Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial.
Identifieur interne : 001168 ( Main/Exploration ); précédent : 001167; suivant : 001169Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial.
Auteurs : Wei Tang [République populaire de Chine] ; Zhujun Cao [République populaire de Chine] ; Mingfeng Han [République populaire de Chine] ; Zhengyan Wang [République populaire de Chine] ; Junwen Chen [République populaire de Chine] ; Wenjin Sun [République populaire de Chine] ; Yaojie Wu [République populaire de Chine] ; Wei Xiao [République populaire de Chine] ; Shengyong Liu [République populaire de Chine] ; Erzhen Chen [République populaire de Chine] ; Wei Chen [République populaire de Chine] ; Xiongbiao Wang [République populaire de Chine] ; Jiuyong Yang [République populaire de Chine] ; Jun Lin [République populaire de Chine] ; Qingxia Zhao [République populaire de Chine] ; Youqin Yan [République populaire de Chine] ; Zhibin Xie [Oman] ; Dan Li [République populaire de Chine] ; Yaofeng Yang [République populaire de Chine] ; Leshan Liu [République populaire de Chine] ; Jieming Qu [République populaire de Chine] ; Guang Ning [République populaire de Chine] ; Guochao Shi [République populaire de Chine] ; Qing Xie [Oman]Source :
- BMJ (Clinical research ed.) [ 1756-1833 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Antiviraux (usage thérapeutique), Chine (MeSH), Femelle (MeSH), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Infections à coronavirus (traitement médicamenteux), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (traitement médicamenteux), Résultat thérapeutique (MeSH).
- MESH :
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antiviraux, Hydroxychloroquine.
- Adulte, Adulte d'âge moyen, Chine, Femelle, Humains, Mâle, Pandémies, Résultat thérapeutique.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiviral Agents, Hydroxychloroquine.
- geographic : China.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- Adult, COVID-19, Female, Humans, Male, Middle Aged, Pandemics, Treatment Outcome.
Abstract
OBJECTIVE
To assess the efficacy and safety of hydroxychloroquine plus standard of care compared with standard of care alone in adults with coronavirus disease 2019 (covid-19).
DESIGN
Multicentre, open label, randomised controlled trial.
SETTING
16 government designated covid-19 treatment centres in China, 11 to 29 February 2020.
PARTICIPANTS
150 patients admitted to hospital with laboratory confirmed covid-19 were included in the intention to treat analysis (75 patients assigned to hydroxychloroquine plus standard of care, 75 to standard of care alone).
INTERVENTIONS
Hydroxychloroquine administrated at a loading dose of 1200 mg daily for three days followed by a maintenance dose of 800 mg daily (total treatment duration: two or three weeks for patients with mild to moderate or severe disease, respectively).
MAIN OUTCOME MEASURE
Negative conversion of severe acute respiratory syndrome coronavirus 2 by 28 days, analysed according to the intention to treat principle. Adverse events were analysed in the safety population in which hydroxychloroquine recipients were participants who received at least one dose of hydroxychloroquine and hydroxychloroquine non-recipients were those managed with standard of care alone.
RESULTS
Of 150 patients, 148 had mild to moderate disease and two had severe disease. The mean duration from symptom onset to randomisation was 16.6 (SD 10.5; range 3-41) days. A total of 109 (73%) patients (56 standard of care; 53 standard of care plus hydroxychloroquine) had negative conversion well before 28 days, and the remaining 41 (27%) patients (19 standard of care; 22 standard of care plus hydroxychloroquine) were censored as they did not reach negative conversion of virus. The probability of negative conversion by 28 days in the standard of care plus hydroxychloroquine group was 85.4% (95% confidence interval 73.8% to 93.8%), similar to that in the standard of care group (81.3%, 71.2% to 89.6%). The difference between groups was 4.1% (95% confidence interval -10.3% to 18.5%). In the safety population, adverse events were recorded in 7/80 (9%) hydroxychloroquine non-recipients and in 21/70 (30%) hydroxychloroquine recipients. The most common adverse event in the hydroxychloroquine recipients was diarrhoea, reported in 7/70 (10%) patients. Two hydroxychloroquine recipients reported serious adverse events.
