Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
Identifieur interne : 000C96 ( Main/Exploration ); précédent : 000C95; suivant : 000C97Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
Auteurs : Qian Zhang [France] ; Paul Bastard [France] ; Zhiyong Liu [France] ; Jérémie Le Pen [France] ; Marcela Moncada-Velez [France] ; Jie Chen [France] ; Masato Ogishi [France] ; Ira K D. Sabli [France] ; Stephanie Hodeib [France] ; Cecilia Korol [France] ; Jérémie Rosain [France] ; Kaya Bilguvar [France] ; Junqiang Ye [France] ; Alexandre Bolze [France] ; Benedetta Bigio [France] ; Rui Yang [France] ; Andrés Augusto Arias [France] ; Qinhua Zhou [France] ; Yu Zhang [France] ; Fanny Onodi [France] ; Sarantis Korniotis [France] ; Léa Karpf [France] ; Quentin Philippot [France] ; Marwa Chbihi [France] ; Lucie Bonnet-Madin [France] ; Karim Dorgham [France] ; Nikaïa Smith [France] ; William M. Schneider [France] ; Brandon S. Razooky [France] ; Hans-Heinrich Hoffmann [France] ; Eleftherios Michailidis [France] ; Leen Moens [France] ; Ji Eun Han [France] ; Lazaro Lorenzo [France] ; Lucy Bizien [France] ; Philip Meade [France] ; Anna-Lena Neehus [France] ; Aileen Camille Ugurbil [France] ; Aurélien Corneau [France] ; Gaspard Kerner [France] ; Peng Zhang [France] ; Franck Rapaport [France] ; Yoann Seeleuthner [France] ; Jeremy Manry [France] ; Cecile Masson [France] ; Yohann Schmitt [France] ; Agatha Schlüter [France] ; Tom Le Voyer [France] ; Taushif Khan [France] ; Juan Li [France] ; Jacques Fellay [France] ; Lucie Roussel [France] ; Mohammad Shahrooei [France] ; Mohammed F. Alosaimi [France] ; Davood Mansouri [France] ; Haya Al-Saud [France] ; Fahd Al-Mulla [France] ; Feras Almourfi [France] ; Saleh Zaid Al-Muhsen [France] ; Fahad Alsohime [France] ; Saeed Al Turki [France] ; Rana Hasanato [France] ; Diederik Van De Beek [France] ; Andrea Biondi [France] ; Laura Rachele Bettini [France] ; Mariella D'Angio [France] ; Paolo Bonfanti [France] ; Luisa Imberti [France] ; Alessandra Sottini [France] ; Simone Paghera [France] ; Eugenia Quiros-Roldan [France] ; Camillo Rossi [France] ; Andrew J. Oler [France] ; Miranda F. Tompkins [France] ; Camille Alba [France] ; Isabelle Vandernoot [France] ; Jean-Christophe Goffard [France] ; Guillaume Smits [France] ; Isabelle Migeotte [France] ; Filomeen Haerynck [France] ; Pere Soler-Palacin [France] ; Andrea Martin-Nalda [France] ; Roger Colobran [France] ; Pierre-Emmanuel Morange [France] ; Sevgi Keles [France] ; Fatma Çölkesen [France] ; Tayfun Ozcelik [France] ; Kadriye Kart Yasar [France] ; Sevtap Senoglu [France] ; Emsi Nur Karabela [France] ; Carlos Rodríguez Gallego [France] ; Giuseppe Novelli [France] ; Sami Hraiech [France] ; Yacine Tandjaoui-Lambiotte [France] ; Xavier Duval [France] ; Cédric Laouénan [France] ; Andrew L. Snow [France] ; Clifton L. Dalgard [France] ; Joshua Milner [France] ; Donald C. Vinh [France] ; Trine H. Mogensen [France] ; Nico Marr [France] ; András N. Spaan [France] ; Bertrand Boisson [France] ; Stéphanie Boisson-Dupuis [France] ; Jacinta Bustamante [France] ; Anne Puel [France] ; Michael Ciancanelli [France] ; Isabelle Meyts [France] ; Tom Maniatis [France] ; Vassili Soumelis [France] ; Ali Amara [France] ; Michel Nussenzweig [France] ; Adolfo García-Sastre [France] ; Florian Krammer [France] ; Aurora Pujol [France] ; Darragh Duffy [France] ; Richard Lifton [France] ; Shen-Ying Zhang [France] ; Guy Gorochov [France] ; Vivien Béziat [France] ; Emmanuelle Jouanguy [France] ; Vanessa Sancho-Shimizu [France] ; Charles M. Rice [France] ; Laurent Abel [France] ; Luigi D. Notarangelo [France] ; Aurélie Cobat [France] ; Helen C. Su [France] ; Jean-Laurent Casanova [France]Source :
- Science (New York, N.Y.) [ 1095-9203 ] ; 2020.
Abstract
Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern TLR3- and IRF7-dependent type I interferon (IFN) immunity to influenza virus, in 659 patients with life-threatening COVID-19 pneumonia, relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally define LOF variants in 23 patients (3.5%), aged 17 to 77 years, underlying autosomal recessive or dominant deficiencies. We show that human fibroblasts with mutations affecting this pathway are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.
DOI: 10.1126/science.abd4570
PubMed: 32972995
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.</title><author><name sortKey="Zhang, Qian" sort="Zhang, Qian" uniqKey="Zhang Q" first="Qian" last="Zhang">Qian Zhang</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bastard, Paul" sort="Bastard, Paul" uniqKey="Bastard P" first="Paul" last="Bastard">Paul Bastard</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Liu, Zhiyong" sort="Liu, Zhiyong" uniqKey="Liu Z" first="Zhiyong" last="Liu">Zhiyong Liu</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Le Pen, Jeremie" sort="Le Pen, Jeremie" uniqKey="Le Pen J" first="Jérémie" last="Le Pen">Jérémie Le Pen</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Moncada Velez, Marcela" sort="Moncada Velez, Marcela" uniqKey="Moncada Velez M" first="Marcela" last="Moncada-Velez">Marcela Moncada-Velez</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chen, Jie" sort="Chen, Jie" uniqKey="Chen J" first="Jie" last="Chen">Jie Chen</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ogishi, Masato" sort="Ogishi, Masato" uniqKey="Ogishi M" first="Masato" last="Ogishi">Masato Ogishi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sabli, Ira K D" sort="Sabli, Ira K D" uniqKey="Sabli I" first="Ira K D" last="Sabli">Ira K D. Sabli</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hodeib, Stephanie" sort="Hodeib, Stephanie" uniqKey="Hodeib S" first="Stephanie" last="Hodeib">Stephanie Hodeib</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Korol, Cecilia" sort="Korol, Cecilia" uniqKey="Korol C" first="Cecilia" last="Korol">Cecilia Korol</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rosain, Jeremie" sort="Rosain, Jeremie" uniqKey="Rosain J" first="Jérémie" last="Rosain">Jérémie Rosain</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bilguvar, Kaya" sort="Bilguvar, Kaya" uniqKey="Bilguvar K" first="Kaya" last="Bilguvar">Kaya Bilguvar</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ye, Junqiang" sort="Ye, Junqiang" uniqKey="Ye J" first="Junqiang" last="Ye">Junqiang Ye</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bolze, Alexandre" sort="Bolze, Alexandre" uniqKey="Bolze A" first="Alexandre" last="Bolze">Alexandre Bolze</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bigio, Benedetta" sort="Bigio, Benedetta" uniqKey="Bigio B" first="Benedetta" last="Bigio">Benedetta Bigio</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Yang, Rui" sort="Yang, Rui" uniqKey="Yang R" first="Rui" last="Yang">Rui Yang</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Arias, Andres Augusto" sort="Arias, Andres Augusto" uniqKey="Arias A" first="Andrés Augusto" last="Arias">Andrés Augusto Arias</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zhou, Qinhua" sort="Zhou, Qinhua" uniqKey="Zhou Q" first="Qinhua" last="Zhou">Qinhua Zhou</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Onodi, Fanny" sort="Onodi, Fanny" uniqKey="Onodi F" first="Fanny" last="Onodi">Fanny Onodi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Korniotis, Sarantis" sort="Korniotis, Sarantis" uniqKey="Korniotis S" first="Sarantis" last="Korniotis">Sarantis Korniotis</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Karpf, Lea" sort="Karpf, Lea" uniqKey="Karpf L" first="Léa" last="Karpf">Léa Karpf</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Philippot, Quentin" sort="Philippot, Quentin" uniqKey="Philippot Q" first="Quentin" last="Philippot">Quentin Philippot</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chbihi, Marwa" sort="Chbihi, Marwa" uniqKey="Chbihi M" first="Marwa" last="Chbihi">Marwa Chbihi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bonnet Madin, Lucie" sort="Bonnet Madin, Lucie" uniqKey="Bonnet Madin L" first="Lucie" last="Bonnet-Madin">Lucie Bonnet-Madin</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Dorgham, Karim" sort="Dorgham, Karim" uniqKey="Dorgham K" first="Karim" last="Dorgham">Karim Dorgham</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Smith, Nikaia" sort="Smith, Nikaia" uniqKey="Smith N" first="Nikaïa" last="Smith">Nikaïa Smith</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schneider, William M" sort="Schneider, William M" uniqKey="Schneider W" first="William M" last="Schneider">William M. Schneider</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Razooky, Brandon S" sort="Razooky, Brandon S" uniqKey="Razooky B" first="Brandon S" last="Razooky">Brandon S. Razooky</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hoffmann, Hans Heinrich" sort="Hoffmann, Hans Heinrich" uniqKey="Hoffmann H" first="Hans-Heinrich" last="Hoffmann">Hans-Heinrich Hoffmann</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Michailidis, Eleftherios" sort="Michailidis, Eleftherios" uniqKey="Michailidis E" first="Eleftherios" last="Michailidis">Eleftherios Michailidis</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Moens, Leen" sort="Moens, Leen" uniqKey="Moens L" first="Leen" last="Moens">Leen Moens</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Han, Ji Eun" sort="Han, Ji Eun" uniqKey="Han J" first="Ji Eun" last="Han">Ji Eun Han</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lorenzo, Lazaro" sort="Lorenzo, Lazaro" uniqKey="Lorenzo L" first="Lazaro" last="Lorenzo">Lazaro Lorenzo</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bizien, Lucy" sort="Bizien, Lucy" uniqKey="Bizien L" first="Lucy" last="Bizien">Lucy Bizien</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meade, Philip" sort="Meade, Philip" uniqKey="Meade