CovidChloroV1, Main, Exploration, bibRecordById, pubmed:32391667

[A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19].

Identifieur interne : 000958 ( Main/Exploration ); précédent : 000957; suivant : 000959

[A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19].

Source :

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [ 1008-9292 ] ; 2020.

RBID : pubmed:32391667

Descripteurs français

KwdFr :
- ARN viral (isolement et purification), Betacoronavirus (isolement et purification), Chine (MeSH), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Infections à coronavirus (imagerie diagnostique), Infections à coronavirus (traitement médicamenteux), Pandémies (MeSH), Pneumopathie virale (imagerie diagnostique), Pneumopathie virale (traitement médicamenteux), Projets pilotes (MeSH), Résultat thérapeutique (MeSH).
MESH :
- imagerie diagnostique : Infections à coronavirus, Pneumopathie virale.
- isolement et purification : ARN viral, Betacoronavirus.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Hydroxychloroquine.
- Chine, Humains, Pandémies, Projets pilotes, Résultat thérapeutique.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Betacoronavirus (isolation & purification), COVID-19 (MeSH), China (MeSH), Coronavirus Infections (diagnostic imaging), Coronavirus Infections (drug therapy), Humans (MeSH), Hydroxychloroquine (therapeutic use), Pandemics (MeSH), Pilot Projects (MeSH), Pneumonia, Viral (diagnostic imaging), Pneumonia, Viral (drug therapy), RNA, Viral (isolation & purification), SARS-CoV-2 (MeSH), Treatment Outcome (MeSH).
MESH :
- chemical , isolation & purification : RNA, Viral.
- chemical , therapeutic use : Hydroxychloroquine.
- geographic : China.
- diagnostic imaging : Coronavirus Infections, Pneumonia, Viral.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- isolation & purification : Betacoronavirus.
- COVID-19, Humans, Pandemics, Pilot Projects, SARS-CoV-2, Treatment Outcome.

Abstract

OBJECTIVE

To evaluate the efficacy and safety of hydroxychloroquine (HCQ) in the treatment of patients with moderate coronavirus disease 2019 (COVID-19).

METHODS

We prospectively enrolled 30 treatment-naïve patients with confirmed COVID-19 after informed consent at Shanghai Public Health Clinical Center. The patients were randomized 1：1 to HCQ group and the control group. Patients in HCQ group were given HCQ 400 mg per day for 5 days plus conventional treatments, while those in the control group were given conventional treatment only. The primary endpoint was negative conversion rate of SARS-CoV-2 nucleic acid in respiratory pharyngeal swab on days 7 after randomization. This study has been approved by the Ethics Committee of Shanghai Public Health Clinical Center and registered online (NCT04261517).

RESULTS

One patient in HCQ group developed to severe during the treatment. On day 7, nucleic acid of throat swabs was negative in 13 (86.7%) cases in the HCQ group and 14 (93.3%) cases in the control group (

CONCLUSIONS

The prognosis of COVID-19 moderate patients is good. Larger sample size study are needed to investigate the effects of HCQ in the treatment of COVID-19. Subsequent research should determine better endpoint and fully consider the feasibility of experiments such as sample size.

DOI: 10.3785/j.issn.1008-9292.2020.03.03
PubMed: 32391667

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001742
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Le document en format XML