CONCLUSIONS
Administration of hydroxychloroquine did not result in a significantly higher probability of negative conversion than standard of care alone in patients admitted to hospital with mainly persistent mild to moderate covid-19. Adverse events were higher in hydroxychloroquine recipients than in non-recipients.
TRIAL REGISTRATION
ChiCTR2000029868.
DOI: 10.1136/bmj.m1849
PubMed: 32409561
PubMed Central: PMC7221473
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial.</title>
<author><name sortKey="Tang, Wei" sort="Tang, Wei" uniqKey="Tang W" first="Wei" last="Tang">Wei Tang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cao, Zhujun" sort="Cao, Zhujun" uniqKey="Cao Z" first="Zhujun" last="Cao">Zhujun Cao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025</wicri:regionArea>
<wicri:noRegion>Shanghai 200025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Han, Mingfeng" sort="Han, Mingfeng" uniqKey="Han M" first="Mingfeng" last="Han">Mingfeng Han</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, No 2 People's Hospital of Fuyang City, Fuyang, Anhui, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, No 2 People's Hospital of Fuyang City, Fuyang, Anhui</wicri:regionArea>
<wicri:noRegion>Anhui</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Zhengyan" sort="Wang, Zhengyan" uniqKey="Wang Z" first="Zhengyan" last="Wang">Zhengyan Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Junwen" sort="Chen, Junwen" uniqKey="Chen J" first="Junwen" last="Chen">Junwen Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Xiangyang No 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Xiangyang No 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sun, Wenjin" sort="Sun, Wenjin" uniqKey="Sun W" first="Wenjin" last="Sun">Wenjin Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Central Hospital of Ezhou, Ezhou, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Diseases, Central Hospital of Ezhou, Ezhou, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Yaojie" sort="Wu, Yaojie" uniqKey="Wu Y" first="Yaojie" last="Wu">Yaojie Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Medicine, Yunmeng People's Hospital, Xiaogan, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Cardiovascular Medicine, Yunmeng People's Hospital, Xiaogan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiao, Wei" sort="Xiao, Wei" uniqKey="Xiao W" first="Wei" last="Xiao">Wei Xiao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, First People's Hospital of Jingzhou City, Jingzhou, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, First People's Hospital of Jingzhou City, Jingzhou, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Shengyong" sort="Liu, Shengyong" uniqKey="Liu S" first="Shengyong" last="Liu">Shengyong Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Diseases, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Erzhen" sort="Chen, Erzhen" uniqKey="Chen E" first="Erzhen" last="Chen">Erzhen Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Emergency Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Emergency Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Xiongbiao" sort="Wang, Xiongbiao" uniqKey="Wang X" first="Xiongbiao" last="Wang">Xiongbiao Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Jiuyong" sort="Yang, Jiuyong" uniqKey="Yang J" first="Jiuyong" last="Yang">Jiuyong Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Hubei Space Hospital of Xiaogan, Xiaogan, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Hubei Space Hospital of Xiaogan, Xiaogan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Jun" sort="Lin, Jun" uniqKey="Lin J" first="Jun" last="Lin">Jun Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Qingxia" sort="Zhao, Qingxia" uniqKey="Zhao Q" first="Qingxia" last="Zhao">Qingxia Zhao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, The Sixth People's Hospital of Zhengzhou, Zhengzhou, Henan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Disease, The Sixth People's Hospital of Zhengzhou, Zhengzhou, Henan</wicri:regionArea>
<wicri:noRegion>Henan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yan, Youqin" sort="Yan, Youqin" uniqKey="Yan Y" first="Youqin" last="Yan">Youqin Yan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Wuhan No 7 Hospital, Wuhan, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Disease, Wuhan No 7 Hospital, Wuhan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xie, Zhibin" sort="Xie, Zhibin" uniqKey="Xie Z" first="Zhibin" last="Xie">Zhibin Xie</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Respiratory Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei, China xieqingrjh@163.com.</nlm:affiliation>
<country wicri:rule="url">Oman</country>
<wicri:regionArea>Departments of Respiratory Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Dan" sort="Li, Dan" uniqKey="Li D" first="Dan" last="Li">Dan Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, The Third People's Hospital of Yichang, Yichang, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, The Third People's Hospital of Yichang, Yichang, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Yaofeng" sort="Yang, Yaofeng" uniqKey="Yang Y" first="Yaofeng" last="Yang">Yaofeng Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Xiao Gan First People's Hospital, Xiaogan, Hubei Province, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Xiao Gan First People's Hospital, Xiaogan, Hubei Province</wicri:regionArea>
