Hydroxychloroquine versus Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS). Protocol for a Pragmatic, Open-Label, Active Comparator Trial.
Identifieur interne : 001142 ( Main/Exploration ); précédent : 001141; suivant : 001143Hydroxychloroquine versus Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS). Protocol for a Pragmatic, Open-Label, Active Comparator Trial.
Auteurs : Samuel M. Brown ; Ithan D. Peltan ; Brandon Webb [États-Unis] ; Naresh Kumar ; Nathan Starr [États-Unis] ; Colin Grissom ; Whitney R. Buckel ; Raj Srivastava [États-Unis] ; Estelle S. Harris ; Lindsay M. Leither ; Stacy A. Johnson ; Robert Paine ; Tom Greene [États-Unis]Source :
- Annals of the American Thoracic Society [ 2325-6621 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Anti-infectieux (administration et posologie), Anti-infectieux (effets indésirables), Azithromycine (administration et posologie), Azithromycine (effets indésirables), Betacoronavirus (effets des médicaments et des substances chimiques), Betacoronavirus (isolement et purification), Essais contrôlés randomisés comme sujet (MeSH), Femelle (MeSH), Humains (MeSH), Hydroxychloroquine (administration et posologie), Hydroxychloroquine (effets indésirables), Infections à coronavirus (diagnostic), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (épidémiologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (diagnostic), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (épidémiologie), Résultat thérapeutique (MeSH), Surveillance des médicaments (méthodes), Utah (MeSH).
- MESH :
- administration et posologie : Anti-infectieux, Azithromycine, Hydroxychloroquine.
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- effets des médicaments et des substances chimiques : Betacoronavirus.
- effets indésirables : Anti-infectieux, Azithromycine, Hydroxychloroquine.
- isolement et purification : Betacoronavirus.
- méthodes : Surveillance des médicaments.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Infections à coronavirus, Pneumopathie virale.
- Adulte, Essais contrôlés randomisés comme sujet, Femelle, Humains, Mâle, Pandémies, Résultat thérapeutique, Utah.
English descriptors
- KwdEn :
- Adult (MeSH), Anti-Infective Agents (administration & dosage), Anti-Infective Agents (adverse effects), Azithromycin (administration & dosage), Azithromycin (adverse effects), Betacoronavirus (drug effects), Betacoronavirus (isolation & purification), COVID-19 (MeSH), Coronavirus Infections (diagnosis), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Drug Monitoring (methods), Female (MeSH), Humans (MeSH), Hydroxychloroquine (administration & dosage), Hydroxychloroquine (adverse effects), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (drug therapy), Pneumonia, Viral (epidemiology), Randomized Controlled Trials as Topic (MeSH), SARS-CoV-2 (MeSH), Treatment Outcome (MeSH), Utah (MeSH).
- MESH :
- chemical , administration & dosage : Anti-Infective Agents, Azithromycin, Hydroxychloroquine.
- chemical , adverse effects : Anti-Infective Agents, Azithromycin, Hydroxychloroquine.
- geographic : Utah.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- drug effects : Betacoronavirus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- isolation & purification : Betacoronavirus.
- methods : Drug Monitoring.
- Adult, COVID-19, Female, Humans, Male, Pandemics, Randomized Controlled Trials as Topic, SARS-CoV-2, Treatment Outcome.
Abstract
Coronavirus disease (COVID-19) is a potentially fatal illness with no proven therapy beyond excellent supportive care. Treatments are urgently sought. Adaptations to traditional trial logistics and design to allow rapid implementation, evaluation of trials within a global trials context, flexible interim monitoring, and access outside traditional research hospitals (even in settings where formal placebos are unavailable) may be helpful. Thoughtful adaptations to traditional trial designs, especially within the global context of related studies, may also foster collaborative relationships among government, community, and the research enterprise. Here, we describe the protocol for a pragmatic, active comparator trial in as many as 300 patients comparing two current "off-label" treatments for COVID-19-hydroxychloroquine and azithromycin-in academic and nonacademic hospitals in Utah. We developed the trial in response to local pressures for widespread, indiscriminate off-label use of these medications. We used a hybrid Bayesian-frequentist design for interim monitoring to allow rapid, contextual assessment of the available evidence. We also developed an inference grid for interpreting the range of possible results from this trial within the context of parallel trials and prepared for a network meta-analysis of the resulting data. This trial was prospectively registered (ClinicalTrials.gov Identifier: NCT04329832) before enrollment of the first patient.Clinical trial registered with www.clinicaltrials.gov (NCT04329832).
