SARS-CoV-2 Pneumonia in Hospitalized Asthmatic Patients Did Not Induce Severe Exacerbation.
Identifieur interne : 000B55 ( Main/Corpus ); précédent : 000B54; suivant : 000B56SARS-CoV-2 Pneumonia in Hospitalized Asthmatic Patients Did Not Induce Severe Exacerbation.
Auteurs : Manon Grandbastien ; Anays Piotin ; Julien Godet ; Ines Abessolo-Amougou ; Carole Ederlé ; Irina Enache ; Philippe Fraisse ; Thi Cam Tu Hoang ; Loic Kassegne ; Aissam Labani ; Pierre Leyendecker ; Louise Manien ; Christophe Marcot ; Guillaume Pamart ; Benjamin Renaud-Picard ; Marianne Riou ; Virginie Doyen ; Romain Kessler ; Samira Fafi-Kremer ; Carine Metz-Favre ; Naji Khayath ; Frédéric De BlaySource :
- The journal of allergy and clinical immunology. In practice [ 2213-2201 ] ; 2020.
English descriptors
- KwdEn :
- Adrenergic beta-Agonists (therapeutic use), Aged (MeSH), Asthma (drug therapy), Asthma (epidemiology), Asthma (physiopathology), Betacoronavirus (MeSH), Comorbidity (MeSH), Coronavirus Infections (epidemiology), Coronavirus Infections (physiopathology), Female (MeSH), Glucocorticoids (therapeutic use), Hospitalization (statistics & numerical data), Humans (MeSH), Intensive Care Units (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Pneumonia, Viral (physiopathology), Respiration, Artificial (MeSH), Retrospective Studies (MeSH), Severity of Illness Index (MeSH), Socioeconomic Factors (MeSH).
- MESH :
- chemical , therapeutic use : Adrenergic beta-Agonists, Glucocorticoids.
- drug therapy : Asthma.
- epidemiology : Asthma, Coronavirus Infections, Pneumonia, Viral.
- physiopathology : Asthma, Coronavirus Infections, Pneumonia, Viral.
- statistics & numerical data : Hospitalization.
- Aged, Betacoronavirus, Comorbidity, Female, Humans, Intensive Care Units, Male, Middle Aged, Pandemics, Respiration, Artificial, Retrospective Studies, Severity of Illness Index, Socioeconomic Factors.
Abstract
BACKGROUND
Viral infections are known to exacerbate asthma in adults. Previous studies have found few patients with asthma among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia cases. However, the relationship between SARS-CoV-2 infection and severe asthma exacerbation is not known.
OBJECTIVE
To assess the frequency of asthma exacerbation in patients with asthma hospitalized for SARS-CoV-2 pneumonia and compare symptoms and laboratory and radiological findings in patients with and without asthma with SARS-CoV-2 pneumonia.
METHODS
We included 106 patients between March 4 and April 6, 2020, who were hospitalized in the Chest Diseases Department of Strasbourg University Hospital; 23 had asthma. To assess the patients' asthma status, 3 periods were defined: the last month before the onset of COVID-19 symptoms (p1), prehospitalization (p2), and during hospitalization (p3). Severe asthma exacerbations were defined according to Global INitiative for Asthma guidelines during p1 and p2. During p3, we defined severe asthma deterioration as the onset of breathlessness and wheezing requiring systemic corticosteroids and inhaled β2 agonist.
RESULTS
We found no significant difference between patients with and without asthma in terms of severity (length of stay, maximal oxygen flow needed, noninvasive ventilation requirement, and intensive care unit transfer); 52.2% of the patients with asthma had Global INitiative for Asthma step 1 asthma. One patient had a severe exacerbation during p1, 2 patients during p2, and 5 patients were treated with systemic corticosteroids and inhaled β2 agonist during p3.
CONCLUSIONS
Our results demonstrate that patients with asthma appeared not to be at risk for severe SARS-CoV-2 pneumonia. Moreover, SARS-CoV-2 pneumonia did not induce severe asthma exacerbation.
