Randomized double-blinded placebo-controlled trial of hydroxychloroquine with or without azithromycin for virologic cure of non-severe Covid-19.
Identifieur interne : 000D73 ( Main/Exploration ); précédent : 000D72; suivant : 000D74Randomized double-blinded placebo-controlled trial of hydroxychloroquine with or without azithromycin for virologic cure of non-severe Covid-19.
Auteurs : Ali S. Omrani [Qatar] ; Sameer A. Pathan [Qatar, Royaume-Uni, Australie] ; Sarah A. Thomas [Royaume-Uni] ; Tim R E. Harris [Qatar, Royaume-Uni] ; Peter V. Coyle ; Caroline E. Thomas [Qatar] ; Isma Qureshi [Qatar] ; Zain A. Bhutta [Qatar] ; Naema Al Mawlawi ; Reham Al Kahlout ; Ashraf Elmalik [Qatar] ; Aftab M. Azad [Qatar] ; Joanne Daghfal [Qatar] ; Mulham Mustafa [Qatar] ; Andrew Jeremijenko [Qatar] ; Hussam Al Soub [Qatar] ; Mohammed Abu Khattab [Qatar] ; Muna Al Maslamani [Qatar] ; Stephen H. Thomas [Qatar, Royaume-Uni]Source :
- EClinicalMedicine [ 2589-5370 ] ; 2020.
Abstract
Background
Hydroxychloroquine (HC) ± azithromycin (AZ) is widely used for Covid-19. The Qatar Prospective RCT of Expediting Coronavirus Tapering (Q-PROTECT) aimed to assess virologic cure rates of HC±AZ in cases of low-acuity Covid-19.
Methods
Q-PROTECT employed a prospective, placebo-controlled design with blinded randomization to three parallel arms: placebo, oral HC (600 mg daily for one week), or oral HC plus oral AZ (500 mg day one, 250 mg daily on days two through five). At enrollment, non-hospitalized participants had mild or no symptoms and were within a day of Covid-19 positivity by polymerase chain reaction (PCR). After six days, intent-to-treat (ITT) analysis of the primary endpoint of virologic cure was assessed using binomial exact 95% confidence intervals (CIs) and χ
Findings
The study enrolled 456 participants (152 in each of three groups: HC+AZ, HC, placebo) between 13 April and 1 August 2020. HC+AZ, HC, and placebo groups had 6 (3·9%), 7 (4·6%), and 9 (5·9%) participants go off study medications before completing the medication course (
Interpretation
HC±AZ does not facilitate virologic cure in patients with mild or asymptomatic Covid-19.
Funding
The study was supported by internal institutional funds of the Hamad Medical Corporation (government health service of the State of Qatar).
DOI: 10.1016/j.eclinm.2020.100645
PubMed: 33251500
PubMed Central: PMC7678437
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<author><name sortKey="Pathan, Sameer A" sort="Pathan, Sameer A" uniqKey="Pathan S" first="Sameer A" last="Pathan">Sameer A. Pathan</name>
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<author><name sortKey="Thomas, Sarah A" sort="Thomas, Sarah A" uniqKey="Thomas S" first="Sarah A" last="Thomas">Sarah A. Thomas</name>
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<author><name sortKey="Harris, Tim R E" sort="Harris, Tim R E" uniqKey="Harris T" first="Tim R E" last="Harris">Tim R E. Harris</name>
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<author><name sortKey="Coyle, Peter V" sort="Coyle, Peter V" uniqKey="Coyle P" first="Peter V" last="Coyle">Peter V. Coyle</name>
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<author><name sortKey="Bhutta, Zain A" sort="Bhutta, Zain A" uniqKey="Bhutta Z" first="Zain A" last="Bhutta">Zain A. Bhutta</name>
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<author><name sortKey="Mawlawi, Naema Al" sort="Mawlawi, Naema Al" uniqKey="Mawlawi N" first="Naema Al" last="Mawlawi">Naema Al Mawlawi</name>
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<author><name sortKey="Kahlout, Reham Al" sort="Kahlout, Reham Al" uniqKey="Kahlout R" first="Reham Al" last="Kahlout">Reham Al Kahlout</name>
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<author><name sortKey="Elmalik, Ashraf" sort="Elmalik, Ashraf" uniqKey="Elmalik A" first="Ashraf" last="Elmalik">Ashraf Elmalik</name>
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<author><name sortKey="Azad, Aftab M" sort="Azad, Aftab M" uniqKey="Azad A" first="Aftab M" last="Azad">Aftab M. Azad</name>
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<author><name sortKey="Daghfal, Joanne" sort="Daghfal, Joanne" uniqKey="Daghfal J" first="Joanne" last="Daghfal">Joanne Daghfal</name>
