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Corona Virus Disease 2019 and Paediatric Inflammatory Bowel Diseases: Global Experience and Provisional Guidance (March 2020) from the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology, and Nutrition.

Identifieur interne : 001159 ( Main/Corpus ); précédent : 001158; suivant : 001160

Corona Virus Disease 2019 and Paediatric Inflammatory Bowel Diseases: Global Experience and Provisional Guidance (March 2020) from the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology, and Nutrition.

Auteurs : Dan Turner ; Ying Huang ; Javier Martín-De-Carpi ; Marina Aloi ; Gili Focht ; Ben Kang ; Ying Zhou ; Cesar Sanchez ; Michael D. Kappelman ; Holm H. Uhlig ; Gemma Pujol-Muncunill ; Oren Ledder ; Paolo Lionetti ; Jorge Amil Dias ; Frank M. Ruemmele ; Richard K. Russell

Source :

RBID : pubmed:32443020

English descriptors

Abstract

INTRODUCTION

With the current coronavirus disease 2019 (COVID-19) pandemic, concerns have been raised about the risk to children with inflammatory bowel diseases (IBD). We aimed to collate global experience and provide provisional guidance for managing paediatric IBD (PIBD) in the era of COVID-19.

METHODS

An electronic reporting system of children with IBD infected with SARS-CoV-2 has been circulated among 102 PIBD centres affiliated with the Porto and Interest-group of ESPGHAN. A survey has been completed by major PIBD centres in China and South-Korea to explore management during the pandemic. A third survey collected current practice of PIBD treatment. Finally, guidance points for practice have been formulated and voted upon by 37 PIBD authors and Porto group members.

RESULTS

Eight PIBD children had COVID-19 globally, all with mild infection without needing hospitalization despite treatment with immunomodulators and/or biologics. No cases have been reported in China and South Korea but biologic treatment has been delayed in 79 children, of whom 17 (22%) had exacerbation of their IBD. Among the Porto group members, face-to-face appointments were often replaced by remote consultations but almost all did not change current IBD treatment. Ten guidance points for clinicians caring for PIBD patients in epidemic areas have been endorsed with consensus rate of 92% to 100%.

CONCLUSIONS

Preliminary data for PIBD patients during COVID-19 outbreak are reassuring. Standard IBD treatments including biologics should continue at present through the pandemic, especially in children who generally have more severe IBD course on one hand, and milder SARS-CoV-2 infection on the other.


DOI: 10.1097/MPG.0000000000002729
PubMed: 32443020
PubMed Central: PMC7273950

Links to Exploration step

pubmed:32443020

Le document en format XML

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<name sortKey="Pujol Muncunill, Gemma" sort="Pujol Muncunill, Gemma" uniqKey="Pujol Muncunill G" first="Gemma" last="Pujol-Muncunill">Gemma Pujol-Muncunill</name>
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<term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Child (MeSH)</term>
<term>Consensus (MeSH)</term>
<term>Coronavirus Infections (chemically induced)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Health Care Surveys (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunologic Factors (adverse effects)</term>
<term>Inflammatory Bowel Diseases (complications)</term>
<term>Inflammatory Bowel Diseases (epidemiology)</term>
<term>Inflammatory Bowel Diseases (therapy)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (chemically induced)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Severity of Illness Index (MeSH)</term>
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<term>Immunologic Factors</term>
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<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
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<term>Coronavirus Infections</term>
<term>Inflammatory Bowel Diseases</term>
<term>Pneumonia, Viral</term>
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<term>Coronavirus Infections</term>
<term>Inflammatory Bowel Diseases</term>
<term>Pneumonia, Viral</term>
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<term>Coronavirus Infections</term>
<term>Inflammatory Bowel Diseases</term>
<term>Pneumonia, Viral</term>
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<term>Adult</term>
<term>Betacoronavirus</term>
<term>Child</term>
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<p>
<b>INTRODUCTION</b>
</p>
<p>With the current coronavirus disease 2019 (COVID-19) pandemic, concerns have been raised about the risk to children with inflammatory bowel diseases (IBD). We aimed to collate global experience and provide provisional guidance for managing paediatric IBD (PIBD) in the era of COVID-19.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>An electronic reporting system of children with IBD infected with SARS-CoV-2 has been circulated among 102 PIBD centres affiliated with the Porto and Interest-group of ESPGHAN. A survey has been completed by major PIBD centres in China and South-Korea to explore management during the pandemic. A third survey collected current practice of PIBD treatment. Finally, guidance points for practice have been formulated and voted upon by 37 PIBD authors and Porto group members.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>Eight PIBD children had COVID-19 globally, all with mild infection without needing hospitalization despite treatment with immunomodulators and/or biologics. No cases have been reported in China and South Korea but biologic treatment has been delayed in 79 children, of whom 17 (22%) had exacerbation of their IBD. Among the Porto group members, face-to-face appointments were often replaced by remote consultations but almost all did not change current IBD treatment. Ten guidance points for clinicians caring for PIBD patients in epidemic areas have been endorsed with consensus rate of 92% to 100%.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>Preliminary data for PIBD patients during COVID-19 outbreak are reassuring. Standard IBD treatments including biologics should continue at present through the pandemic, especially in children who generally have more severe IBD course on one hand, and milder SARS-CoV-2 infection on the other.</p>
</div>
</front>
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<AbstractText Label="INTRODUCTION">With the current coronavirus disease 2019 (COVID-19) pandemic, concerns have been raised about the risk to children with inflammatory bowel diseases (IBD). We aimed to collate global experience and provide provisional guidance for managing paediatric IBD (PIBD) in the era of COVID-19.</AbstractText>
<AbstractText Label="METHODS">An electronic reporting system of children with IBD infected with SARS-CoV-2 has been circulated among 102 PIBD centres affiliated with the Porto and Interest-group of ESPGHAN. A survey has been completed by major PIBD centres in China and South-Korea to explore management during the pandemic. A third survey collected current practice of PIBD treatment. Finally, guidance points for practice have been formulated and voted upon by 37 PIBD authors and Porto group members.</AbstractText>
<AbstractText Label="RESULTS">Eight PIBD children had COVID-19 globally, all with mild infection without needing hospitalization despite treatment with immunomodulators and/or biologics. No cases have been reported in China and South Korea but biologic treatment has been delayed in 79 children, of whom 17 (22%) had exacerbation of their IBD. Among the Porto group members, face-to-face appointments were often replaced by remote consultations but almost all did not change current IBD treatment. Ten guidance points for clinicians caring for PIBD patients in epidemic areas have been endorsed with consensus rate of 92% to 100%.</AbstractText>
<AbstractText Label="CONCLUSIONS">Preliminary data for PIBD patients during COVID-19 outbreak are reassuring. Standard IBD treatments including biologics should continue at present through the pandemic, especially in children who generally have more severe IBD course on one hand, and milder SARS-CoV-2 infection on the other.</AbstractText>
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<Affiliation>Department of Gastroenterology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.</Affiliation>
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</AffiliationInfo>
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<ForeName>Holm H</ForeName>
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<Affiliation>Translational Gastroenterology Unit, University of Oxford, Department of Paediatrics, John Radcliffe Hospital, University of Oxford, Biomedical Research Center Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
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</AffiliationInfo>
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</AffiliationInfo>
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