Diagnostic approaches and potential therapeutic options for coronavirus disease 2019.
Identifieur interne : 001424 ( Main/Exploration ); précédent : 001423; suivant : 001425Diagnostic approaches and potential therapeutic options for coronavirus disease 2019.
Auteurs : Z. Khan [République populaire de Chine] ; D. Ghafoor [République populaire de Chine] ; A. Khan [République populaire de Chine] ; D. Ualiyeva [République populaire de Chine] ; S A Khan [Pakistan] ; H. Bilal [Pakistan] ; B. Khan [Pakistan] ; A. Khan [Pakistan] ; W. Sajjad [République populaire de Chine]Source :
- New microbes and new infections [ 2052-2975 ] ; 2020.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city of China in late December 2019 and identified as a novel coronavirus. Due to its contagious nature, the virus spreads rapidly and causes coronavirus disease 2019 (COVID-19). The global tally of COVID-19 was 28 million in early September 2020. The fears and stress associated with SARS-CoV-2 has demolished the socio-economic status worldwide. Researchers are trying to identify treatments, especially antiviral drugs and/or vaccines, that could potentially control the viral spread and manage the ongoing unprecedented global crisis. To date, more than 300 clinical trials have been conducted on various antiviral drugs, and immunomodulators are being evaluated at various stages of COVID-19. This review aims to collect and summarize a list of drugs used to treat COVID-19, including dexamethasone, chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir, remdesivir, tociluzimab, nitazoxanide and ivermectin. However, some of these drugs are not effective and their use has been suspended by WHO.
DOI: 10.1016/j.nmni.2020.100770
PubMed: 33014380
PubMed Central: PMC7525249
Affiliations:
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Khan</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>University of Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ghafoor, D" sort="Ghafoor, D" uniqKey="Ghafoor D" first="D" last="Ghafoor">D. Ghafoor</name><affiliation wicri:level="3"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>University of Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Wuhan Institute of Virology, Chinese Academy of Sciences Xiao Hong Shan No.44, Wuhan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan Institute of Virology, Chinese Academy of Sciences Xiao Hong Shan No.44, Wuhan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Khan, A" sort="Khan, A" uniqKey="Khan A" first="A" last="Khan">A. Khan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, School of Life Sciences, Lanzhou University, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, School of Life Sciences, Lanzhou University</wicri:regionArea><wicri:noRegion>Lanzhou University</wicri:noRegion></affiliation></author><author><name sortKey="Ualiyeva, D" sort="Ualiyeva, D" uniqKey="Ualiyeva D" first="D" last="Ualiyeva">D. Ualiyeva</name><affiliation wicri:level="3"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>University of Chinese Academy of Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular Biology and Evolution, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Biology and Evolution, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Khan, S A" sort="Khan, S A" uniqKey="Khan S" first="S A" last="Khan">S A Khan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathobiology, University of Poonch Rawalakot Azad Kashmir, Rawalakot, Azad Kashmir, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Pathobiology, University of Poonch Rawalakot Azad Kashmir, Rawalakot, Azad Kashmir</wicri:regionArea><wicri:noRegion>Azad Kashmir</wicri:noRegion></affiliation></author><author><name sortKey="Bilal, H" sort="Bilal, H" uniqKey="Bilal H" first="H" last="Bilal">H. Bilal</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Management and Commerce, University of Swat, Mingora, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Centre for Management and Commerce, University of Swat, Mingora</wicri:regionArea><wicri:noRegion>Mingora</wicri:noRegion></affiliation></author><author><name sortKey="Khan, B" sort="Khan, B" uniqKey="Khan B" first="B" last="Khan">B. Khan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Optometry, Isra University Islamabad, Islamabad, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Optometry, Isra University Islamabad, Islamabad</wicri:regionArea><wicri:noRegion>Islamabad</wicri:noRegion></affiliation></author><author><name sortKey="Khan, A" sort="Khan, A" uniqKey="Khan A" first="A" last="Khan">A. Khan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Computer and Software Technology, University of Swat, Mingora, Pakistan.