DOI: 10.1016/j.jaip.2020.06.032
PubMed: 32603901
PubMed Central: PMC7320869
Links to Exploration step
pubmed:32603901Le document en format XML
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Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Doyen, Virginie" sort="Doyen, Virginie" uniqKey="Doyen V" first="Virginie" last="Doyen">Virginie Doyen</name><affiliation><nlm:affiliation>Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Kessler, Romain" sort="Kessler, Romain" uniqKey="Kessler R" first="Romain" last="Kessler">Romain Kessler</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France; Department of Radiology B, Strasbourg University Hospital, Strasbourg, France; Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium; INSERM-UNISTRA, UMR 1260 "Regenerative NanoMedecine," University of Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fafi Kremer, Samira" sort="Fafi Kremer, Samira" uniqKey="Fafi Kremer S" first="Samira" last="Fafi-Kremer">Samira Fafi-Kremer</name><affiliation><nlm:affiliation>Department of Virology, Strasbourg University Hospital, INSERM U748, University of Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Metz Favre, Carine" sort="Metz Favre, Carine" uniqKey="Metz Favre C" first="Carine" last="Metz-Favre">Carine Metz-Favre</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Khayath, Naji" sort="Khayath, Naji" uniqKey="Khayath N" first="Naji" last="Khayath">Naji Khayath</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="De Blay, Frederic" sort="De Blay, Frederic" uniqKey="De Blay F" first="Frédéric" last="De Blay">Frédéric De Blay</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France. Electronic address: frederic.deblay@chru-strasbourg.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32603901</idno><idno type="pmid">32603901</idno><idno type="doi">10.1016/j.jaip.2020.06.032</idno><idno type="pmc">PMC7320869</idno><idno type="wicri:Area/Main/Corpus">000B55</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000B55</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">SARS-CoV-2 Pneumonia in Hospitalized Asthmatic Patients Did Not Induce Severe Exacerbation.</title><author><name sortKey="Grandbastien, Manon" sort="Grandbastien, Manon" uniqKey="Grandbastien M" first="Manon" last="Grandbastien">Manon Grandbastien</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Piotin, Anays" sort="Piotin, Anays" uniqKey="Piotin A" first="Anays" last="Piotin">Anays Piotin</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Godet, Julien" sort="Godet, Julien" uniqKey="Godet J" first="Julien" last="Godet">Julien Godet</name><affiliation><nlm:affiliation>Public Health Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Abessolo Amougou, Ines" sort="Abessolo Amougou, Ines" uniqKey="Abessolo Amougou I" first="Ines" last="Abessolo-Amougou">Ines Abessolo-Amougou</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ederle, Carole" sort="Ederle, Carole" uniqKey="Ederle C" first="Carole" last="Ederlé">Carole Ederlé</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Enache, Irina" sort="Enache, Irina" uniqKey="Enache I" first="Irina" last="Enache">Irina Enache</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fraisse, Philippe" sort="Fraisse, Philippe" uniqKey="Fraisse P" first="Philippe" last="Fraisse">Philippe Fraisse</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tu Hoang, Thi Cam" sort="Tu Hoang, Thi Cam" uniqKey="Tu Hoang T" first="Thi Cam" last="Tu Hoang">Thi Cam Tu Hoang</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kassegne, Loic" sort="Kassegne, Loic" uniqKey="Kassegne L" first="Loic" last="Kassegne">Loic Kassegne</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Labani, Aissam" sort="Labani, Aissam" uniqKey="Labani A" first="Aissam" last="Labani">Aissam Labani</name><affiliation><nlm:affiliation>Department of Radiology B, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Leyendecker, Pierre" sort="Leyendecker, Pierre" uniqKey="Leyendecker P" first="Pierre" last="Leyendecker">Pierre Leyendecker</name><affiliation><nlm:affiliation>Department of Radiology B, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Manien, Louise" sort="Manien, Louise" uniqKey="Manien L" first="Louise" last="Manien">Louise Manien</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Marcot, Christophe" sort="Marcot, Christophe" uniqKey="Marcot C" first="Christophe" last="Marcot">Christophe Marcot</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pamart, Guillaume" sort="Pamart, Guillaume" uniqKey="Pamart G" first="Guillaume" last="Pamart">Guillaume Pamart</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Renaud Picard, Benjamin" sort="Renaud Picard, Benjamin" uniqKey="Renaud Picard B" first="Benjamin" last="Renaud-Picard">Benjamin Renaud-Picard</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Riou, Marianne" sort="Riou, Marianne" uniqKey="Riou M" first="Marianne" last="Riou">Marianne Riou</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Doyen, Virginie" sort="Doyen, Virginie" uniqKey="Doyen V" first="Virginie" last="Doyen">Virginie Doyen</name><affiliation><nlm:affiliation>Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Kessler, Romain" sort="Kessler, Romain" uniqKey="Kessler R" first="Romain" last="Kessler">Romain Kessler</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France; Department of Radiology B, Strasbourg University Hospital, Strasbourg, France; Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium; INSERM-UNISTRA, UMR 