P" first="Philip" last="Meade">Philip Meade</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Neehus, Anna Lena" sort="Neehus, Anna Lena" uniqKey="Neehus A" first="Anna-Lena" last="Neehus">Anna-Lena Neehus</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ugurbil, Aileen Camille" sort="Ugurbil, Aileen Camille" uniqKey="Ugurbil A" first="Aileen Camille" last="Ugurbil">Aileen Camille Ugurbil</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Corneau, Aurelien" sort="Corneau, Aurelien" uniqKey="Corneau A" first="Aurélien" last="Corneau">Aurélien Corneau</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kerner, Gaspard" sort="Kerner, Gaspard" uniqKey="Kerner G" first="Gaspard" last="Kerner">Gaspard Kerner</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rapaport, Franck" sort="Rapaport, Franck" uniqKey="Rapaport F" first="Franck" last="Rapaport">Franck Rapaport</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Seeleuthner, Yoann" sort="Seeleuthner, Yoann" uniqKey="Seeleuthner Y" first="Yoann" last="Seeleuthner">Yoann Seeleuthner</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Manry, Jeremy" sort="Manry, Jeremy" uniqKey="Manry J" first="Jeremy" last="Manry">Jeremy Manry</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Masson, Cecile" sort="Masson, Cecile" uniqKey="Masson C" first="Cecile" last="Masson">Cecile Masson</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schmitt, Yohann" sort="Schmitt, Yohann" uniqKey="Schmitt Y" first="Yohann" last="Schmitt">Yohann Schmitt</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schluter, Agatha" sort="Schluter, Agatha" uniqKey="Schluter A" first="Agatha" last="Schlüter">Agatha Schlüter</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Le Voyer, Tom" sort="Le Voyer, Tom" uniqKey="Le Voyer T" first="Tom" last="Le Voyer">Tom Le Voyer</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Khan, Taushif" sort="Khan, Taushif" uniqKey="Khan T" first="Taushif" last="Khan">Taushif Khan</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fellay, Jacques" sort="Fellay, Jacques" uniqKey="Fellay J" first="Jacques" last="Fellay">Jacques Fellay</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Roussel, Lucie" sort="Roussel, Lucie" uniqKey="Roussel L" first="Lucie" last="Roussel">Lucie Roussel</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Shahrooei, Mohammad" sort="Shahrooei, Mohammad" uniqKey="Shahrooei M" first="Mohammad" last="Shahrooei">Mohammad Shahrooei</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Alosaimi, Mohammed F" sort="Alosaimi, Mohammed F" uniqKey="Alosaimi M" first="Mohammed F" last="Alosaimi">Mohammed F. Alosaimi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mansouri, Davood" sort="Mansouri, Davood" uniqKey="Mansouri D" first="Davood" last="Mansouri">Davood Mansouri</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Al Saud, Haya" sort="Al Saud, Haya" uniqKey="Al Saud H" first="Haya" last="Al-Saud">Haya Al-Saud</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Al Mulla, Fahd" sort="Al Mulla, Fahd" uniqKey="Al Mulla F" first="Fahd" last="Al-Mulla">Fahd Al-Mulla</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Almourfi, Feras" sort="Almourfi, Feras" uniqKey="Almourfi F" first="Feras" last="Almourfi">Feras Almourfi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Al Muhsen, Saleh Zaid" sort="Al Muhsen, Saleh Zaid" uniqKey="Al Muhsen S" first="Saleh Zaid" last="Al-Muhsen">Saleh Zaid Al-Muhsen</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Alsohime, Fahad" sort="Alsohime, Fahad" uniqKey="Alsohime F" first="Fahad" last="Alsohime">Fahad Alsohime</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Al Turki, Saeed" sort="Al Turki, Saeed" uniqKey="Al Turki S" first="Saeed" last="Al Turki">Saeed Al Turki</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hasanato, Rana" sort="Hasanato, Rana" uniqKey="Hasanato R" first="Rana" last="Hasanato">Rana Hasanato</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Van De Beek, Diederik" sort="Van De Beek, Diederik" uniqKey="Van De Beek D" first="Diederik" last="Van De Beek">Diederik Van De Beek</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Biondi, Andrea" sort="Biondi, Andrea" uniqKey="Biondi A" first="Andrea" last="Biondi">Andrea Biondi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bettini, Laura Rachele" sort="Bettini, Laura Rachele" uniqKey="Bettini L" first="Laura Rachele" last="Bettini">Laura Rachele Bettini</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="D Angio, Mariella" sort="D Angio, Mariella" uniqKey="D Angio M" first="Mariella" last="D'Angio">Mariella D'Angio</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bonfanti, Paolo" sort="Bonfanti, Paolo" uniqKey="Bonfanti P" first="Paolo" last="Bonfanti">Paolo Bonfanti</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Imberti, Luisa" sort="Imberti, Luisa" uniqKey="Imberti L" first="Luisa" last="Imberti">Luisa Imberti</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sottini, Alessandra" sort="Sottini, Alessandra" uniqKey="Sottini A" first="Alessandra" last="Sottini">Alessandra Sottini</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Paghera, Simone" sort="Paghera, Simone" uniqKey="Paghera S" first="Simone" last="Paghera">Simone Paghera</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Quiros Roldan, Eugenia" sort="Quiros Roldan, Eugenia" uniqKey="Quiros Roldan E" first="Eugenia" last="Quiros-Roldan">Eugenia Quiros-Roldan</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rossi, Camillo" sort="Rossi, Camillo" uniqKey="Rossi C" first="Camillo" last="Rossi">Camillo Rossi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Oler, Andrew J" sort="Oler, Andrew J" uniqKey="Oler A" first="Andrew J" last="Oler">Andrew J. Oler</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tompkins, Miranda F" sort="Tompkins, Miranda F" uniqKey="Tompkins M" first="Miranda F" last="Tompkins">Miranda F. Tompkins</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Alba, Camille" sort="Alba, Camille" uniqKey="Alba C" first="Camille" last="Alba">Camille Alba</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vandernoot, Isabelle" sort="Vandernoot, Isabelle" uniqKey="Vandernoot I" first="Isabelle" last="Vandernoot">Isabelle Vandernoot</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Goffard, Jean Christophe" sort="Goffard, Jean Christophe" uniqKey="Goffard J" first="Jean-Christophe" last="Goffard">Jean-Christophe Goffard</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Smits, Guillaume" sort="Smits, Guillaume" uniqKey="Smits G" first="Guillaume" last="Smits">Guillaume Smits</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Migeotte, Isabelle" sort="Migeotte, Isabelle" uniqKey="Migeotte I" first="Isabelle" last="Migeotte">Isabelle Migeotte</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Haerynck, Filomeen" sort="Haerynck, Filomeen" uniqKey="Haerynck F" first="Filomeen" last="Haerynck">Filomeen Haerynck</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Soler Palacin, Pere" sort="Soler Palacin, Pere" uniqKey="Soler Palacin P" first="Pere" last="Soler-Palacin">Pere Soler-Palacin</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Martin Nalda, Andrea" sort="Martin Nalda, Andrea" uniqKey="Martin Nalda A" first="Andrea" last="Martin-Nalda">Andrea Martin-Nalda</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Colobran, Roger" sort="Colobran, Roger" uniqKey="Colobran R" first="Roger" last="Colobran">Roger Colobran</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Keles, Sevgi" sort="Keles, Sevgi" uniqKey="Keles S" first="Sevgi" last="Keles">Sevgi Keles</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Colkesen, Fatma" sort="Colkesen, Fatma" uniqKey="Colkesen F" first="Fatma" last="Çölkesen">Fatma Çölkesen</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ozcelik, Tayfun" sort="Ozcelik, Tayfun" uniqKey="Ozcelik T" first="Tayfun" last="Ozcelik">Tayfun Ozcelik</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Yasar, Kadriye Kart" sort="Yasar, Kadriye Kart" uniqKey="Yasar K" first="Kadriye Kart" last="Yasar">Kadriye Kart Yasar</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Senoglu, Sevtap" sort="Senoglu, Sevtap" uniqKey="Senoglu S" first="Sevtap" last="Senoglu">Sevtap Senoglu</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Karabela, Emsi Nur" sort="Karabela, Emsi Nur" uniqKey="Karabela " first=" Emsi Nur" last="Karabela"> Emsi Nur Karabela</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gallego, Carlos Rodriguez" sort="Gallego, Carlos Rodriguez" uniqKey="Gallego C" first="Carlos Rodríguez" last="Gallego">Carlos Rodríguez Gallego</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Novelli, Giuseppe" sort="Novelli, Giuseppe" uniqKey="Novelli G" first="Giuseppe" last="Novelli">Giuseppe Novelli</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hraiech, Sami" sort="Hraiech, Sami" uniqKey="Hraiech S" first="Sami" last="Hraiech">Sami Hraiech</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tandjaoui Lambiotte, Yacine" sort="Tandjaoui Lambiotte, Yacine" uniqKey="Tandjaoui Lambiotte Y" first="Yacine" last="Tandjaoui-Lambiotte">Yacine Tandjaoui-Lambiotte</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duval, Xavier" sort="Duval, Xavier" uniqKey="Duval X" first="Xavier" last="Duval">Xavier Duval</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Laouenan, Cedric" sort="Laouenan, Cedric" uniqKey="Laouenan C" first="Cédric" last="Laouénan">Cédric Laouénan</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Snow, Andrew L" sort="Snow, Andrew L" uniqKey="Snow A" first="Andrew L" last="Snow">Andrew