Do Zinc Supplements Enhance the Clinical Efficacy of Hydroxychloroquine?: a Randomized, Multicenter Trial.
Identifieur interne : 001418 ( Main/Exploration ); précédent : 001417; suivant : 001419Do Zinc Supplements Enhance the Clinical Efficacy of Hydroxychloroquine?: a Randomized, Multicenter Trial.
Auteurs : Sherief Abd-Elsalam [Égypte] ; Shaimaa Soliman [Égypte] ; Eslam Saber Esmail [Égypte] ; Mai Khalaf [Égypte] ; Ehab F. Mostafa [Égypte] ; Mohammed A. Medhat [Égypte] ; Ossama Ashraf Ahmed [Égypte] ; Mohamed Samir Abd El Ghafar [Égypte] ; Mohamed Alboraie [Égypte] ; Sahar M. Hassany [Égypte]Source :
- Biological trace element research [ 1559-0720 ] ; 2020.
Abstract
No specific treatment for COVID-19 infection is available up till now, and there is a great urge for effective treatment to reduce morbidity and mortality during this pandemic. We aimed to evaluate the effect of combining chloroquine/hydroxychloroquine (CQ/HCQ) and zinc in the treatment of COVID-19 patients. This was a randomized clinical trial conducted at three major University hospitals in Egypt. One hundred ninety-one patients with a confirmed diagnosis of COVID-19 infection were randomized into two groups: group I (96) patients received both HCQ and zinc, and group II (95) received HCQ only. The primary endpoints were the recovery within 28 days, the need for mechanical ventilation, and death. The two groups were matched for age and gender. They had no significant difference regarding any of the baseline laboratory parameters or clinical severity grading. Clinical recovery after 28 days was achieved by 79.2% in the zinc group and 77.9% in zinc-free treatment group, without any significant difference (p = 0.969). The need for mechanical ventilation and the overall mortality rates did not show any significant difference between the 2 groups either (p = 0.537 and 0.986, respectively). The age of the patient and the need for mechanical ventilation were the only risk factors associated with the patients' mortality by the univariate regression analysis (p = 0.001 and < 0.001, respectively). Zinc supplements did not enhance the clinical efficacy of HCQ. More randomized studies are needed to evaluate the value of adding zinc to other therapies for COVID 19. ClinicalTrials.gov Identifier: NCT04447534.
DOI: 10.1007/s12011-020-02512-1
PubMed: 33247380
PubMed Central: PMC7695238
Affiliations:
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Mostafa</name><affiliation wicri:level="1"><nlm:affiliation>Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut</wicri:regionArea><wicri:noRegion>Assiut</wicri:noRegion></affiliation></author><author><name sortKey="Medhat, Mohammed A" sort="Medhat, Mohammed A" uniqKey="Medhat M" first="Mohammed A" last="Medhat">Mohammed A. Medhat</name><affiliation wicri:level="1"><nlm:affiliation>Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut</wicri:regionArea><wicri:noRegion>Assiut</wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Ossama Ashraf" sort="Ahmed, Ossama Ashraf" uniqKey="Ahmed O" first="Ossama Ashraf" last="Ahmed">Ossama Ashraf Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>Internal Medicine Department, Ain-shams University, Cairo, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Internal Medicine Department, Ain-shams University, Cairo</wicri:regionArea><wicri:noRegion>Cairo</wicri:noRegion></affiliation></author><author><name sortKey="El Ghafar, Mohamed Samir Abd" sort="El Ghafar, Mohamed Samir Abd" uniqKey="El Ghafar M" first="Mohamed Samir Abd" last="El Ghafar">Mohamed Samir Abd El Ghafar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesia, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Anesthesia, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta</wicri:regionArea><wicri:noRegion>Tanta</wicri:noRegion></affiliation></author><author><name sortKey="Alboraie, Mohamed" sort="Alboraie, Mohamed" uniqKey="Alboraie M" first="Mohamed" last="Alboraie">Mohamed Alboraie</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Al-Azhar University, Cairo, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Internal Medicine, Al-Azhar University, Cairo</wicri:regionArea><wicri:noRegion>Cairo</wicri:noRegion></affiliation></author><author><name sortKey="Hassany, Sahar M" sort="Hassany, Sahar M" uniqKey="Hassany S" first="Sahar M" last="Hassany">Sahar M. Hassany</name><affiliation wicri:level="1"><nlm:affiliation>Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut</wicri:regionArea><wicri:noRegion>Assiut</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biological trace element research</title><idno type="eISSN">1559-0720</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">No specific treatment for COVID-19 infection is available up till now, and there is a great urge for effective treatment to reduce morbidity and mortality during this pandemic. We aimed to evaluate the effect of combining chloroquine/hydroxychloroquine (CQ/HCQ) and zinc in the treatment of COVID-19 patients. This was a randomized clinical trial conducted at three major University hospitals in Egypt. One hundred ninety-one patients with a confirmed diagnosis of COVID-19 infection were randomized into two groups: group I (96) patients received both HCQ and zinc, and group II (95) received HCQ only. The primary endpoints were the recovery within 28 days, the need for mechanical ventilation, and death. The two groups were matched for age and gender. They had no significant difference regarding any of the baseline laboratory parameters or clinical severity grading. Clinical recovery after 28 days was achieved by 79.2% in the zinc group and 77.9% in zinc-free treatment group, without any significant difference (p = 0.969). The need for mechanical ventilation and the overall mortality rates did not show any significant difference between the 2 groups either (p = 0.537 and 0.986, respectively). The age of the patient and the need for mechanical ventilation were the only risk factors associated with the patients' mortality by the univariate regression analysis (p = 0.001 and < 0.001, respectively). Zinc supplements did not enhance the clinical efficacy of HCQ. More randomized studies are needed to evaluate the value of adding zinc to other therapies for COVID 19. ClinicalTrials.gov Identifier: NCT04447534.