Administration of Immunoglobulins in SARS-CoV-2-Positive Patient Is Associated With Fast Clinical and Radiological Healing: Case Report.
Identifieur interne : 001934 ( Main/Exploration ); précédent : 001933; suivant : 001935Administration of Immunoglobulins in SARS-CoV-2-Positive Patient Is Associated With Fast Clinical and Radiological Healing: Case Report.
Auteurs : Novella Carannante [Italie] ; Giuseppe Fiorentino [Italie] ; Antonio Corcione [Italie] ; Raffaele Di Sarno [Italie] ; Micaela Spatarella [Italie] ; Nicola Maturo [Italie] ; Fiorentino Fragranza [Italie] ; Pierpaolo Di Micco [Italie]Source :
- Frontiers in medicine [ 2296-858X ] ; 2020.
Abstract
Polyclonal preparation of IgM as an adjuvant therapy has been reported as a relevant immunomodulant therapy in several infectious diseases, exhibiting, in most cases, improvement of the clinical course. No drug has demonstrated therapeutic efficacy for COVID-19. Immunomodulatory treatment with hydroxychloroquine and biologics as tocilizumab, in fact, has not proven to show satisfactory results in several reports. We therefore treated a selected patient with interstitial multifocal pneumonia, positive to COVID-19, with polyclonal preparation of immunoglobulins as an adjuvant therapy, obtaining in few days clinical remission and improvements in radiological findings. Based on this case report, we suggest that clinical trials are conducted to test the efficacy and safety of polyclonal immunoglobulins for adjunctive therapy of COVID-19.
DOI: 10.3389/fmed.2020.00388
PubMed: 32766266
PubMed Central: PMC7378528
Affiliations:
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Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Fiorentino, Giuseppe" sort="Fiorentino, Giuseppe" uniqKey="Fiorentino G" first="Giuseppe" last="Fiorentino">Giuseppe Fiorentino</name><affiliation wicri:level="1"><nlm:affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Corcione, Antonio" sort="Corcione, Antonio" uniqKey="Corcione A" first="Antonio" last="Corcione">Antonio Corcione</name><affiliation wicri:level="1"><nlm:affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Di Sarno, Raffaele" sort="Di Sarno, Raffaele" uniqKey="Di Sarno R" first="Raffaele" last="Di Sarno">Raffaele Di Sarno</name><affiliation wicri:level="1"><nlm:affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Spatarella, Micaela" sort="Spatarella, Micaela" uniqKey="Spatarella M" first="Micaela" last="Spatarella">Micaela Spatarella</name><affiliation wicri:level="1"><nlm:affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Maturo, Nicola" sort="Maturo, Nicola" uniqKey="Maturo N" first="Nicola" last="Maturo">Nicola Maturo</name><affiliation wicri:level="1"><nlm:affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Fragranza, Fiorentino" sort="Fragranza, Fiorentino" uniqKey="Fragranza F" first="Fiorentino" last="Fragranza">Fiorentino Fragranza</name><affiliation wicri:level="1"><nlm:affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Di Micco, Pierpaolo" sort="Di Micco, Pierpaolo" uniqKey="Di Micco P" first="Pierpaolo" last="Di Micco">Pierpaolo Di Micco</name><affiliation wicri:level="1"><nlm:affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in medicine</title><idno type="ISSN">2296-858X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Polyclonal preparation of IgM as an adjuvant therapy has been reported as a relevant immunomodulant therapy in several infectious diseases, exhibiting, in most cases, improvement of the clinical course. No drug has demonstrated therapeutic efficacy for COVID-19. Immunomodulatory treatment with hydroxychloroquine and biologics as tocilizumab, in fact, has not proven to show satisfactory results in several reports. We therefore treated a selected patient with interstitial multifocal pneumonia, positive to COVID-19, with polyclonal preparation of immunoglobulins as an adjuvant therapy, obtaining in few days clinical remission and improvements in radiological findings. Based on this case report, we suggest that clinical trials are conducted to test the efficacy and safety of polyclonal immunoglobulins for adjunctive therapy of COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32766266</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2296-858X</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Frontiers in medicine</Title><ISOAbbreviation>Front Med (Lausanne)</ISOAbbreviation></Journal><ArticleTitle>Administration of Immunoglobulins in SARS-CoV-2-Positive Patient Is Associated With Fast Clinical and Radiological Healing: Case Report.