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<author><name sortKey="Mustafa, Mulham" sort="Mustafa, Mulham" uniqKey="Mustafa M" first="Mulham" last="Mustafa">Mulham Mustafa</name>
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<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Department of Medicine, Hamad Medical Corporation Communicable Diseases Center, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jeremijenko, Andrew" sort="Jeremijenko, Andrew" uniqKey="Jeremijenko A" first="Andrew" last="Jeremijenko">Andrew Jeremijenko</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Hamad Medical Corporation Communicable Diseases Center, Doha, Qatar.</nlm:affiliation>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Department of Medicine, Hamad Medical Corporation Communicable Diseases Center, Doha</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Soub, Hussam Al" sort="Soub, Hussam Al" uniqKey="Soub H" first="Hussam Al" last="Soub">Hussam Al Soub</name>
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<country xml:lang="fr">Qatar</country>
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<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khattab, Mohammed Abu" sort="Khattab, Mohammed Abu" uniqKey="Khattab M" first="Mohammed Abu" last="Khattab">Mohammed Abu Khattab</name>
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<country xml:lang="fr">Qatar</country>
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<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maslamani, Muna Al" sort="Maslamani, Muna Al" uniqKey="Maslamani M" first="Muna Al" last="Maslamani">Muna Al Maslamani</name>
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<country xml:lang="fr">Qatar</country>
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<wicri:noRegion>Doha</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Weill Cornell Medical College in Qatar, Doha, Qatar.</nlm:affiliation>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Department of Medicine, Weill Cornell Medical College in Qatar, Doha</wicri:regionArea>
<wicri:noRegion>Doha</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thomas, Stephen H" sort="Thomas, Stephen H" uniqKey="Thomas S" first="Stephen H" last="Thomas">Stephen H. Thomas</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Emergency Medicine, Hamad General Hospital, Doha 3050, Qatar.</nlm:affiliation>
<country xml:lang="fr">Qatar</country>
<wicri:regionArea>Department of Emergency Medicine, Hamad General Hospital, Doha 3050</wicri:regionArea>
<wicri:noRegion>Doha 3050</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Blizard Institute, Barts and The London School of Medicine, Queen Mary Univ. of London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Blizard Institute, Barts and The London School of Medicine, Queen Mary Univ. of London</wicri:regionArea>
<wicri:noRegion>Queen Mary Univ. of London</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">EClinicalMedicine</title>
<idno type="eISSN">2589-5370</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
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</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>Background</b>
</p>
<p>Hydroxychloroquine (HC) ± azithromycin (AZ) is widely used for Covid-19. The Qatar Prospective RCT of Expediting Coronavirus Tapering (Q-PROTECT) aimed to assess virologic cure rates of HC±AZ in cases of low-acuity Covid-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Methods</b>
</p>
<p>Q-PROTECT employed a prospective, placebo-controlled design with blinded randomization to three parallel arms: placebo, oral HC (600 mg daily for one week), or oral HC plus oral AZ (500 mg day one, 250 mg daily on days two through five). At enrollment, non-hospitalized participants had mild or no symptoms and were within a day of Covid-19 positivity by polymerase chain reaction (PCR). After six days, intent-to-treat (ITT) analysis of the primary endpoint of virologic cure was assessed using binomial exact 95% confidence intervals (CIs) and χ</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Findings</b>
</p>