L. Snow</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Dalgard, Clifton L" sort="Dalgard, Clifton L" uniqKey="Dalgard C" first="Clifton L" last="Dalgard">Clifton L. Dalgard</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Milner, Joshua" sort="Milner, Joshua" uniqKey="Milner J" first="Joshua" last="Milner">Joshua Milner</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vinh, Donald C" sort="Vinh, Donald C" uniqKey="Vinh D" first="Donald C" last="Vinh">Donald C. Vinh</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mogensen, Trine H" sort="Mogensen, Trine H" uniqKey="Mogensen T" first="Trine H" last="Mogensen">Trine H. Mogensen</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Marr, Nico" sort="Marr, Nico" uniqKey="Marr N" first="Nico" last="Marr">Nico Marr</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Spaan, Andras N" sort="Spaan, Andras N" uniqKey="Spaan A" first="András N" last="Spaan">András N. Spaan</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Boisson, Bertrand" sort="Boisson, Bertrand" uniqKey="Boisson B" first="Bertrand" last="Boisson">Bertrand Boisson</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stéphanie" last="Boisson-Dupuis">Stéphanie Boisson-Dupuis</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Puel, Anne" sort="Puel, Anne" uniqKey="Puel A" first="Anne" last="Puel">Anne Puel</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ciancanelli, Michael" sort="Ciancanelli, Michael" uniqKey="Ciancanelli M" first="Michael" last="Ciancanelli">Michael Ciancanelli</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meyts, Isabelle" sort="Meyts, Isabelle" uniqKey="Meyts I" first="Isabelle" last="Meyts">Isabelle Meyts</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Maniatis, Tom" sort="Maniatis, Tom" uniqKey="Maniatis T" first="Tom" last="Maniatis">Tom Maniatis</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Soumelis, Vassili" sort="Soumelis, Vassili" uniqKey="Soumelis V" first="Vassili" last="Soumelis">Vassili Soumelis</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Amara, Ali" sort="Amara, Ali" uniqKey="Amara A" first="Ali" last="Amara">Ali Amara</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Nussenzweig, Michel" sort="Nussenzweig, Michel" uniqKey="Nussenzweig M" first="Michel" last="Nussenzweig">Michel Nussenzweig</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pujol, Aurora" sort="Pujol, Aurora" uniqKey="Pujol A" first="Aurora" last="Pujol">Aurora Pujol</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duffy, Darragh" sort="Duffy, Darragh" uniqKey="Duffy D" first="Darragh" last="Duffy">Darragh Duffy</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lifton, Richard" sort="Lifton, Richard" uniqKey="Lifton R" first="Richard" last="Lifton">Richard Lifton</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Shen Ying" sort="Zhang, Shen Ying" uniqKey="Zhang S" first="Shen-Ying" last="Zhang">Shen-Ying Zhang</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gorochov, Guy" sort="Gorochov, Guy" uniqKey="Gorochov G" first="Guy" last="Gorochov">Guy Gorochov</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Beziat, Vivien" sort="Beziat, Vivien" uniqKey="Beziat V" first="Vivien" last="Béziat">Vivien Béziat</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sancho Shimizu, Vanessa" sort="Sancho Shimizu, Vanessa" uniqKey="Sancho Shimizu V" first="Vanessa" last="Sancho-Shimizu">Vanessa Sancho-Shimizu</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rice, Charles M" sort="Rice, Charles M" uniqKey="Rice C" first="Charles M" last="Rice">Charles M. Rice</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Notarangelo, Luigi D" sort="Notarangelo, Luigi D" uniqKey="Notarangelo L" first="Luigi D" last="Notarangelo">Luigi D. Notarangelo</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cobat, Aurelie" sort="Cobat, Aurelie" uniqKey="Cobat A" first="Aurélie" last="Cobat">Aurélie Cobat</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Su, Helen C" sort="Su, Helen C" uniqKey="Su H" first="Helen C" last="Su">Helen C. Su</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France. casanova@rockefeller.edu.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32972995</idno><idno type="pmid">32972995</idno><idno type="doi">10.1126/science.abd4570</idno><idno type="wicri:Area/Main/Corpus">000011</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000011</idno><idno type="wicri:Area/Main/Curation">000011</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000011</idno><idno type="wicri:Area/Main/Exploration">000011</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.</title><author><name sortKey="Zhang, Qian" sort="Zhang, Qian" uniqKey="Zhang Q" first="Qian" last="Zhang">Qian Zhang</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bastard, Paul" sort="Bastard, Paul" uniqKey="Bastard P" first="Paul" last="Bastard">Paul Bastard</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Liu, Zhiyong" sort="Liu, Zhiyong" uniqKey="Liu Z" first="Zhiyong" last="Liu">Zhiyong Liu</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Le Pen, Jeremie" sort="Le Pen, Jeremie" uniqKey="Le Pen J" first="Jérémie" last="Le Pen">Jérémie Le Pen</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Moncada Velez, Marcela" sort="Moncada Velez, Marcela" uniqKey="Moncada Velez M" first="Marcela" last="Moncada-Velez">Marcela Moncada-Velez</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chen, Jie" sort="Chen, Jie" uniqKey="Chen J" first="Jie" last="Chen">Jie Chen</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ogishi, Masato" sort="Ogishi, Masato" uniqKey="Ogishi M" first="Masato" last="Ogishi">Masato Ogishi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sabli, Ira K D" sort="Sabli, Ira K D" uniqKey="Sabli I" first="Ira K D" last="Sabli">Ira K D. Sabli</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hodeib, Stephanie" sort="Hodeib, Stephanie" uniqKey="Hodeib S" first="Stephanie" last="Hodeib">Stephanie Hodeib</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Korol, Cecilia" sort="Korol, Cecilia" uniqKey="Korol C" first="Cecilia" last="Korol">Cecilia Korol</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rosain, Jeremie" sort="Rosain, Jeremie" uniqKey="Rosain J" first="Jérémie" last="Rosain">Jérémie Rosain</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bilguvar, Kaya" sort="Bilguvar, Kaya" uniqKey="Bilguvar K" first="Kaya" last="Bilguvar">Kaya Bilguvar</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ye, Junqiang" sort="Ye, Junqiang" uniqKey="Ye J" first="Junqiang" last="Ye">Junqiang Ye</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bolze, Alexandre" sort="Bolze, Alexandre" uniqKey="Bolze A" first="Alexandre" last="Bolze">Alexandre Bolze</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bigio, Benedetta" sort="Bigio, Benedetta" uniqKey="Bigio B" first="Benedetta" last="Bigio">Benedetta Bigio</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Yang, Rui" sort="Yang, Rui" uniqKey="Yang R" first="Rui" last="Yang">Rui Yang</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Arias, Andres Augusto" sort="Arias, Andres Augusto" uniqKey="Arias A" first="Andrés Augusto" last="Arias">Andrés Augusto Arias</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zhou, Qinhua" sort="Zhou, Qinhua" uniqKey="Zhou Q" first="Qinhua" last="Zhou">Qinhua Zhou</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Onodi, Fanny" sort="Onodi, Fanny" uniqKey="Onodi F" first="Fanny" last="Onodi">Fanny Onodi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Korniotis, Sarantis" sort="Korniotis, Sarantis" uniqKey="Korniotis S" first="Sarantis" last="Korniotis">Sarantis Korniotis</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Karpf, Lea" sort="Karpf, Lea" uniqKey="Karpf L" first="Léa" last="Karpf">Léa Karpf</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Philippot, Quentin" sort="Philippot, Quentin" uniqKey="Philippot Q" first="Quentin" last="Philippot">Quentin Philippot</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chbihi, Marwa" sort="Chbihi, Marwa" uniqKey="Chbihi M" first="Marwa" last="Chbihi">Marwa Chbihi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bonnet Madin, Lucie" sort="Bonnet Madin, Lucie" uniqKey="Bonnet Madin L" first="Lucie" last="Bonnet-Madin">Lucie Bonnet-Madin</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Dorgham, Karim" sort="Dorgham, Karim" uniqKey="Dorgham K" first="Karim" last="Dorgham">Karim Dorgham</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Smith, Nikaia" sort="Smith, Nikaia" uniqKey="Smith N" first="Nikaïa" last="Smith">Nikaïa Smith</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schneider, William M" sort="Schneider, William M" uniqKey="Schneider W" first="William M" last="Schneider">William M. Schneider</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Razooky, Brandon S" sort="Razooky, Brandon S" uniqKey="Razooky B" first="Brandon S" last="Razooky">Brandon S. Razooky</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hoffmann, Hans Heinrich" sort="Hoffmann, Hans Heinrich" uniqKey="Hoffmann H" first="Hans-Heinrich" last="Hoffmann">Hans-Heinrich Hoffmann</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Michailidis, Eleftherios" sort="Michailidis, Eleftherios" uniqKey="Michailidis E" first="Eleftherios" last="Michailidis">Eleftherios Michailidis</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Moens, Leen" sort="Moens, Leen" uniqKey="Moens L" first="Leen" last="Moens">Leen Moens</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Han, Ji Eun" sort="Han, Ji Eun" uniqKey="Han J" first="Ji Eun" last="Han">Ji Eun Han</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lorenzo, Lazaro" sort="Lorenzo, Lazaro" uniqKey="Lorenzo