DOI: 10.1513/AnnalsATS.202004-309SD
PubMed: 32425051
PubMed Central: PMC7393787
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hydroxychloroquine versus Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS). Protocol for a Pragmatic, Open-Label, Active Comparator Trial.</title><author><name sortKey="Brown, Samuel M" sort="Brown, Samuel M" uniqKey="Brown S" first="Samuel M" last="Brown">Samuel M. Brown</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Peltan, Ithan D" sort="Peltan, Ithan D" uniqKey="Peltan I" first="Ithan D" last="Peltan">Ithan D. Peltan</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Webb, Brandon" sort="Webb, Brandon" uniqKey="Webb B" first="Brandon" last="Webb">Brandon Webb</name><affiliation><nlm:affiliation>Infectious Disease, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Infectious Disease.</nlm:affiliation><wicri:noCountry code="no comma">Infectious Disease.</wicri:noCountry><wicri:noCountry code="no comma">Infectious Disease.</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:affiliation>Infectious Disease, Stanford University, Stanford, California; and.</nlm:affiliation><orgName type="university">Université Stanford</orgName><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kumar, Naresh" sort="Kumar, Naresh" uniqKey="Kumar N" first="Naresh" last="Kumar">Naresh Kumar</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Infectious Disease, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Starr, Nathan" sort="Starr, Nathan" uniqKey="Starr N" first="Nathan" last="Starr">Nathan Starr</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Medicine, Intermountain Medical Center, Murray, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Hospital Medicine, Intermountain Medical Center, Murray</wicri:cityArea></affiliation></author><author><name sortKey="Grissom, Colin" sort="Grissom, Colin" uniqKey="Grissom C" first="Colin" last="Grissom">Colin Grissom</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Buckel, Whitney R" sort="Buckel, Whitney R" uniqKey="Buckel W" first="Whitney R" last="Buckel">Whitney R. Buckel</name><affiliation><nlm:affiliation>Pharmacy Services and.</nlm:affiliation><wicri:noCountry code="no comma">Pharmacy Services and.</wicri:noCountry><wicri:noCountry code="no comma">Pharmacy Services and.</wicri:noCountry></affiliation></author><author><name sortKey="Srivastava, Raj" sort="Srivastava, Raj" uniqKey="Srivastava R" first="Raj" last="Srivastava">Raj Srivastava</name><affiliation><nlm:affiliation>Inpatient Medicine, Department of Pediatrics.</nlm:affiliation><wicri:noCountry code="subField">Department of Pediatrics</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:affiliation>Healthcare Delivery Institute, Intermountain Healthcare, Murray, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Healthcare Delivery Institute, Intermountain Healthcare, Murray</wicri:cityArea></affiliation></author><author><name sortKey="Harris, Estelle S" sort="Harris, Estelle S" uniqKey="Harris E" first="Estelle S" last="Harris">Estelle S. Harris</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Leither, Lindsay M" sort="Leither, Lindsay M" uniqKey="Leither L" first="Lindsay M" last="Leither">Lindsay M. Leither</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Johnson, Stacy A" sort="Johnson, Stacy A" uniqKey="Johnson S" first="Stacy A" last="Johnson">Stacy A. Johnson</name><affiliation><nlm:affiliation>Hospital Medicine, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Paine, Robert" sort="Paine, Robert" uniqKey="Paine R" first="Robert" last="Paine">Robert Paine</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Greene, Tom" sort="Greene, Tom" uniqKey="Greene T" first="Tom" last="Greene">Tom Greene</name><affiliation wicri:level="2"><nlm:affiliation>Biostatistics, University of Utah, Salt Lake City, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Biostatistics, University of Utah, Salt Lake City</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32425051</idno><idno type="pmid">32425051</idno><idno type="doi">10.1513/AnnalsATS.202004-309SD</idno><idno type="pmc">PMC7393787</idno><idno type="wicri:Area/Main/Corpus">001659</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001659</idno><idno type="wicri:Area/Main/Curation">001659</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001659</idno><idno type="wicri:Area/Main/Exploration">001659</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine versus Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS). Protocol for a Pragmatic, Open-Label, Active Comparator Trial.