Pragmatic Recommendations for Therapeutics of Hospitalized COVID-19 Patients in Low- and Middle-Income Countries.
Identifieur interne : 000E28 ( Main/Exploration ); précédent : 000E27; suivant : 000E29Pragmatic Recommendations for Therapeutics of Hospitalized COVID-19 Patients in Low- and Middle-Income Countries.
Auteurs : Varun U. Shetty [États-Unis] ; Brian Jason Brotherton [Kenya, États-Unis] ; Andrew Achilleos [Canada] ; Kevan M. Akrami [États-Unis, Brésil] ; Lia M. Barros [États-Unis] ; William Checkley [États-Unis] ; Natalie Cobb [États-Unis] ; Stephanie Maximous [États-Unis] ; David Misango [Kenya] ; Casey Park [Canada] ; Shaurya Taran [Canada] ; Burton W. Lee [États-Unis] ; For The Covid-Lmic Task Force And The Mahidol-Oxford Research Unit Moru Bangkok ThailandSource :
- The American journal of tropical medicine and hygiene [ 1476-1645 ] ; 2020.
Abstract
The therapeutic options for COVID-19 patients are currently limited, but numerous randomized controlled trials are being completed, and many are on the way. For COVID-19 patients in low- and middle-income countries (LMICs), we recommend against using remdesivir outside of a clinical trial. We recommend against using hydroxychloroquine ± azithromycin or lopinavir-ritonavir. We suggest empiric antimicrobial treatment for likely coinfecting pathogens if an alternative infectious cause is likely. We suggest close monitoring without additional empiric antimicrobials if there are no clinical or laboratory signs of other infections. We recommend using oral or intravenous low-dose dexamethasone in adults with COVID-19 disease who require oxygen or mechanical ventilation. We recommend against using dexamethasone in patients with COVID-19 who do not require supplemental oxygen. We recommend using alternate equivalent doses of steroids in the event that dexamethasone is unavailable. We also recommend using low-dose corticosteroids in patients with refractory shock requiring vasopressor support. We recommend against the use of convalescent plasma and interleukin-6 inhibitors, such as tocilizumab, for the treatment of COVID-19 in LMICs outside of clinical trials.
DOI: 10.4269/ajtmh.20-1106
PubMed: 33377451
PubMed Central: PMC7957231
Affiliations:
- Brésil, Canada, Kenya, États-Unis
- Californie, Maryland, Ontario, Pennsylvanie, Washington (État)
- Toronto
Links toward previous steps (curation, corpus...)
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<front><div type="abstract" xml:lang="en">The therapeutic options for COVID-19 patients are currently limited, but numerous randomized controlled trials are being completed, and many are on the way. For COVID-19 patients in low- and middle-income countries (LMICs), we recommend against using remdesivir outside of a clinical trial. We recommend against using hydroxychloroquine ± azithromycin or lopinavir-ritonavir. We suggest empiric antimicrobial treatment for likely coinfecting pathogens if an alternative infectious cause is likely. We suggest close monitoring without additional empiric antimicrobials if there are no clinical or laboratory signs of other infections. We recommend using oral or intravenous low-dose dexamethasone in adults with COVID-19 disease who require oxygen or mechanical ventilation. We recommend against using dexamethasone in patients with COVID-19 who do not require supplemental oxygen. We recommend using alternate equivalent doses of steroids in the event that dexamethasone is unavailable. We also recommend using low-dose corticosteroids in patients with refractory shock requiring vasopressor support. We recommend against the use of convalescent plasma and interleukin-6 inhibitors, such as tocilizumab, for the treatment of COVID-19 in LMICs outside of clinical trials.</div>
</front>
</TEI>
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<DateRevised><Year>2021</Year>
<Month>03</Month>
<Day>19</Day>
</DateRevised>
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<Month>Dec</Month>
<Day>29</Day>
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<Title>The American journal of tropical medicine and hygiene</Title>
<ISOAbbreviation>Am J Trop Med Hyg</ISOAbbreviation>
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<ArticleTitle>Pragmatic Recommendations for Therapeutics of Hospitalized COVID-19 Patients in Low- and Middle-Income Countries.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.4269/ajtmh.20-1106</ELocationID>
<Abstract><AbstractText>The therapeutic options for COVID-19 patients are currently limited, but numerous randomized controlled trials are being completed, and many are on the way. For COVID-19 patients in low- and middle-income countries (LMICs), we recommend against using remdesivir outside of a clinical trial. We recommend against using hydroxychloroquine ± azithromycin or lopinavir-ritonavir. We suggest empiric antimicrobial treatment for likely coinfecting pathogens if an alternative infectious cause is likely. We suggest close monitoring without additional empiric antimicrobials if there are no clinical or laboratory signs of other infections. We recommend using oral or intravenous low-dose dexamethasone in adults with COVID-19 disease who require oxygen or mechanical ventilation. We recommend against using dexamethasone in patients with COVID-19 who do not require supplemental oxygen. We recommend using alternate equivalent doses of steroids in the event that dexamethasone is unavailable. We also recommend using low-dose corticosteroids in patients with refractory shock requiring vasopressor support. We recommend against the use of convalescent plasma and interleukin-6 inhibitors, such as tocilizumab, for the treatment of COVID-19 in LMICs outside of clinical trials.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shetty</LastName>
<ForeName>Varun U</ForeName>
<Initials>VU</Initials>
<AffiliationInfo><Affiliation>Critical Care Medicine Department, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation>
</AffiliationInfo>
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<Initials>BJ</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Kijabe Medical Center, Kijabe, Kenya.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Critical Care Medicine Department, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Achilleos</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care, Sunnybrook Health Sciences Center, Toronto, Canada.</Affiliation>
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<ForeName>Kevan M</ForeName>
<Initials>KM</Initials>
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<AffiliationInfo><Affiliation>Divisions of Infectious Disease, University of California San Diego, San Diego, California.</Affiliation>
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<AffiliationInfo><Affiliation>Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil.</Affiliation>
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<Author ValidYN="Y"><LastName>Barros</LastName>
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<Initials>LM</Initials>
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</ArticleIdList>
