Clinical efficacy and safety profile of hydroxychloroquine and azithromycin against COVID-19.
Identifieur interne : 000615 ( Main/Exploration ); précédent : 000614; suivant : 000616Clinical efficacy and safety profile of hydroxychloroquine and azithromycin against COVID-19.
Auteurs : Philippe Gautret [France] ; Jean-Christophe Lagier [France] ; Stéphane Honoré [France] ; Van Thuan Hoang [Viêt Nam] ; Didier Raoult [France]Source :
- International journal of antimicrobial agents [ 1872-7913 ] ; 2021.
Descripteurs français
- KwdFr :
- ARN viral (antagonistes et inhibiteurs), ARN viral (génétique), Antibactériens (usage thérapeutique), Antipaludiques (usage thérapeutique), Antiviraux (usage thérapeutique), Association médicamenteuse (MeSH), Azithromycine (usage thérapeutique), Essais cliniques comme sujet (MeSH), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Hyperkaliémie (prévention et contrôle), Hypokaliémie (prévention et contrôle), Interactions médicamenteuses (MeSH), Magnésium (administration et posologie), Repositionnement des médicaments (MeSH), Résultat thérapeutique (MeSH), Syndrome du QT long (prévention et contrôle), Synergie des médicaments (MeSH), Sécurité des patients (MeSH), Électrocardiographie (MeSH).
- MESH :
- administration et posologie : Magnésium.
- antagonistes et inhibiteurs : ARN viral.
- génétique : ARN viral.
- prévention et contrôle : Hyperkaliémie, Hypokaliémie, Syndrome du QT long.
- usage thérapeutique : Antibactériens, Antipaludiques, Antiviraux, Azithromycine, Hydroxychloroquine.
- Association médicamenteuse, Essais cliniques comme sujet, Humains, Interactions médicamenteuses, Repositionnement des médicaments, Résultat thérapeutique, Synergie des médicaments, Sécurité des patients, Électrocardiographie.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (therapeutic use), Antimalarials (therapeutic use), Antiviral Agents (therapeutic use), Azithromycin (therapeutic use), COVID-19 (drug therapy), COVID-19 (virology), Clinical Trials as Topic (MeSH), Drug Combinations (MeSH), Drug Interactions (MeSH), Drug Repositioning (MeSH), Drug Synergism (MeSH), Electrocardiography (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Hyperkalemia (prevention & control), Hypokalemia (prevention & control), Long QT Syndrome (prevention & control), Magnesium (administration & dosage), Patient Safety (MeSH), RNA, Viral (antagonists & inhibitors), RNA, Viral (genetics), SARS-CoV-2 (drug effects), SARS-CoV-2 (genetics), SARS-CoV-2 (pathogenicity), Treatment Outcome (MeSH).
- MESH :
- chemical , administration & dosage : Magnesium.
- chemical , antagonists & inhibitors : RNA, Viral.
- chemical , genetics : RNA, Viral.
- chemical , therapeutic use : Anti-Bacterial Agents, Antimalarials, Antiviral Agents, Azithromycin, Hydroxychloroquine.
- drug effects : SARS-CoV-2.
- drug therapy : COVID-19.
- genetics : SARS-CoV-2.
- pathogenicity : SARS-CoV-2.
- prevention & control : Hyperkalemia, Hypokalemia, Long QT Syndrome.
- virology : COVID-19.
- Clinical Trials as Topic, Drug Combinations, Drug Interactions, Drug Repositioning, Drug Synergism, Electrocardiography, Humans, Patient Safety, Treatment Outcome.
DOI: 10.1016/j.ijantimicag.2020.106242
PubMed: 33408033
PubMed Central: PMC7779282
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<MeshHeading><DescriptorName UI="D006947" MajorTopicYN="N">Hyperkalemia</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007008" MajorTopicYN="N">Hypokalemia</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008133" MajorTopicYN="N">Long QT Syndrome</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008274" MajorTopicYN="N">Magnesium</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061214" MajorTopicYN="N">Patient Safety</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>Declaration of competing interest The authors declare no competing interests.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2021</Year>
<Month>1</Month>
<Day>7</Day>
<Hour>5</Hour>
<Minute>53</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2021</Year>
<Month>1</Month>
<Day>8</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2021</Year>
<Month>1</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">33408033</ArticleId>
<ArticleId IdType="pii">S0924-8579(20)30461-1</ArticleId>
<ArticleId IdType="doi">10.1016/j.ijantimicag.2020.106242</ArticleId>
<ArticleId IdType="pmc">PMC7779282</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Travel Med Infect Dis. 2020 Jul - Aug;36:101791</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32593867</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2021 Jan;57(1):106175</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33408021</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
<li>Viêt Nam</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
</settlement>
<orgName><li>Université d'Aix-Marseille</li>
</orgName>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Gautret, Philippe" sort="Gautret, Philippe" uniqKey="Gautret P" first="Philippe" last="Gautret">Philippe Gautret</name>
</region>
<name sortKey="Honore, Stephane" sort="Honore, Stephane" uniqKey="Honore S" first="Stéphane" last="Honoré">Stéphane Honoré</name>
<name sortKey="Lagier, Jean Christophe" sort="Lagier, Jean Christophe" uniqKey="Lagier J" first="Jean-Christophe" last="Lagier">Jean-Christophe Lagier</name>
<name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name>
</country>
<country name="Viêt Nam"><noRegion><name sortKey="Hoang, Van Thuan" sort="Hoang, Van Thuan" uniqKey="Hoang V" first="Van Thuan" last="Hoang">Van Thuan Hoang</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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