Serveur d'exploration COVID et hydrochloroquine

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Current status of potential therapeutic candidates for the COVID-19 crisis.

Identifieur interne : 001449 ( Main/Exploration ); précédent : 001448; suivant : 001450

Current status of potential therapeutic candidates for the COVID-19 crisis.

Auteurs : Jiancheng Zhang [République populaire de Chine] ; Bing Xie [République populaire de Chine] ; Kenji Hashimoto [Japon]

Source :

RBID : pubmed:32334062

Descripteurs français

English descriptors

Abstract

As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept through 213 countries and infected more than 1,870,000 individuals, posing an unprecedented threat to international health and the economy. There is currently no specific treatment available for patients with COVID-19 infection. The lessons learned from past management of respiratory viral infections have provided insights into treating COVID-19. Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been tentatively applied in clinical settings. A number of these therapies have provided substantially curative benefits in treating patients with COVID-19 infection. Furthermore, intensive research and clinical trials are underway to assess the efficacy of existing drugs and identify potential therapeutic targets to develop new drugs for treating COVID-19. Herein, we summarize the current potential therapeutic approaches for diseases related to COVID-19 infection and introduce their mechanisms of action, safety, and effectiveness.

DOI: 10.1016/j.bbi.2020.04.046
PubMed: 32334062
PubMed Central: PMC7175848


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<term>Antibodies, Monoclonal, Humanized (therapeutic use)</term>
<term>Anticoagulants (therapeutic use)</term>
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<term>Bevacizumab (therapeutic use)</term>
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<term>Chloroquine (therapeutic use)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Immunization, Passive (MeSH)</term>
<term>Immunoglobulins, Intravenous (therapeutic use)</term>
<term>Immunologic Factors (therapeutic use)</term>
<term>Interferons (therapeutic use)</term>
<term>Janus Kinase Inhibitors (therapeutic use)</term>
<term>Killer Cells, Natural (MeSH)</term>
<term>Medicine, Chinese Traditional (MeSH)</term>
<term>Mesenchymal Stem Cell Transplantation (MeSH)</term>
<term>Nitric Oxide (therapeutic use)</term>
<term>Pandemics (MeSH)</term>
<term>Peptidyl-Dipeptidase A (MeSH)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Spike Glycoprotein, Coronavirus (MeSH)</term>
<term>Trace Elements (therapeutic use)</term>
<term>Viral Vaccines (therapeutic use)</term>
<term>Vitamins (therapeutic use)</term>
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<term>Antiviraux (usage thérapeutique)</term>
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<term>Hydroxychloroquine (usage thérapeutique)</term>
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<term>Immunoglobulines par voie veineuse (usage thérapeutique)</term>
<term>Infections à coronavirus (prévention et contrôle)</term>
<term>Infections à coronavirus (thérapie)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
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<term>Interférons (usage thérapeutique)</term>
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<term>Médecine traditionnelle chinoise (MeSH)</term>
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<term>Pandémies (MeSH)</term>
<term>Peptidyl-Dipeptidase A (MeSH)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Transplantation de cellules souches mésenchymateuses (MeSH)</term>
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<term>Vitamines (usage thérapeutique)</term>
<term>Zinc (usage thérapeutique)</term>
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<Keyword MajorTopicYN="Y">ACE2 blocker</Keyword>
<Keyword MajorTopicYN="Y">Antimalaria</Keyword>
<Keyword MajorTopicYN="Y">Antiviral: Chinese traditional medicine</Keyword>
<Keyword MajorTopicYN="Y">COVID-19</Keyword>
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<CoiStatement>Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</CoiStatement>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2020</Year>
<Month>04</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2020</Year>
<Month>04</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2020</Year>
<Month>04</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2020</Year>
<Month>4</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Year>2020</Year>
<Month>7</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="entrez">
<Year>2020</Year>
<Month>4</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">32334062</ArticleId>
<ArticleId IdType="pii">S0889-1591(20)30589-4</ArticleId>
<ArticleId IdType="doi">10.1016/j.bbi.2020.04.046</ArticleId>
<ArticleId IdType="pmc">PMC7175848</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Japon</li>
<li>République populaire de Chine</li>
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<region>
<li>Hubei</li>
</region>
<settlement>
<li>Wuhan</li>
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<country name="République populaire de Chine">
<region name="Hubei">
<name sortKey="Zhang, Jiancheng" sort="Zhang, Jiancheng" uniqKey="Zhang J" first="Jiancheng" last="Zhang">Jiancheng Zhang</name>
</region>
<name sortKey="Xie, Bing" sort="Xie, Bing" uniqKey="Xie B" first="Bing" last="Xie">Bing Xie</name>
</country>
<country name="Japon">
<noRegion>
<name sortKey="Hashimoto, Kenji" sort="Hashimoto, Kenji" uniqKey="Hashimoto K" first="Kenji" last="Hashimoto">Kenji Hashimoto</name>
</noRegion>
</country>
</tree>
</affiliations>
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