CovidChloroV1, Main, Exploration, bibRecordById, pubmed:32841688

First report on clinical and radiological features of COVID-19 pneumonitis in a Caucasian population: Factors predicting fibrotic evolution.

Identifieur interne : 001287 ( Main/Exploration ); précédent : 001286; suivant : 001288

First report on clinical and radiological features of COVID-19 pneumonitis in a Caucasian population: Factors predicting fibrotic evolution.

Auteurs : Maurizio Marvisi [Italie] ; Francesco Ferrozzi [Italie] ; Laura Balzarini [Italie] ; Chiara Mancini [Italie] ; Sara Ramponi [Italie] ; Mario Uccelli [Italie]

Source :

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [ 1878-3511 ] ; 2020.

RBID : pubmed:32841688

Descripteurs français

KwdFr :
- Adulte d'âge moyen (MeSH), Antiviraux (usage thérapeutique), Association médicamenteuse (MeSH), Betacoronavirus (MeSH), Femelle (MeSH), Fibrose pulmonaire (étiologie), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Infections à coronavirus (anatomopathologie), Infections à coronavirus (complications), Infections à coronavirus (imagerie diagnostique), Lopinavir (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (anatomopathologie), Pneumopathie virale (complications), Pneumopathie virale (imagerie diagnostique), Radiographie (MeSH), Ritonavir (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Tomodensitométrie (MeSH), Études rétrospectives (MeSH).
MESH :
- anatomopathologie : Infections à coronavirus, Pneumopathie virale.
- imagerie diagnostique : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antiviraux, Hydroxychloroquine, Infections à coronavirus, Pneumopathie virale.
- étiologie : Fibrose pulmonaire.
- Adulte d'âge moyen, Association médicamenteuse, Betacoronavirus, Femelle, Humains, Lopinavir, Mâle, Pandémies, Radiographie, Ritonavir, Sujet âgé, Sujet âgé de 80 ans ou plus, Tomodensitométrie, Études rétrospectives.

English descriptors

KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Antiviral Agents (therapeutic use), Betacoronavirus (MeSH), COVID-19 (MeSH), Coronavirus Infections (complications), Coronavirus Infections (diagnostic imaging), Coronavirus Infections (pathology), Drug Combinations (MeSH), Female (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Lopinavir (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (diagnostic imaging), Pneumonia, Viral (pathology), Pulmonary Fibrosis (etiology), Radiography (MeSH), Retrospective Studies (MeSH), Ritonavir (MeSH), SARS-CoV-2 (MeSH), Tomography, X-Ray Computed (MeSH).
MESH :
- chemical , therapeutic use : Antiviral Agents, Hydroxychloroquine.
- complications : Coronavirus Infections, Pneumonia, Viral.
- diagnostic imaging : Coronavirus Infections, Pneumonia, Viral.
- etiology : Pulmonary Fibrosis.
- pathology : Coronavirus Infections, Pneumonia, Viral.
- Aged, Aged, 80 and over, Betacoronavirus, COVID-19, Drug Combinations, Female, Humans, Lopinavir, Male, Middle Aged, Pandemics, Radiography, Retrospective Studies, Ritonavir, SARS-CoV-2, Tomography, X-Ray Computed.

Abstract

BACKGROUND

At the end of February, the Lombardy region (Northern Italy) was involved in the pandemic spread of the new COVID-19. We here summarize the clinical and radiological characteristics of 90 confirmed cases and analyze their role in predicting the evolution of fibrosis.

METHODS

We retrospectively analyzed the clinical and radiological data of 90 patients with COVID-19 pneumonitis. All subjects underwent an HRCT study on the day of admission and eight weeks later, and were treated with lopinavir + ritonavir (Kaletra) 400/100 mg two times a day or darunavir + ritonavir two times a day, and Hydroxychloroquine 200 mg two times a day. Pulmonary fibrosis was defined according to the Fleischner Society glossary of terms for thoracic imaging.

RESULTS

Twenty-three patients developed pulmonary fibrosis (25.5%): 15 were males, whose mean age was 75 ± 15. The majority were active smokers (60.8%) and had comorbidities (78.2%), above all, hypertension (47.8%), and diabetes (34.7%). Interestingly, in our series of cases, the "reversed halo sign" is frequent (63%) and seems to be a typical COVID-19 pneumonitis pattern. The patients showing fibrosis had a higher grade of systemic inflammation (ESR and PCR) and appeared to have bone marrow inhibition with a significant reduction in platelets, leukocytes, and hemoglobin.

CONCLUSIONS

To conclude, our data showed that the reversed halo sign associated with a ground-glass pattern may be a typical HRCT pattern of COVID-19 pneumonitis. The evolution to pulmonary fibrosis is frequent in older males and patients with comorbidities and bone marrow involvement.