<wicri:noRegion>Hubei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Leshan" sort="Liu, Leshan" uniqKey="Liu L" first="Leshan" last="Liu">Leshan Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Research Centre, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Clinical Research Centre, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qu, Jieming" sort="Qu, Jieming" uniqKey="Qu J" first="Jieming" last="Qu">Jieming Qu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ning, Guang" sort="Ning, Guang" uniqKey="Ning G" first="Guang" last="Ning">Guang Ning</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shi, Guochao" sort="Shi, Guochao" uniqKey="Shi G" first="Guochao" last="Shi">Guochao Shi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xie, Qing" sort="Xie, Qing" uniqKey="Xie Q" first="Qing" last="Xie">Qing Xie</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China xieqingrjh@163.com.</nlm:affiliation>
<country wicri:rule="url">Oman</country>
<wicri:regionArea>Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025</wicri:regionArea>
<wicri:noRegion>Shanghai 200025</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32409561</idno>
<idno type="pmid">32409561</idno>
<idno type="doi">10.1136/bmj.m1849</idno>
<idno type="pmc">PMC7221473</idno>
<idno type="wicri:Area/Main/Corpus">001691</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001691</idno>
<idno type="wicri:Area/Main/Curation">001691</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001691</idno>
<idno type="wicri:Area/Main/Exploration">001691</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial.</title>
<author><name sortKey="Tang, Wei" sort="Tang, Wei" uniqKey="Tang W" first="Wei" last="Tang">Wei Tang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cao, Zhujun" sort="Cao, Zhujun" uniqKey="Cao Z" first="Zhujun" last="Cao">Zhujun Cao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025</wicri:regionArea>
<wicri:noRegion>Shanghai 200025</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Han, Mingfeng" sort="Han, Mingfeng" uniqKey="Han M" first="Mingfeng" last="Han">Mingfeng Han</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, No 2 People's Hospital of Fuyang City, Fuyang, Anhui, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, No 2 People's Hospital of Fuyang City, Fuyang, Anhui</wicri:regionArea>
<wicri:noRegion>Anhui</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Zhengyan" sort="Wang, Zhengyan" uniqKey="Wang Z" first="Zhengyan" last="Wang">Zhengyan Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Junwen" sort="Chen, Junwen" uniqKey="Chen J" first="Junwen" last="Chen">Junwen Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Xiangyang No 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory and Critical Care Medicine, Xiangyang No 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sun, Wenjin" sort="Sun, Wenjin" uniqKey="Sun W" first="Wenjin" last="Sun">Wenjin Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Central Hospital of Ezhou, Ezhou, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Diseases, Central Hospital of Ezhou, Ezhou, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Yaojie" sort="Wu, Yaojie" uniqKey="Wu Y" first="Yaojie" last="Wu">Yaojie Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Medicine, Yunmeng People's Hospital, Xiaogan, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Cardiovascular Medicine, Yunmeng People's Hospital, Xiaogan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiao, Wei" sort="Xiao, Wei" uniqKey="Xiao W" first="Wei" last="Xiao">Wei Xiao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, First People's Hospital of Jingzhou City, Jingzhou, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, First People's Hospital of Jingzhou City, Jingzhou, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Shengyong" sort="Liu, Shengyong" uniqKey="Liu S" first="Shengyong" last="Liu">Shengyong Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Diseases, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Erzhen" sort="Chen, Erzhen" uniqKey="Chen E" first="Erzhen" last="Chen">Erzhen Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Emergency Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Emergency Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Xiongbiao" sort="Wang, Xiongbiao" uniqKey="Wang X" first="Xiongbiao" last="Wang">Xiongbiao Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Jiuyong" sort="Yang, Jiuyong" uniqKey="Yang J" first="Jiuyong" last="Yang">Jiuyong Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Hubei Space Hospital of Xiaogan, Xiaogan, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Hubei Space Hospital of Xiaogan, Xiaogan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Jun" sort="Lin, Jun" uniqKey="Lin J" first="Jun" last="Lin">Jun Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhao, Qingxia" sort="Zhao, Qingxia" uniqKey="Zhao Q" first="Qingxia" last="Zhao">Qingxia Zhao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, The Sixth People's Hospital of Zhengzhou, Zhengzhou, Henan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Disease, The Sixth People's Hospital of Zhengzhou, Zhengzhou, Henan</wicri:regionArea>
