CovidChloroV1, Main, Exploration, bibRecord, 001845

Baricitinib as rescue therapy in a patient with COVID-19 with no complete response to sarilumab.

Identifieur interne : 001845 ( Main/Exploration ); précédent : 001844; suivant : 001846

Baricitinib as rescue therapy in a patient with COVID-19 with no complete response to sarilumab.

Auteurs : A. Cingolani [Italie] ; A M Tummolo [Italie] ; G. Montemurro [Italie] ; E. Gremese [Italie] ; L. Larosa [Italie] ; M C Cipriani [Italie] ; G. Pasciuto [Italie] ; R. Liperoti [Italie] ; R. Murri [Italie] ; T. Pirronti [Italie] ; R. Cauda [Italie] ; M. Fantoni [Italie]

Source :

Infection [ 1439-0973 ] ; 2020.

RBID : pubmed:32642806

Descripteurs français

KwdFr :
- Anticorps monoclonaux humanisés (usage thérapeutique), Antiviraux (usage thérapeutique), Association médicamenteuse (MeSH), Azithromycine (usage thérapeutique), Azétidines (usage thérapeutique), Betacoronavirus (effets des médicaments et des substances chimiques), Betacoronavirus (pathogénicité), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Infections à coronavirus (physiopathologie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Insuffisance respiratoire (physiopathologie), Insuffisance respiratoire (traitement médicamenteux), Insuffisance respiratoire (virologie), Lopinavir (usage thérapeutique), Maladie aigüe (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (physiopathologie), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (virologie), Repositionnement des médicaments (MeSH), Ritonavir (usage thérapeutique), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Sulfonamides (usage thérapeutique).
MESH :
- effets des médicaments et des substances chimiques : Betacoronavirus.
- pathogénicité : Betacoronavirus.
- physiopathologie : Infections à coronavirus, Insuffisance respiratoire, Pneumopathie virale.
- traitement médicamenteux : Infections à coronavirus, Insuffisance respiratoire, Pneumopathie virale.
- usage thérapeutique : Anticorps monoclonaux humanisés, Antiviraux, Azithromycine, Azétidines, Hydroxychloroquine, Lopinavir, Ritonavir, Sulfonamides.
- virologie : Infections à coronavirus, Insuffisance respiratoire, Pneumopathie virale.
- Association médicamenteuse, Humains, Maladie aigüe, Mâle, Pandémies, Repositionnement des médicaments, Résultat thérapeutique, Sujet âgé.

English descriptors

KwdEn :
- Acute Disease (MeSH), Aged (MeSH), Antibodies, Monoclonal, Humanized (therapeutic use), Antiviral Agents (therapeutic use), Azetidines (therapeutic use), Azithromycin (therapeutic use), Betacoronavirus (drug effects), Betacoronavirus (pathogenicity), COVID-19 (MeSH), Coronavirus Infections (drug therapy), Coronavirus Infections (physiopathology), Coronavirus Infections (virology), Drug Combinations (MeSH), Drug Repositioning (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Lopinavir (therapeutic use), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (physiopathology), Pneumonia, Viral (virology), Respiratory Insufficiency (drug therapy), Respiratory Insufficiency (physiopathology), Respiratory Insufficiency (virology), Ritonavir (therapeutic use), SARS-CoV-2 (MeSH), Sulfonamides (therapeutic use), Treatment Outcome (MeSH).
MESH :
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Antiviral Agents, Azetidines, Azithromycin, Hydroxychloroquine, Lopinavir, Ritonavir, Sulfonamides.
- drug effects : Betacoronavirus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral, Respiratory Insufficiency.
- pathogenicity : Betacoronavirus.
- physiopathology : Coronavirus Infections, Pneumonia, Viral, Respiratory Insufficiency.
- virology : Coronavirus Infections, Pneumonia, Viral, Respiratory Insufficiency.
- Acute Disease, Aged, COVID-19, Drug Combinations, Drug Repositioning, Humans, Male, Pandemics, SARS-CoV-2, Treatment Outcome.

Abstract

A patient with COVID-19-related severe respiratory failure, with insufficient response to an antiretroviral therapy, hydroxychloroquine and Interleukin-6 (IL-6) antagonist therapy, presented a prompt resolution of the respiratory function and improvement in the radiological picture after baricitinib at an oral dose of 4 mg per day for 2 weeks.