L" first="Lazaro" last="Lorenzo">Lazaro Lorenzo</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bizien, Lucy" sort="Bizien, Lucy" uniqKey="Bizien L" first="Lucy" last="Bizien">Lucy Bizien</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meade, Philip" sort="Meade, Philip" uniqKey="Meade P" first="Philip" last="Meade">Philip Meade</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Neehus, Anna Lena" sort="Neehus, Anna Lena" uniqKey="Neehus A" first="Anna-Lena" last="Neehus">Anna-Lena Neehus</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ugurbil, Aileen Camille" sort="Ugurbil, Aileen Camille" uniqKey="Ugurbil A" first="Aileen Camille" last="Ugurbil">Aileen Camille Ugurbil</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Corneau, Aurelien" sort="Corneau, Aurelien" uniqKey="Corneau A" first="Aurélien" last="Corneau">Aurélien Corneau</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kerner, Gaspard" sort="Kerner, Gaspard" uniqKey="Kerner G" first="Gaspard" last="Kerner">Gaspard Kerner</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rapaport, Franck" sort="Rapaport, Franck" uniqKey="Rapaport F" first="Franck" last="Rapaport">Franck Rapaport</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Seeleuthner, Yoann" sort="Seeleuthner, Yoann" uniqKey="Seeleuthner Y" first="Yoann" last="Seeleuthner">Yoann Seeleuthner</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Manry, Jeremy" sort="Manry, Jeremy" uniqKey="Manry J" first="Jeremy" last="Manry">Jeremy Manry</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Masson, Cecile" sort="Masson, Cecile" uniqKey="Masson C" first="Cecile" last="Masson">Cecile Masson</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schmitt, Yohann" sort="Schmitt, Yohann" uniqKey="Schmitt Y" first="Yohann" last="Schmitt">Yohann Schmitt</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schluter, Agatha" sort="Schluter, Agatha" uniqKey="Schluter A" first="Agatha" last="Schlüter">Agatha Schlüter</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Le Voyer, Tom" sort="Le Voyer, Tom" uniqKey="Le Voyer T" first="Tom" last="Le Voyer">Tom Le Voyer</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Khan, Taushif" sort="Khan, Taushif" uniqKey="Khan T" first="Taushif" last="Khan">Taushif Khan</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fellay, Jacques" sort="Fellay, Jacques" uniqKey="Fellay J" first="Jacques" last="Fellay">Jacques Fellay</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Roussel, Lucie" sort="Roussel, Lucie" uniqKey="Roussel L" first="Lucie" last="Roussel">Lucie Roussel</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Shahrooei, Mohammad" sort="Shahrooei, Mohammad" uniqKey="Shahrooei M" first="Mohammad" last="Shahrooei">Mohammad Shahrooei</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Alosaimi, Mohammed F" sort="Alosaimi, Mohammed F" uniqKey="Alosaimi M" first="Mohammed F" last="Alosaimi">Mohammed F. Alosaimi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mansouri, Davood" sort="Mansouri, Davood" uniqKey="Mansouri D" first="Davood" last="Mansouri">Davood Mansouri</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Al Saud, Haya" sort="Al Saud, Haya" uniqKey="Al Saud H" first="Haya" last="Al-Saud">Haya Al-Saud</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Al Mulla, Fahd" sort="Al Mulla, Fahd" uniqKey="Al Mulla F" first="Fahd" last="Al-Mulla">Fahd Al-Mulla</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Almourfi, Feras" sort="Almourfi, Feras" uniqKey="Almourfi F" first="Feras" last="Almourfi">Feras Almourfi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Al Muhsen, Saleh Zaid" sort="Al Muhsen, Saleh Zaid" uniqKey="Al Muhsen S" first="Saleh Zaid" last="Al-Muhsen">Saleh Zaid Al-Muhsen</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Alsohime, Fahad" sort="Alsohime, Fahad" uniqKey="Alsohime F" first="Fahad" last="Alsohime">Fahad Alsohime</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Al Turki, Saeed" sort="Al Turki, Saeed" uniqKey="Al Turki S" first="Saeed" last="Al Turki">Saeed Al Turki</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hasanato, Rana" sort="Hasanato, Rana" uniqKey="Hasanato R" first="Rana" last="Hasanato">Rana Hasanato</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Van De Beek, Diederik" sort="Van De Beek, Diederik" uniqKey="Van De Beek D" first="Diederik" last="Van De Beek">Diederik Van De Beek</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Biondi, Andrea" sort="Biondi, Andrea" uniqKey="Biondi A" first="Andrea" last="Biondi">Andrea Biondi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bettini, Laura Rachele" sort="Bettini, Laura Rachele" uniqKey="Bettini L" first="Laura Rachele" last="Bettini">Laura Rachele Bettini</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="D Angio, Mariella" sort="D Angio, Mariella" uniqKey="D Angio M" first="Mariella" last="D'Angio">Mariella D'Angio</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bonfanti, Paolo" sort="Bonfanti, Paolo" uniqKey="Bonfanti P" first="Paolo" last="Bonfanti">Paolo Bonfanti</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Imberti, Luisa" sort="Imberti, Luisa" uniqKey="Imberti L" first="Luisa" last="Imberti">Luisa Imberti</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sottini, Alessandra" sort="Sottini, Alessandra" uniqKey="Sottini A" first="Alessandra" last="Sottini">Alessandra Sottini</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Paghera, Simone" sort="Paghera, Simone" uniqKey="Paghera S" first="Simone" last="Paghera">Simone Paghera</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Quiros Roldan, Eugenia" sort="Quiros Roldan, Eugenia" uniqKey="Quiros Roldan E" first="Eugenia" last="Quiros-Roldan">Eugenia Quiros-Roldan</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rossi, Camillo" sort="Rossi, Camillo" uniqKey="Rossi C" first="Camillo" last="Rossi">Camillo Rossi</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Oler, Andrew J" sort="Oler, Andrew J" uniqKey="Oler A" first="Andrew J" last="Oler">Andrew J. Oler</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tompkins, Miranda F" sort="Tompkins, Miranda F" uniqKey="Tompkins M" first="Miranda F" last="Tompkins">Miranda F. Tompkins</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Alba, Camille" sort="Alba, Camille" uniqKey="Alba C" first="Camille" last="Alba">Camille Alba</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vandernoot, Isabelle" sort="Vandernoot, Isabelle" uniqKey="Vandernoot I" first="Isabelle" last="Vandernoot">Isabelle Vandernoot</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Goffard, Jean Christophe" sort="Goffard, Jean Christophe" uniqKey="Goffard J" first="Jean-Christophe" last="Goffard">Jean-Christophe Goffard</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Smits, Guillaume" sort="Smits, Guillaume" uniqKey="Smits G" first="Guillaume" last="Smits">Guillaume Smits</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Migeotte, Isabelle" sort="Migeotte, Isabelle" uniqKey="Migeotte I" first="Isabelle" last="Migeotte">Isabelle Migeotte</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Haerynck, Filomeen" sort="Haerynck, Filomeen" uniqKey="Haerynck F" first="Filomeen" last="Haerynck">Filomeen Haerynck</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Soler Palacin, Pere" sort="Soler Palacin, Pere" uniqKey="Soler Palacin P" first="Pere" last="Soler-Palacin">Pere Soler-Palacin</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Martin Nalda, Andrea" sort="Martin Nalda, Andrea" uniqKey="Martin Nalda A" first="Andrea" last="Martin-Nalda">Andrea Martin-Nalda</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Colobran, Roger" sort="Colobran, Roger" uniqKey="Colobran R" first="Roger" last="Colobran">Roger Colobran</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Keles, Sevgi" sort="Keles, Sevgi" uniqKey="Keles S" first="Sevgi" last="Keles">Sevgi Keles</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Colkesen, Fatma" sort="Colkesen, Fatma" uniqKey="Colkesen F" first="Fatma" last="Çölkesen">Fatma Çölkesen</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ozcelik, Tayfun" sort="Ozcelik, Tayfun" uniqKey="Ozcelik T" first="Tayfun" last="Ozcelik">Tayfun Ozcelik</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Yasar, Kadriye Kart" sort="Yasar, Kadriye Kart" uniqKey="Yasar K" first="Kadriye Kart" last="Yasar">Kadriye Kart Yasar</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Senoglu, Sevtap" sort="Senoglu, Sevtap" uniqKey="Senoglu S" first="Sevtap" last="Senoglu">Sevtap Senoglu</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Karabela, Emsi Nur" sort="Karabela, Emsi Nur" uniqKey="Karabela " first=" Emsi Nur" last="Karabela"> Emsi Nur Karabela</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gallego, Carlos Rodriguez" sort="Gallego, Carlos Rodriguez" uniqKey="Gallego C" first="Carlos Rodríguez" last="Gallego">Carlos Rodríguez Gallego</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Novelli, Giuseppe" sort="Novelli, Giuseppe" uniqKey="Novelli G" first="Giuseppe" last="Novelli">Giuseppe Novelli</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hraiech, Sami" sort="Hraiech, Sami" uniqKey="Hraiech S" first="Sami" last="Hraiech">Sami Hraiech</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tandjaoui Lambiotte, Yacine" sort="Tandjaoui Lambiotte, Yacine" uniqKey="Tandjaoui Lambiotte Y" first="Yacine" last="Tandjaoui-Lambiotte">Yacine Tandjaoui-Lambiotte</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duval, Xavier" sort="Duval, Xavier" uniqKey="Duval X" first="Xavier" last="Duval">Xavier