<wicri:noRegion>Henan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yan, Youqin" sort="Yan, Youqin" uniqKey="Yan Y" first="Youqin" last="Yan">Youqin Yan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Wuhan No 7 Hospital, Wuhan, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infectious Disease, Wuhan No 7 Hospital, Wuhan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xie, Zhibin" sort="Xie, Zhibin" uniqKey="Xie Z" first="Zhibin" last="Xie">Zhibin Xie</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Respiratory Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei, China xieqingrjh@163.com.</nlm:affiliation>
<country wicri:rule="url">Oman</country>
<wicri:regionArea>Departments of Respiratory Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Dan" sort="Li, Dan" uniqKey="Li D" first="Dan" last="Li">Dan Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, The Third People's Hospital of Yichang, Yichang, Hubei, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, The Third People's Hospital of Yichang, Yichang, Hubei</wicri:regionArea>
<wicri:noRegion>Hubei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Yaofeng" sort="Yang, Yaofeng" uniqKey="Yang Y" first="Yaofeng" last="Yang">Yaofeng Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, Xiao Gan First People's Hospital, Xiaogan, Hubei Province, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Respiratory Medicine, Xiao Gan First People's Hospital, Xiaogan, Hubei Province</wicri:regionArea>
<wicri:noRegion>Hubei Province</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Leshan" sort="Liu, Leshan" uniqKey="Liu L" first="Leshan" last="Liu">Leshan Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Research Centre, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Clinical Research Centre, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qu, Jieming" sort="Qu, Jieming" uniqKey="Qu J" first="Jieming" last="Qu">Jieming Qu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ning, Guang" sort="Ning, Guang" uniqKey="Ning G" first="Guang" last="Ning">Guang Ning</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shi, Guochao" sort="Shi, Guochao" uniqKey="Shi G" first="Guochao" last="Shi">Guochao Shi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xie, Qing" sort="Xie, Qing" uniqKey="Xie Q" first="Qing" last="Xie">Qing Xie</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China xieqingrjh@163.com.</nlm:affiliation>
<country wicri:rule="url">Oman</country>
<wicri:regionArea>Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025</wicri:regionArea>
<wicri:noRegion>Shanghai 200025</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">BMJ (Clinical research ed.)</title>
<idno type="eISSN">1756-1833</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>COVID-19 (MeSH)</term>
<term>China (MeSH)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Treatment Outcome (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Chine (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
<term>Résultat thérapeutique (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>COVID-19</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Chine</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Résultat thérapeutique</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To assess the efficacy and safety of hydroxychloroquine plus standard of care compared with standard of care alone in adults with coronavirus disease 2019 (covid-19).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>DESIGN</b>
</p>
<p>Multicentre, open label, randomised controlled trial.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>SETTING</b>
</p>
<p>16 government designated covid-19 treatment centres in China, 11 to 29 February 2020.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>PARTICIPANTS</b>
</p>
<p>150 patients admitted to hospital with laboratory confirmed covid-19 were included in the intention to treat analysis (75 patients assigned to hydroxychloroquine plus standard of care, 75 to standard of care alone).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>INTERVENTIONS</b>
</p>
<p>Hydroxychloroquine administrated at a loading dose of 1200 mg daily for three days followed by a maintenance dose of 800 mg daily (total treatment duration: two or three weeks for patients with mild to moderate or severe disease, respectively).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>MAIN OUTCOME MEASURE</b>
</p>