DOI: 10.1007/s15010-020-01476-7
PubMed: 32642806
PubMed Central: PMC7340855

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001197
to stream Main, to step Curation: 001197

Le document en format XML

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<affiliation wicri:level="3"><nlm:affiliation>Dipartimento di Sicurezza e Bioetica, Università Cattolica S. Cuore, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
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<author><name sortKey="Pirronti, T" sort="Pirronti, T" uniqKey="Pirronti T" first="T" last="Pirronti">T. Pirronti</name>
<affiliation wicri:level="3"><nlm:affiliation>Dipartimento di Diagnostica per immagini, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Diagnostica per immagini, Fondazione Policlinico Gemelli IRCCS, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
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<affiliation wicri:level="3"><nlm:affiliation>Dipartimento di Scienze Radiologiche e Ematologiche, Università Cattolica S. Cuore, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Radiologiche e Ematologiche, Università Cattolica S. Cuore, Milan</wicri:regionArea>
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<author><name sortKey="Cauda, R" sort="Cauda, R" uniqKey="Cauda R" first="R" last="Cauda">R. Cauda</name>
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<country xml:lang="fr">Italie</country>
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<affiliation wicri:level="3"><nlm:affiliation>Dipartimento di Sicurezza e Bioetica, Università Cattolica S. Cuore, Milan, Italy.</nlm:affiliation>
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<author><name sortKey="Fantoni, M" sort="Fantoni, M" uniqKey="Fantoni M" first="M" last="Fantoni">M. Fantoni</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Gemelli IRCCS, Rome</wicri:regionArea>
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</placeName>
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<affiliation wicri:level="3"><nlm:affiliation>Dipartimento di Sicurezza e Bioetica, Università Cattolica S. Cuore, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
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<series><title level="j">Infection</title>
<idno type="eISSN">1439-0973</idno>
<imprint><date when="2020" type="published">2020</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Disease (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Antibodies, Monoclonal, Humanized (therapeutic use)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Azetidines (therapeutic use)</term>
<term>Azithromycin (therapeutic use)</term>
<term>Betacoronavirus (drug effects)</term>
<term>Betacoronavirus (pathogenicity)</term>
<term>COVID-19 (MeSH)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (physiopathology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Drug Combinations (MeSH)</term>
<term>Drug Repositioning (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Lopinavir (therapeutic use)</term>
<term>Male (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (physiopathology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Respiratory Insufficiency (drug therapy)</term>
<term>Respiratory Insufficiency (physiopathology)</term>
<term>Respiratory Insufficiency (virology)</term>
<term>Ritonavir (therapeutic use)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Sulfonamides (therapeutic use)</term>
<term>Treatment Outcome (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps monoclonaux humanisés (usage thérapeutique)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Association médicamenteuse (MeSH)</term>
<term>Azithromycine (usage thérapeutique)</term>
<term>Azétidines (usage thérapeutique)</term>
<term>Betacoronavirus (effets des médicaments et des substances chimiques)</term>
<term>Betacoronavirus (pathogénicité)</term>
<term>Humains (MeSH)</term>
<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Infections à coronavirus (physiopathologie)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Insuffisance respiratoire (physiopathologie)</term>
<term>Insuffisance respiratoire (traitement médicamenteux)</term>
<term>Insuffisance respiratoire (virologie)</term>
<term>Lopinavir (usage thérapeutique)</term>
<term>Maladie aigüe (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (physiopathologie)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Repositionnement des médicaments (MeSH)</term>
<term>Ritonavir (usage thérapeutique)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sulfonamides (usage thérapeutique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term>
<term>Antiviral Agents</term>
<term>Azetidines</term>
<term>Azithromycin</term>
<term>Hydroxychloroquine</term>
<term>Lopinavir</term>
<term>Ritonavir</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Insufficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Insuffisance respiratoire</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Insufficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Insuffisance respiratoire</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term>
<term>Antiviraux</term>
<term>Azithromycine</term>
<term>Azétidines</term>
<term>Hydroxychloroquine</term>
<term>Lopinavir</term>
<term>Ritonavir</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Insuffisance respiratoire</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Insufficiency</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Acute Disease</term>
<term>Aged</term>
<term>COVID-19</term>
<term>Drug Combinations</term>
<term>Drug Repositioning</term>
<term>Humans</term>
<term>Male</term>
<term>Pandemics</term>
<term>SARS-CoV-2</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Association médicamenteuse</term>
<term>Humains</term>
<term>Maladie aigüe</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Repositionnement des médicaments</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
</keywords>
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<front><div type="abstract" xml:lang="en">A patient with COVID-19-related severe respiratory failure, with insufficient response to an antiretroviral therapy, hydroxychloroquine and Interleukin-6 (IL-6) antagonist therapy, presented a prompt resolution of the respiratory function and improvement in the radiological picture after baricitinib at an oral dose of 4 mg per day for 2 weeks.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32642806</PMID>
<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>01</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1439-0973</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>48</Volume>
<Issue>5</Issue>