</nlm:affiliation><country xml:lang="fr">Pakistan</country><wicri:regionArea>Department of Computer and Software Technology, University of Swat, Mingora</wicri:regionArea><wicri:noRegion>Mingora</wicri:noRegion></affiliation></author><author><name sortKey="Sajjad, W" sort="Sajjad, W" uniqKey="Sajjad W" first="W" last="Sajjad">W. Sajjad</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou</wicri:regionArea><wicri:noRegion>Lanzhou</wicri:noRegion></affiliation></author></analytic><series><title level="j">New microbes and new infections</title><idno type="ISSN">2052-2975</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city of China in late December 2019 and identified as a novel coronavirus. Due to its contagious nature, the virus spreads rapidly and causes coronavirus disease 2019 (COVID-19). The global tally of COVID-19 was 28 million in early September 2020. The fears and stress associated with SARS-CoV-2 has demolished the socio-economic status worldwide. Researchers are trying to identify treatments, especially antiviral drugs and/or vaccines, that could potentially control the viral spread and manage the ongoing unprecedented global crisis. To date, more than 300 clinical trials have been conducted on various antiviral drugs, and immunomodulators are being evaluated at various stages of COVID-19. This review aims to collect and summarize a list of drugs used to treat COVID-19, including dexamethasone, chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir, remdesivir, tociluzimab, nitazoxanide and ivermectin. However, some of these drugs are not effective and their use has been suspended by WHO.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33014380</PMID><DateRevised><Year>2021</Year><Month>04</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2052-2975</ISSN><JournalIssue CitedMedium="Print"><Volume>38</Volume><PubDate><Year>2020</Year><Month>Nov</Month></PubDate></JournalIssue><Title>New microbes and new infections</Title><ISOAbbreviation>New Microbes New Infect</ISOAbbreviation></Journal><ArticleTitle>Diagnostic approaches and potential therapeutic options for coronavirus disease 2019.</ArticleTitle><Pagination><MedlinePgn>100770</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nmni.2020.100770</ELocationID><Abstract><AbstractText>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city of China in late December 2019 and identified as a novel coronavirus. Due to its contagious nature, the virus spreads rapidly and causes coronavirus disease 2019 (COVID-19). The global tally of COVID-19 was 28 million in early September 2020. The fears and stress associated with SARS-CoV-2 has demolished the socio-economic status worldwide. Researchers are trying to identify treatments, especially antiviral drugs and/or vaccines, that could potentially control the viral spread and manage the ongoing unprecedented global crisis. To date, more than 300 clinical trials have been conducted on various antiviral drugs, and immunomodulators are being evaluated at various stages of COVID-19. This review aims to collect and summarize a list of drugs used to treat COVID-19, including dexamethasone, chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir, remdesivir, tociluzimab, nitazoxanide and ivermectin. However, some of these drugs are not effective and their use has been suspended by WHO.</AbstractText><CopyrightInformation>© 2020 The Authors.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Khan</LastName><ForeName>Z</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghafoor</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Wuhan Institute of Virology, Chinese Academy of Sciences Xiao Hong Shan No.44, Wuhan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khan</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Microbiology, School of Life Sciences, Lanzhou University, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ualiyeva</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Molecular Biology and Evolution, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khan</LastName><ForeName>S A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Pathobiology, University of Poonch Rawalakot Azad Kashmir, Rawalakot, Azad Kashmir, Pakistan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bilal</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Centre for Management and Commerce, University of Swat, Mingora, Pakistan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khan</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Optometry, Isra University Islamabad, Islamabad, Pakistan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khan</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Computer and Software Technology, University of Swat, Mingora, Pakistan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sajjad</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>New Microbes New Infect</MedlineTA><NlmUniqueID>101624750</NlmUniqueID><ISSNLinking>2052-2975</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">2019-nCoV</Keyword><Keyword MajorTopicYN="N">Coronavirus 2019</Keyword><Keyword MajorTopicYN="N">WHO</Keyword><Keyword MajorTopicYN="N">drugs</Keyword><Keyword MajorTopicYN="N">global tally</Keyword><Keyword MajorTopicYN="N">severe acute respiratory syndrome coronavirus 2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>09</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>10</Month><Day>5</Day><Hour>6</Hour><Minute>18</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33014380</ArticleId><ArticleId IdType="doi">10.1016/j.nmni.2020.100770</ArticleId><ArticleId IdType="pii">S2052-2975(20)30122-0</ArticleId><ArticleId IdType="pmc">PMC7525249</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
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