High mortality rate in cancer patients with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR.
Identifieur interne : 000E37 ( Main/Exploration ); précédent : 000E36; suivant : 000E38High mortality rate in cancer patients with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR.
Auteurs : Souad Assaad [France] ; Virginie Avrillon [France] ; Marie-Line Fournier [France] ; Benedicte Mastroianni [France] ; Bruno Russias [France] ; Aurélie Swalduz [France] ; Philippe Cassier [France] ; Lauriane Eberst [France] ; Marie-Pierre Steineur [France] ; Marianne Kazes [France] ; Maurice Perol [France] ; Anne-Sophie Michallet [France] ; Philippe Rey [France] ; Anne-Sophie Erena-Penet [France] ; Astrid Morel [France] ; Mehdi Brahmi [France] ; Armelle Dufresne [France] ; Olivier Tredan [France] ; Gisèle Chvetzoff [France] ; Jérome Fayette [France] ; Christelle De La Fouchardiere [France] ; Isabelle Ray-Coquard [France] ; Thomas Bachelot [France] ; Pierre Saintigny [France] ; Mayeul Tabutin [France] ; Aurélien Dupré [France] ; Emmanuelle Nicolas-Virelizier [France] ; Amine Belhabri [France] ; Pierre-Eric Roux [France] ; Christine Fuhrmann [France] ; Franck Pilleul [France] ; Alexandre Basle [France] ; Amine Bouhamama [France] ; Christelle Galvez [France] ; Andrée-Laure Herr [France] ; Julien Gautier [France] ; Sylvie Chabaud [France] ; Philippe Zrounba [France] ; David Perol [France] ; Jean-Yves Blay [France]Source :
- European journal of cancer (Oxford, England : 1990) [ 1879-0852 ] ; 2020.
Descripteurs français
- KwdFr :
- ARN viral (isolement et purification), Adulte d'âge moyen (MeSH), Analyse de survie (MeSH), Betacoronavirus (génétique), Betacoronavirus (isolement et purification), Facteurs de risque (MeSH), Facteurs sexuels (MeSH), Facteurs temps (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Humains (MeSH), Indice de performance de Karnofsky (statistiques et données numériques), Infections à coronavirus (complications), Infections à coronavirus (diagnostic), Infections à coronavirus (mortalité), Infections à coronavirus (virologie), Mortalité (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (diagnostic), Pneumopathie virale (mortalité), Pneumopathie virale (virologie), RT-PCR (statistiques et données numériques), Récidive tumorale locale (complications), Récidive tumorale locale (mortalité), Techniques de laboratoire clinique (statistiques et données numériques), Tumeurs (complications), Tumeurs (mortalité), Études de suivi (MeSH), Études rétrospectives (MeSH).
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- génétique : Betacoronavirus.
- isolement et purification : ARN viral, Betacoronavirus, Infections à coronavirus, Pneumopathie virale, Récidive tumorale locale, Tumeurs.
- mortalité : Infections à coronavirus, Pneumopathie virale, Récidive tumorale locale, Tumeurs.
- statistiques et données numériques : Indice de performance de Karnofsky, RT-PCR, Techniques de laboratoire clinique.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Adulte d'âge moyen, Analyse de survie, Facteurs de risque, Facteurs sexuels, Facteurs temps, Facteurs âges, Femelle, Humains, Mortalité, Mâle, Pandémies, Études de suivi, Études rétrospectives.
English descriptors
- KwdEn :
- Age Factors (MeSH), Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Clinical Laboratory Techniques (statistics & numerical data), Coronavirus Infections (complications), Coronavirus Infections (diagnosis), Coronavirus Infections (mortality), Coronavirus Infections (virology), Female (MeSH), Follow-Up Studies (MeSH), Humans (MeSH), Karnofsky Performance Status (statistics & numerical data), Male (MeSH), Middle Aged (MeSH), Mortality (MeSH), Neoplasm Recurrence, Local (complications), Neoplasm Recurrence, Local (mortality), Neoplasms (complications), Neoplasms (mortality), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (diagnosis), Pneumonia, Viral (mortality), Pneumonia, Viral (virology), RNA, Viral (isolation & purification), Retrospective Studies (MeSH), Reverse Transcriptase Polymerase Chain Reaction (statistics & numerical data), Risk Factors (MeSH), Sex Factors (MeSH), Survival Analysis (MeSH), Time Factors (MeSH).
- MESH :
- chemical , isolation & purification : RNA, Viral.