</title><author><name sortKey="Brown, Samuel M" sort="Brown, Samuel M" uniqKey="Brown S" first="Samuel M" last="Brown">Samuel M. Brown</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Peltan, Ithan D" sort="Peltan, Ithan D" uniqKey="Peltan I" first="Ithan D" last="Peltan">Ithan D. Peltan</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Webb, Brandon" sort="Webb, Brandon" uniqKey="Webb B" first="Brandon" last="Webb">Brandon Webb</name><affiliation><nlm:affiliation>Infectious Disease, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Infectious Disease.</nlm:affiliation><wicri:noCountry code="no comma">Infectious Disease.</wicri:noCountry><wicri:noCountry code="no comma">Infectious Disease.</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:affiliation>Infectious Disease, Stanford University, Stanford, California; and.</nlm:affiliation><orgName type="university">Université Stanford</orgName><country>États-Unis</country><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kumar, Naresh" sort="Kumar, Naresh" uniqKey="Kumar N" first="Naresh" last="Kumar">Naresh Kumar</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Infectious Disease, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Starr, Nathan" sort="Starr, Nathan" uniqKey="Starr N" first="Nathan" last="Starr">Nathan Starr</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Medicine, Intermountain Medical Center, Murray, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Hospital Medicine, Intermountain Medical Center, Murray</wicri:cityArea></affiliation></author><author><name sortKey="Grissom, Colin" sort="Grissom, Colin" uniqKey="Grissom C" first="Colin" last="Grissom">Colin Grissom</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Buckel, Whitney R" sort="Buckel, Whitney R" uniqKey="Buckel W" first="Whitney R" last="Buckel">Whitney R. Buckel</name><affiliation><nlm:affiliation>Pharmacy Services and.</nlm:affiliation><wicri:noCountry code="no comma">Pharmacy Services and.</wicri:noCountry><wicri:noCountry code="no comma">Pharmacy Services and.</wicri:noCountry></affiliation></author><author><name sortKey="Srivastava, Raj" sort="Srivastava, Raj" uniqKey="Srivastava R" first="Raj" last="Srivastava">Raj Srivastava</name><affiliation><nlm:affiliation>Inpatient Medicine, Department of Pediatrics.</nlm:affiliation><wicri:noCountry code="subField">Department of Pediatrics</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:affiliation>Healthcare Delivery Institute, Intermountain Healthcare, Murray, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Healthcare Delivery Institute, Intermountain Healthcare, Murray</wicri:cityArea></affiliation></author><author><name sortKey="Harris, Estelle S" sort="Harris, Estelle S" uniqKey="Harris E" first="Estelle S" last="Harris">Estelle S. Harris</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Leither, Lindsay M" sort="Leither, Lindsay M" uniqKey="Leither L" first="Lindsay M" last="Leither">Lindsay M. Leither</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Johnson, Stacy A" sort="Johnson, Stacy A" uniqKey="Johnson S" first="Stacy A" last="Johnson">Stacy A. Johnson</name><affiliation><nlm:affiliation>Hospital Medicine, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Paine, Robert" sort="Paine, Robert" uniqKey="Paine R" first="Robert" last="Paine">Robert Paine</name><affiliation><nlm:affiliation>Pulmonary and Critical Care Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry><wicri:noCountry code="no comma">Pulmonary and Critical Care Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Greene, Tom" sort="Greene, Tom" uniqKey="Greene T" first="Tom" last="Greene">Tom Greene</name><affiliation wicri:level="2"><nlm:affiliation>Biostatistics, University of Utah, Salt Lake City, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Biostatistics, University of Utah, Salt Lake City</wicri:cityArea></affiliation></author></analytic><series><title level="j">Annals of the American Thoracic Society</title><idno type="eISSN">2325-6621</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Anti-Infective Agents (administration & dosage)</term><term>Anti-Infective Agents (adverse effects)</term><term>Azithromycin (administration & dosage)</term><term>Azithromycin (adverse effects)</term><term>Betacoronavirus (drug effects)</term><term>Betacoronavirus (isolation & purification)</term><term>COVID-19 (MeSH)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (epidemiology)</term><term>Drug Monitoring (methods)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (administration & dosage)</term><term>Hydroxychloroquine (adverse effects)</term><term>Male (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (epidemiology)</term><term>Randomized Controlled Trials as