</ArticleTitle><Pagination><MedlinePgn>388</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fmed.2020.00388</ELocationID><Abstract><AbstractText>Polyclonal preparation of IgM as an adjuvant therapy has been reported as a relevant immunomodulant therapy in several infectious diseases, exhibiting, in most cases, improvement of the clinical course. No drug has demonstrated therapeutic efficacy for COVID-19. Immunomodulatory treatment with hydroxychloroquine and biologics as tocilizumab, in fact, has not proven to show satisfactory results in several reports. We therefore treated a selected patient with interstitial multifocal pneumonia, positive to COVID-19, with polyclonal preparation of immunoglobulins as an adjuvant therapy, obtaining in few days clinical remission and improvements in radiological findings. Based on this case report, we suggest that clinical trials are conducted to test the efficacy and safety of polyclonal immunoglobulins for adjunctive therapy of COVID-19.</AbstractText><CopyrightInformation>Copyright © 2020 Carannante, Fiorentino, Corcione, Di Sarno, Spatarella, Maturo, Fragranza and Di Micco.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Carannante</LastName><ForeName>Novella</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiorentino</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corcione</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Sarno</LastName><ForeName>Raffaele</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spatarella</LastName><ForeName>Micaela</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maturo</LastName><ForeName>Nicola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fragranza</LastName><ForeName>Fiorentino</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Micco</LastName><ForeName>Pierpaolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Emergency Infectious Disease p.o. Cotugno-Monaldi, A.O. dei Colli, Naples, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UOC Medicina, Ospedale Fatebenefratelli di Naples, Naples, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Med (Lausanne)</MedlineTA><NlmUniqueID>101648047</NlmUniqueID><ISSNLinking>2296-858X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID 19</Keyword><Keyword MajorTopicYN="N">PENTAGLOBIN</Keyword><Keyword MajorTopicYN="N">SARS-CoV2</Keyword><Keyword MajorTopicYN="N">case report</Keyword><Keyword MajorTopicYN="N">immunoglobulin</Keyword><Keyword 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IdType="pubmed">12848745</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Carannante, Novella" sort="Carannante, Novella" uniqKey="Carannante N" first="Novella" last="Carannante">Novella Carannante</name></noRegion><name sortKey="Carannante, Novella" sort="Carannante, Novella" uniqKey="Carannante N" first="Novella" last="Carannante">Novella Carannante</name><name sortKey="Corcione, Antonio" sort="Corcione, Antonio" uniqKey="Corcione A" first="Antonio" last="Corcione">Antonio Corcione</name><name sortKey="Corcione, Antonio" sort="Corcione, Antonio" uniqKey="Corcione A" first="Antonio" last="Corcione">Antonio Corcione</name><name sortKey="Di Micco, Pierpaolo" sort="Di Micco, Pierpaolo" uniqKey="Di Micco P" first="Pierpaolo" last="Di Micco">Pierpaolo Di Micco</name><name sortKey="Di Micco, Pierpaolo" sort="Di Micco, Pierpaolo" uniqKey="Di Micco P" first="Pierpaolo" last="Di Micco">Pierpaolo Di Micco</name><name sortKey="Di Sarno, Raffaele" sort="Di Sarno, Raffaele" uniqKey="Di Sarno R" first="Raffaele" last="Di Sarno">Raffaele Di Sarno</name><name sortKey="Di Sarno, Raffaele" sort="Di Sarno, Raffaele" uniqKey="Di Sarno R" first="Raffaele" last="Di Sarno">Raffaele Di Sarno</name><name sortKey="Fiorentino, Giuseppe" sort="Fiorentino, Giuseppe" uniqKey="Fiorentino G" first="Giuseppe" last="Fiorentino">Giuseppe Fiorentino</name><name sortKey="Fiorentino, Giuseppe" sort="Fiorentino, Giuseppe" uniqKey="Fiorentino G" first="Giuseppe" last="Fiorentino">Giuseppe Fiorentino</name><name sortKey="Fragranza, Fiorentino" sort="Fragranza, Fiorentino" uniqKey="Fragranza F" first="Fiorentino" last="Fragranza">Fiorentino Fragranza</name><name sortKey="Fragranza, Fiorentino" sort="Fragranza, Fiorentino" uniqKey="Fragranza F" first="Fiorentino" last="Fragranza">Fiorentino Fragranza</name><name sortKey="Maturo, Nicola" sort="Maturo, Nicola" uniqKey="Maturo N" first="Nicola" last="Maturo">Nicola Maturo</name><name sortKey="Maturo, Nicola" sort="Maturo, Nicola" uniqKey="Maturo N" first="Nicola" last="Maturo">Nicola Maturo</name><name sortKey="Spatarella, Micaela" sort="Spatarella, Micaela" uniqKey="Spatarella M" first="Micaela" last="Spatarella">Micaela Spatarella</name><name sortKey="Spatarella, Micaela" sort="Spatarella, Micaela" uniqKey="Spatarella M" first="Micaela" last="Spatarella">Micaela Spatarella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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