- complications : Coronavirus Infections, Neoplasm Recurrence, Local, Neoplasms, Pneumonia, Viral.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- genetics : Betacoronavirus.
- isolation & purification : Betacoronavirus.
- mortality : Coronavirus Infections, Neoplasm Recurrence, Local, Neoplasms, Pneumonia, Viral.
- statistics & numerical data : Clinical Laboratory Techniques, Karnofsky Performance Status, Reverse Transcriptase Polymerase Chain Reaction.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Age Factors, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mortality, Pandemics, Retrospective Studies, Risk Factors, Sex Factors, Survival Analysis, Time Factors.
Abstract
BACKGROUND
Cancer patients presenting with COVID-19 have a high risk of death. In this work, predictive factors for survival in cancer patients with suspected SARS-COV-2 infection were investigated.
METHODS
PRE-COVID-19 is a retrospective study of all 302 cancer patients presenting to this institute with a suspicion of COVID-19 from March 1st to April 25th 2020. Data were collected using a web-based tool within electronic patient record approved by the Institutional Review Board. Patient characteristics symptoms and survival were collected and compared in SARS-COV-2 real-time or reverse-transcriptase PCR (RT-PCR)-positive and RT-PCR-negative patients.
RESULTS
Fifty-five of the 302 (18.2%) patients with suspected COVID-19 had detectable SARS-COV-2 with RT-PCR in nasopharyngeal samples. RT-PCR-positive patients were older, had more frequently haematological malignancies, respiratory symptoms and suspected COVID-19 pneumonia of computed tomography (CT) scan. However, respectively, 38% and 20% of SARS-COV-2 RT-PCR-negative patients presented similar respiratory symptoms and CT scan images. Thirty of the 302 (9.9%) patients died during the observation period, including 24 (80%) with advanced disease. At the median follow-up of 25 days after the first symptoms, the death rate in RT-PCR-positive and RT-PCR-negative patients were 21% and 10%, respectively. In both groups, independent risk factors for death were male gender, Karnofsky performance status <60, cancer in relapse and respiratory symptoms. Detection of SARS-COV-2 on RT-PCR was not associated with an increased death rate (p = 0.10). None of the treatment given in the previous month (including cytotoxics, PD1 Ab, anti-CD20, VEGFR2…) correlated with survival. The survival of RT-PCR-positive and -negative patients with respiratory symptoms and/or COVID-19 type pneumonia on CT scan was similar with a 18.4% and 19.7% death rate at day 25. Most (22/30, 73%) cancer patients dying during this period were RT-PCR negative.
CONCLUSION
The 30-day death rate of cancer patients with or without documented SARS-COV-2 infection is poor, but the majority of deaths occur in RT-PCR-negative patients.
DOI: 10.1016/j.ejca.2020.05.028
PubMed: 32540204
PubMed Central: PMC7275994
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<author><name sortKey="Tredan, Olivier" sort="Tredan, Olivier" uniqKey="Tredan O" first="Olivier" last="Tredan">Olivier Tredan</name>
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<author><name sortKey="Fayette, Jerome" sort="Fayette, Jerome" uniqKey="Fayette J" first="Jérome" last="Fayette">Jérome Fayette</name>
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<author><name sortKey="De La Fouchardiere, Christelle" sort="De La Fouchardiere, Christelle" uniqKey="De La Fouchardiere C" first="Christelle" last="De La Fouchardiere">Christelle De La Fouchardiere</name>
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<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Dupre, Aurelien" sort="Dupre, Aurelien" uniqKey="Dupre A" first="Aurélien" last="Dupré">Aurélien Dupré</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<region type="old region">Île-de-France</region>
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<author><name sortKey="Nicolas Virelizier, Emmanuelle" sort="Nicolas Virelizier, Emmanuelle" uniqKey="Nicolas Virelizier E" first="Emmanuelle" last="Nicolas-Virelizier">Emmanuelle Nicolas-Virelizier</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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</affiliation>
</author>
<author><name sortKey="Belhabri, Amine" sort="Belhabri, Amine" uniqKey="Belhabri A" first="Amine" last="Belhabri">Amine Belhabri</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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</affiliation>
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<author><name sortKey="Roux, Pierre Eric" sort="Roux, Pierre Eric" uniqKey="Roux P" first="Pierre-Eric" last="Roux">Pierre-Eric Roux</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Fuhrmann, Christine" sort="Fuhrmann, Christine" uniqKey="Fuhrmann C" first="Christine" last="Fuhrmann">Christine Fuhrmann</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<region type="old region">Île-de-France</region>