Topic (MeSH)</term><term>SARS-CoV-2 (MeSH)</term><term>Treatment Outcome (MeSH)</term><term>Utah (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Anti-infectieux (administration et posologie)</term><term>Anti-infectieux (effets indésirables)</term><term>Azithromycine (administration et posologie)</term><term>Azithromycine (effets indésirables)</term><term>Betacoronavirus (effets des médicaments et des substances chimiques)</term><term>Betacoronavirus (isolement et purification)</term><term>Essais contrôlés randomisés comme sujet (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Hydroxychloroquine (administration et posologie)</term><term>Hydroxychloroquine (effets indésirables)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Pneumopathie virale (épidémiologie)</term><term>Résultat thérapeutique (MeSH)</term><term>Surveillance des médicaments (méthodes)</term><term>Utah (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Infective Agents</term><term>Azithromycin</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anti-Infective Agents</term><term>Azithromycin</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Utah</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anti-infectieux</term><term>Azithromycine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anti-infectieux</term><term>Azithromycine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Monitoring</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Surveillance des médicaments</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>COVID-19</term><term>Female</term><term>Humans</term><term>Male</term><term>Pandemics</term><term>Randomized Controlled Trials as Topic</term><term>SARS-CoV-2</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Essais contrôlés randomisés comme sujet</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pandémies</term><term>Résultat thérapeutique</term><term>Utah</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronavirus disease (COVID-19) is a potentially fatal illness with no proven therapy beyond excellent supportive care. Treatments are urgently sought. Adaptations to traditional trial logistics and design to allow rapid implementation, evaluation of trials within a global trials context, flexible interim monitoring, and access outside traditional research hospitals (even in settings where formal placebos are unavailable) may be helpful. Thoughtful adaptations to traditional trial designs, especially within the global context of related studies, may also foster collaborative relationships among government, community, and the research enterprise. Here, we describe the protocol for a pragmatic, active comparator trial in as many as 300 patients comparing two current "off-label" treatments for COVID-19-hydroxychloroquine and azithromycin-in academic and nonacademic hospitals in Utah. We developed the trial in response to local pressures for widespread, indiscriminate off-label use of these medications. We used a hybrid Bayesian-frequentist design for interim monitoring to allow rapid, contextual assessment of the available evidence. We also developed an inference grid for interpreting the range of possible results from this trial within the context of parallel trials and prepared for a network meta-analysis of the resulting data. This trial was prospectively registered (ClinicalTrials.gov Identifier: NCT04329832) before enrollment of the first patient.Clinical trial registered with www.clinicaltrials.gov (NCT04329832).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32425051</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>13</Day></DateCompleted><DateRevised><Year>2021</Year><Month>01</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2325-6621</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>8</Issue><PubDate><Year>2020</Year><Month>08</Month></PubDate></JournalIssue><Title>Annals of the American Thoracic Society</Title><ISOAbbreviation>Ann Am Thorac Soc</ISOAbbreviation></Journal><ArticleTitle>Hydroxychloroquine versus Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS). Protocol for a Pragmatic, Open-Label, Active Comparator Trial.