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33247380</PMID><DateRevised><Year>2020</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1559-0720</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Nov</Month><Day>27</Day></PubDate></JournalIssue><Title>Biological trace element research</Title><ISOAbbreviation>Biol Trace Elem Res</ISOAbbreviation></Journal><ArticleTitle>Do Zinc Supplements Enhance the Clinical Efficacy of Hydroxychloroquine?: a Randomized, Multicenter Trial.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s12011-020-02512-1</ELocationID><Abstract><AbstractText>No specific treatment for COVID-19 infection is available up till now, and there is a great urge for effective treatment to reduce morbidity and mortality during this pandemic. We aimed to evaluate the effect of combining chloroquine/hydroxychloroquine (CQ/HCQ) and zinc in the treatment of COVID-19 patients. This was a randomized clinical trial conducted at three major University hospitals in Egypt. One hundred ninety-one patients with a confirmed diagnosis of COVID-19 infection were randomized into two groups: group I (96) patients received both HCQ and zinc, and group II (95) received HCQ only. The primary endpoints were the recovery within 28 days, the need for mechanical ventilation, and death. The two groups were matched for age and gender. They had no significant difference regarding any of the baseline laboratory parameters or clinical severity grading. Clinical recovery after 28 days was achieved by 79.2% in the zinc group and 77.9% in zinc-free treatment group, without any significant difference (p = 0.969). The need for mechanical ventilation and the overall mortality rates did not show any significant difference between the 2 groups either (p = 0.537 and 0.986, respectively). The age of the patient and the need for mechanical ventilation were the only risk factors associated with the patients' mortality by the univariate regression analysis (p = 0.001 and < 0.001, respectively). Zinc supplements did not enhance the clinical efficacy of HCQ. More randomized studies are needed to evaluate the value of adding zinc to other therapies for COVID 19. ClinicalTrials.gov Identifier: NCT04447534.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Abd-Elsalam</LastName><ForeName>Sherief</ForeName><Initials>S</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-4366-2218</Identifier><AffiliationInfo><Affiliation>Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Tanta University, El-Giash Street, Tanta, 31527, Egypt. sherif.abdelbaky@med.tanta.edu.eg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soliman</LastName><ForeName>Shaimaa</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Public health and Community Medicine, Menoufia University, Menoufia, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esmail</LastName><ForeName>Eslam Saber</ForeName><Initials>ES</Initials><AffiliationInfo><Affiliation>Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Tanta University, El-Giash Street, Tanta, 31527, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khalaf</LastName><ForeName>Mai</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Tropical Medicine and Infectious Diseases Department, Faculty of Medicine, Tanta University, El-Giash Street, Tanta, 31527, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mostafa</LastName><ForeName>Ehab F</ForeName><Initials>EF</Initials><AffiliationInfo><Affiliation>Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Medhat</LastName><ForeName>Mohammed A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Ossama Ashraf</ForeName><Initials>OA</Initials><AffiliationInfo><Affiliation>Internal Medicine Department, Ain-shams University, Cairo, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El Ghafar</LastName><ForeName>Mohamed Samir Abd</ForeName><Initials>MSA</Initials><AffiliationInfo><Affiliation>Department of Anesthesia, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alboraie</LastName><ForeName>Mohamed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Al-Azhar University, Cairo, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hassany</LastName><ForeName>Sahar M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT04447534</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>11</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biol Trace Elem Res</MedlineTA><NlmUniqueID>7911509</NlmUniqueID><ISSNLinking>0163-4984</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antioxidants</Keyword><Keyword MajorTopicYN="N">COVID 19</Keyword><Keyword MajorTopicYN="N">Chloroquine</Keyword><Keyword MajorTopicYN="N">Treatment</Keyword><Keyword 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sortKey="Esmail, Eslam Saber" sort="Esmail, Eslam Saber" uniqKey="Esmail E" first="Eslam Saber" last="Esmail">Eslam Saber Esmail</name><name sortKey="Hassany, Sahar M" sort="Hassany, Sahar M" uniqKey="Hassany S" first="Sahar M" last="Hassany">Sahar M. Hassany</name><name sortKey="Khalaf, Mai" sort="Khalaf, Mai" uniqKey="Khalaf M" first="Mai" last="Khalaf">Mai Khalaf</name><name sortKey="Medhat, Mohammed A" sort="Medhat, Mohammed A" uniqKey="Medhat M" first="Mohammed A" last="Medhat">Mohammed A. Medhat</name><name sortKey="Mostafa, Ehab F" sort="Mostafa, Ehab F" uniqKey="Mostafa E" first="Ehab F" last="Mostafa">Ehab F. Mostafa</name><name sortKey="Soliman, Shaimaa" sort="Soliman, Shaimaa" uniqKey="Soliman S" first="Shaimaa" last="Soliman">Shaimaa Soliman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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