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</affiliation>
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<author><name sortKey="Pilleul, Franck" sort="Pilleul, Franck" uniqKey="Pilleul F" first="Franck" last="Pilleul">Franck Pilleul</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Basle, Alexandre" sort="Basle, Alexandre" uniqKey="Basle A" first="Alexandre" last="Basle">Alexandre Basle</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<region type="old region">Île-de-France</region>
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<author><name sortKey="Bouhamama, Amine" sort="Bouhamama, Amine" uniqKey="Bouhamama A" first="Amine" last="Bouhamama">Amine Bouhamama</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<region type="old region">Île-de-France</region>
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</affiliation>
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<author><name sortKey="Galvez, Christelle" sort="Galvez, Christelle" uniqKey="Galvez C" first="Christelle" last="Galvez">Christelle Galvez</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
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<region type="old region">Île-de-France</region>
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</affiliation>
</author>
<author><name sortKey="Herr, Andree Laure" sort="Herr, Andree Laure" uniqKey="Herr A" first="Andrée-Laure" last="Herr">Andrée-Laure Herr</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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<author><name sortKey="Gautier, Julien" sort="Gautier, Julien" uniqKey="Gautier J" first="Julien" last="Gautier">Julien Gautier</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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</affiliation>
</author>
<author><name sortKey="Chabaud, Sylvie" sort="Chabaud, Sylvie" uniqKey="Chabaud S" first="Sylvie" last="Chabaud">Sylvie Chabaud</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<region type="old region">Île-de-France</region>
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</affiliation>
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<author><name sortKey="Zrounba, Philippe" sort="Zrounba, Philippe" uniqKey="Zrounba P" first="Philippe" last="Zrounba">Philippe Zrounba</name>
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<country xml:lang="fr">France</country>
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<region type="old region">Île-de-France</region>
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<author><name sortKey="Perol, David" sort="Perol, David" uniqKey="Perol D" first="David" last="Perol">David Perol</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<region type="old region">Île-de-France</region>
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</affiliation>
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<author><name sortKey="Blay, Jean Yves" sort="Blay, Jean Yves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France. Electronic address: jean-yves.blay@lyon.unicancer.fr.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">High mortality rate in cancer patients with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR.</title>
<author><name sortKey="Assaad, Souad" sort="Assaad, Souad" uniqKey="Assaad S" first="Souad" last="Assaad">Souad Assaad</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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</affiliation>
</author>
<author><name sortKey="Avrillon, Virginie" sort="Avrillon, Virginie" uniqKey="Avrillon V" first="Virginie" last="Avrillon">Virginie Avrillon</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fournier, Marie Line" sort="Fournier, Marie Line" uniqKey="Fournier M" first="Marie-Line" last="Fournier">Marie-Line Fournier</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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</affiliation>
</author>
<author><name sortKey="Mastroianni, Benedicte" sort="Mastroianni, Benedicte" uniqKey="Mastroianni B" first="Benedicte" last="Mastroianni">Benedicte Mastroianni</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Russias, Bruno" sort="Russias, Bruno" uniqKey="Russias B" first="Bruno" last="Russias">Bruno Russias</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Swalduz, Aurelie" sort="Swalduz, Aurelie" uniqKey="Swalduz A" first="Aurélie" last="Swalduz">Aurélie Swalduz</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cassier, Philippe" sort="Cassier, Philippe" uniqKey="Cassier P" first="Philippe" last="Cassier">Philippe Cassier</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eberst, Lauriane" sort="Eberst, Lauriane" uniqKey="Eberst L" first="Lauriane" last="Eberst">Lauriane Eberst</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steineur, Marie Pierre" sort="Steineur, Marie Pierre" uniqKey="Steineur M" first="Marie-Pierre" last="Steineur">Marie-Pierre Steineur</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kazes, Marianne" sort="Kazes, Marianne" uniqKey="Kazes