</ArticleTitle><Pagination><MedlinePgn>1008-1015</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1513/AnnalsATS.202004-309SD</ELocationID><Abstract><AbstractText>Coronavirus disease (COVID-19) is a potentially fatal illness with no proven therapy beyond excellent supportive care. Treatments are urgently sought. Adaptations to traditional trial logistics and design to allow rapid implementation, evaluation of trials within a global trials context, flexible interim monitoring, and access outside traditional research hospitals (even in settings where formal placebos are unavailable) may be helpful. Thoughtful adaptations to traditional trial designs, especially within the global context of related studies, may also foster collaborative relationships among government, community, and the research enterprise. Here, we describe the protocol for a pragmatic, active comparator trial in as many as 300 patients comparing two current "off-label" treatments for COVID-19-hydroxychloroquine and azithromycin-in academic and nonacademic hospitals in Utah. We developed the trial in response to local pressures for widespread, indiscriminate off-label use of these medications. We used a hybrid Bayesian-frequentist design for interim monitoring to allow rapid, contextual assessment of the available evidence. We also developed an inference grid for interpreting the range of possible results from this trial within the context of parallel trials and prepared for a network meta-analysis of the resulting data. This trial was prospectively registered (ClinicalTrials.gov Identifier: NCT04329832) before enrollment of the first patient.Clinical trial registered with www.clinicaltrials.gov (NCT04329832).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brown</LastName><ForeName>Samuel M</ForeName><Initials>SM</Initials><Identifier Source="ORCID">0000-0003-1206-6261</Identifier><AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peltan</LastName><ForeName>Ithan D</ForeName><Initials>ID</Initials><Identifier Source="ORCID">0000-0003-1730-234X</Identifier><AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Webb</LastName><ForeName>Brandon</ForeName><Initials>B</Initials><Identifier Source="ORCID">0000-0002-1799-3315</Identifier><AffiliationInfo><Affiliation>Infectious Disease, and.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infectious Disease.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infectious Disease, Stanford University, Stanford, California; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Naresh</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infectious Disease, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Starr</LastName><ForeName>Nathan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Hospital Medicine, Intermountain Medical Center, Murray, Utah.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grissom</LastName><ForeName>Colin</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buckel</LastName><ForeName>Whitney R</ForeName><Initials>WR</Initials><Identifier Source="ORCID">0000-0001-9505-2572</Identifier><AffiliationInfo><Affiliation>Pharmacy Services and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Srivastava</LastName><ForeName>Raj</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Inpatient Medicine, Department of Pediatrics.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Healthcare Delivery Institute, Intermountain Healthcare, Murray, Utah.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>Estelle S</ForeName><Initials>ES</Initials><AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leither</LastName><ForeName>Lindsay M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Stacy A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Hospital Medicine, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paine</LastName><ForeName>Robert</ForeName><Initials>R</Initials><Suffix>3rd</Suffix><AffiliationInfo><Affiliation>Pulmonary and Critical Care Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greene</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Biostatistics, University of Utah, Salt Lake City, Utah.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT04329832</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>K23 GM129661</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL144624</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D000078325">Clinical Trial Protocol</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann Am Thorac Soc</MedlineTA><NlmUniqueID>101600811</NlmUniqueID><ISSNLinking>2325-6621</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000890">Anti-Infective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>83905-01-5</RegistryNumber><NameOfSubstance UI="D017963">Azithromycin</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Ann Am Thorac Soc. 2020 Aug;17(8):937-938</RefSource><PMID Version="1">32735169</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000890" MajorTopicYN="N">Anti-Infective Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017963" MajorTopicYN="Y">Azithromycin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="Y">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016903" MajorTopicYN="N">Drug