Biomedical Research in Times of Emergency: Lessons From History.
Identifieur interne : 001830 ( Main/Exploration ); précédent : 001829; suivant : 001831Biomedical Research in Times of Emergency: Lessons From History.
Auteurs : Deborah Doroshow ; Scott Podolsky ; Justin BarrSource :
- Annals of internal medicine [ 1539-3704 ] ; 2020.
Descripteurs français
- KwdFr :
- Betacoronavirus (MeSH), Expérimentation humaine (histoire), Histoire du 20ème siècle (MeSH), Histoire du 21ème siècle (MeSH), Humains (MeSH), Infections à coronavirus (histoire), Infections à coronavirus (thérapie), Infections à coronavirus (traitement médicamenteux), Pandémies (histoire), Pneumopathie virale (histoire), Pneumopathie virale (thérapie), Recherche biomédicale (histoire), Recherche biomédicale (normes), Urgences (histoire).
- MESH :
- histoire : Expérimentation humaine, Infections à coronavirus, Pandémies, Pneumopathie virale, Recherche biomédicale, Urgences.
- normes : Recherche biomédicale.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- traitement médicamenteux : Infections à coronavirus.
- Betacoronavirus, Histoire du 20ème siècle, Histoire du 21ème siècle, Humains.
English descriptors
- KwdEn :
- Betacoronavirus (MeSH), Biomedical Research (history), Biomedical Research (standards), COVID-19 (MeSH), Coronavirus Infections (drug therapy), Coronavirus Infections (history), Coronavirus Infections (therapy), Emergencies (history), History, 20th Century (MeSH), History, 21st Century (MeSH), Human Experimentation (history), Humans (MeSH), Pandemics (history), Pneumonia, Viral (history), Pneumonia, Viral (therapy), SARS-CoV-2 (MeSH).
- MESH :
- drug therapy : Coronavirus Infections.
- history : Biomedical Research, Coronavirus Infections, Emergencies, Human Experimentation, Pandemics, Pneumonia, Viral.
- standards : Biomedical Research.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Betacoronavirus, COVID-19, History, 20th Century, History, 21st Century, Humans, SARS-CoV-2.
Abstract
Coronavirus disease 2019 (COVID-19) has sickened millions, killed hundreds of thousands, and utterly disrupted the daily lives of billions of people around the world. In an effort to ameliorate this devastation, the biomedical research complex has allocated billions of dollars and scientists have initiated hundreds of clinical trials in an expedited effort to understand, prevent, and treat this disease. National emergencies can stimulate significant investment of financial, physical, and intellectual resources that catalyze impressive scientific accomplishments, as evident with the Manhattan Project, penicillin, and the polio vaccines in the 20th century. However, pressurized research has also led to false promises, disastrous consequences, and breaches in ethics. Antiserum in the 1918 flu epidemic, contaminated yellow fever vaccines in World War II, and unethical human experimentation with mustard gas offer just a few cautionary exemplars. It is critical to continue biomedical research efforts to address this pandemic, and it is appropriate that they receive priority in both attention and funding. But history also demonstrates the importance of treating early results-such as those associated with hydroxychloroquine-with caution as we only begin to understand the biology, epidemiology, and potential target points of COVID-19.
DOI: 10.7326/M20-2076
PubMed: 32379854
PubMed Central: PMC7233188
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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(MeSH)</term><term>Histoire du 21ème siècle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (histoire)</term><term>Infections à coronavirus (thérapie)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Pandémies (histoire)</term><term>Pneumopathie virale (histoire)</term><term>Pneumopathie virale (thérapie)</term><term>Recherche biomédicale (histoire)</term><term>Recherche biomédicale (normes)</term><term>Urgences (histoire)</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="histoire" xml:lang="fr"><term>Expérimentation humaine</term><term>Infections à coronavirus</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Recherche biomédicale</term><term>Urgences</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Biomedical Research</term><term>Coronavirus 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In an effort to ameliorate this devastation, the biomedical research complex has allocated billions of dollars and scientists have initiated hundreds of clinical trials in an expedited effort to understand, prevent, and treat this disease. National emergencies can stimulate significant investment of financial, physical, and intellectual resources that catalyze impressive scientific accomplishments, as evident with the Manhattan Project, penicillin, and the polio vaccines in the 20th century. However, pressurized research has also led to false promises, disastrous consequences, and breaches in ethics. Antiserum in the 1918 flu epidemic, contaminated yellow fever vaccines in World War II, and unethical human experimentation with mustard gas offer just a few cautionary exemplars. It is critical to continue biomedical research efforts to address this pandemic, and it is appropriate that they receive priority in both attention and funding. But history also demonstrates the importance of treating early results-such as those associated with hydroxychloroquine-with caution as we only begin to understand the biology, epidemiology, and potential target points of COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32379854</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>27</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1539-3704</ISSN><JournalIssue CitedMedium="Internet"><Volume>173</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>08</Month><Day>18</Day></PubDate></JournalIssue><Title>Annals of internal medicine</Title><ISOAbbreviation>Ann Intern Med</ISOAbbreviation></Journal><ArticleTitle>Biomedical Research in Times of Emergency: Lessons From History.</ArticleTitle><Pagination><MedlinePgn>297-299</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.7326/M20-2076</ELocationID><Abstract><AbstractText>Coronavirus disease 2019 (COVID-19) has sickened millions, killed hundreds of thousands, and utterly disrupted the daily lives of billions of people around the world. In an effort to ameliorate this devastation, the biomedical research complex has allocated billions of dollars and scientists have initiated hundreds of clinical trials in an expedited effort to understand, prevent, and treat this disease. National emergencies can stimulate significant investment of financial, physical, and intellectual resources that catalyze impressive scientific accomplishments, as evident with the Manhattan Project, penicillin, and the polio vaccines in the 20th century. However, pressurized research has also led to false promises, disastrous consequences, and breaches in ethics. Antiserum in the 1918 flu epidemic, contaminated yellow fever vaccines in World War II, and unethical human experimentation with mustard gas offer just a few cautionary exemplars. It is critical to continue biomedical research efforts to address this pandemic, and it is appropriate that they receive priority in both attention and funding. 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first="Deborah" last="Doroshow">Deborah Doroshow</name><name sortKey="Podolsky, Scott" sort="Podolsky, Scott" uniqKey="Podolsky S" first="Scott" last="Podolsky">Scott Podolsky</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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