<p>The study enrolled 456 participants (152 in each of three groups: HC+AZ, HC, placebo) between 13 April and 1 August 2020. HC+AZ, HC, and placebo groups had 6 (3·9%), 7 (4·6%), and 9 (5·9%) participants go off study medications before completing the medication course (</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Interpretation</b>
</p>
<p>HC±AZ does not facilitate virologic cure in patients with mild or asymptomatic Covid-19.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Funding</b>
</p>
<p>The study was supported by internal institutional funds of the Hamad Medical Corporation (government health service of the State of Qatar).</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33251500</PMID>
<DateRevised><Year>2020</Year>
<Month>12</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2589-5370</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>29</Volume>
<PubDate><Year>2020</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>EClinicalMedicine</Title>
<ISOAbbreviation>EClinicalMedicine</ISOAbbreviation>
</Journal>
<ArticleTitle>Randomized double-blinded placebo-controlled trial of hydroxychloroquine with or without azithromycin for virologic cure of non-severe Covid-19.</ArticleTitle>
<Pagination><MedlinePgn>100645</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.eclinm.2020.100645</ELocationID>
<Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Hydroxychloroquine (HC) ± azithromycin (AZ) is widely used for Covid-19. The Qatar Prospective RCT of Expediting Coronavirus Tapering (Q-PROTECT) aimed to assess virologic cure rates of HC±AZ in cases of low-acuity Covid-19.</AbstractText>
<AbstractText Label="Methods" NlmCategory="UNASSIGNED">Q-PROTECT employed a prospective, placebo-controlled design with blinded randomization to three parallel arms: placebo, oral HC (600 mg daily for one week), or oral HC plus oral AZ (500 mg day one, 250 mg daily on days two through five). At enrollment, non-hospitalized participants had mild or no symptoms and were within a day of Covid-19 positivity by polymerase chain reaction (PCR). After six days, intent-to-treat (ITT) analysis of the primary endpoint of virologic cure was assessed using binomial exact 95% confidence intervals (CIs) and χ<sup>2</sup>
testing. (ClinicalTrials.gov NCT04349592, trial status closed to new participants.).</AbstractText>
<AbstractText Label="Findings" NlmCategory="UNASSIGNED">The study enrolled 456 participants (152 in each of three groups: HC+AZ, HC, placebo) between 13 April and 1 August 2020. HC+AZ, HC, and placebo groups had 6 (3·9%), 7 (4·6%), and 9 (5·9%) participants go off study medications before completing the medication course (<i>p</i>
= 0·716). Day six PCR results were available for all 152 HC+AZ participants, 149/152 (98·0%) HC participants, and 147/152 (96·7%) placebo participants. Day six ITT analysis found no difference (<i>p</i>
= 0·821) in groups' proportions achieving virologic cure: HC+AZ 16/152 (10·5%), HC 19/149 (12·8%), placebo 18/147 (12·2%). Day 14 assessment also showed no association (<i>p</i>
= 0·072) between study group and viral cure: HC+AZ 30/149 (20·1%,), HC 42/146 (28·8%), placebo 45/143 (31·5%). There were no serious adverse events.</AbstractText>
<AbstractText Label="Interpretation" NlmCategory="UNASSIGNED">HC±AZ does not facilitate virologic cure in patients with mild or asymptomatic Covid-19.</AbstractText>
<AbstractText Label="Funding" NlmCategory="UNASSIGNED">The study was supported by internal institutional funds of the Hamad Medical Corporation (government health service of the State of Qatar).</AbstractText>
<CopyrightInformation>© 2020 The Authors.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Omrani</LastName>
<ForeName>Ali S</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Hamad Medical Corporation Communicable Diseases Center, Doha, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pathan</LastName>
<ForeName>Sameer A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Hamad General Hospital, Doha 3050, Qatar.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Blizard Institute, Barts and The London School of Medicine, Queen Mary Univ. of London, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thomas</LastName>