<PubDate><Year>2020</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Infection</Title>
<ISOAbbreviation>Infection</ISOAbbreviation>
</Journal>
<ArticleTitle>Baricitinib as rescue therapy in a patient with COVID-19 with no complete response to sarilumab.</ArticleTitle>
<Pagination><MedlinePgn>767-771</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s15010-020-01476-7</ELocationID>
<Abstract><AbstractText>A patient with COVID-19-related severe respiratory failure, with insufficient response to an antiretroviral therapy, hydroxychloroquine and Interleukin-6 (IL-6) antagonist therapy, presented a prompt resolution of the respiratory function and improvement in the radiological picture after baricitinib at an oral dose of 4 mg per day for 2 weeks.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cingolani</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Dipartimento di Sicurezza e Bioetica, Università Cattolica S. Cuore, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tummolo</LastName>
<ForeName>A M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Scienze dell'invecchiamento, Fondazione Policlinico Gemelli IRCCS, Rome, Italy. anita.tummolo@gmail.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Covid 2 Columbus, Fondazione Policlinico Gemelli, IRCCS, Università Cattolica S. Cuore, L.go A. Gemelli 8, 00167, Rome, Italy. anita.tummolo@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Montemurro</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gremese</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Dipartimento di Scienze Geriatriche e Ortopediche, Università Cattolica S. Cuore, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Larosa</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Diagnostica per immagini, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cipriani</LastName>
<ForeName>M C</ForeName>
<Initials>MC</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Scienze dell'invecchiamento, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pasciuto</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liperoti</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Scienze dell'invecchiamento, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Dipartimento di Scienze Geriatriche e Ortopediche, Università Cattolica S. Cuore, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Murri</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Dipartimento di Sicurezza e Bioetica, Università Cattolica S. Cuore, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pirronti</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Diagnostica per immagini, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Dipartimento di Scienze Radiologiche e Ematologiche, Università Cattolica S. Cuore, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cauda</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Dipartimento di Sicurezza e Bioetica, Università Cattolica S. Cuore, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fantoni</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Dipartimento di Sicurezza e Bioetica, Università Cattolica S. Cuore, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>for COVID 2 Columbus Working Group</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>07</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Infection</MedlineTA>
<NlmUniqueID>0365307</NlmUniqueID>
<ISSNLinking>0300-8126</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D061067">Antibodies, Monoclonal, Humanized</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001384">Azetidines</NameOfSubstance>
</Chemical>
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<NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D013449">Sulfonamides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C558899">lopinavir-ritonavir drug combination</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>2494G1JF75</RegistryNumber>
<NameOfSubstance UI="D061466">Lopinavir</NameOfSubstance>
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<NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance>
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<Chemical><RegistryNumber>83905-01-5</RegistryNumber>
<NameOfSubstance UI="D017963">Azithromycin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>ISP4442I3Y</RegistryNumber>
<NameOfSubstance UI="C000596027">baricitinib</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>NU90V55F8I</RegistryNumber>
<NameOfSubstance UI="C000592401">sarilumab</NameOfSubstance>
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<Chemical><RegistryNumber>O3J8G9O825</RegistryNumber>
<NameOfSubstance UI="D019438">Ritonavir</NameOfSubstance>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000208" MajorTopicYN="N">Acute Disease</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061067" MajorTopicYN="N">Antibodies, Monoclonal, Humanized</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
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<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017963" MajorTopicYN="N">Azithromycin</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
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<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058492" MajorTopicYN="N">Drug Repositioning</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061466" MajorTopicYN="N">Lopinavir</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012131" MajorTopicYN="N">Respiratory Insufficiency</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019438" MajorTopicYN="N">Ritonavir</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013449" MajorTopicYN="N">Sulfonamides</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Baricitinib</Keyword>
<Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Immunotherapy</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
<Keyword MajorTopicYN="N">Sarilumab</Keyword>
</KeywordList>
<InvestigatorList><Investigator ValidYN="Y"><LastName>Bellieni</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Brandi</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Calabrese</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Calvello</LastName>
<ForeName>M R</ForeName>
<Initials>MR</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ciccullo</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
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	Serveur d'exploration COVID et hydrochloroquine
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Baricitinib as rescue therapy in a patient with COVID-19 with no complete response to sarilumab.

Baricitinib as rescue therapy in a patient with COVID-19 with no complete response to sarilumab.

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