Duval</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Laouenan, Cedric" sort="Laouenan, Cedric" uniqKey="Laouenan C" first="Cédric" last="Laouénan">Cédric Laouénan</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Snow, Andrew L" sort="Snow, Andrew L" uniqKey="Snow A" first="Andrew L" last="Snow">Andrew L. Snow</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Dalgard, Clifton L" sort="Dalgard, Clifton L" uniqKey="Dalgard C" first="Clifton L" last="Dalgard">Clifton L. Dalgard</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Milner, Joshua" sort="Milner, Joshua" uniqKey="Milner J" first="Joshua" last="Milner">Joshua Milner</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vinh, Donald C" sort="Vinh, Donald C" uniqKey="Vinh D" first="Donald C" last="Vinh">Donald C. Vinh</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mogensen, Trine H" sort="Mogensen, Trine H" uniqKey="Mogensen T" first="Trine H" last="Mogensen">Trine H. Mogensen</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Marr, Nico" sort="Marr, Nico" uniqKey="Marr N" first="Nico" last="Marr">Nico Marr</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Spaan, Andras N" sort="Spaan, Andras N" uniqKey="Spaan A" first="András N" last="Spaan">András N. Spaan</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Boisson, Bertrand" sort="Boisson, Bertrand" uniqKey="Boisson B" first="Bertrand" last="Boisson">Bertrand Boisson</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stéphanie" last="Boisson-Dupuis">Stéphanie Boisson-Dupuis</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Puel, Anne" sort="Puel, Anne" uniqKey="Puel A" first="Anne" last="Puel">Anne Puel</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ciancanelli, Michael" sort="Ciancanelli, Michael" uniqKey="Ciancanelli M" first="Michael" last="Ciancanelli">Michael Ciancanelli</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Meyts, Isabelle" sort="Meyts, Isabelle" uniqKey="Meyts I" first="Isabelle" last="Meyts">Isabelle Meyts</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Maniatis, Tom" sort="Maniatis, Tom" uniqKey="Maniatis T" first="Tom" last="Maniatis">Tom Maniatis</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Soumelis, Vassili" sort="Soumelis, Vassili" uniqKey="Soumelis V" first="Vassili" last="Soumelis">Vassili Soumelis</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Amara, Ali" sort="Amara, Ali" uniqKey="Amara A" first="Ali" last="Amara">Ali Amara</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Nussenzweig, Michel" sort="Nussenzweig, Michel" uniqKey="Nussenzweig M" first="Michel" last="Nussenzweig">Michel Nussenzweig</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pujol, Aurora" sort="Pujol, Aurora" uniqKey="Pujol A" first="Aurora" last="Pujol">Aurora Pujol</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duffy, Darragh" sort="Duffy, Darragh" uniqKey="Duffy D" first="Darragh" last="Duffy">Darragh Duffy</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lifton, Richard" sort="Lifton, Richard" uniqKey="Lifton R" first="Richard" last="Lifton">Richard Lifton</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Shen Ying" sort="Zhang, Shen Ying" uniqKey="Zhang S" first="Shen-Ying" last="Zhang">Shen-Ying Zhang</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gorochov, Guy" sort="Gorochov, Guy" uniqKey="Gorochov G" first="Guy" last="Gorochov">Guy Gorochov</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Beziat, Vivien" sort="Beziat, Vivien" uniqKey="Beziat V" first="Vivien" last="Béziat">Vivien Béziat</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sancho Shimizu, Vanessa" sort="Sancho Shimizu, Vanessa" uniqKey="Sancho Shimizu V" first="Vanessa" last="Sancho-Shimizu">Vanessa Sancho-Shimizu</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rice, Charles M" sort="Rice, Charles M" uniqKey="Rice C" first="Charles M" last="Rice">Charles M. Rice</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Notarangelo, Luigi D" sort="Notarangelo, Luigi D" uniqKey="Notarangelo L" first="Luigi D" last="Notarangelo">Luigi D. Notarangelo</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cobat, Aurelie" sort="Cobat, Aurelie" uniqKey="Cobat A" first="Aurélie" last="Cobat">Aurélie Cobat</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Su, Helen C" sort="Su, Helen C" uniqKey="Su H" first="Helen C" last="Su">Helen C. Su</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation wicri:level="3"><nlm:affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France. casanova@rockefeller.edu.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="eISSN">1095-9203</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern TLR3- and IRF7-dependent type I interferon (IFN) immunity to influenza virus, in 659 patients with life-threatening COVID-19 pneumonia, relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally define LOF variants in 23 patients (3.5%), aged 17 to 77 years, underlying autosomal recessive or dominant deficiencies. We show that human fibroblasts with mutations affecting this pathway are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32972995</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9203</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Sep</Month><Day>24</Day></PubDate></JournalIssue><Title>Science (New York, N.Y.)</Title><ISOAbbreviation>Science</ISOAbbreviation></Journal><ArticleTitle>Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">eabd4570</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1126/science.abd4570</ELocationID><Abstract><AbstractText>Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern TLR3- and IRF7-dependent type I interferon (IFN) immunity to influenza virus, in 659 patients with life-threatening COVID-19 pneumonia, relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally define LOF variants in 23 patients (3.5%), aged 17 to 77 years, underlying autosomal recessive or dominant deficiencies. We show that human fibroblasts with mutations affecting this pathway are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.</AbstractText><CopyrightInformation>Copyright © 2020, American Association for the Advancement of Science.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Qian</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Bastard</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Liu</LastName><ForeName>Zhiyong</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Le Pen</LastName><ForeName>Jérémie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Moncada-Velez</LastName><ForeName>Marcela</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Chen</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Ogishi</LastName><ForeName>Masato</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Sabli</LastName><ForeName>Ira K D</ForeName><Initials>IKD</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Hodeib</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Korol</LastName><ForeName>Cecilia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Rosain</LastName><ForeName>Jérémie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Bilguvar</LastName><ForeName>Kaya</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Ye</LastName><ForeName>Junqiang</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Bolze</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Bigio</LastName><ForeName>Benedetta</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Yang</LastName><ForeName>Rui</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Arias</LastName><ForeName>Andrés Augusto</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Zhou</LastName><ForeName>Qinhua</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Zhang</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Onodi</LastName><ForeName>Fanny</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Korniotis</LastName><ForeName>Sarantis</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karpf</LastName><ForeName>Léa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Philippot</LastName><ForeName>Quentin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chbihi</LastName><ForeName>Marwa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonnet-Madin</LastName><ForeName>Lucie</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dorgham</LastName><ForeName>Karim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Nikaïa</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>William M</ForeName><Initials>WM</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Razooky</LastName><ForeName>Brandon S</ForeName><Initials>BS</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoffmann</LastName><ForeName>Hans-Heinrich</ForeName><Initials>HH</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michailidis</LastName><ForeName>Eleftherios</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moens</LastName><ForeName>Leen</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Ji Eun</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lorenzo</LastName><ForeName>Lazaro</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bizien</LastName><ForeName>Lucy</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meade</LastName><ForeName>Philip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neehus</LastName><ForeName>Anna-Lena</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ugurbil</LastName><ForeName>Aileen