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<author><name sortKey="Huang, Dan" sort="Huang, Dan" uniqKey="Huang D" first="Dan" last="Huang">Dan Huang</name>
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<author><name sortKey="Song, Shuli" sort="Song, Shuli" uniqKey="Song S" first="Shuli" last="Song">Shuli Song</name>
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<author><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name>
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<author><name sortKey="Xia, Lu" sort="Xia, Lu" uniqKey="Xia L" first="Lu" last="Xia">Lu Xia</name>
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<author><name sortKey="Ling, Yun" sort="Ling, Yun" uniqKey="Ling Y" first="Yun" last="Ling">Yun Ling</name>
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<author><name sortKey="Huang, Dan" sort="Huang, Dan" uniqKey="Huang D" first="Dan" last="Huang">Dan Huang</name>
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<wicri:regionArea>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508</wicri:regionArea>
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<author><name sortKey="Song, Shuli" sort="Song, Shuli" uniqKey="Song S" first="Shuli" last="Song">Shuli Song</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508</wicri:regionArea>
<wicri:noRegion>Shanghai 201508</wicri:noRegion>
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<author><name sortKey="Zhang, Dandan" sort="Zhang, Dandan" uniqKey="Zhang D" first="Dandan" last="Zhang">Dandan Zhang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508</wicri:regionArea>
<wicri:noRegion>Shanghai 201508</wicri:noRegion>
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<author><name sortKey="Qian, Zhiping" sort="Qian, Zhiping" uniqKey="Qian Z" first="Zhiping" last="Qian">Zhiping Qian</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508</wicri:regionArea>
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<author><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name>
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<author><name sortKey="Shen, Yinzhong" sort="Shen, Yinzhong" uniqKey="Shen Y" first="Yinzhong" last="Shen">Yinzhong Shen</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (isolation & purification)</term>
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<term>Coronavirus Infections (diagnostic imaging)</term>
<term>Coronavirus Infections (drug therapy)</term>
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<term>Treatment Outcome</term>
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<term>Humains</term>
<term>Pandémies</term>
<term>Projets pilotes</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To evaluate the efficacy and safety of hydroxychloroquine (HCQ) in the treatment of patients with moderate coronavirus disease 2019 (COVID-19).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We prospectively enrolled 30 treatment-naïve patients with confirmed COVID-19 after informed consent at Shanghai Public Health Clinical Center. The patients were randomized 1：1 to HCQ group and the control group. Patients in HCQ group were given HCQ 400 mg per day for 5 days plus conventional treatments, while those in the control group were given conventional treatment only. The primary endpoint was negative conversion rate of SARS-CoV-2 nucleic acid in respiratory pharyngeal swab on days 7 after randomization. This study has been approved by the Ethics Committee of Shanghai Public Health Clinical Center and registered online (NCT04261517).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>One patient in HCQ group developed to severe during the treatment. On day 7, nucleic acid of throat swabs was negative in 13 (86.7%) cases in the HCQ group and 14 (93.3%) cases in the control group (</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>The prognosis of COVID-19 moderate patients is good. Larger sample size study are needed to investigate the effects of HCQ in the treatment of COVID-19. Subsequent research should determine better endpoint and fully consider the feasibility of experiments such as sample size.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32391667</PMID>
<DateCompleted><Year>2020</Year>
<Month>05</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>12</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">1008-9292</ISSN>
<JournalIssue CitedMedium="Print"><Volume>49</Volume>
<Issue>2</Issue>
<PubDate><Year>2020</Year>
<Month>May</Month>
<Day>25</Day>
</PubDate>
</JournalIssue>
<Title>Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences</Title>
<ISOAbbreviation>Zhejiang Da Xue Xue Bao Yi Xue Ban</ISOAbbreviation>
</Journal>
<ArticleTitle>[A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19].</ArticleTitle>
