Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR-positive SARS-CoV-2 infection, including drug-induced changes in the corrected QT interval.
Identifieur interne : 001064 ( Main/Exploration ); précédent : 001063; suivant : 001065Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR-positive SARS-CoV-2 infection, including drug-induced changes in the corrected QT interval.
Auteurs : Sharmeen Samuel [États-Unis] ; Richard A. Friedman [États-Unis] ; Chetan Sharma [États-Unis] ; Madhusudan Ganigara [États-Unis] ; Elizabeth Mitchell [États-Unis] ; Charles Schleien [États-Unis] ; Andrew D. Blaufox [États-Unis]Source :
- Heart rhythm [ 1556-3871 ] ; 2020.
Descripteurs français
- KwdFr :
- Anti-infectieux (administration et posologie), Anti-infectieux (effets indésirables), Azithromycine (administration et posologie), Azithromycine (effets indésirables), Betacoronavirus (isolement et purification), Enfant (MeSH), Facteurs de risque (MeSH), Femelle (MeSH), Humains (MeSH), Hydroxychloroquine (administration et posologie), Hydroxychloroquine (effets indésirables), Incidence (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (physiopathologie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (épidémiologie), Mâle (MeSH), New York (ville) (épidémiologie), Pandémies (MeSH), Pneumopathie virale (diagnostic), Pneumopathie virale (physiopathologie), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (épidémiologie), Syndrome du QT long (diagnostic), Syndrome du QT long (induit chimiquement), Techniques de laboratoire clinique (méthodes), Troubles du rythme cardiaque (diagnostic), Troubles du rythme cardiaque (épidémiologie), Électrocardiographie (méthodes), Électrocardiographie (statistiques et données numériques), Études rétrospectives (MeSH).
- MESH :
- administration et posologie : Anti-infectieux, Azithromycine, Hydroxychloroquine.
- diagnostic : Infections à coronavirus, Pneumopathie virale, Syndrome du QT long, Troubles du rythme cardiaque.
- effets indésirables : Anti-infectieux, Azithromycine, Hydroxychloroquine.
- induit chimiquement : Syndrome du QT long.
- isolement et purification : Betacoronavirus.
- méthodes : Techniques de laboratoire clinique, Électrocardiographie.
- physiopathologie : Infections à coronavirus, Pneumopathie virale.
- statistiques et données numériques : Électrocardiographie.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Infections à coronavirus, New York (ville), Pneumopathie virale, Troubles du rythme cardiaque.
- Enfant, Facteurs de risque, Femelle, Humains, Incidence, Mâle, Pandémies, Études rétrospectives.
English descriptors
- KwdEn :
- Anti-Infective Agents (administration & dosage), Anti-Infective Agents (adverse effects), Arrhythmias, Cardiac (diagnosis), Arrhythmias, Cardiac (epidemiology), Azithromycin (administration & dosage), Azithromycin (adverse effects), Betacoronavirus (isolation & purification), COVID-19 (MeSH), COVID-19 Testing (MeSH), Child (MeSH), Clinical Laboratory Techniques (methods), Coronavirus Infections (diagnosis), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Coronavirus Infections (physiopathology), Electrocardiography (methods), Electrocardiography (statistics & numerical data), Female (MeSH), Humans (MeSH), Hydroxychloroquine (administration & dosage), Hydroxychloroquine (adverse effects), Incidence (MeSH), Long QT Syndrome (chemically induced), Long QT Syndrome (diagnosis), Male (MeSH), New York City (epidemiology), Outcome and Process Assessment, Health Care (MeSH), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (drug therapy), Pneumonia, Viral (epidemiology), Pneumonia, Viral (physiopathology), Retrospective Studies (MeSH), Risk Factors (MeSH), SARS-CoV-2 (MeSH).
- MESH :
- chemical , administration & dosage : Anti-Infective Agents, Azithromycin, Hydroxychloroquine.
- chemical , adverse effects : Anti-Infective Agents, Azithromycin, Hydroxychloroquine.
- geographic , epidemiology : New York City.
- chemically induced : Long QT Syndrome.
- diagnosis : Arrhythmias, Cardiac, Coronavirus Infections, Long QT Syndrome, Pneumonia, Viral.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Arrhythmias, Cardiac, Coronavirus Infections, Pneumonia, Viral.