Camille</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corneau</LastName><ForeName>Aurélien</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kerner</LastName><ForeName>Gaspard</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Peng</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rapaport</LastName><ForeName>Franck</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seeleuthner</LastName><ForeName>Yoann</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manry</LastName><ForeName>Jeremy</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masson</LastName><ForeName>Cecile</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmitt</LastName><ForeName>Yohann</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schlüter</LastName><ForeName>Agatha</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Voyer</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khan</LastName><ForeName>Taushif</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fellay</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roussel</LastName><ForeName>Lucie</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shahrooei</LastName><ForeName>Mohammad</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alosaimi</LastName><ForeName>Mohammed F</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mansouri</LastName><ForeName>Davood</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Saud</LastName><ForeName>Haya</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Mulla</LastName><ForeName>Fahd</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Almourfi</LastName><ForeName>Feras</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Muhsen</LastName><ForeName>Saleh Zaid</ForeName><Initials>SZ</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alsohime</LastName><ForeName>Fahad</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al Turki</LastName><ForeName>Saeed</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hasanato</LastName><ForeName>Rana</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van de Beek</LastName><ForeName>Diederik</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biondi</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bettini</LastName><ForeName>Laura Rachele</ForeName><Initials>LR</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Angio</LastName><ForeName>Mariella</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonfanti</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Imberti</LastName><ForeName>Luisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sottini</LastName><ForeName>Alessandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paghera</LastName><ForeName>Simone</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quiros-Roldan</LastName><ForeName>Eugenia</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rossi</LastName><ForeName>Camillo</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oler</LastName><ForeName>Andrew J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tompkins</LastName><ForeName>Miranda F</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alba</LastName><ForeName>Camille</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vandernoot</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goffard</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smits</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Migeotte</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haerynck</LastName><ForeName>Filomeen</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soler-Palacin</LastName><ForeName>Pere</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin-Nalda</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colobran</LastName><ForeName>Roger</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morange</LastName><ForeName>Pierre-Emmanuel</ForeName><Initials>PE</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keles</LastName><ForeName>Sevgi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Çölkesen</LastName><ForeName>Fatma</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ozcelik</LastName><ForeName>Tayfun</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yasar</LastName><ForeName>Kadriye Kart</ForeName><Initials>KK</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Senoglu</LastName><ForeName>Sevtap</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karabela</LastName><ForeName>Şemsi Nur</ForeName><Initials>ŞN</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gallego</LastName><ForeName>Carlos Rodríguez</ForeName><Initials>CR</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Novelli</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hraiech</LastName><ForeName>Sami</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tandjaoui-Lambiotte</LastName><ForeName>Yacine</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duval</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laouénan</LastName><ForeName>Cédric</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>COVID-STORM Clinicians</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>COVID Clinicians</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>Imagine COVID Group</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>French COVID Cohort Study Group</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>CoV-Contact Cohort</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>Amsterdam UMC Covid-19</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>Biobank</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>COVID Human Genetic Effort</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>NIAID-USUHS</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>TAGC COVID Immunity Group</CollectiveName></Author><Author ValidYN="Y"><LastName>Snow</LastName><ForeName>Andrew L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dalgard</LastName><ForeName>Clifton L</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milner</LastName><ForeName>Joshua</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vinh</LastName><ForeName>Donald C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mogensen</LastName><ForeName>Trine H</ForeName><Initials>TH</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marr</LastName><ForeName>Nico</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spaan</LastName><ForeName>András N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boisson</LastName><ForeName>Bertrand</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boisson-Dupuis</LastName><ForeName>Stéphanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bustamante</LastName><ForeName>Jacinta</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Puel</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ciancanelli</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyts</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maniatis</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soumelis</LastName><ForeName>Vassili</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amara</LastName><ForeName>Ali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nussenzweig</LastName><ForeName>Michel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Sastre</LastName><ForeName>Adolfo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krammer</LastName><ForeName>Florian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pujol</LastName><ForeName>Aurora</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duffy</LastName><ForeName>Darragh</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Lifton</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Zhang</LastName><ForeName>Shen-Ying</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Gorochov</LastName><ForeName>Guy</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Béziat</LastName><ForeName>Vivien</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Jouanguy</LastName><ForeName>Emmanuelle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Sancho-Shimizu</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Rice</LastName><ForeName>Charles M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Abel</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Notarangelo</LastName><ForeName>Luigi D</ForeName><Initials>LD</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Cobat</LastName><ForeName>Aurélie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Su</LastName><ForeName>Helen C</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Casanova</LastName><ForeName>Jean-Laurent</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. University of Paris, Imagine Institute, Paris, France. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Department of Paediatric Infectious Diseases & Virology, Imperial College London, Norfolk Place, London, UK. Yale Center for Genome Analysis and Department of Genetics, Yale School of Medicine, New Haven, CT, USA. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. Helix, San Mateo, CA, USA. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. Université de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hôpital Saint-Louis, 75010 Paris, France. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Université de Paris, Institut de Recherche Saint-Louis, Hôpital Saint-Louis, Paris, France. Sorbonne Université, Inserm, Centre d'immunologie et des maladies infectieuses-Paris (CIMI PARIS), AP-HP Hôpital Pitié-Salpêtrière, Paris, France. Translational Immunology Lab, Institut Pasteur, Paris, France. Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Sorbonne Université, UMS037, PASS, Plateforme de cytométrie de la Pitié-Salpêtrière CyPS, F-75013 Paris, France. Bioinformatics Platform, Structure Fédérative de Recherche Necker, INSERM UMR1163, Université de Paris, Imagine Institute, Paris, France. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain. Department of Immunology, Research Branch, Sidra Medicine, Doha, Qatar. School of Life sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Swiss Institue of Bioinformatics, Lausanne, Switzerland. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montréal, Québec, Canada. Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti, Iran. National Center of Genomics Technology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Kuwait. Immunology Research Laboratory, Department of Pediatrics, College of Medicine and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia. Translational Pathology, Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Misery of National Guard- Health Affairs, Riyadh, Saudi Arabia. Cancer & Blood Research, King Abdullah International Medical Research Center, Riyadh, KSA. Amsterdam UMC, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy. Department of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy. CREA Laboratory, Diagnostic Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy. Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy. Chief Medical Officer, ASST Spedali Civili di Brescia, Brescia, Italy. Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Fonds de la Recherche Scientifique (FNRS) and Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Immunology Division, Genetics Department. Hospital Universitari Vall d'Hebron. Vall d'Hebron Research Institute. Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB). Barcelona, Catalonia, Spain. Aix Marseille Univ, INSERM, INRAE, C2VN, CHU Timone, Marseille, France. Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. Bilkent University, Department of Molecular Biology and Genetics, Bilkent - Ankara 06800, Turkey. Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Intensive Care Unit, AP-HM, Marseille, France. Avicenne Hospital Intensive Care Unit, APHP, Bobigny, INSERM U1272 Hypoxia & Lung, Paris, France. PH Réanimation CHU Avicenne, Bobigny, INSERM U1272 Hypoxie & Poumon, Paris, France. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France, EU. Inserm CIC 1425, Paris, France. AP-HP, Département Epidémiologie Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France, EU. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Division of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, USA. Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark. Department of Biomedicine, Aarhus University, Denmark. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France. Turnstone Biologics, New York, NY, USA. Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium. New York Genome Center, New York, NY, USA. Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Louis, Laboratoire d'Immunologie, Paris, France. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, New York, NY, USA. Department of Medicine, Division of Infectiosu Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Laboratory of Genetics and Genomics, The Rockefeller University, New York, NY, USA. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA. Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France. casanova@rockefeller.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Science</MedlineTA><NlmUniqueID>0404511</NlmUniqueID><ISSNLinking>0036-8075</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>25</Day><Hour>5</Hour><Minute>53</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32972995</ArticleId><ArticleId IdType="pii">science.abd4570</ArticleId><ArticleId IdType="doi">10.1126/science.abd4570</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Zhang, Qian" sort="Zhang, Qian" uniqKey="Zhang Q" first="Qian" last="Zhang">Qian Zhang</name></region><name sortKey="Abel, Laurent" sort="Abel, Laurent" uniqKey="Abel L" first="Laurent" last="Abel">Laurent Abel</name><name sortKey="Al Muhsen, Saleh Zaid" sort="Al Muhsen, Saleh Zaid" uniqKey="Al Muhsen S" first="Saleh Zaid" last="Al-Muhsen">Saleh Zaid Al-Muhsen</name><name sortKey="Al Mulla, Fahd" sort="Al Mulla, Fahd" uniqKey="Al Mulla F" first="Fahd" last="Al-Mulla">Fahd Al-Mulla</name><name sortKey="Al Saud, Haya" sort="Al Saud, Haya" uniqKey="Al Saud H" first="Haya" last="Al-Saud">Haya Al-Saud</name><name sortKey="Al Turki, Saeed" sort="Al Turki, Saeed" uniqKey="Al Turki S" first="Saeed" last="Al Turki">Saeed Al Turki</name><name sortKey="Alba, Camille" sort="Alba, Camille" uniqKey="Alba C" first="Camille" last="Alba">Camille Alba</name><name sortKey="Almourfi, Feras" sort="Almourfi, Feras" uniqKey="Almourfi F" first="Feras" last="Almourfi">Feras Almourfi</name><name sortKey="Alosaimi, Mohammed F" sort="Alosaimi, Mohammed F" uniqKey="Alosaimi M" first="Mohammed F" last="Alosaimi">Mohammed F. Alosaimi</name><name sortKey="Alsohime, Fahad" sort="Alsohime, Fahad" uniqKey="Alsohime F" first="Fahad" last="Alsohime">Fahad Alsohime</name><name sortKey="Amara, Ali" sort="Amara, Ali" uniqKey="Amara A" first="Ali" last="Amara">Ali Amara</name><name sortKey="Arias, Andres Augusto" sort="Arias, Andres Augusto" uniqKey="Arias A" first="Andrés Augusto" last="Arias">Andrés Augusto Arias</name><name sortKey="Bastard, Paul" sort="Bastard, Paul" uniqKey="Bastard P" first="Paul" last="Bastard">Paul Bastard</name><name sortKey="Bettini, Laura Rachele" sort="Bettini, Laura Rachele" uniqKey="Bettini L" first="Laura Rachele" last="Bettini">Laura Rachele Bettini</name><name sortKey="Beziat, Vivien" sort="Beziat, Vivien" uniqKey="Beziat V" first="Vivien" last="Béziat">Vivien Béziat</name><name sortKey="Bigio, Benedetta" sort="Bigio, Benedetta" uniqKey="Bigio B" first="Benedetta" last="Bigio">Benedetta Bigio</name><name sortKey="Bilguvar, Kaya" sort="Bilguvar, Kaya" uniqKey="Bilguvar K" first="Kaya" last="Bilguvar">Kaya Bilguvar</name><name sortKey="Biondi, Andrea" sort="Biondi, Andrea" uniqKey="Biondi A" first="Andrea" last="Biondi">Andrea Biondi</name><name sortKey="Bizien, Lucy" sort="Bizien, Lucy" uniqKey="Bizien L" first="Lucy" last="Bizien">Lucy Bizien</name><name sortKey="Boisson Dupuis, Stephanie" sort="Boisson Dupuis, Stephanie" uniqKey="Boisson Dupuis S" first="Stéphanie" last="Boisson-Dupuis">Stéphanie Boisson-Dupuis</name><name sortKey="Boisson, Bertrand" sort="Boisson, Bertrand" uniqKey="Boisson B" first="Bertrand" last="Boisson">Bertrand Boisson</name><name sortKey="Bolze, Alexandre" sort="Bolze, Alexandre" uniqKey="Bolze A" first="Alexandre" last="Bolze">Alexandre Bolze</name><name sortKey="Bonfanti, Paolo" sort="Bonfanti, Paolo" uniqKey="Bonfanti P" first="Paolo" last="Bonfanti">Paolo Bonfanti</name><name sortKey="Bonnet Madin, Lucie" sort="Bonnet Madin, Lucie" uniqKey="Bonnet Madin L" first="Lucie" last="Bonnet-Madin">Lucie Bonnet-Madin</name><name sortKey="Bustamante, Jacinta" sort="Bustamante, Jacinta" uniqKey="Bustamante J" first="Jacinta" last="Bustamante">Jacinta Bustamante</name><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><name sortKey="Chbihi, Marwa" sort="Chbihi, Marwa" uniqKey="Chbihi M" first="Marwa" last="Chbihi">Marwa Chbihi</name><name sortKey="Chen, Jie" sort="Chen, Jie" uniqKey="Chen J" first="Jie" last="Chen">Jie Chen</name><name sortKey="Ciancanelli, Michael" sort="Ciancanelli, Michael" uniqKey="Ciancanelli M" first="Michael" last="Ciancanelli">Michael Ciancanelli</name><name sortKey="Cobat, Aurelie" sort="Cobat, Aurelie" uniqKey="Cobat A" first="Aurélie" last="Cobat">Aurélie Cobat</name><name sortKey="Colkesen, Fatma" sort="Colkesen, Fatma" uniqKey="Colkesen F" first="Fatma" last="Çölkesen">Fatma Çölkesen</name><name sortKey="Colobran, Roger" sort="Colobran, Roger" uniqKey="Colobran R" first="Roger" last="Colobran">Roger Colobran</name><name sortKey="Corneau, Aurelien" sort="Corneau, Aurelien" uniqKey="Corneau A" first="Aurélien" last="Corneau">Aurélien Corneau</name><name sortKey="D Angio, Mariella" sort="D Angio, Mariella" uniqKey="D Angio M" first="Mariella" last="D'Angio">Mariella D'Angio</name><name sortKey="Dalgard, Clifton L" sort="Dalgard, Clifton L" uniqKey="Dalgard C" first="Clifton L" last="Dalgard">Clifton L. Dalgard</name><name sortKey="Dorgham, Karim" sort="Dorgham, Karim" uniqKey="Dorgham K" first="Karim" last="Dorgham">Karim Dorgham</name><name sortKey="Duffy, Darragh" sort="Duffy, Darragh" uniqKey="Duffy D" first="Darragh" last="Duffy">Darragh Duffy</name><name sortKey="Duval, Xavier" sort="Duval, Xavier" uniqKey="Duval X" first="Xavier" last="Duval">Xavier Duval</name><name sortKey="Fellay, Jacques" sort="Fellay, Jacques" uniqKey="Fellay J" first="Jacques" last="Fellay">Jacques Fellay</name><name sortKey="Gallego, Carlos Rodriguez" sort="Gallego, Carlos Rodriguez" uniqKey="Gallego C" first="Carlos Rodríguez" last="Gallego">Carlos Rodríguez Gallego</name><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><name sortKey="Goffard, Jean Christophe" sort="Goffard, Jean Christophe" uniqKey="Goffard J" first="Jean-Christophe" last="Goffard">Jean-Christophe Goffard</name><name sortKey="Gorochov, Guy" sort="Gorochov, Guy" uniqKey="Gorochov G" first="Guy" last="Gorochov">Guy Gorochov</name><name sortKey="Haerynck, Filomeen" sort="Haerynck, Filomeen" uniqKey="Haerynck F" first="Filomeen" last="Haerynck">Filomeen Haerynck</name><name sortKey="Han, Ji Eun" sort="Han, Ji Eun" uniqKey="Han J" first="Ji Eun" last="Han">Ji Eun Han</name><name sortKey="Hasanato, Rana" sort="Hasanato, Rana" uniqKey="Hasanato R" first="Rana" last="Hasanato">Rana Hasanato</name><name sortKey="Hodeib, Stephanie" sort="Hodeib, Stephanie" uniqKey="Hodeib S" first="Stephanie" last="Hodeib">Stephanie Hodeib</name><name sortKey="Hoffmann, Hans Heinrich" sort="Hoffmann, Hans Heinrich" uniqKey="Hoffmann H" first="Hans-Heinrich" last="Hoffmann">Hans-Heinrich Hoffmann</name><name sortKey="Hraiech, Sami" sort="Hraiech, Sami" uniqKey="Hraiech S" first="Sami" last="Hraiech">Sami Hraiech</name><name sortKey="Imberti, Luisa" sort="Imberti, Luisa" uniqKey="Imberti L" first="Luisa" last="Imberti">Luisa Imberti</name><name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name><name sortKey="Karabela, Emsi Nur" sort="Karabela, Emsi Nur" uniqKey="Karabela " first=" Emsi