<p>Negative conversion of severe acute respiratory syndrome coronavirus 2 by 28 days, analysed according to the intention to treat principle. Adverse events were analysed in the safety population in which hydroxychloroquine recipients were participants who received at least one dose of hydroxychloroquine and hydroxychloroquine non-recipients were those managed with standard of care alone.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Of 150 patients, 148 had mild to moderate disease and two had severe disease. The mean duration from symptom onset to randomisation was 16.6 (SD 10.5; range 3-41) days. A total of 109 (73%) patients (56 standard of care; 53 standard of care plus hydroxychloroquine) had negative conversion well before 28 days, and the remaining 41 (27%) patients (19 standard of care; 22 standard of care plus hydroxychloroquine) were censored as they did not reach negative conversion of virus. The probability of negative conversion by 28 days in the standard of care plus hydroxychloroquine group was 85.4% (95% confidence interval 73.8% to 93.8%), similar to that in the standard of care group (81.3%, 71.2% to 89.6%). The difference between groups was 4.1% (95% confidence interval -10.3% to 18.5%). In the safety population, adverse events were recorded in 7/80 (9%) hydroxychloroquine non-recipients and in 21/70 (30%) hydroxychloroquine recipients. The most common adverse event in the hydroxychloroquine recipients was diarrhoea, reported in 7/70 (10%) patients. Two hydroxychloroquine recipients reported serious adverse events.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Administration of hydroxychloroquine did not result in a significantly higher probability of negative conversion than standard of care alone in patients admitted to hospital with mainly persistent mild to moderate covid-19. Adverse events were higher in hydroxychloroquine recipients than in non-recipients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION</b>
</p>
<p>ChiCTR2000029868.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32409561</PMID>
<DateCompleted><Year>2020</Year>
<Month>05</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1756-1833</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>369</Volume>
<PubDate><Year>2020</Year>
<Month>05</Month>
<Day>14</Day>
</PubDate>
</JournalIssue>
<Title>BMJ (Clinical research ed.)</Title>
<ISOAbbreviation>BMJ</ISOAbbreviation>
</Journal>
<ArticleTitle>Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial.</ArticleTitle>
<Pagination><MedlinePgn>m1849</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1136/bmj.m1849</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE">To assess the efficacy and safety of hydroxychloroquine plus standard of care compared with standard of care alone in adults with coronavirus disease 2019 (covid-19).</AbstractText>
<AbstractText Label="DESIGN">Multicentre, open label, randomised controlled trial.</AbstractText>
<AbstractText Label="SETTING">16 government designated covid-19 treatment centres in China, 11 to 29 February 2020.</AbstractText>
<AbstractText Label="PARTICIPANTS">150 patients admitted to hospital with laboratory confirmed covid-19 were included in the intention to treat analysis (75 patients assigned to hydroxychloroquine plus standard of care, 75 to standard of care alone).</AbstractText>
<AbstractText Label="INTERVENTIONS">Hydroxychloroquine administrated at a loading dose of 1200 mg daily for three days followed by a maintenance dose of 800 mg daily (total treatment duration: two or three weeks for patients with mild to moderate or severe disease, respectively).</AbstractText>
<AbstractText Label="MAIN OUTCOME MEASURE">Negative conversion of severe acute respiratory syndrome coronavirus 2 by 28 days, analysed according to the intention to treat principle. Adverse events were analysed in the safety population in which hydroxychloroquine recipients were participants who received at least one dose of hydroxychloroquine and hydroxychloroquine non-recipients were those managed with standard of care alone.</AbstractText>
<AbstractText Label="RESULTS">Of 150 patients, 148 had mild to moderate disease and two had severe disease. The mean duration from symptom onset to randomisation was 16.6 (SD 10.5; range 3-41) days. A total of 109 (73%) patients (56 standard of care; 53 standard of care plus hydroxychloroquine) had negative conversion well before 28 days, and the remaining 41 (27%) patients (19 standard of care; 22 standard of care plus hydroxychloroquine) were censored as they did not reach negative conversion of virus. The probability of negative conversion by 28 days in the standard of care plus hydroxychloroquine group was 85.4% (95% confidence interval 73.8% to 93.8%), similar to that in the standard of care group (81.3%, 71.2% to 89.6%). The difference between groups was 4.1% (95% confidence interval -10.3% to 18.5%). In the safety population, adverse events were recorded in 7/80 (9%) hydroxychloroquine non-recipients and in 21/70 (30%) hydroxychloroquine recipients. The most common adverse event in the hydroxychloroquine recipients was diarrhoea, reported in 7/70 (10%) patients. Two hydroxychloroquine recipients reported serious adverse events.</AbstractText>