- isolation & purification : Betacoronavirus.
- methods : Clinical Laboratory Techniques, Electrocardiography.
- physiopathology : Coronavirus Infections, Pneumonia, Viral.
- statistics & numerical data : Electrocardiography.
- COVID-19, COVID-19 Testing, Child, Female, Humans, Incidence, Male, Outcome and Process Assessment, Health Care, Pandemics, Retrospective Studies, Risk Factors, SARS-CoV-2.
Abstract
BACKGROUND
There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially proarrhythmic hydroxychloroquine (HCQ) and azithromycin (AZN).
OBJECTIVES
To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment.
METHODS
A single-center retrospective chart review was undertaken and included all patients with (1) symptoms of COVID-19 and (2) PCR-positive nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020.
RESULTS
Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (nonsustained ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving and half prompted prophylactic antiarrhythmic therapy. Patients with significant arrhythmias were likely to have noncardiac comorbidities (4/6), but these were not more common than in patients without arrhythmias (20/30, P = 1). The use of HCQ was associated with statistically significant QTc prolongation (413 ± 19 ms vs 425 ± 16 ms, P =.005). QTc was not statistically different in patients with and without arrhythmias (425 ± 15 ms vs 425 ± 15 ms, P = 1).
CONCLUSIONS
In pediatric patients with PCR-positive active COVID-19 infection, significant arrhythmias are infrequent, but are more common than expected in a general pediatric population. Comorbidities are not more common in patients with arrhythmias than in patients without arrhythmias. COVID-19 treatment using HCQ is associated with QTc prolongation but was not associated with arrhythmias in pediatric patients.
DOI: 10.1016/j.hrthm.2020.06.033
PubMed: 32621881
PubMed Central: PMC7328618
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Electronic address: ssamuel21@northwell.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park</wicri:cityArea></affiliation></author><author><name sortKey="Friedman, Richard A" sort="Friedman, Richard A" uniqKey="Friedman R" first="Richard A" last="Friedman">Richard A. Friedman</name><affiliation wicri:level="2"><nlm:affiliation>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park</wicri:cityArea></affiliation></author><author><name sortKey="Sharma, Chetan" sort="Sharma, Chetan" uniqKey="Sharma C" first="Chetan" last="Sharma">Chetan Sharma</name><affiliation wicri:level="2"><nlm:affiliation>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park</wicri:cityArea></affiliation></author><author><name sortKey="Ganigara, Madhusudan" sort="Ganigara, Madhusudan" uniqKey="Ganigara M" first="Madhusudan" last="Ganigara">Madhusudan Ganigara</name><affiliation wicri:level="2"><nlm:affiliation>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park</wicri:cityArea></affiliation></author><author><name sortKey="Mitchell, Elizabeth" sort="Mitchell, Elizabeth" uniqKey="Mitchell E" first="Elizabeth" last="Mitchell">Elizabeth Mitchell</name><affiliation wicri:level="2"><nlm:affiliation>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park</wicri:cityArea></affiliation></author><author><name sortKey="Schleien, Charles" sort="Schleien, Charles" uniqKey="Schleien C" first="Charles" last="Schleien">Charles Schleien</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park</wicri:cityArea></affiliation></author><author><name sortKey="Blaufox, Andrew D" sort="Blaufox, Andrew D" uniqKey="Blaufox A" first="Andrew D" last="Blaufox">Andrew D. Blaufox</name><affiliation wicri:level="2"><nlm:affiliation>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park</wicri:cityArea></affiliation></author></analytic><series><title level="j">Heart rhythm</title><idno type="eISSN">1556-3871</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Infective Agents (administration & dosage)</term><term>Anti-Infective Agents (adverse effects)</term><term>Arrhythmias, Cardiac (diagnosis)</term><term>Arrhythmias, Cardiac (epidemiology)</term><term>Azithromycin (administration & dosage)</term><term>Azithromycin (adverse effects)</term><term>Betacoronavirus (isolation & purification)</term><term>COVID-19 (MeSH)</term><term>COVID-19 Testing (MeSH)</term><term>Child (MeSH)</term><term>Clinical Laboratory Techniques (methods)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (physiopathology)</term><term>Electrocardiography (methods)</term><term>Electrocardiography (statistics & numerical data)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (administration & dosage)</term><term>Hydroxychloroquine (adverse effects)</term><term>Incidence (MeSH)</term><term>Long QT Syndrome (chemically induced)</term><term>Long QT Syndrome (diagnosis)</term><term>Male (MeSH)</term><term>New York City (epidemiology)</term><term>Outcome and Process Assessment, Health Care (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (physiopathology)</term><term>Retrospective Studies (MeSH)</term><term>Risk Factors (MeSH)</term><term>SARS-CoV-2 (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anti-infectieux (administration et posologie)</term><term>Anti-infectieux (effets indésirables)</term><term>Azithromycine (administration et posologie)</term><term>Azithromycine (effets indésirables)</term><term>Betacoronavirus (isolement et purification)</term><term>Enfant (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Hydroxychloroquine (administration et posologie)</term><term>Hydroxychloroquine (effets indésirables)</term><term>Incidence (MeSH)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (physiopathologie)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mâle (MeSH)</term><term>New York (ville) (épidémiologie)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (physiopathologie)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Pneumopathie virale (épidémiologie)</term><term>Syndrome du QT long (diagnostic)</term><term>Syndrome du QT long (induit chimiquement)</term><term>Techniques de laboratoire clinique (méthodes)</term><term>Troubles du rythme cardiaque (diagnostic)</term><term>Troubles du rythme cardiaque (épidémiologie)</term><term>Électrocardiographie (méthodes)</term><term>Électrocardiographie (statistiques et données numériques)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Infective Agents</term><term>Azithromycin</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anti-Infective Agents</term><term>Azithromycin</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>New York City</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anti-infectieux</term><term>Azithromycine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Long QT Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Arrhythmias, Cardiac</term><term>Coronavirus Infections</term><term>Long QT Syndrome</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Syndrome du QT long</term><term>Troubles du rythme cardiaque</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anti-infectieux</term><term>Azithromycine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Arrhythmias, Cardiac</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Syndrome du QT long</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Clinical Laboratory Techniques</term><term>Electrocardiography</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Techniques de laboratoire clinique</term><term>Électrocardiographie</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Electrocardiography</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Électrocardiographie</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>New York (ville)</term><term>Pneumopathie virale</term><term>Troubles du rythme cardiaque</term></keywords><keywords scheme="MESH" xml:lang="en"><term>COVID-19</term><term>COVID-19 Testing</term><term>Child</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Outcome and Process Assessment, Health Care</term><term>Pandemics</term><term>Retrospective Studies</term><term>Risk Factors</term><term>SARS-CoV-2</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Enfant</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Mâle</term><term>Pandémies</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially proarrhythmic hydroxychloroquine (HCQ) and azithromycin (AZN).</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A single-center retrospective chart review was undertaken and included all patients with (1) symptoms of COVID-19 and (2) PCR-positive nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (nonsustained ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving and half prompted prophylactic antiarrhythmic therapy. Patients with significant arrhythmias were likely to have noncardiac comorbidities (4/6), but these were not more common than in patients without arrhythmias (20/30, P = 1). The use of HCQ was associated with statistically significant QTc prolongation (413 ± 19 ms vs 425 ± 16 ms, P =.005). QTc was not statistically different in patients with and without arrhythmias (425 ± 15 ms vs 425 ± 15 ms, P = 1).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>In pediatric patients with PCR-positive active COVID-19 infection, significant arrhythmias are infrequent, but are more common than expected in a general pediatric population. Comorbidities are not more common in patients with arrhythmias than in patients without arrhythmias. COVID-19 treatment using HCQ is associated with QTc prolongation but was not associated with arrhythmias in pediatric patients.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32621881</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>16</Day></DateCompleted><DateRevised><Year>2021</Year><Month>01</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1556-3871</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>11</Issue><PubDate><Year>2020</Year><Month>11</Month></PubDate></JournalIssue><Title>Heart rhythm</Title><ISOAbbreviation>Heart Rhythm</ISOAbbreviation></Journal><ArticleTitle>Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR-positive SARS-CoV-2 infection, including drug-induced changes in the corrected QT interval.</ArticleTitle><Pagination><MedlinePgn>1960-1966</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1547-5271(20)30632-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.hrthm.2020.06.033</ELocationID><Abstract><AbstractText Label="BACKGROUND">There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially proarrhythmic hydroxychloroquine (HCQ) and azithromycin (AZN).