Nur" last="Karabela"> Emsi Nur Karabela</name><name sortKey="Karpf, Lea" sort="Karpf, Lea" uniqKey="Karpf L" first="Léa" last="Karpf">Léa Karpf</name><name sortKey="Keles, Sevgi" sort="Keles, Sevgi" uniqKey="Keles S" first="Sevgi" last="Keles">Sevgi Keles</name><name sortKey="Kerner, Gaspard" sort="Kerner, Gaspard" uniqKey="Kerner G" first="Gaspard" last="Kerner">Gaspard Kerner</name><name sortKey="Khan, Taushif" sort="Khan, Taushif" uniqKey="Khan T" first="Taushif" last="Khan">Taushif Khan</name><name sortKey="Korniotis, Sarantis" sort="Korniotis, Sarantis" uniqKey="Korniotis S" first="Sarantis" last="Korniotis">Sarantis Korniotis</name><name sortKey="Korol, Cecilia" sort="Korol, Cecilia" uniqKey="Korol C" first="Cecilia" last="Korol">Cecilia Korol</name><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name><name sortKey="Laouenan, Cedric" sort="Laouenan, Cedric" uniqKey="Laouenan C" first="Cédric" last="Laouénan">Cédric Laouénan</name><name sortKey="Le Pen, Jeremie" sort="Le Pen, Jeremie" uniqKey="Le Pen J" first="Jérémie" last="Le Pen">Jérémie Le Pen</name><name sortKey="Le Voyer, Tom" sort="Le Voyer, Tom" uniqKey="Le Voyer T" first="Tom" last="Le Voyer">Tom Le Voyer</name><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name><name sortKey="Lifton, Richard" sort="Lifton, Richard" uniqKey="Lifton R" first="Richard" last="Lifton">Richard Lifton</name><name sortKey="Liu, Zhiyong" sort="Liu, Zhiyong" uniqKey="Liu Z" first="Zhiyong" last="Liu">Zhiyong Liu</name><name sortKey="Lorenzo, Lazaro" sort="Lorenzo, Lazaro" uniqKey="Lorenzo L" first="Lazaro" last="Lorenzo">Lazaro Lorenzo</name><name sortKey="Maniatis, Tom" sort="Maniatis, Tom" uniqKey="Maniatis T" first="Tom" last="Maniatis">Tom Maniatis</name><name sortKey="Manry, Jeremy" sort="Manry, Jeremy" uniqKey="Manry J" first="Jeremy" last="Manry">Jeremy Manry</name><name sortKey="Mansouri, Davood" sort="Mansouri, Davood" uniqKey="Mansouri D" first="Davood" last="Mansouri">Davood Mansouri</name><name sortKey="Marr, Nico" sort="Marr, Nico" uniqKey="Marr N" first="Nico" last="Marr">Nico Marr</name><name sortKey="Martin Nalda, Andrea" sort="Martin Nalda, Andrea" uniqKey="Martin Nalda A" first="Andrea" last="Martin-Nalda">Andrea Martin-Nalda</name><name sortKey="Masson, Cecile" sort="Masson, Cecile" uniqKey="Masson C" first="Cecile" last="Masson">Cecile Masson</name><name sortKey="Meade, Philip" sort="Meade, Philip" uniqKey="Meade P" first="Philip" last="Meade">Philip Meade</name><name sortKey="Meyts, Isabelle" sort="Meyts, Isabelle" uniqKey="Meyts I" first="Isabelle" last="Meyts">Isabelle Meyts</name><name sortKey="Michailidis, Eleftherios" sort="Michailidis, Eleftherios" uniqKey="Michailidis E" first="Eleftherios" last="Michailidis">Eleftherios Michailidis</name><name sortKey="Migeotte, Isabelle" sort="Migeotte, Isabelle" uniqKey="Migeotte I" first="Isabelle" last="Migeotte">Isabelle Migeotte</name><name sortKey="Milner, Joshua" sort="Milner, Joshua" uniqKey="Milner J" first="Joshua" last="Milner">Joshua Milner</name><name sortKey="Moens, Leen" sort="Moens, Leen" uniqKey="Moens L" first="Leen" last="Moens">Leen Moens</name><name sortKey="Mogensen, Trine H" sort="Mogensen, Trine H" uniqKey="Mogensen T" first="Trine H" last="Mogensen">Trine H. Mogensen</name><name sortKey="Moncada Velez, Marcela" sort="Moncada Velez, Marcela" uniqKey="Moncada Velez M" first="Marcela" last="Moncada-Velez">Marcela Moncada-Velez</name><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name><name sortKey="Neehus, Anna Lena" sort="Neehus, Anna Lena" uniqKey="Neehus A" first="Anna-Lena" last="Neehus">Anna-Lena Neehus</name><name sortKey="Notarangelo, Luigi D" sort="Notarangelo, Luigi D" uniqKey="Notarangelo L" first="Luigi D" last="Notarangelo">Luigi D. Notarangelo</name><name sortKey="Novelli, Giuseppe" sort="Novelli, Giuseppe" uniqKey="Novelli G" first="Giuseppe" last="Novelli">Giuseppe Novelli</name><name sortKey="Nussenzweig, Michel" sort="Nussenzweig, Michel" uniqKey="Nussenzweig M" first="Michel" last="Nussenzweig">Michel Nussenzweig</name><name sortKey="Ogishi, Masato" sort="Ogishi, Masato" uniqKey="Ogishi M" first="Masato" last="Ogishi">Masato Ogishi</name><name sortKey="Oler, Andrew J" sort="Oler, Andrew J" uniqKey="Oler A" first="Andrew J" last="Oler">Andrew J. Oler</name><name sortKey="Onodi, Fanny" sort="Onodi, Fanny" uniqKey="Onodi F" first="Fanny" last="Onodi">Fanny Onodi</name><name sortKey="Ozcelik, Tayfun" sort="Ozcelik, Tayfun" uniqKey="Ozcelik T" first="Tayfun" last="Ozcelik">Tayfun Ozcelik</name><name sortKey="Paghera, Simone" sort="Paghera, Simone" uniqKey="Paghera S" first="Simone" last="Paghera">Simone Paghera</name><name sortKey="Philippot, Quentin" sort="Philippot, Quentin" uniqKey="Philippot Q" first="Quentin" last="Philippot">Quentin Philippot</name><name sortKey="Puel, Anne" sort="Puel, Anne" uniqKey="Puel A" first="Anne" last="Puel">Anne Puel</name><name sortKey="Pujol, Aurora" sort="Pujol, Aurora" uniqKey="Pujol A" first="Aurora" last="Pujol">Aurora Pujol</name><name sortKey="Quiros Roldan, Eugenia" sort="Quiros Roldan, Eugenia" uniqKey="Quiros Roldan E" first="Eugenia" last="Quiros-Roldan">Eugenia Quiros-Roldan</name><name sortKey="Rapaport, Franck" sort="Rapaport, Franck" uniqKey="Rapaport F" first="Franck" last="Rapaport">Franck Rapaport</name><name sortKey="Razooky, Brandon S" sort="Razooky, Brandon S" uniqKey="Razooky B" first="Brandon S" last="Razooky">Brandon S. Razooky</name><name sortKey="Rice, Charles M" sort="Rice, Charles M" uniqKey="Rice C" first="Charles M" last="Rice">Charles M. Rice</name><name sortKey="Rosain, Jeremie" sort="Rosain, Jeremie" uniqKey="Rosain J" first="Jérémie" last="Rosain">Jérémie Rosain</name><name sortKey="Rossi, Camillo" sort="Rossi, Camillo" uniqKey="Rossi C" first="Camillo" last="Rossi">Camillo Rossi</name><name sortKey="Roussel, Lucie" sort="Roussel, Lucie" uniqKey="Roussel L" first="Lucie" last="Roussel">Lucie Roussel</name><name sortKey="Sabli, Ira K D" sort="Sabli, Ira K D" uniqKey="Sabli I" first="Ira K D" last="Sabli">Ira K D. Sabli</name><name sortKey="Sancho Shimizu, Vanessa" sort="Sancho Shimizu, Vanessa" uniqKey="Sancho Shimizu V" first="Vanessa" last="Sancho-Shimizu">Vanessa Sancho-Shimizu</name><name sortKey="Schluter, Agatha" sort="Schluter, Agatha" uniqKey="Schluter A" first="Agatha" last="Schlüter">Agatha Schlüter</name><name sortKey="Schmitt, Yohann" sort="Schmitt, Yohann" uniqKey="Schmitt Y" first="Yohann" last="Schmitt">Yohann Schmitt</name><name sortKey="Schneider, William M" sort="Schneider, William M" uniqKey="Schneider W" first="William M" last="Schneider">William M. Schneider</name><name sortKey="Seeleuthner, Yoann" sort="Seeleuthner, Yoann" uniqKey="Seeleuthner Y" first="Yoann" last="Seeleuthner">Yoann Seeleuthner</name><name sortKey="Senoglu, Sevtap" sort="Senoglu, Sevtap" uniqKey="Senoglu S" first="Sevtap" last="Senoglu">Sevtap Senoglu</name><name sortKey="Shahrooei, Mohammad" sort="Shahrooei, Mohammad" uniqKey="Shahrooei M" first="Mohammad" last="Shahrooei">Mohammad Shahrooei</name><name sortKey="Smith, Nikaia" sort="Smith, Nikaia" uniqKey="Smith N" first="Nikaïa" last="Smith">Nikaïa Smith</name><name sortKey="Smits, Guillaume" sort="Smits, Guillaume" uniqKey="Smits G" first="Guillaume" last="Smits">Guillaume Smits</name><name sortKey="Snow, Andrew L" sort="Snow, Andrew L" uniqKey="Snow A" first="Andrew L" last="Snow">Andrew L. Snow</name><name sortKey="Soler Palacin, Pere" sort="Soler Palacin, Pere" uniqKey="Soler Palacin P" first="Pere" last="Soler-Palacin">Pere Soler-Palacin</name><name sortKey="Sottini, Alessandra" sort="Sottini, Alessandra" uniqKey="Sottini A" first="Alessandra" last="Sottini">Alessandra Sottini</name><name sortKey="Soumelis, Vassili" sort="Soumelis, Vassili" uniqKey="Soumelis V" first="Vassili" last="Soumelis">Vassili Soumelis</name><name sortKey="Spaan, Andras N" sort="Spaan, Andras N" uniqKey="Spaan A" first="András N" last="Spaan">András N. Spaan</name><name sortKey="Su, Helen C" sort="Su, Helen C" uniqKey="Su H" first="Helen C" last="Su">Helen C. Su</name><name sortKey="Tandjaoui Lambiotte, Yacine" sort="Tandjaoui Lambiotte, Yacine" uniqKey="Tandjaoui Lambiotte Y" first="Yacine" last="Tandjaoui-Lambiotte">Yacine Tandjaoui-Lambiotte</name><name sortKey="Tompkins, Miranda F" sort="Tompkins, Miranda F" uniqKey="Tompkins M" first="Miranda F" last="Tompkins">Miranda F. Tompkins</name><name sortKey="Ugurbil, Aileen Camille" sort="Ugurbil, Aileen Camille" uniqKey="Ugurbil A" first="Aileen Camille" last="Ugurbil">Aileen Camille Ugurbil</name><name sortKey="Van De Beek, Diederik" sort="Van De Beek, Diederik" uniqKey="Van De Beek D" first="Diederik" last="Van De Beek">Diederik Van De Beek</name><name sortKey="Vandernoot, Isabelle" sort="Vandernoot, Isabelle" uniqKey="Vandernoot I" first="Isabelle" last="Vandernoot">Isabelle Vandernoot</name><name sortKey="Vinh, Donald C" sort="Vinh, Donald C" uniqKey="Vinh D" first="Donald C" last="Vinh">Donald C. Vinh</name><name sortKey="Yang, Rui" sort="Yang, Rui" uniqKey="Yang R" first="Rui" last="Yang">Rui Yang</name><name sortKey="Yasar, Kadriye Kart" sort="Yasar, Kadriye Kart" uniqKey="Yasar K" first="Kadriye Kart" last="Yasar">Kadriye Kart Yasar</name><name sortKey="Ye, Junqiang" sort="Ye, Junqiang" uniqKey="Ye J" first="Junqiang" last="Ye">Junqiang Ye</name><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name><name sortKey="Zhang, Shen Ying" sort="Zhang, Shen Ying" uniqKey="Zhang S" first="Shen-Ying" last="Zhang">Shen-Ying Zhang</name><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><name sortKey="Zhou, Qinhua" sort="Zhou, Qinhua" uniqKey="Zhou Q" first="Qinhua" last="Zhou">Qinhua Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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