Thrombotic microangiopathy, DIC-syndrome and COVID-19: link with pregnancy prothrombotic state.
Identifieur interne : 000363 ( Main/Exploration ); précédent : 000362; suivant : 000364Thrombotic microangiopathy, DIC-syndrome and COVID-19: link with pregnancy prothrombotic state.
Auteurs : A D Makatsariya [Russie] ; E V Slukhanchuk [Russie] ; V O Bitsadze [Russie] ; J K H. Khizroeva [Russie] ; M V Tretyakova [Russie] ; V I Tsibizova [Russie] ; I. Elalamy [Russie, France] ; J-C Gris [Russie, France] ; E. Grandone [Russie, Italie] ; N A Makatsariya [Russie] ; T. Mashkova [Russie]Source :
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [ 1476-4954 ] ; 2020.
Abstract
For last months, humanity has faced a formidable unknown enemy, which is presented as a new coronavirus infection. Despite the fact that the causative agents of new diseases appear at a certain frequency and that the virus SARS-CoV-2 has certain common properties with its predecessors, at the moment we are dealing with a new unknown pathogenesis of the development of severe complications in patients with risk factors. A final understanding of pathological process mechanisms is the goal of the scientific community. Summarizing research data from different countries, it became obvious that in severe cases of viral infection, we are dealing with a combination of the systemic inflammatory response syndrome, disseminated intravascular coagulation and thrombotic microangiopathy (TMA). Thrombotic microangiopathy is represented by a group of different conditions in which thrombocytopenia, hemolytic anemia, and multiple organ failure occur. The article reflects the main types of TMA, pathogenesis and principles of therapy. The main participants in the process are described in detail, including the von Willebrand factor and ADAMTS-13. Based on the knowledge available, as well as new data obtained from patients with COVID-19, we proposed possible models for the implementation of conditions such as sepsis, TMA, and DIC in patients with severe new coronavirus infection. Through a deeper understanding of pathogenesis, it will be possible to develop more effective diagnosis and therapy.
DOI: 10.1080/14767058.2020.1786811
PubMed: 32627622
Affiliations:
- France, Italie, Russie
- District fédéral central, Languedoc-Roussillon, Occitanie (région administrative), Île-de-France
- Montpellier, Moscou, Paris
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Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Grandone, E" sort="Grandone, E" uniqKey="Grandone E" first="E" last="Grandone">E. Grandone</name><affiliation wicri:level="3"><nlm:affiliation>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Hemostasis and Thrombosis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", Puglia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Hemostasis and Thrombosis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", Puglia</wicri:regionArea><wicri:noRegion>Puglia</wicri:noRegion></affiliation></author><author><name sortKey="Makatsariya, N A" sort="Makatsariya, N A" uniqKey="Makatsariya N" first="N A" last="Makatsariya">N A Makatsariya</name><affiliation wicri:level="3"><nlm:affiliation>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Mashkova, T" sort="Mashkova, T" uniqKey="Mashkova T" first="T" last="Mashkova">T. Mashkova</name><affiliation wicri:level="3"><nlm:affiliation>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author></analytic><series><title level="j">The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians</title><idno type="eISSN">1476-4954</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For last months, humanity has faced a formidable unknown enemy, which is presented as a new coronavirus infection. Despite the fact that the causative agents of new diseases appear at a certain frequency and that the virus SARS-CoV-2 has certain common properties with its predecessors, at the moment we are dealing with a new unknown pathogenesis of the development of severe complications in patients with risk factors. A final understanding of pathological process mechanisms is the goal of the scientific community. Summarizing research data from different countries, it became obvious that in severe cases of viral infection, we are dealing with a combination of the systemic inflammatory response syndrome, disseminated intravascular coagulation and thrombotic microangiopathy (TMA). Thrombotic microangiopathy is represented by a group of different conditions in which thrombocytopenia, hemolytic anemia, and multiple organ failure occur. The article reflects the main types of TMA, pathogenesis and principles of therapy. The main participants in the process are described in detail, including the von Willebrand factor and ADAMTS-13. Based on the knowledge available, as well as new data obtained from patients with COVID-19, we proposed possible models for the implementation of conditions such as sepsis, TMA, and DIC in patients with severe new coronavirus infection. Through a deeper understanding of pathogenesis, it will be possible to develop more effective diagnosis and therapy.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32627622</PMID><DateRevised><Year>2020</Year><Month>07</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-4954</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jul</Month><Day>06</Day></PubDate></JournalIssue><Title>The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians</Title><ISOAbbreviation>J. Matern. Fetal. Neonatal. Med.</ISOAbbreviation></Journal><ArticleTitle>Thrombotic microangiopathy, DIC-syndrome and COVID-19: link with pregnancy prothrombotic state.