<AbstractText Label="CONCLUSIONS">Administration of hydroxychloroquine did not result in a significantly higher probability of negative conversion than standard of care alone in patients admitted to hospital with mainly persistent mild to moderate covid-19. Adverse events were higher in hydroxychloroquine recipients than in non-recipients.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION">ChiCTR2000029868.</AbstractText>
<CopyrightInformation>© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. No commercial re-use. See rights and permissions. Published by BMJ.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tang</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Zhujun</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Han</LastName>
<ForeName>Mingfeng</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, No 2 People's Hospital of Fuyang City, Fuyang, Anhui, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Zhengyan</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Junwen</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Xiangyang No 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Wenjin</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Central Hospital of Ezhou, Ezhou, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Yaojie</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Yunmeng People's Hospital, Xiaogan, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xiao</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, First People's Hospital of Jingzhou City, Jingzhou, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Shengyong</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Erzhen</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Xiongbiao</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Jiuyong</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Hubei Space Hospital of Xiaogan, Xiaogan, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Jun</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Qingxia</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Disease, The Sixth People's Hospital of Zhengzhou, Zhengzhou, Henan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Youqin</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Disease, Wuhan No 7 Hospital, Wuhan, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Zhibin</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Departments of Respiratory Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei, China xieqingrjh@163.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Dan</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, The Third People's Hospital of Yichang, Yichang, Hubei, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Yaofeng</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, Xiao Gan First People's Hospital, Xiaogan, Hubei Province, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Leshan</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Clinical Research Centre, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qu</LastName>
<ForeName>Jieming</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ning</LastName>
<ForeName>Guang</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Guochao</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Qing</ForeName>
<Initials>Q</Initials>
<Identifier Source="ORCID">0000-0002-2582-8803</Identifier>
<AffiliationInfo><Affiliation>Department of Infectious Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China xieqingrjh@163.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>05</Month>
<Day>14</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>BMJ</MedlineTA>
<NlmUniqueID>8900488</NlmUniqueID>
<ISSNLinking>0959-8138</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber>
<NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName>
</SupplMeshList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>BMJ. 2020 May 19;369:m2018</RefSource>
<PMID Version="1">32430461</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: no support from any organisation for the submitted work other than those listed above; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>5</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>5</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>5</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32409561</ArticleId>
<ArticleId IdType="doi">10.1136/bmj.m1849</ArticleId>
<ArticleId IdType="pmc">PMC7221473</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>N Engl J Med. 2020 May 7;382(19):1787-1799</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32187464</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2006 Dec 15;43(12):1603-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17109296</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Res. 2020 Mar;30(3):269-271</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32020029</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Ther. 2009 Aug;31(8):1737-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19808132</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arthritis Rheum. 2002 Jun;46(6):1460-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12115175</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Rheumatol. 