</AbstractText><AbstractText Label="OBJECTIVES">To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment.</AbstractText><AbstractText Label="METHODS">A single-center retrospective chart review was undertaken and included all patients with (1) symptoms of COVID-19 and (2) PCR-positive nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020.</AbstractText><AbstractText Label="RESULTS">Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (nonsustained ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving and half prompted prophylactic antiarrhythmic therapy. Patients with significant arrhythmias were likely to have noncardiac comorbidities (4/6), but these were not more common than in patients without arrhythmias (20/30, P = 1). The use of HCQ was associated with statistically significant QTc prolongation (413 ± 19 ms vs 425 ± 16 ms, P =.005). QTc was not statistically different in patients with and without arrhythmias (425 ± 15 ms vs 425 ± 15 ms, P = 1).</AbstractText><AbstractText Label="CONCLUSIONS">In pediatric patients with PCR-positive active COVID-19 infection, significant arrhythmias are infrequent, but are more common than expected in a general pediatric population. Comorbidities are not more common in patients with arrhythmias than in patients without arrhythmias. COVID-19 treatment using HCQ is associated with QTc prolongation but was not associated with arrhythmias in pediatric patients.</AbstractText><CopyrightInformation>Copyright © 2020 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Samuel</LastName><ForeName>Sharmeen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York. Electronic address: ssamuel21@northwell.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Friedman</LastName><ForeName>Richard A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Chetan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ganigara</LastName><ForeName>Madhusudan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schleien</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blaufox</LastName><ForeName>Andrew D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Section of Pediatric Cardiology and; Department of Pediatrics, Cohen Children's Medical Center, Northwell Health System, Donald and Barbara Zucker School of Medicine at Hofstra University, New Hyde Park, New York.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Heart Rhythm</MedlineTA><NlmUniqueID>101200317</NlmUniqueID><ISSNLinking>1547-5271</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000890">Anti-Infective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>83905-01-5</RegistryNumber><NameOfSubstance UI="D017963">Azithromycin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000890" MajorTopicYN="N">Anti-Infective Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001145" MajorTopicYN="Y">Arrhythmias, Cardiac</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017963" MajorTopicYN="Y">Azithromycin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086742" MajorTopicYN="N">COVID-19 Testing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="Y">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004562" MajorTopicYN="Y">Electrocardiography</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="Y">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008133" MajorTopicYN="Y">Long QT Syndrome</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009519" MajorTopicYN="N" Type="Geographic">New York City</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010043" MajorTopicYN="N">Outcome and Process Assessment, Health Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="Y">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Arrhythmias</Keyword><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Drug-induced prolonged QT</Keyword><Keyword MajorTopicYN="Y">Hydroxychloroquine</Keyword><Keyword MajorTopicYN="Y">Pediatric</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32621881</ArticleId><ArticleId IdType="pii">S1547-5271(20)30632-9</ArticleId><ArticleId 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IdType="pubmed">24814375</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Samuel, Sharmeen" sort="Samuel, Sharmeen" uniqKey="Samuel S" first="Sharmeen" last="Samuel">Sharmeen Samuel</name></region><name sortKey="Blaufox, Andrew D" sort="Blaufox, Andrew D" uniqKey="Blaufox A" first="Andrew D" last="Blaufox">Andrew D. Blaufox</name><name sortKey="Friedman, Richard A" sort="Friedman, Richard A" uniqKey="Friedman R" first="Richard A" last="Friedman">Richard A. Friedman</name><name sortKey="Ganigara, Madhusudan" sort="Ganigara, Madhusudan" uniqKey="Ganigara M" first="Madhusudan" last="Ganigara">Madhusudan Ganigara</name><name sortKey="Mitchell, Elizabeth" sort="Mitchell, Elizabeth" uniqKey="Mitchell E" first="Elizabeth" last="Mitchell">Elizabeth Mitchell</name><name sortKey="Schleien, Charles" sort="Schleien, Charles" uniqKey="Schleien C" first="Charles" last="Schleien">Charles Schleien</name><name sortKey="Sharma, Chetan" sort="Sharma, Chetan" uniqKey="Sharma C" first="Chetan" last="Sharma">Chetan Sharma</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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