CovidChloroV1, Main, Exploration, bibRecordById, pubmed:32330521

COVID-19 coronavirus research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine.

Identifieur interne : 001784 ( Main/Exploration ); précédent : 001783; suivant : 001785

COVID-19 coronavirus research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine.

Auteurs : Paul Elias Alexander [Canada] ; Victoria Borg Debono [Canada] ; Manoj J. Mammen [États-Unis] ; Alfonso Iorio [Canada] ; Komal Aryal [Canada] ; Dianna Deng [Canada] ; Eva Brocard [France] ; Waleed Alhazzani [Canada]

Source :

Journal of clinical epidemiology [ 1878-5921 ] ; 2020.

RBID : pubmed:32330521

Descripteurs français

KwdFr :
- Chloroquine (usage thérapeutique), Essais contrôlés randomisés comme sujet (MeSH), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (épidémiologie), Pandémies (MeSH), Plan de recherche (normes), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (épidémiologie), Recherche biomédicale (méthodes), Études observationnelles comme sujet (MeSH).
MESH :
- méthodes : Recherche biomédicale.
- normes : Plan de recherche.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Chloroquine, Hydroxychloroquine.
- épidémiologie : Infections à coronavirus, Pneumopathie virale.
- Essais contrôlés randomisés comme sujet, Humains, Pandémies, Études observationnelles comme sujet.

English descriptors

KwdEn :
- Biomedical Research (methods), COVID-19 (MeSH), Chloroquine (therapeutic use), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Humans (MeSH), Hydroxychloroquine (therapeutic use), Observational Studies as Topic (MeSH), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (epidemiology), Randomized Controlled Trials as Topic (MeSH), Research Design (standards).
MESH :
- chemical , therapeutic use : Chloroquine, Hydroxychloroquine.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- methods : Biomedical Research.
- standards : Research Design.
- COVID-19, Humans, Observational Studies as Topic, Pandemics, Randomized Controlled Trials as Topic.

Abstract

OBJECTIVES/BACKGROUND AND OBJECTIVES

Prior epidemics of high-mortality human coronaviruses, such as the acute respiratory syndrome coronavirus (SARS-CoV or SARS-1) in 2003, have driven the characterization of compounds that could be possibly active against the currently emerging novel coronavirus SARS-CoV-2 (COVID-19). Presently, no approved treatment or prophylaxis is available for COVID-19. We comment on the existing COVID-19 research methodologies in general and the published reporting. Given the media attention and claims of effectiveness, we chose chloroquine and hydroxychloroquine, in combination with azithromycin, as an area of COVID-19 research to examine.

METHODS/STUDY DESIGN AND SETTING

MEDLINE and EMBASE electronic databases were searched from 2019 to present (April 3rd, 2020) using a mix of keywords such as COVID-19 and chloroquine and hydroxychloroquine. We also searched the largest clinical medicine preprint repository, medRxiv.org.

RESULTS

We found 6 studies, 3 randomized control trials and 3 observational studies, focusing on chloroquine and hydroxychloroquine (with azithromycin). We critically appraised the evidence.

CONCLUSION

We found that the COVID-19 research methodology is very poor in the area of chloroquine/hydroxychloroquine research. In screening the literature, we observed the same across COVID-19 research in relation to potential treatments. The reporting is very poor and sparse, and patient-important outcomes needed to discern decision-making priorities are not reported. We do understand the barriers to perform rigorous research in health care settings overwhelmed by a novel deadly disease. However, this emergency pandemic situation does not transform flawed methods and data into credible results. The adequately powered, comparative, and robust clinical research that is needed for optimal evidence-informed decision-making remains absent in COVID-19.