M" first="Marianne" last="Kazes">Marianne Kazes</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perol, Maurice" sort="Perol, Maurice" uniqKey="Perol M" first="Maurice" last="Perol">Maurice Perol</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Michallet, Anne Sophie" sort="Michallet, Anne Sophie" uniqKey="Michallet A" first="Anne-Sophie" last="Michallet">Anne-Sophie Michallet</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rey, Philippe" sort="Rey, Philippe" uniqKey="Rey P" first="Philippe" last="Rey">Philippe Rey</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Erena Penet, Anne Sophie" sort="Erena Penet, Anne Sophie" uniqKey="Erena Penet A" first="Anne-Sophie" last="Erena-Penet">Anne-Sophie Erena-Penet</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morel, Astrid" sort="Morel, Astrid" uniqKey="Morel A" first="Astrid" last="Morel">Astrid Morel</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brahmi, Mehdi" sort="Brahmi, Mehdi" uniqKey="Brahmi M" first="Mehdi" last="Brahmi">Mehdi Brahmi</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dufresne, Armelle" sort="Dufresne, Armelle" uniqKey="Dufresne A" first="Armelle" last="Dufresne">Armelle Dufresne</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tredan, Olivier" sort="Tredan, Olivier" uniqKey="Tredan O" first="Olivier" last="Tredan">Olivier Tredan</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chvetzoff, Gisele" sort="Chvetzoff, Gisele" uniqKey="Chvetzoff G" first="Gisèle" last="Chvetzoff">Gisèle Chvetzoff</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fayette, Jerome" sort="Fayette, Jerome" uniqKey="Fayette J" first="Jérome" last="Fayette">Jérome Fayette</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="De La Fouchardiere, Christelle" sort="De La Fouchardiere, Christelle" uniqKey="De La Fouchardiere C" first="Christelle" last="De La Fouchardiere">Christelle De La Fouchardiere</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ray Coquard, Isabelle" sort="Ray Coquard, Isabelle" uniqKey="Ray Coquard I" first="Isabelle" last="Ray-Coquard">Isabelle Ray-Coquard</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bachelot, Thomas" sort="Bachelot, Thomas" uniqKey="Bachelot T" first="Thomas" last="Bachelot">Thomas Bachelot</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saintigny, Pierre" sort="Saintigny, Pierre" uniqKey="Saintigny P" first="Pierre" last="Saintigny">Pierre Saintigny</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tabutin, Mayeul" sort="Tabutin, Mayeul" uniqKey="Tabutin M" first="Mayeul" last="Tabutin">Mayeul Tabutin</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dupre, Aurelien" sort="Dupre, Aurelien" uniqKey="Dupre A" first="Aurélien" last="Dupré">Aurélien Dupré</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nicolas Virelizier, Emmanuelle" sort="Nicolas Virelizier, Emmanuelle" uniqKey="Nicolas Virelizier E" first="Emmanuelle" last="Nicolas-Virelizier">Emmanuelle Nicolas-Virelizier</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Belhabri, Amine" sort="Belhabri, Amine" uniqKey="Belhabri A" first="Amine" last="Belhabri">Amine Belhabri</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roux, Pierre Eric" sort="Roux, Pierre Eric" uniqKey="Roux P" first="Pierre-Eric" last="Roux">Pierre-Eric Roux</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fuhrmann, Christine" sort="Fuhrmann, Christine" uniqKey="Fuhrmann C" first="Christine" last="Fuhrmann">Christine Fuhrmann</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pilleul, Franck" sort="Pilleul, Franck" uniqKey="Pilleul F" first="Franck" last="Pilleul">Franck Pilleul</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Basle, Alexandre" sort="Basle, Alexandre" uniqKey="Basle A" first="Alexandre" last="Basle">Alexandre Basle</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bouhamama, Amine" sort="Bouhamama, Amine" uniqKey="Bouhamama A" first="Amine" last="Bouhamama">Amine Bouhamama</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galvez, Christelle" sort="Galvez, Christelle" uniqKey="Galvez C" first="Christelle" last="Galvez">Christelle Galvez</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Herr, Andree Laure" sort="Herr, Andree Laure" uniqKey="Herr A" first="Andrée-Laure" last="Herr">Andrée-Laure Herr</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gautier, Julien" sort="Gautier, Julien" uniqKey="Gautier J" first="Julien" last="Gautier">Julien Gautier</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chabaud, Sylvie" sort="Chabaud, Sylvie" uniqKey="Chabaud S" first="Sylvie" last="Chabaud">Sylvie Chabaud</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zrounba, Philippe" sort="Zrounba, Philippe" uniqKey="Zrounba P" first="Philippe" last="Zrounba">Philippe Zrounba</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perol, David" sort="Perol, David" uniqKey="Perol D" first="David" last="Perol">David Perol</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blay, Jean Yves" sort="Blay, Jean Yves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France. Electronic address: jean-yves.blay@lyon.unicancer.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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</author>