<ForeName>Sarah A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>BSc Candidate in Medical Biosciences, Faculty of Medicine, Imperial College London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harris</LastName>
<ForeName>Tim R E</ForeName>
<Initials>TRE</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Hamad General Hospital, Doha 3050, Qatar.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Blizard Institute, Barts and The London School of Medicine, Queen Mary Univ. of London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Coyle</LastName>
<ForeName>Peter V</ForeName>
<Initials>PV</Initials>
<AffiliationInfo><Affiliation>Departments of Virology and Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thomas</LastName>
<ForeName>Caroline E</ForeName>
<Initials>CE</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Hamad General Hospital, Doha 3050, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qureshi</LastName>
<ForeName>Isma</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Hamad General Hospital, Doha 3050, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bhutta</LastName>
<ForeName>Zain A</ForeName>
<Initials>ZA</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Hamad General Hospital, Doha 3050, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mawlawi</LastName>
<ForeName>Naema Al</ForeName>
<Initials>NA</Initials>
<AffiliationInfo><Affiliation>Departments of Virology and Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kahlout</LastName>
<ForeName>Reham Al</ForeName>
<Initials>RA</Initials>
<AffiliationInfo><Affiliation>Departments of Virology and Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Elmalik</LastName>
<ForeName>Ashraf</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacy, Hamad General Hospital, Doha, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Azad</LastName>
<ForeName>Aftab M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Hamad General Hospital, Doha 3050, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Daghfal</LastName>
<ForeName>Joanne</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Hamad Medical Corporation Communicable Diseases Center, Doha, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mustafa</LastName>
<ForeName>Mulham</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Hamad Medical Corporation Communicable Diseases Center, Doha, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jeremijenko</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Hamad Medical Corporation Communicable Diseases Center, Doha, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Soub</LastName>
<ForeName>Hussam Al</ForeName>
<Initials>HA</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Hamad Medical Corporation Communicable Diseases Center, Doha, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Khattab</LastName>
<ForeName>Mohammed Abu</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Hamad Medical Corporation Communicable Diseases Center, Doha, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maslamani</LastName>
<ForeName>Muna Al</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Hamad Medical Corporation Communicable Diseases Center, Doha, Qatar.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medicine, Weill Cornell Medical College in Qatar, Doha, Qatar.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thomas</LastName>
<ForeName>Stephen H</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Hamad General Hospital, Doha 3050, Qatar.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Blizard Institute, Barts and The London School of Medicine, Queen Mary Univ. of London, UK.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName>
<AccessionNumberList><AccessionNumber>NCT04349592</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>11</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>EClinicalMedicine</MedlineTA>
<NlmUniqueID>101733727</NlmUniqueID>
<ISSNLinking>2589-5370</ISSNLinking>
</MedlineJournalInfo>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Azithromycin</Keyword>
<Keyword MajorTopicYN="N">Covid-19</Keyword>
<Keyword MajorTopicYN="N">Hyodroxychloroquine</Keyword>
</KeywordList>
<CoiStatement>The authors have no financial or personal relationships with other people or organizations that could represent a conflict of interest.</CoiStatement>
