Cytokine Storm in COVID-19: "When You Come Out of the Storm, You Won't Be the Same Person Who Walked in".
Identifieur interne : 001443 ( Main/Exploration ); précédent : 001442; suivant : 001444Cytokine Storm in COVID-19: "When You Come Out of the Storm, You Won't Be the Same Person Who Walked in".
Auteurs : Vanessa Castelli [Italie] ; Annamaria Cimini [Italie] ; Claudio Ferri [Italie]Source :
- Frontiers in immunology [ 1664-3224 ]
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antagoniste du récepteur à l'interleukine-1 (usage thérapeutique), Anticorps monoclonaux humanisés (pharmacologie), Anticorps monoclonaux humanisés (usage thérapeutique), Betacoronavirus (immunologie), Chimiokines (immunologie), Chimiokines (sang), Glucocorticoïdes (usage thérapeutique), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Infections à coronavirus (immunologie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Pandémies (MeSH), Pneumopathie virale (immunologie), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (virologie), Récepteurs à l'interleukine-6 (antagonistes et inhibiteurs).
- MESH :
- antagonistes et inhibiteurs : Récepteurs à l'interleukine-6.
- immunologie : Betacoronavirus, Chimiokines, Infections à coronavirus, Pneumopathie virale.
- pharmacologie : Anticorps monoclonaux humanisés.
- sang : Chimiokines.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antagoniste du récepteur à l'interleukine-1, Anticorps monoclonaux humanisés, Glucocorticoïdes, Hydroxychloroquine.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Animaux, Humains, Pandémies.
English descriptors
- KwdEn :
- Animals (MeSH), Antibodies, Monoclonal, Humanized (pharmacology), Antibodies, Monoclonal, Humanized (therapeutic use), Betacoronavirus (immunology), COVID-19 (MeSH), Chemokines (blood), Chemokines (immunology), Coronavirus Infections (drug therapy), Coronavirus Infections (immunology), Coronavirus Infections (virology), Glucocorticoids (therapeutic use), Humans (MeSH), Hydroxychloroquine (therapeutic use), Interleukin 1 Receptor Antagonist Protein (therapeutic use), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (immunology), Pneumonia, Viral (virology), Receptors, Interleukin-6 (antagonists & inhibitors), Respiratory Distress Syndrome (drug therapy), Respiratory Distress Syndrome (immunology), SARS-CoV-2 (MeSH).
- MESH :
- chemical , antagonists & inhibitors : Receptors, Interleukin-6.
- chemical , blood : Chemokines.
- chemical , immunology : Chemokines.
- chemical , pharmacology : Antibodies, Monoclonal, Humanized.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Glucocorticoids, Hydroxychloroquine, Interleukin 1 Receptor Antagonist Protein.
- drug therapy : Coronavirus Infections, Pneumonia, Viral, Respiratory Distress Syndrome.
- immunology : Betacoronavirus, Coronavirus Infections, Pneumonia, Viral, Respiratory Distress Syndrome.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Animals, COVID-19, Humans, Pandemics, SARS-CoV-2.
Abstract
In December 2019, a novel coronavirus, COVID-19, was discovered to be the causal agent of a severe respiratory infection named SARS-CoV-2, and it has since been recognized worldwide as a pandemic. There are still numerous doubts concerning its pathogenesis and particularly the underlying causes of the various clinical courses, ranging from severe manifestations to asymptomatic forms, including acute respiratory distress syndrome. The major factor responsible for acute respiratory distress syndrome is the so-called "cytokine storm," which is an aberrant response from the host immune system that induces an exaggerated release of proinflammatory cytokines/chemokines. In this review, we will discuss the role of cytokine storm in COVID-19 and potential treatments with which counteract this aberrant response, which may be valuable in the clinical translation.
DOI: 10.3389/fimmu.2020.02132
PubMed: 32983172
PubMed Central: PMC7492381
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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December 2019, a novel coronavirus, COVID-19, was discovered to be the causal agent of a severe respiratory infection named SARS-CoV-2, and it has since been recognized worldwide as a pandemic. There are still numerous doubts concerning its pathogenesis and particularly the underlying causes of the various clinical courses, ranging from severe manifestations to asymptomatic forms, including acute respiratory distress syndrome. The major factor responsible for acute respiratory distress syndrome is the so-called "cytokine storm," which is an aberrant response from the host immune system that induces an exaggerated release of proinflammatory cytokines/chemokines. In this review, we will discuss the role of cytokine storm in COVID-19 and potential treatments with which counteract this aberrant response, which may be valuable in the clinical translation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32983172</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>14</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1664-3224</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><PubDate><MedlineDate>2020</MedlineDate></PubDate></JournalIssue><Title>Frontiers in immunology</Title><ISOAbbreviation>Front Immunol</ISOAbbreviation></Journal><ArticleTitle>Cytokine Storm in COVID-19: "When You Come Out of the Storm, You Won't Be the Same Person Who Walked in".</ArticleTitle><Pagination><MedlinePgn>2132</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fimmu.2020.02132</ELocationID><Abstract><AbstractText>In December 2019, a novel coronavirus, COVID-19, was discovered to be the causal agent of a severe respiratory infection named SARS-CoV-2, and it has since been recognized worldwide as a pandemic. There are still numerous doubts concerning its pathogenesis and particularly the underlying causes of the various clinical courses, ranging from severe manifestations to asymptomatic forms, including acute respiratory distress syndrome. The major factor responsible for acute respiratory distress syndrome is the so-called "cytokine storm," which is an aberrant response from the host immune system that induces an exaggerated release of proinflammatory cytokines/chemokines. In this review, we will discuss the role of cytokine storm in COVID-19 and potential treatments with which counteract this aberrant response, which may be valuable in the clinical translation.</AbstractText><CopyrightInformation>Copyright © 2020 Castelli, Cimini and Ferri.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Castelli</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cimini</LastName><ForeName>Annamaria</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferri</LastName><ForeName>Claudio</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department 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