</analytic>
<series><title level="j">European journal of cancer (Oxford, England : 1990)</title>
<idno type="eISSN">1879-0852</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors (MeSH)</term>
<term>Betacoronavirus (genetics)</term>
<term>Betacoronavirus (isolation & purification)</term>
<term>Clinical Laboratory Techniques (statistics & numerical data)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female (MeSH)</term>
<term>Follow-Up Studies (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Karnofsky Performance Status (statistics & numerical data)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Mortality (MeSH)</term>
<term>Neoplasm Recurrence, Local (complications)</term>
<term>Neoplasm Recurrence, Local (mortality)</term>
<term>Neoplasms (complications)</term>
<term>Neoplasms (mortality)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (virology)</term>
<term>RNA, Viral (isolation & purification)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction (statistics & numerical data)</term>
<term>Risk Factors (MeSH)</term>
<term>Sex Factors (MeSH)</term>
<term>Survival Analysis (MeSH)</term>
<term>Time Factors (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (isolement et purification)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse de survie (MeSH)</term>
<term>Betacoronavirus (génétique)</term>
<term>Betacoronavirus (isolement et purification)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Facteurs sexuels (MeSH)</term>
<term>Facteurs temps (MeSH)</term>
<term>Facteurs âges (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Indice de performance de Karnofsky (statistiques et données numériques)</term>
<term>Infections à coronavirus (complications)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Mortalité (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (complications)</term>
<term>Pneumopathie virale (diagnostic)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (virologie)</term>
<term>RT-PCR (statistiques et données numériques)</term>
<term>Récidive tumorale locale (complications)</term>
<term>Récidive tumorale locale (mortalité)</term>
<term>Techniques de laboratoire clinique (statistiques et données numériques)</term>
<term>Tumeurs (complications)</term>
<term>Tumeurs (mortalité)</term>
<term>Études de suivi (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasms</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>ARN viral</term>
<term>Betacoronavirus</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Récidive tumorale locale</term>
<term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasms</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Récidive tumorale locale</term>
<term>Tumeurs</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Clinical Laboratory Techniques</term>
<term>Karnofsky Performance Status</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Indice de performance de Karnofsky</term>
<term>RT-PCR</term>
<term>Techniques de laboratoire clinique</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mortality</term>
<term>Pandemics</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
<term>Survival Analysis</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Facteurs de risque</term>
<term>Facteurs sexuels</term>
<term>Facteurs temps</term>
<term>Facteurs âges</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mortalité</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Études de suivi</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Cancer patients presenting with COVID-19 have a high risk of death. In this work, predictive factors for survival in cancer patients with suspected SARS-COV-2 infection were investigated.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>PRE-COVID-19 is a retrospective study of all 302 cancer patients presenting to this institute with a suspicion of COVID-19 from March 1st to April 25th 2020. Data were collected using a web-based tool within electronic patient record approved by the Institutional Review Board. Patient characteristics symptoms and survival were collected and compared in SARS-COV-2 real-time or reverse-transcriptase PCR (RT-PCR)-positive and RT-PCR-negative patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Fifty-five of the 302 (18.2%) patients with suspected COVID-19 had detectable SARS-COV-2 with RT-PCR in nasopharyngeal samples. RT-PCR-positive patients were older, had more frequently haematological malignancies, respiratory symptoms and suspected COVID-19 pneumonia of computed tomography (CT) scan. However, respectively, 38% and 20% of SARS-COV-2 RT-PCR-negative patients presented similar respiratory symptoms and CT scan images. Thirty of the 302 (9.9%) patients died during the observation period, including 24 (80%) with advanced