1260 "Regenerative NanoMedecine," University of Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fafi Kremer, Samira" sort="Fafi Kremer, Samira" uniqKey="Fafi Kremer S" first="Samira" last="Fafi-Kremer">Samira Fafi-Kremer</name><affiliation><nlm:affiliation>Department of Virology, Strasbourg University Hospital, INSERM U748, University of Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Metz Favre, Carine" sort="Metz Favre, Carine" uniqKey="Metz Favre C" first="Carine" last="Metz-Favre">Carine Metz-Favre</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Khayath, Naji" sort="Khayath, Naji" uniqKey="Khayath N" first="Naji" last="Khayath">Naji Khayath</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="De Blay, Frederic" sort="De Blay, Frederic" uniqKey="De Blay F" first="Frédéric" last="De Blay">Frédéric De Blay</name><affiliation><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France. Electronic address: frederic.deblay@chru-strasbourg.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The journal of allergy and clinical immunology. In practice</title><idno type="eISSN">2213-2201</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic beta-Agonists (therapeutic use)</term><term>Aged (MeSH)</term><term>Asthma (drug therapy)</term><term>Asthma (epidemiology)</term><term>Asthma (physiopathology)</term><term>Betacoronavirus (MeSH)</term><term>Comorbidity (MeSH)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (physiopathology)</term><term>Female (MeSH)</term><term>Glucocorticoids (therapeutic use)</term><term>Hospitalization (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Intensive Care Units (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (physiopathology)</term><term>Respiration, Artificial (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Severity of Illness Index (MeSH)</term><term>Socioeconomic Factors (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenergic beta-Agonists</term><term>Glucocorticoids</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Asthma</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Asthma</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Asthma</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Betacoronavirus</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Intensive Care Units</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Respiration, Artificial</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>Socioeconomic Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Viral infections are known to exacerbate asthma in adults. Previous studies have found few patients with asthma among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia cases. However, the relationship between SARS-CoV-2 infection and severe asthma exacerbation is not known.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To assess the frequency of asthma exacerbation in patients with asthma hospitalized for SARS-CoV-2 pneumonia and compare symptoms and laboratory and radiological findings in patients with and without asthma with SARS-CoV-2 pneumonia.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We included 106 patients between March 4 and April 6, 2020, who were hospitalized in the Chest Diseases Department of Strasbourg University Hospital; 23 had asthma. To assess the patients' asthma status, 3 periods were defined: the last month before the onset of COVID-19 symptoms (p1), prehospitalization (p2), and during hospitalization (p3). Severe asthma exacerbations were defined according to Global INitiative for Asthma guidelines during p1 and p2. During p3, we defined severe asthma deterioration as the onset of breathlessness and wheezing requiring systemic corticosteroids and inhaled β2 agonist.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We found no significant difference between patients with and without asthma in terms of severity (length of stay, maximal oxygen flow needed, noninvasive ventilation requirement, and intensive care unit transfer); 52.2% of the patients with asthma had Global INitiative for Asthma step 1 asthma. One patient had a severe exacerbation during p1, 2 patients during p2, and 5 patients were treated with systemic corticosteroids and inhaled β2 agonist during p3.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Our results demonstrate that patients with asthma appeared not to be at risk for severe SARS-CoV-2 pneumonia. Moreover, SARS-CoV-2 pneumonia did not induce severe asthma exacerbation.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32603901</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>17</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2213-2201</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>8</Issue><PubDate><Year>2020</Year><Month>Sep</Month></PubDate></JournalIssue><Title>The journal of allergy and clinical immunology. In practice</Title><ISOAbbreviation>J Allergy Clin Immunol Pract</ISOAbbreviation></Journal><ArticleTitle>SARS-CoV-2 Pneumonia in Hospitalized Asthmatic Patients Did Not Induce Severe Exacerbation.</ArticleTitle><Pagination><MedlinePgn>2600-2607</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S2213-2198(20)30667-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jaip.2020.06.032</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Viral infections are known to exacerbate asthma in adults. Previous studies have found few patients with asthma among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia cases. However, the relationship between SARS-CoV-2 infection and severe asthma exacerbation is not known.