<ReferenceList><Reference><Citation>JAMA Intern Med. 2019 Feb 1;179(2):213-223</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30575845</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Intern Med. 2020 Oct 20;173(8):623-631</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32673060</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trials. 2020 Oct 20;21(1):866</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33081849</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Dec 31;383(27):2598-2600</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33264539</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 May 12;323(18):1824-1836</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32282022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Intern Med. 2017 Apr 1;177(4):554-560</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28192563</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2021 Feb 25;384(8):693-704</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32678530</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trials. 2020 Oct 20;21(1):867</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33081817</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2021 Feb 11;384(6):497-511</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33264556</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 May 7;382(19):1787-1799</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32187464</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Sep 15;324(11):1048-1057</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32821939</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2020 Sep 1;130(9):4791-4797</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32525844</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 May 30;395(10238):1695-1704</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32401715</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Heart Rhythm. 2020 Sep;17(9):1425-1433</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32407884</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2011 Feb 15;52(4):447-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21248066</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cochrane Database Syst Rev. 2019 Dec 6;12:CD002243</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31808551</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Intensive Care Med. 2020 May;46(5):854-887</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32222812</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trials. 2020 Oct 13;21(1):846</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33050924</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Oct 5;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33031764</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 Sep 4;370:m3379</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32887691</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Virol. 2020 Jun;127:104388</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32361326</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Dec 1;324(21):2165-2176</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33165621</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2015 Jan 1;211(1):80-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25030060</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Aug 6;383(6):517-525</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32492293</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Transplant. 2020 Nov;20(11):3191-3197</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32476261</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 May 16;395(10236):1569-1578</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32423584</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Intensive Care. 2020 Jun 30;8:43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32612838</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Oct 6;324(13):1307-1316</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32876695</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 May 14;369:m1844</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32409486</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Nov 5;383(19):1827-1837</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32459919</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Oct 6;324(13):1317-1329</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32876697</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Oct 6;324(13):1330-1341</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32876694</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Rheumatol. 2020 Aug;2(8):e474-e484</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32835257</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transfus Apher Sci. 2020 Oct;59(5):102875</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32694043</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2020 Jun 16;222(1):38-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32348485</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Netw Open. 2020 Apr 24;3(4):e208857</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32330277</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chest. 2020 Jul;158(1):e9-e13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32243945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Microbiol Infect. 2004 Jul;10(7):676-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15214887</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circ Arrhythm Electrophysiol. 2020 Aug;13(8):e008798</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32809882</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Dec 10;383(24):2333-2344</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33085857</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Diabetes Metab Syndr. 2020 Jul - Aug;14(4):589-596</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32417708</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trials. 2020 Aug 27;21(1):748</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32854751</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Respir Med. 2020 Mar;8(3):267-276</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32043986</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 May 22;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32450107</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pharmacotherapy. 2020 May;40(5):416-437</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32259313</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trials. 2020 Aug 17;21(1):718</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32807209</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2020 Oct;92(10):1890-1901</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32293713</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2020 May 19;117(20):10970-10975</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32350134</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Pathol. 2020 Aug;190(8):1680-1690</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32473109</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2007 Nov 22;357(21):2189-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18032770</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9490-9496</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32253318</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autoimmun Rev. 2020 Jul;19(7):102554</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32380316</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Jun 18;382(25):2411-2418</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32379955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Dec 3;71(9):2459-2468</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32358954</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Intern Med. 2021 Feb 1;181(2):195-202</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33001138</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Oct 3;396(10256):959-967</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32896292</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2020 Jul 23;58(8):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32404482</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 Oct 22;371:m3939</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33093056</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Aug 4;324(5):460-470</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32492084</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Oct 6;324(13):1298-1306</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32876689</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Jun 13;395(10240):1820</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32511943</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Nov 5;383(19):1813-1826</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32445440</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trials. 2020 Aug 31;21(1):754</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32867852</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA Cardiol. 2020 Sep 1;5(9):1036-1041</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32936252</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Drug Investig. 2020 Jun;40(6):511-518</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32337664</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
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