disease. At the median follow-up of 25 days after the first symptoms, the death rate in RT-PCR-positive and RT-PCR-negative patients were 21% and 10%, respectively. In both groups, independent risk factors for death were male gender, Karnofsky performance status <60, cancer in relapse and respiratory symptoms. Detection of SARS-COV-2 on RT-PCR was not associated with an increased death rate (p = 0.10). None of the treatment given in the previous month (including cytotoxics, PD1 Ab, anti-CD20, VEGFR2…) correlated with survival. The survival of RT-PCR-positive and -negative patients with respiratory symptoms and/or COVID-19 type pneumonia on CT scan was similar with a 18.4% and 19.7% death rate at day 25. Most (22/30, 73%) cancer patients dying during this period were RT-PCR negative.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>The 30-day death rate of cancer patients with or without documented SARS-COV-2 infection is poor, but the majority of deaths occur in RT-PCR-negative patients.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32540204</PMID>
<DateCompleted><Year>2020</Year>
<Month>07</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>07</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0852</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>135</Volume>
<PubDate><Year>2020</Year>
<Month>08</Month>
</PubDate>
</JournalIssue>
<Title>European journal of cancer (Oxford, England : 1990)</Title>
<ISOAbbreviation>Eur. J. Cancer</ISOAbbreviation>
</Journal>
<ArticleTitle>High mortality rate in cancer patients with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR.</ArticleTitle>
<Pagination><MedlinePgn>251-259</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0959-8049(20)30314-2</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejca.2020.05.028</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Cancer patients presenting with COVID-19 have a high risk of death. In this work, predictive factors for survival in cancer patients with suspected SARS-COV-2 infection were investigated.</AbstractText>
<AbstractText Label="METHODS">PRE-COVID-19 is a retrospective study of all 302 cancer patients presenting to this institute with a suspicion of COVID-19 from March 1st to April 25th 2020. Data were collected using a web-based tool within electronic patient record approved by the Institutional Review Board. Patient characteristics symptoms and survival were collected and compared in SARS-COV-2 real-time or reverse-transcriptase PCR (RT-PCR)-positive and RT-PCR-negative patients.</AbstractText>
<AbstractText Label="RESULTS">Fifty-five of the 302 (18.2%) patients with suspected COVID-19 had detectable SARS-COV-2 with RT-PCR in nasopharyngeal samples. RT-PCR-positive patients were older, had more frequently haematological malignancies, respiratory symptoms and suspected COVID-19 pneumonia of computed tomography (CT) scan. However, respectively, 38% and 20% of SARS-COV-2 RT-PCR-negative patients presented similar respiratory symptoms and CT scan images. Thirty of the 302 (9.9%) patients died during the observation period, including 24 (80%) with advanced disease. At the median follow-up of 25 days after the first symptoms, the death rate in RT-PCR-positive and RT-PCR-negative patients were 21% and 10%, respectively. In both groups, independent risk factors for death were male gender, Karnofsky performance status <60, cancer in relapse and respiratory symptoms. Detection of SARS-COV-2 on RT-PCR was not associated with an increased death rate (p = 0.10). None of the treatment given in the previous month (including cytotoxics, PD1 Ab, anti-CD20, VEGFR2…) correlated with survival. The survival of RT-PCR-positive and -negative patients with respiratory symptoms and/or COVID-19 type pneumonia on CT scan was similar with a 18.4% and 19.7% death rate at day 25. Most (22/30, 73%) cancer patients dying during this period were RT-PCR negative.</AbstractText>
<AbstractText Label="CONCLUSION">The 30-day death rate of cancer patients with or without documented SARS-COV-2 infection is poor, but the majority of deaths occur in RT-PCR-negative patients.</AbstractText>
<CopyrightInformation>Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Assaad</LastName>
<ForeName>Souad</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Avrillon</LastName>
<ForeName>Virginie</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fournier</LastName>
<ForeName>Marie-Line</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mastroianni</LastName>
<ForeName>Benedicte</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Russias</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Swalduz</LastName>
<ForeName>Aurélie</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cassier</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eberst</LastName>
<ForeName>Lauriane</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Steineur</LastName>
<ForeName>Marie-Pierre</ForeName>
<Initials>MP</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kazes</LastName>