</MedlineCitation>
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<Month>09</Month>
<Day>05</Day>
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<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>10</Month>
<Day>27</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>10</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>11</Month>
<Day>30</Day>
<Hour>5</Hour>
<Minute>56</Minute>
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<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<affiliations><list><country><li>Australie</li>
<li>Qatar</li>
<li>Royaume-Uni</li>
</country>
<region><li>Victoria (État)</li>
</region>
<settlement><li>Melbourne</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Coyle, Peter V" sort="Coyle, Peter V" uniqKey="Coyle P" first="Peter V" last="Coyle">Peter V. Coyle</name>
<name sortKey="Kahlout, Reham Al" sort="Kahlout, Reham Al" uniqKey="Kahlout R" first="Reham Al" last="Kahlout">Reham Al Kahlout</name>
<name sortKey="Mawlawi, Naema Al" sort="Mawlawi, Naema Al" uniqKey="Mawlawi N" first="Naema Al" last="Mawlawi">Naema Al Mawlawi</name>
</noCountry>
<country name="Qatar"><noRegion><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S" last="Omrani">Ali S. Omrani</name>
</noRegion>
<name sortKey="Azad, Aftab M" sort="Azad, Aftab M" uniqKey="Azad A" first="Aftab M" last="Azad">Aftab M. Azad</name>
<name sortKey="Bhutta, Zain A" sort="Bhutta, Zain A" uniqKey="Bhutta Z" first="Zain A" last="Bhutta">Zain A. Bhutta</name>
<name sortKey="Daghfal, Joanne" sort="Daghfal, Joanne" uniqKey="Daghfal J" first="Joanne" last="Daghfal">Joanne Daghfal</name>
<name sortKey="Elmalik, Ashraf" sort="Elmalik, Ashraf" uniqKey="Elmalik A" first="Ashraf" last="Elmalik">Ashraf Elmalik</name>
<name sortKey="Harris, Tim R E" sort="Harris, Tim R E" uniqKey="Harris T" first="Tim R E" last="Harris">Tim R E. Harris</name>
<name sortKey="Jeremijenko, Andrew" sort="Jeremijenko, Andrew" uniqKey="Jeremijenko A" first="Andrew" last="Jeremijenko">Andrew Jeremijenko</name>
<name sortKey="Khattab, Mohammed Abu" sort="Khattab, Mohammed Abu" uniqKey="Khattab M" first="Mohammed Abu" last="Khattab">Mohammed Abu Khattab</name>
<name sortKey="Maslamani, Muna Al" sort="Maslamani, Muna Al" uniqKey="Maslamani M" first="Muna Al" last="Maslamani">Muna Al Maslamani</name>
<name sortKey="Maslamani, Muna Al" sort="Maslamani, Muna Al" uniqKey="Maslamani M" first="Muna Al" last="Maslamani">Muna Al Maslamani</name>
<name sortKey="Mustafa, Mulham" sort="Mustafa, Mulham" uniqKey="Mustafa M" first="Mulham" last="Mustafa">Mulham Mustafa</name>
<name sortKey="Pathan, Sameer A" sort="Pathan, Sameer A" uniqKey="Pathan S" first="Sameer A" last="Pathan">Sameer A. Pathan</name>
<name sortKey="Qureshi, Isma" sort="Qureshi, Isma" uniqKey="Qureshi I" first="Isma" last="Qureshi">Isma Qureshi</name>
<name sortKey="Soub, Hussam Al" sort="Soub, Hussam Al" uniqKey="Soub H" first="Hussam Al" last="Soub">Hussam Al Soub</name>
<name sortKey="Thomas, Caroline E" sort="Thomas, Caroline E" uniqKey="Thomas C" first="Caroline E" last="Thomas">Caroline E. Thomas</name>
<name sortKey="Thomas, Stephen H" sort="Thomas, Stephen H" uniqKey="Thomas S" first="Stephen H" last="Thomas">Stephen H. Thomas</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Pathan, Sameer A" sort="Pathan, Sameer A" uniqKey="Pathan S" first="Sameer A" last="Pathan">Sameer A. Pathan</name>
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<name sortKey="Harris, Tim R E" sort="Harris, Tim R E" uniqKey="Harris T" first="Tim R E" last="Harris">Tim R E. Harris</name>
<name sortKey="Thomas, Sarah A" sort="Thomas, Sarah A" uniqKey="Thomas S" first="Sarah A" last="Thomas">Sarah A. Thomas</name>
<name sortKey="Thomas, Stephen H" sort="Thomas, Stephen H" uniqKey="Thomas S" first="Stephen H" last="Thomas">Stephen H. Thomas</name>
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<country name="Australie"><region name="Victoria (État)"><name sortKey="Pathan, Sameer A" sort="Pathan, Sameer A" uniqKey="Pathan S" first="Sameer A" last="Pathan">Sameer A. Pathan</name>
</region>
</country>
</tree>
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</record>
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