</ArticleTitle><Pagination><MedlinePgn>1-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/14767058.2020.1786811</ELocationID><Abstract><AbstractText>For last months, humanity has faced a formidable unknown enemy, which is presented as a new coronavirus infection. Despite the fact that the causative agents of new diseases appear at a certain frequency and that the virus SARS-CoV-2 has certain common properties with its predecessors, at the moment we are dealing with a new unknown pathogenesis of the development of severe complications in patients with risk factors. A final understanding of pathological process mechanisms is the goal of the scientific community. Summarizing research data from different countries, it became obvious that in severe cases of viral infection, we are dealing with a combination of the systemic inflammatory response syndrome, disseminated intravascular coagulation and thrombotic microangiopathy (TMA). Thrombotic microangiopathy is represented by a group of different conditions in which thrombocytopenia, hemolytic anemia, and multiple organ failure occur. The article reflects the main types of TMA, pathogenesis and principles of therapy. The main participants in the process are described in detail, including the von Willebrand factor and ADAMTS-13. Based on the knowledge available, as well as new data obtained from patients with COVID-19, we proposed possible models for the implementation of conditions such as sepsis, TMA, and DIC in patients with severe new coronavirus infection. Through a deeper understanding of pathogenesis, it will be possible to develop more effective diagnosis and therapy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Makatsariya</LastName><ForeName>A D</ForeName><Initials>AD</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-7415-4633</Identifier><AffiliationInfo><Affiliation>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slukhanchuk</LastName><ForeName>E V</ForeName><Initials>EV</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-7441-2778</Identifier><AffiliationInfo><Affiliation>Head of Gynecology Unit, Petrovsky National Research Center of Surgery, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bitsadze</LastName><ForeName>V O</ForeName><Initials>VO</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-8404-1042</Identifier><AffiliationInfo><Affiliation>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khizroeva</LastName><ForeName>J K H</ForeName><Initials>JKH</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0725-9686</Identifier><AffiliationInfo><Affiliation>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tretyakova</LastName><ForeName>M V</ForeName><Initials>MV</Initials><AffiliationInfo><Affiliation>Gynecology Department, «Medical Center» LLC, Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsibizova</LastName><ForeName>V I</ForeName><Initials>VI</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5888-0774</Identifier><AffiliationInfo><Affiliation>Almazov National Medical Research Centre, Saint Petersburg, Health Ministry of Russian Federation, Saint Petersburg, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elalamy</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Director of Hematology Department of Thrombosis Center, Medicine Sorbonne University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gris</LastName><ForeName>J-C</ForeName><Initials>JC</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-9899-9910</Identifier><AffiliationInfo><Affiliation>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University Montpellier, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grandone</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hemostasis and Thrombosis Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza", Puglia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Makatsariya</LastName><ForeName>N A</ForeName><Initials>NA</Initials><AffiliationInfo><Affiliation>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mashkova</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Obstetrics and Gynecology, The First I.M. Sechenov Moscow State Medical University, (Sechenov University), Moscow, Russia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Matern Fetal Neonatal Med</MedlineTA><NlmUniqueID>101136916</NlmUniqueID><ISSNLinking>1476-4954</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19 and coagulopathy</Keyword><Keyword MajorTopicYN="N">DIC-syndrome</Keyword><Keyword MajorTopicYN="N">complement system activation</Keyword><Keyword MajorTopicYN="N">prothrombotic state in pregnancy</Keyword><Keyword MajorTopicYN="N">thrombotic microangiopathy and COVID-19</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32627622</ArticleId><ArticleId IdType="doi">10.1080/14767058.2020.1786811</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li><li>Italie</li><li>Russie</li></country><region><li>District fédéral central</li><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Île-de-France</li></region><settlement><li>Montpellier</li><li>Moscou</li><li>Paris</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Makatsariya, A D" sort="Makatsariya, A D" uniqKey="Makatsariya A" first="A D" last="Makatsariya">A D Makatsariya</name></region><name sortKey="Bitsadze, V O" sort="Bitsadze, V O" uniqKey="Bitsadze V" first="V O" last="Bitsadze">V O Bitsadze</name><name sortKey="Elalamy, I" sort="Elalamy, I" uniqKey="Elalamy I" first="I" last="Elalamy">I. Elalamy</name><name sortKey="Grandone, E" sort="Grandone, E" uniqKey="Grandone E" first="E" last="Grandone">E. Grandone</name><name sortKey="Gris, J C" sort="Gris, J C" uniqKey="Gris J" first="J-C" last="Gris">J-C Gris</name><name sortKey="Khizroeva, J K H" sort="Khizroeva, J K H" uniqKey="Khizroeva J" first="J K H" last="Khizroeva">J K H. Khizroeva</name><name sortKey="Makatsariya, N A" sort="Makatsariya, N A" uniqKey="Makatsariya N" first="N A" last="Makatsariya">N A Makatsariya</name><name sortKey="Mashkova, T" sort="Mashkova, T" uniqKey="Mashkova T" first="T" last="Mashkova">T. Mashkova</name><name sortKey="Slukhanchuk, E V" sort="Slukhanchuk, E V" uniqKey="Slukhanchuk E" first="E V" last="Slukhanchuk">E V Slukhanchuk</name><name sortKey="Tretyakova, M V" sort="Tretyakova, M V" uniqKey="Tretyakova M" first="M V" last="Tretyakova">M V Tretyakova</name><name sortKey="Tsibizova, V I" sort="Tsibizova, V I" uniqKey="Tsibizova V" first="V I" last="Tsibizova">V I Tsibizova</name></country><country name="France"><region name="Île-de-France"><name sortKey="Elalamy, I" sort="Elalamy, I" uniqKey="Elalamy I" first="I" last="Elalamy">I. Elalamy</name></region><name sortKey="Gris, J C" sort="Gris, J C" uniqKey="Gris J" first="J-C" last="Gris">J-C Gris</name></country><country name="Italie"><noRegion><name sortKey="Grandone, E" sort="Grandone, E" uniqKey="Grandone E" first="E" last="Grandone">E. Grandone</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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