<ForeName>Marianne</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Perol</LastName>
<ForeName>Maurice</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Michallet</LastName>
<ForeName>Anne-Sophie</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rey</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Erena-Penet</LastName>
<ForeName>Anne-Sophie</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morel</LastName>
<ForeName>Astrid</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brahmi</LastName>
<ForeName>Mehdi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dufresne</LastName>
<ForeName>Armelle</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tredan</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chvetzoff</LastName>
<ForeName>Gisèle</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fayette</LastName>
<ForeName>Jérome</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de la Fouchardiere</LastName>
<ForeName>Christelle</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ray-Coquard</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bachelot</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saintigny</LastName>
<ForeName>Pierre</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tabutin</LastName>
<ForeName>Mayeul</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dupré</LastName>
<ForeName>Aurélien</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nicolas-Virelizier</LastName>
<ForeName>Emmanuelle</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Belhabri</LastName>
<ForeName>Amine</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roux</LastName>
<ForeName>Pierre-Eric</ForeName>
<Initials>PE</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fuhrmann</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pilleul</LastName>
<ForeName>Franck</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Basle</LastName>
<ForeName>Alexandre</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bouhamama</LastName>
<ForeName>Amine</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Galvez</LastName>
<ForeName>Christelle</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Herr</LastName>
<ForeName>Andrée-Laure</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gautier</LastName>
<ForeName>Julien</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chabaud</LastName>
<ForeName>Sylvie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zrounba</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Perol</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blay</LastName>
<ForeName>Jean-Yves</ForeName>
<Initials>JY</Initials>
<AffiliationInfo><Affiliation>Centre Léon Bérard, 28 Rue Laënnec, 69373, Lyon Cedex 08, France; Université Claude Bernard Lyon I, France; Unicancer, Paris, France. Electronic address: jean-yves.blay@lyon.unicancer.fr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>06</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Eur J Cancer</MedlineTA>
<NlmUniqueID>9005373</NlmUniqueID>
<ISSNLinking>0959-8049</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Protocol" UI="C000657964">COVID-19 diagnostic testing</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017567" MajorTopicYN="N">Karnofsky Performance Status</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009026" MajorTopicYN="N">Mortality</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009364" MajorTopicYN="N">Neoplasm Recurrence, Local</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">Cancer patients</Keyword>
<Keyword MajorTopicYN="Y">RT-PCR</Keyword>
<Keyword MajorTopicYN="Y">Risk factors</Keyword>
<Keyword MajorTopicYN="Y">SARS-COV-2</Keyword>
<Keyword MajorTopicYN="Y">Survival</Keyword>
</KeywordList>
<CoiStatement>Conflict of interest statement The authors declare no conflict of interest.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>05</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>05</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>05</Month>
<Day>31</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>6</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>7</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>6</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32540204</ArticleId>
<ArticleId IdType="pii">S0959-8049(20)30314-2</ArticleId>
<ArticleId IdType="doi">10.1016/j.ejca.2020.05.028</ArticleId>
<ArticleId IdType="pmc">PMC7275994</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Assaad, Souad" sort="Assaad, Souad" uniqKey="Assaad S" first="Souad" last="Assaad">Souad Assaad</name>
</region>
<name sortKey="Avrillon, Virginie" sort="Avrillon, Virginie" uniqKey="Avrillon V" first="Virginie" last="Avrillon">Virginie Avrillon</name>
<name sortKey="Bachelot, Thomas" sort="Bachelot, Thomas" uniqKey="Bachelot T" first="Thomas" last="Bachelot">Thomas Bachelot</name>
<name sortKey="Basle, Alexandre" sort="Basle, Alexandre" uniqKey="Basle A" first="Alexandre" last="Basle">Alexandre Basle</name>