Monitoring</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="Y">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="Y">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014589" MajorTopicYN="N" Type="Geographic">Utah</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">clinical trial</Keyword><Keyword MajorTopicYN="Y">hydroxychloroquine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32425051</ArticleId><ArticleId IdType="doi">10.1513/AnnalsATS.202004-309SD</ArticleId><ArticleId IdType="pmc">PMC7393787</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>JAMA. 2020 Apr 7;323(13):1239-1242</Citation><ArticleIdList><ArticleId IdType="pubmed">32091533</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):732-739</Citation><ArticleIdList><ArticleId IdType="pubmed">32150618</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2004 Jul 22;351(4):327-36</Citation><ArticleIdList><ArticleId IdType="pubmed">15269312</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 May 19;323(19):1897-1898</Citation><ArticleIdList><ArticleId IdType="pubmed">32208486</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2011 Aug 16;343:d4909</Citation><ArticleIdList><ArticleId IdType="pubmed">21846695</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Emerg Med. 2018 Oct;72(4):457-466</Citation><ArticleIdList><ArticleId IdType="pubmed">29753517</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2013 May 2;368(18):1704-12</Citation><ArticleIdList><ArticleId IdType="pubmed">23635050</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Emerg Med. 2012 Jan;59(1):35-41</Citation><ArticleIdList><ArticleId IdType="pubmed">21907451</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Feb 12;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32049269</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2017 Oct 10;318(14):1335-1345</Citation><ArticleIdList><ArticleId IdType="pubmed">28973363</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Resusc. 2017 Dec;19(4):344-354</Citation><ArticleIdList><ArticleId IdType="pubmed">29202261</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2018 Jan 3;360:j5748</Citation><ArticleIdList><ArticleId IdType="pubmed">29298779</ArticleId></ArticleIdList></Reference><Reference><Citation>Wien Klin Wochenschr. 2002 Jun 14;114(10-11):396-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12708094</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2003 Nov;3(11):722-7</Citation><ArticleIdList><ArticleId IdType="pubmed">14592603</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2012 May 17;366(20):1881-90</Citation><ArticleIdList><ArticleId IdType="pubmed">22591294</ArticleId></ArticleIdList></Reference><Reference><Citation>J Rheumatol. 2020 Jun 1;47(6):787-790</Citation><ArticleIdList><ArticleId IdType="pubmed">32269064</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2000 May 4;342(18):1301-8</Citation><ArticleIdList><ArticleId IdType="pubmed">10793162</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2018 Mar 1;378(9):819-828</Citation><ArticleIdList><ArticleId IdType="pubmed">29485926</ArticleId></ArticleIdList></Reference><Reference><Citation>Stat Med. 2002 Aug 30;21(16):2313-24</Citation><ArticleIdList><ArticleId IdType="pubmed">12210616</ArticleId></ArticleIdList></Reference><Reference><Citation>Intensive Care Med. 2020 May;46(5):854-887</Citation><ArticleIdList><ArticleId IdType="pubmed">32222812</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2013 May 14;346:f2914</Citation><ArticleIdList><ArticleId IdType="pubmed">23674332</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Feb 20;382(8):727-733</Citation><ArticleIdList><ArticleId IdType="pubmed">31978945</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2020 May;8(5):433-434</Citation><ArticleIdList><ArticleId IdType="pubmed">32203709</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Respir J. 2010 Sep;36(3):646-54</Citation><ArticleIdList><ArticleId IdType="pubmed">20150207</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Transl Med. 2018 Jan;6(2):24</Citation><ArticleIdList><ArticleId IdType="pubmed">29430441</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2003 Sep 17;290(11):1459-66</Citation><ArticleIdList><ArticleId IdType="pubmed">13129985</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2020 Feb;48(2):158-166</Citation><ArticleIdList><ArticleId IdType="pubmed">31939783</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Intern Med. 2015 Jun;175(6):1019-26</Citation><ArticleIdList><ArticleId IdType="pubmed">25822402</ArticleId></ArticleIdList></Reference><Reference><Citation>Springerplus. 