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To assess the frequency of asthma exacerbation in patients with asthma hospitalized for SARS-CoV-2 pneumonia and compare symptoms and laboratory and radiological findings in patients with and without asthma with SARS-CoV-2 pneumonia.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We included 106 patients between March 4 and April 6, 2020, who were hospitalized in the Chest Diseases Department of Strasbourg University Hospital; 23 had asthma. To assess the patients' asthma status, 3 periods were defined: the last month before the onset of COVID-19 symptoms (p1), prehospitalization (p2), and during hospitalization (p3). Severe asthma exacerbations were defined according to Global INitiative for Asthma guidelines during p1 and p2. During p3, we defined severe asthma deterioration as the onset of breathlessness and wheezing requiring systemic corticosteroids and inhaled β2 agonist.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We found no significant difference between patients with and without asthma in terms of severity (length of stay, maximal oxygen flow needed, noninvasive ventilation requirement, and intensive care unit transfer); 52.2% of the patients with asthma had Global INitiative for Asthma step 1 asthma. One patient had a severe exacerbation during p1, 2 patients during p2, and 5 patients were treated with systemic corticosteroids and inhaled β2 agonist during p3.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our results demonstrate that patients with asthma appeared not to be at risk for severe SARS-CoV-2 pneumonia. Moreover, SARS-CoV-2 pneumonia did not induce severe asthma exacerbation.</AbstractText><CopyrightInformation>Copyright © 2020 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Grandbastien</LastName><ForeName>Manon</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piotin</LastName><ForeName>Anays</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Godet</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Public Health Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abessolo-Amougou</LastName><ForeName>Ines</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ederlé</LastName><ForeName>Carole</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Enache</LastName><ForeName>Irina</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fraisse</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tu Hoang</LastName><ForeName>Thi Cam</ForeName><Initials>TC</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kassegne</LastName><ForeName>Loic</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Labani</LastName><ForeName>Aissam</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Radiology B, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leyendecker</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Radiology B, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manien</LastName><ForeName>Louise</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marcot</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pamart</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Renaud-Picard</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riou</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doyen</LastName><ForeName>Virginie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kessler</LastName><ForeName>Romain</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France; Department of Radiology B, Strasbourg University Hospital, Strasbourg, France; Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium; INSERM-UNISTRA, UMR 1260 "Regenerative NanoMedecine," University of Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fafi-Kremer</LastName><ForeName>Samira</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Virology, Strasbourg University Hospital, INSERM U748, University of Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Metz-Favre</LastName><ForeName>Carine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khayath</LastName><ForeName>Naji</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Blay</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France. Electronic address: frederic.deblay@chru-strasbourg.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Allergy Clin Immunol Pract</MedlineTA><NlmUniqueID>101597220</NlmUniqueID></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000318">Adrenergic beta-Agonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005938">Glucocorticoids</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000318" MajorTopicYN="N">Adrenergic beta-Agonists</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005938" MajorTopicYN="N">Glucocorticoids</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012959" MajorTopicYN="N">Socioeconomic Factors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Asthma</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">Europe</Keyword><Keyword MajorTopicYN="N">Exacerbation</Keyword><Keyword MajorTopicYN="N">France</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2 pneumonia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32603901</ArticleId><ArticleId IdType="pii">S2213-2198(20)30667-X</ArticleId><ArticleId IdType="doi">10.1016/j.jaip.2020.06.032</ArticleId><ArticleId IdType="pmc">PMC7320869</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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