<name sortKey="Belhabri, Amine" sort="Belhabri, Amine" uniqKey="Belhabri A" first="Amine" last="Belhabri">Amine Belhabri</name>
<name sortKey="Blay, Jean Yves" sort="Blay, Jean Yves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name>
<name sortKey="Bouhamama, Amine" sort="Bouhamama, Amine" uniqKey="Bouhamama A" first="Amine" last="Bouhamama">Amine Bouhamama</name>
<name sortKey="Brahmi, Mehdi" sort="Brahmi, Mehdi" uniqKey="Brahmi M" first="Mehdi" last="Brahmi">Mehdi Brahmi</name>
<name sortKey="Cassier, Philippe" sort="Cassier, Philippe" uniqKey="Cassier P" first="Philippe" last="Cassier">Philippe Cassier</name>
<name sortKey="Chabaud, Sylvie" sort="Chabaud, Sylvie" uniqKey="Chabaud S" first="Sylvie" last="Chabaud">Sylvie Chabaud</name>
<name sortKey="Chvetzoff, Gisele" sort="Chvetzoff, Gisele" uniqKey="Chvetzoff G" first="Gisèle" last="Chvetzoff">Gisèle Chvetzoff</name>
<name sortKey="De La Fouchardiere, Christelle" sort="De La Fouchardiere, Christelle" uniqKey="De La Fouchardiere C" first="Christelle" last="De La Fouchardiere">Christelle De La Fouchardiere</name>
<name sortKey="Dufresne, Armelle" sort="Dufresne, Armelle" uniqKey="Dufresne A" first="Armelle" last="Dufresne">Armelle Dufresne</name>
<name sortKey="Dupre, Aurelien" sort="Dupre, Aurelien" uniqKey="Dupre A" first="Aurélien" last="Dupré">Aurélien Dupré</name>
<name sortKey="Eberst, Lauriane" sort="Eberst, Lauriane" uniqKey="Eberst L" first="Lauriane" last="Eberst">Lauriane Eberst</name>
<name sortKey="Erena Penet, Anne Sophie" sort="Erena Penet, Anne Sophie" uniqKey="Erena Penet A" first="Anne-Sophie" last="Erena-Penet">Anne-Sophie Erena-Penet</name>
<name sortKey="Fayette, Jerome" sort="Fayette, Jerome" uniqKey="Fayette J" first="Jérome" last="Fayette">Jérome Fayette</name>
<name sortKey="Fournier, Marie Line" sort="Fournier, Marie Line" uniqKey="Fournier M" first="Marie-Line" last="Fournier">Marie-Line Fournier</name>
<name sortKey="Fuhrmann, Christine" sort="Fuhrmann, Christine" uniqKey="Fuhrmann C" first="Christine" last="Fuhrmann">Christine Fuhrmann</name>
<name sortKey="Galvez, Christelle" sort="Galvez, Christelle" uniqKey="Galvez C" first="Christelle" last="Galvez">Christelle Galvez</name>
<name sortKey="Gautier, Julien" sort="Gautier, Julien" uniqKey="Gautier J" first="Julien" last="Gautier">Julien Gautier</name>
<name sortKey="Herr, Andree Laure" sort="Herr, Andree Laure" uniqKey="Herr A" first="Andrée-Laure" last="Herr">Andrée-Laure Herr</name>
<name sortKey="Kazes, Marianne" sort="Kazes, Marianne" uniqKey="Kazes M" first="Marianne" last="Kazes">Marianne Kazes</name>
<name sortKey="Mastroianni, Benedicte" sort="Mastroianni, Benedicte" uniqKey="Mastroianni B" first="Benedicte" last="Mastroianni">Benedicte Mastroianni</name>
<name sortKey="Michallet, Anne Sophie" sort="Michallet, Anne Sophie" uniqKey="Michallet A" first="Anne-Sophie" last="Michallet">Anne-Sophie Michallet</name>
<name sortKey="Morel, Astrid" sort="Morel, Astrid" uniqKey="Morel A" first="Astrid" last="Morel">Astrid Morel</name>
<name sortKey="Nicolas Virelizier, Emmanuelle" sort="Nicolas Virelizier, Emmanuelle" uniqKey="Nicolas Virelizier E" first="Emmanuelle" last="Nicolas-Virelizier">Emmanuelle Nicolas-Virelizier</name>
<name sortKey="Perol, David" sort="Perol, David" uniqKey="Perol D" first="David" last="Perol">David Perol</name>
<name sortKey="Perol, Maurice" sort="Perol, Maurice" uniqKey="Perol M" first="Maurice" last="Perol">Maurice Perol</name>
<name sortKey="Pilleul, Franck" sort="Pilleul, Franck" uniqKey="Pilleul F" first="Franck" last="Pilleul">Franck Pilleul</name>
<name sortKey="Ray Coquard, Isabelle" sort="Ray Coquard, Isabelle" uniqKey="Ray Coquard I" first="Isabelle" last="Ray-Coquard">Isabelle Ray-Coquard</name>
<name sortKey="Rey, Philippe" sort="Rey, Philippe" uniqKey="Rey P" first="Philippe" last="Rey">Philippe Rey</name>
<name sortKey="Roux, Pierre Eric" sort="Roux, Pierre Eric" uniqKey="Roux P" first="Pierre-Eric" last="Roux">Pierre-Eric Roux</name>
<name sortKey="Russias, Bruno" sort="Russias, Bruno" uniqKey="Russias B" first="Bruno" last="Russias">Bruno Russias</name>
<name sortKey="Saintigny, Pierre" sort="Saintigny, Pierre" uniqKey="Saintigny P" first="Pierre" last="Saintigny">Pierre Saintigny</name>
<name sortKey="Steineur, Marie Pierre" sort="Steineur, Marie Pierre" uniqKey="Steineur M" first="Marie-Pierre" last="Steineur">Marie-Pierre Steineur</name>
<name sortKey="Swalduz, Aurelie" sort="Swalduz, Aurelie" uniqKey="Swalduz A" first="Aurélie" last="Swalduz">Aurélie Swalduz</name>
<name sortKey="Tabutin, Mayeul" sort="Tabutin, Mayeul" uniqKey="Tabutin M" first="Mayeul" last="Tabutin">Mayeul Tabutin</name>
<name sortKey="Tredan, Olivier" sort="Tredan, Olivier" uniqKey="Tredan O" first="Olivier" last="Tredan">Olivier Tredan</name>
<name sortKey="Zrounba, Philippe" sort="Zrounba, Philippe" uniqKey="Zrounba P" first="Philippe" last="Zrounba">Philippe Zrounba</name>
</country>
</tree>
</affiliations>
</record>
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