID-19 substantially varies according to the age and the sex characteristics of patients. Olfactory dysfunction seems to be an important underestimated symptom of mild-to-moderate COVID-19 that needs to be recognized as such by the WHO.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32352202</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>26</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2796</ISSN><JournalIssue CitedMedium="Internet"><Volume>288</Volume><Issue>3</Issue><PubDate><Year>2020</Year><Month>09</Month></PubDate></JournalIssue><Title>Journal of internal medicine</Title><ISOAbbreviation>J. Intern. Med.</ISOAbbreviation></Journal><ArticleTitle>Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019.</ArticleTitle><Pagination><MedlinePgn>335-344</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/joim.13089</ELocationID><Abstract><AbstractText Label="BACKGROUND">The clinical presentation of European patients with mild-to-moderate COVID-19 infection is still unknown.</AbstractText><AbstractText Label="OBJECTIVE">To study the clinical presentation of COVID-19 in Europe.</AbstractText><AbstractText Label="METHODS">Patients with positive diagnosis of COVID-19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analysing the relationship between outcomes.</AbstractText><AbstractText Label="RESULTS">A total of 1,420 patients completed the study (962 females, 30.7% of healthcare workers). The mean age of patients was 39.17 ± 12.09 years. The most common symptoms were headache (70.3%), loss of smell (70.2%), nasal obstruction (67.8%), cough (63.2%), asthenia (63.3%), myalgia (62.5%), rhinorrhea (60.1%), gustatory dysfunction (54.2%) and sore throat (52.9%). Fever was reported by 45.4%. The mean duration of COVID-19 symptoms of mild-to-moderate cured patients was 11.5 ± 5.7 days. The prevalence of symptoms significantly varied according to age and sex. Young patients more frequently had ear, nose and throat complaints, whereas elderly individuals often presented fever, fatigue and loss of appetite. Loss of smell, headache, nasal obstruction and fatigue were more prevalent in female patients. The loss of smell was a key symptom of mild-to-moderate COVID-19 patients and was not associated with nasal obstruction and rhinorrhea. Loss of smell persisted at least 7 days after the disease in 37.5% of cured patients.</AbstractText><AbstractText Label="CONCLUSION">The clinical presentation of mild-to-moderate COVID-19 substantially varies according to the age and the sex characteristics of patients. Olfactory dysfunction seems to be an important underestimated symptom of mild-to-moderate COVID-19 that needs to be recognized as such by the WHO.</AbstractText><CopyrightInformation>© 2020 The Association for the Publication of the Journal of Internal Medicine.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lechien</LastName><ForeName>Jerome R</ForeName><Initials>JR</Initials><Identifier Source="ORCID">0000-0002-0845-0845</Identifier><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chiesa-Estomba</LastName><ForeName>Carlos M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Place</LastName><ForeName>Sammy</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine, Infectiology, EpiCURA Hospital, Baudour, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Laethem</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Infectiology, CHU Saint-Pierre, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cabaraux</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Neurology, CHU de Charleroi, Charleroi, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mat</LastName><ForeName>Quentin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Neurology, CHU de Charleroi, Charleroi, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huet</LastName><ForeName>Kathy</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Statistics, Language Sciences, University of Mons, Mons, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plzak</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology - Head & Neck Surgery, 1st Faculty of Medicine, University Hospital Motol, Prague, Czech Republic.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Confederation of European Otorhinolaryngology-Head & Neck Surgery, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horoi</LastName><ForeName>Mihaela</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hans</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosaria Barillari</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cammaroto</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head & Neck Surgery, Morgagni Pierantoni Hospital, Forli, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fakhry</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otorhinolaryngology- Head & Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martiny</LastName><ForeName>Delphine</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles, Universitair Laboratorium Brussel (LHUB-ULB), Brussels, Faculté de Médecine et Pharmacie, Université de Mons (UMONS), Mons, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ayad</LastName><ForeName>Tareck</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Otolaryngology-Head & Neck Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jouffe</LastName><ForeName>Lionel</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>BayesiaLab, Changé, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hopkins</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Guy's and St Thomas NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>British Rhinological Society (President), London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saussez</LastName><ForeName>Sven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head & Neck Surgery, EpiCURA Hospital, Hornu, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>COVID-19 Task Force of YO-IFOS</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Intern Med</MedlineTA><NlmUniqueID>8904841</NlmUniqueID><ISSNLinking>0954-6820</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001499" MajorTopicYN="N">Bayes Theorem</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006261" MajorTopicYN="N">Headache</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D063806" MajorTopicYN="N">Myalgia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000857" MajorTopicYN="N">Olfaction Disorders</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D063189" MajorTopicYN="N">Symptom Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013651" MajorTopicYN="N">Taste Disorders</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Europe</Keyword><Keyword MajorTopicYN="Y">clinical</Keyword><Keyword MajorTopicYN="Y">coronavirus</Keyword><Keyword MajorTopicYN="Y">epidemiological</Keyword><Keyword MajorTopicYN="Y">medicine</Keyword><Keyword MajorTopicYN="Y">patients</Keyword><Keyword MajorTopicYN="Y">symptoms</Keyword></KeywordList><InvestigatorList><Investigator ValidYN="Y"><LastName>Blecic</LastName><ForeName>Serge</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>De Siati</LastName><ForeName>Daniele R</ForeName><Initials>DR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Leich</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Souchay</LastName><ForeName>Christel</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rossi</LastName><ForeName>Camelia</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Journe</LastName><ForeName>Fabrice</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hsieh</LastName><ForeName>Julien</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ris</LastName><ForeName>Laurence</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>El Afia</LastName><ForeName>Fahd</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Harmegnies</LastName><ForeName>Bernard</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Distinguin</LastName><ForeName>Lea</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chekkoury-Idrissi</LastName><ForeName>Younes</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Circiu</LastName><ForeName>Marta</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lavigne</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lopez Delgado</LastName><ForeName>Irene</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Calvo-Henriquez</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Falanga</LastName><ForeName>Chiara</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Coppee</LastName><ForeName>Frederique</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bon</LastName><ForeName>Serge D</ForeName><Initials>SD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodriguez</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials></Investigator><Investigator 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