<Pagination><MedlinePgn>215-219</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3785/j.issn.1008-9292.2020.03.03</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate the efficacy and safety of hydroxychloroquine (HCQ) in the treatment of patients with moderate coronavirus disease 2019 (COVID-19).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We prospectively enrolled 30 treatment-naïve patients with confirmed COVID-19 after informed consent at Shanghai Public Health Clinical Center. The patients were randomized 1：1 to HCQ group and the control group. Patients in HCQ group were given HCQ 400 mg per day for 5 days plus conventional treatments, while those in the control group were given conventional treatment only. The primary endpoint was negative conversion rate of SARS-CoV-2 nucleic acid in respiratory pharyngeal swab on days 7 after randomization. This study has been approved by the Ethics Committee of Shanghai Public Health Clinical Center and registered online (NCT04261517).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">One patient in HCQ group developed to severe during the treatment. On day 7, nucleic acid of throat swabs was negative in 13 (86.7%) cases in the HCQ group and 14 (93.3%) cases in the control group (<i>P</i>
>0.05). The median duration from hospitalization to virus nucleic acid negative conservation was 4 (1,9) days in HCQ group, which is comparable to that in the control group [2 (1,4) days, Z=1.27, <i>P</i>
>0.05]. The median time for body temperature normalization in HCQ group was 1 (0,2) day after hospitalization, which was also comparable to that in the control group [1 (0,3) day]. Radiological progression was shown on CT images in 5 cases (33.3%) of the HCQ group and 7 cases (46.7%) of the control group, and all patients showed improvement in follow-up examinations. Four cases (26.7%) of the HCQ group and 3 cases (20%) of the control group had transient diarrhea and abnormal liver function (<i>P</i>
>0.05).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The prognosis of COVID-19 moderate patients is good. Larger sample size study are needed to investigate the effects of HCQ in the treatment of COVID-19. Subsequent research should determine better endpoint and fully consider the feasibility of experiments such as sample size.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Jun</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Danping</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Ping</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Qingnian</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xia</LastName>
<ForeName>Lu</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ling</LastName>
<ForeName>Yun</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Dan</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Shuli</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Dandan</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qian</LastName>
<ForeName>Zhiping</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Tao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shen</LastName>
<ForeName>Yinzhong</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Hongzhou</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>chi</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName>
<AccessionNumberList><AccessionNumber>NCT04261517</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>China</Country>
<MedlineTA>Zhejiang Da Xue Xue Bao Yi Xue Ban</MedlineTA>
<NlmUniqueID>100927946</NlmUniqueID>
<ISSNLinking>1008-9292</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber>
<NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006886" MajorTopicYN="Y">Hydroxychloroquine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010865" MajorTopicYN="N">Pilot Projects</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>5</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>5</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>5</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32391667</ArticleId>
<ArticleId IdType="doi">10.3785/j.issn.1008-9292.2020.03.03</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Jun" sort="Chen, Jun" uniqKey="Chen J" first="Jun" last="Chen">Jun Chen</name>
</noRegion>
<name sortKey="Huang, Dan" sort="Huang, Dan" uniqKey="Huang D" first="Dan" last="Huang">Dan Huang</name>
<name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name>
<name sortKey="Ling, Yun" sort="Ling, Yun" uniqKey="Ling Y" first="Yun" last="Ling">Yun Ling</name>
<name sortKey="Liu, Danping" sort="Liu, Danping" uniqKey="Liu D" first="Danping" last="Liu">Danping Liu</name>
<name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name>
<name sortKey="Liu, Ping" sort="Liu, Ping" uniqKey="Liu P" first="Ping" last="Liu">Ping Liu</name>
<name sortKey="Lu, Hongzhou" sort="Lu, Hongzhou" uniqKey="Lu H" first="Hongzhou" last="Lu">Hongzhou Lu</name>
<name sortKey="Qian, Zhiping" sort="Qian, Zhiping" uniqKey="Qian Z" first="Zhiping" last="Qian">Zhiping Qian</name>
<name sortKey="Shen, Yinzhong" sort="Shen, Yinzhong" uniqKey="Shen Y" first="Yinzhong" last="Shen">Yinzhong Shen</name>
<name sortKey="Song, Shuli" sort="Song, Shuli" uniqKey="Song S" first="Shuli" last="Song">Shuli Song</name>
<name sortKey="Xia, Lu" sort="Xia, Lu" uniqKey="Xia L" first="Lu" last="Xia">Lu Xia</name>
<name sortKey="Xu, Qingnian" sort="Xu, Qingnian" uniqKey="Xu Q" first="Qingnian" last="Xu">Qingnian Xu</name>
<name sortKey="Zhang, Dandan" sort="Zhang, Dandan" uniqKey="Zhang D" first="Dandan" last="Zhang">Dandan Zhang</name>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration COVID et hydrochloroquine
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Serveur d'exploration COVID et hydrochloroquine

[A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19].

[A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19].

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