2020 Mar;16(3):155-166</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32034323</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2009 Apr 15;48(8):1003-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19281331</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 Mar 26;368:m1091</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32217556</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2004 Sep 9;351(11):1089-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15356306</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 May 7;382(19):1851-1852</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32187463</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Ophthalmol. 2015 Oct;160(4):799-805.e1</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26189086</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 Mar 11;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32159775</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2020 Apr 21;369:m1443</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32317267</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biosci Trends. 2020 Mar 16;14(1):72-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32074550</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drugs. 2017 Dec;77(18):1935-1966</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29143192</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2020 Mar 09;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32150618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Inflammopharmacology. 2015 Oct;23(5):231-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26246395</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Oman</li>
<li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Tang, Wei" sort="Tang, Wei" uniqKey="Tang W" first="Wei" last="Tang">Wei Tang</name>
</noRegion>
<name sortKey="Cao, Zhujun" sort="Cao, Zhujun" uniqKey="Cao Z" first="Zhujun" last="Cao">Zhujun Cao</name>
<name sortKey="Chen, Erzhen" sort="Chen, Erzhen" uniqKey="Chen E" first="Erzhen" last="Chen">Erzhen Chen</name>
<name sortKey="Chen, Junwen" sort="Chen, Junwen" uniqKey="Chen J" first="Junwen" last="Chen">Junwen Chen</name>
<name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name>
<name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name>
<name sortKey="Han, Mingfeng" sort="Han, Mingfeng" uniqKey="Han M" first="Mingfeng" last="Han">Mingfeng Han</name>
<name sortKey="Li, Dan" sort="Li, Dan" uniqKey="Li D" first="Dan" last="Li">Dan Li</name>
<name sortKey="Lin, Jun" sort="Lin, Jun" uniqKey="Lin J" first="Jun" last="Lin">Jun Lin</name>
<name sortKey="Liu, Leshan" sort="Liu, Leshan" uniqKey="Liu L" first="Leshan" last="Liu">Leshan Liu</name>
<name sortKey="Liu, Shengyong" sort="Liu, Shengyong" uniqKey="Liu S" first="Shengyong" last="Liu">Shengyong Liu</name>
<name sortKey="Ning, Guang" sort="Ning, Guang" uniqKey="Ning G" first="Guang" last="Ning">Guang Ning</name>
<name sortKey="Qu, Jieming" sort="Qu, Jieming" uniqKey="Qu J" first="Jieming" last="Qu">Jieming Qu</name>
<name sortKey="Qu, Jieming" sort="Qu, Jieming" uniqKey="Qu J" first="Jieming" last="Qu">Jieming Qu</name>
<name sortKey="Shi, Guochao" sort="Shi, Guochao" uniqKey="Shi G" first="Guochao" last="Shi">Guochao Shi</name>
<name sortKey="Shi, Guochao" sort="Shi, Guochao" uniqKey="Shi G" first="Guochao" last="Shi">Guochao Shi</name>
<name sortKey="Sun, Wenjin" sort="Sun, Wenjin" uniqKey="Sun W" first="Wenjin" last="Sun">Wenjin Sun</name>
<name sortKey="Tang, Wei" sort="Tang, Wei" uniqKey="Tang W" first="Wei" last="Tang">Wei Tang</name>
<name sortKey="Wang, Xiongbiao" sort="Wang, Xiongbiao" uniqKey="Wang X" first="Xiongbiao" last="Wang">Xiongbiao Wang</name>
<name sortKey="Wang, Zhengyan" sort="Wang, Zhengyan" uniqKey="Wang Z" first="Zhengyan" last="Wang">Zhengyan Wang</name>
<name sortKey="Wu, Yaojie" sort="Wu, Yaojie" uniqKey="Wu Y" first="Yaojie" last="Wu">Yaojie Wu</name>
<name sortKey="Xiao, Wei" sort="Xiao, Wei" uniqKey="Xiao W" first="Wei" last="Xiao">Wei Xiao</name>
<name sortKey="Yan, Youqin" sort="Yan, Youqin" uniqKey="Yan Y" first="Youqin" last="Yan">Youqin Yan</name>
<name sortKey="Yang, Jiuyong" sort="Yang, Jiuyong" uniqKey="Yang J" first="Jiuyong" last="Yang">Jiuyong Yang</name>
<name sortKey="Yang, Yaofeng" sort="Yang, Yaofeng" uniqKey="Yang Y" first="Yaofeng" last="Yang">Yaofeng Yang</name>
<name sortKey="Zhao, Qingxia" sort="Zhao, Qingxia" uniqKey="Zhao Q" first="Qingxia" last="Zhao">Qingxia Zhao</name>
</country>
<country name="Oman"><noRegion><name sortKey="Xie, Zhibin" sort="Xie, Zhibin" uniqKey="Xie Z" first="Zhibin" last="Xie">Zhibin Xie</name>
</noRegion>
<name sortKey="Xie, Qing" sort="Xie, Qing" uniqKey="Xie Q" first="Qing" last="Xie">Qing Xie</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001168 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001168 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= CovidChloroV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:32409561 |texte= Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32409561" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a CovidChloroV1
![]() | This area was generated with Dilib version V0.6.38. | ![]() |