DOI: 10.1016/j.ijid.2020.08.054
PubMed: 32841688
PubMed Central: PMC7443096

Affiliations:

Italie

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000D92
to stream Main, to step Curation: 000D92

Le document en format XML

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<term>Aged, 80 and over (MeSH)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Betacoronavirus (MeSH)</term>
<term>COVID-19 (MeSH)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (diagnostic imaging)</term>
<term>Coronavirus Infections (pathology)</term>
<term>Drug Combinations (MeSH)</term>
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<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Lopinavir (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (diagnostic imaging)</term>
<term>Pneumonia, Viral (pathology)</term>
<term>Pulmonary Fibrosis (etiology)</term>
<term>Radiography (MeSH)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Ritonavir (MeSH)</term>
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<term>Tomography, X-Ray Computed (MeSH)</term>
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<term>Association médicamenteuse (MeSH)</term>
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<term>Infections à coronavirus (complications)</term>
<term>Infections à coronavirus (imagerie diagnostique)</term>
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<term>Pneumonia, Viral</term>
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<term>Humains</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>At the end of February, the Lombardy region (Northern Italy) was involved in the pandemic spread of the new COVID-19. We here summarize the clinical and radiological characteristics of 90 confirmed cases and analyze their role in predicting the evolution of fibrosis.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We retrospectively analyzed the clinical and radiological data of 90 patients with COVID-19 pneumonitis. All subjects underwent an HRCT study on the day of admission and eight weeks later, and were treated with lopinavir + ritonavir (Kaletra) 400/100 mg two times a day or darunavir + ritonavir two times a day, and Hydroxychloroquine 200 mg two times a day. Pulmonary fibrosis was defined according to the Fleischner Society glossary of terms for thoracic imaging.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Twenty-three patients developed pulmonary fibrosis (25.5%): 15 were males, whose mean age was 75 ± 15. The majority were active smokers (60.8%) and had comorbidities (78.2%), above all, hypertension (47.8%), and diabetes (34.7%). Interestingly, in our series of cases, the "reversed halo sign" is frequent (63%) and seems to be a typical COVID-19 pneumonitis pattern. The patients showing fibrosis had a higher grade of systemic inflammation (ESR and PCR) and appeared to have bone marrow inhibition with a significant reduction in platelets, leukocytes, and hemoglobin.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>To conclude, our data showed that the reversed halo sign associated with a ground-glass pattern may be a typical HRCT pattern of COVID-19 pneumonitis. The evolution to pulmonary fibrosis is frequent in older males and patients with comorbidities and bone marrow involvement.</p>
</div>
</front>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">At the end of February, the Lombardy region (Northern Italy) was involved in the pandemic spread of the new COVID-19. We here summarize the clinical and radiological characteristics of 90 confirmed cases and analyze their role in predicting the evolution of fibrosis.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We retrospectively analyzed the clinical and radiological data of 90 patients with COVID-19 pneumonitis. All subjects underwent an HRCT study on the day of admission and eight weeks later, and were treated with lopinavir + ritonavir (Kaletra) 400/100 mg two times a day or darunavir + ritonavir two times a day, and Hydroxychloroquine 200 mg two times a day. Pulmonary fibrosis was defined according to the Fleischner Society glossary of terms for thoracic imaging.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Twenty-three patients developed pulmonary fibrosis (25.5%): 15 were males, whose mean age was 75 ± 15. The majority were active smokers (60.8%) and had comorbidities (78.2%), above all, hypertension (47.8%), and diabetes (34.7%). Interestingly, in our series of cases, the "reversed halo sign" is frequent (63%) and seems to be a typical COVID-19 pneumonitis pattern. The patients showing fibrosis had a higher grade of systemic inflammation (ESR and PCR) and appeared to have bone marrow inhibition with a significant reduction in platelets, leukocytes, and hemoglobin.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">To conclude, our data showed that the reversed halo sign associated with a ground-glass pattern may be a typical HRCT pattern of COVID-19 pneumonitis. The evolution to pulmonary fibrosis is frequent in older males and patients with comorbidities and bone marrow involvement.</AbstractText>
<CopyrightInformation>Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation>
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<ForeName>Maurizio</ForeName>
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<AffiliationInfo><Affiliation>Dept. of Internal Medicine and Pneumology, Istituto Figlie di San Camillo, Cremona, Italy.</Affiliation>
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<AffiliationInfo><Affiliation>Dept. of Internal Medicine and Pneumology, Istituto Figlie di San Camillo, Cremona, Italy.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Uccelli</LastName>
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<AffiliationInfo><Affiliation>Dept. of Radiology, Istituto Figlie di San Camillo, Cremona, Italy.</Affiliation>
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First report on clinical and radiological features of COVID-19 pneumonitis in a Caucasian population: Factors predicting fibrotic evolution.

First report on clinical and radiological features of COVID-19 pneumonitis in a Caucasian population: Factors predicting fibrotic evolution.

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