2016 Jul 28;5(1):1193</Citation><ArticleIdList><ArticleId IdType="pubmed">27516931</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Rep. 2016 Jun 28;6:28698</Citation><ArticleIdList><ArticleId IdType="pubmed">27350308</ArticleId></ArticleIdList></Reference><Reference><Citation>Chest. 2012 May;141(5):1153-1159</Citation><ArticleIdList><ArticleId IdType="pubmed">22116799</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2020 Jun 16;172(12):819-821</Citation><ArticleIdList><ArticleId IdType="pubmed">32227189</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2019 Dec 12;381(24):2293-2303</Citation><ArticleIdList><ArticleId IdType="pubmed">31774950</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2017 Aug 12;390(10095):659-668</Citation><ArticleIdList><ArticleId IdType="pubmed">28687413</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Mar 12;382(11):999-1008</Citation><ArticleIdList><ArticleId IdType="pubmed">32160661</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2019 Dec 26;381(26):2529-2540</Citation><ArticleIdList><ArticleId IdType="pubmed">31826336</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2018 Mar 1;378(9):829-839</Citation><ArticleIdList><ArticleId IdType="pubmed">29485925</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biopharm Stat. 2008;18(1):54-80</Citation><ArticleIdList><ArticleId IdType="pubmed">18161542</ArticleId></ArticleIdList></Reference><Reference><Citation>Biostatistics. 2019 Apr 1;20(2):273-286</Citation><ArticleIdList><ArticleId IdType="pubmed">29394327</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Am Thorac Soc. 2007 Oct 1;4(7):577-82</Citation><ArticleIdList><ArticleId IdType="pubmed">17878473</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2017 Jun;45(6):1011-1018</Citation><ArticleIdList><ArticleId IdType="pubmed">28426466</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2015 Apr 2;372(14):1312-23</Citation><ArticleIdList><ArticleId IdType="pubmed">25830421</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2015 Nov 26;373(22):2103-16</Citation><ArticleIdList><ArticleId IdType="pubmed">26551272</ArticleId></ArticleIdList></Reference><Reference><Citation>Stat Med. 1997 Jun 30;16(12):1413-30</Citation><ArticleIdList><ArticleId IdType="pubmed">9232762</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Utah</li></region><settlement><li>Stanford (Californie)</li></settlement><orgName><li>Université Stanford</li></orgName></list><tree><noCountry><name sortKey="Brown, Samuel M" sort="Brown, Samuel M" uniqKey="Brown S" first="Samuel M" last="Brown">Samuel M. Brown</name><name sortKey="Buckel, Whitney R" sort="Buckel, Whitney R" uniqKey="Buckel W" first="Whitney R" last="Buckel">Whitney R. Buckel</name><name sortKey="Grissom, Colin" sort="Grissom, Colin" uniqKey="Grissom C" first="Colin" last="Grissom">Colin Grissom</name><name sortKey="Harris, Estelle S" sort="Harris, Estelle S" uniqKey="Harris E" first="Estelle S" last="Harris">Estelle S. Harris</name><name sortKey="Johnson, Stacy A" sort="Johnson, Stacy A" uniqKey="Johnson S" first="Stacy A" last="Johnson">Stacy A. Johnson</name><name sortKey="Kumar, Naresh" sort="Kumar, Naresh" uniqKey="Kumar N" first="Naresh" last="Kumar">Naresh Kumar</name><name sortKey="Leither, Lindsay M" sort="Leither, Lindsay M" uniqKey="Leither L" first="Lindsay M" last="Leither">Lindsay M. Leither</name><name sortKey="Paine, Robert" sort="Paine, Robert" uniqKey="Paine R" first="Robert" last="Paine">Robert Paine</name><name sortKey="Peltan, Ithan D" sort="Peltan, Ithan D" uniqKey="Peltan I" first="Ithan D" last="Peltan">Ithan D. Peltan</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Webb, Brandon" sort="Webb, Brandon" uniqKey="Webb B" first="Brandon" last="Webb">Brandon Webb</name></region><name sortKey="Greene, Tom" sort="Greene, Tom" uniqKey="Greene T" first="Tom" last="Greene">Tom Greene</name><name sortKey="Srivastava, Raj" sort="Srivastava, Raj" uniqKey="Srivastava R" first="Raj" last="Srivastava">Raj Srivastava</name><name sortKey="Starr, Nathan" sort="Starr, Nathan" uniqKey="Starr N" first="Nathan" last="Starr">Nathan Starr</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001142 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001142 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidChloroV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32425051
|texte= Hydroxychloroquine versus Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS). Protocol for a Pragmatic, Open-Label, Active Comparator Trial.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32425051" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidChloroV1
| This area was generated with Dilib version V0.6.38. |  |