DOI: 10.1016/j.jclinepi.2020.04.016
PubMed: 32330521
PubMed Central: PMC7194626

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Observational Studies as Topic (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (epidemiology)</term>
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<term>Essais contrôlés randomisés comme sujet (MeSH)</term>
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<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Pandémies (MeSH)</term>
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<term>Hydroxychloroquine</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES/BACKGROUND AND OBJECTIVES</b>
</p>
<p>Prior epidemics of high-mortality human coronaviruses, such as the acute respiratory syndrome coronavirus (SARS-CoV or SARS-1) in 2003, have driven the characterization of compounds that could be possibly active against the currently emerging novel coronavirus SARS-CoV-2 (COVID-19). Presently, no approved treatment or prophylaxis is available for COVID-19. We comment on the existing COVID-19 research methodologies in general and the published reporting. Given the media attention and claims of effectiveness, we chose chloroquine and hydroxychloroquine, in combination with azithromycin, as an area of COVID-19 research to examine.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS/STUDY DESIGN AND SETTING</b>
</p>
<p>MEDLINE and EMBASE electronic databases were searched from 2019 to present (April 3rd, 2020) using a mix of keywords such as COVID-19 and chloroquine and hydroxychloroquine. We also searched the largest clinical medicine preprint repository, medRxiv.org.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>We found 6 studies, 3 randomized control trials and 3 observational studies, focusing on chloroquine and hydroxychloroquine (with azithromycin). We critically appraised the evidence.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>We found that the COVID-19 research methodology is very poor in the area of chloroquine/hydroxychloroquine research. In screening the literature, we observed the same across COVID-19 research in relation to potential treatments. The reporting is very poor and sparse, and patient-important outcomes needed to discern decision-making priorities are not reported. We do understand the barriers to perform rigorous research in health care settings overwhelmed by a novel deadly disease. However, this emergency pandemic situation does not transform flawed methods and data into credible results. The adequately powered, comparative, and robust clinical research that is needed for optimal evidence-informed decision-making remains absent in COVID-19.</p>
</div>
</front>
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<ArticleTitle>COVID-19 coronavirus research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine.</ArticleTitle>
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<Abstract><AbstractText Label="OBJECTIVES/BACKGROUND AND OBJECTIVES">Prior epidemics of high-mortality human coronaviruses, such as the acute respiratory syndrome coronavirus (SARS-CoV or SARS-1) in 2003, have driven the characterization of compounds that could be possibly active against the currently emerging novel coronavirus SARS-CoV-2 (COVID-19). Presently, no approved treatment or prophylaxis is available for COVID-19. We comment on the existing COVID-19 research methodologies in general and the published reporting. Given the media attention and claims of effectiveness, we chose chloroquine and hydroxychloroquine, in combination with azithromycin, as an area of COVID-19 research to examine.</AbstractText>
<AbstractText Label="METHODS/STUDY DESIGN AND SETTING">MEDLINE and EMBASE electronic databases were searched from 2019 to present (April 3rd, 2020) using a mix of keywords such as COVID-19 and chloroquine and hydroxychloroquine. We also searched the largest clinical medicine preprint repository, medRxiv.org.</AbstractText>
<AbstractText Label="RESULTS">We found 6 studies, 3 randomized control trials and 3 observational studies, focusing on chloroquine and hydroxychloroquine (with azithromycin). We critically appraised the evidence.</AbstractText>
<AbstractText Label="CONCLUSION">We found that the COVID-19 research methodology is very poor in the area of chloroquine/hydroxychloroquine research. In screening the literature, we observed the same across COVID-19 research in relation to potential treatments. The reporting is very poor and sparse, and patient-important outcomes needed to discern decision-making priorities are not reported. We do understand the barriers to perform rigorous research in health care settings overwhelmed by a novel deadly disease. However, this emergency pandemic situation does not transform flawed methods and data into credible results. The adequately powered, comparative, and robust clinical research that is needed for optimal evidence-informed decision-making remains absent in COVID-19.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Alexander</LastName>
<ForeName>Paul Elias</ForeName>
<Initials>PE</Initials>
<AffiliationInfo><Affiliation>Health Research Methods, Evidence and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada; GUIDE Research Methods Group, McMaster University, Hamilton, Ontario, Canada. Electronic address: alexap@mcmaster.ca.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Debono</LastName>
<ForeName>Victoria Borg</ForeName>
<Initials>VB</Initials>
<AffiliationInfo><Affiliation>Health Research Methods, Evidence and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada; Department of Anesthesia, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mammen</LastName>
<ForeName>Manoj J</ForeName>
<Initials>MJ</Initials>
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	Serveur d'exploration COVID et hydrochloroquine
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Serveur d'exploration COVID et hydrochloroquine

COVID-19 coronavirus research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine.

COVID-19 coronavirus research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine.

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