PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti-SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships.
Identifieur interne : 000E88 ( Main/Exploration ); précédent : 000E87; suivant : 000E89PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti-SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships.
Auteurs : Carmen Abate [Italie] ; Mauro Niso [Italie] ; Francesca Serena Abatematteo [Italie] ; Marialessandra Contino [Italie] ; Nicola Antonio Colabufo [Italie] ; Francesco Berardi [Italie]Source :
- Frontiers in pharmacology [ 1663-9812 ] ; 2020.
Abstract
These unprecedented times have forced the scientific community to gather to face the COVID-19 pandemic. Efforts in diverse directions have been made. A multi-university team has focused on the identification of the host (human) proteins interacting with SARS-CoV-2 viral proteins, with the aim of hampering these interactions that may cause severe COVID-19 symptoms. Sigma-1 and sigma-2 receptors surprisingly belong to the "druggable" host proteins found, with the pan-sigma receptor modulator PB28 displaying the most potent anti-SARS-CoV-2 activity in in vitro assays. Being 20-fold more active than hydroxychloroquine, without cardiac side effects, PB28 is a promising antiviral candidate worthy of further investigation. Our research group developed PB28 in 1996 and have thoroughly characterized its biological properties since then. Structure-affinity relationship (SAfiR) studies at the sigma receptor subtypes were also undertaken with PB28 as the lead compound. We herein report our knowledge of PB28 to share information that may help to gain insight into the antiviral action of this compound and sigma receptors, while providing structural hints that may speed up the translation into therapeutics of this class of ligands.
DOI: 10.3389/fphar.2020.589810
PubMed: 33364961
PubMed Central: PMC7750835
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">These unprecedented times have forced the scientific community to gather to face the COVID-19 pandemic. Efforts in diverse directions have been made. A multi-university team has focused on the identification of the host (human) proteins interacting with SARS-CoV-2 viral proteins, with the aim of hampering these interactions that may cause severe COVID-19 symptoms. Sigma-1 and sigma-2 receptors surprisingly belong to the "druggable" host proteins found, with the pan-sigma receptor modulator PB28 displaying the most potent anti-SARS-CoV-2 activity in in vitro assays. Being 20-fold more active than hydroxychloroquine, without cardiac side effects, PB28 is a promising antiviral candidate worthy of further investigation. Our research group developed PB28 in 1996 and have thoroughly characterized its biological properties since then. Structure-affinity relationship (SAfiR) studies at the sigma receptor subtypes were also undertaken with PB28 as the lead compound. We herein report our knowledge of PB28 to share information that may help to gain insight into the antiviral action of this compound and sigma receptors, while providing structural hints that may speed up the translation into therapeutics of this class of ligands.</div>
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<Abstract><AbstractText>These unprecedented times have forced the scientific community to gather to face the COVID-19 pandemic. Efforts in diverse directions have been made. A multi-university team has focused on the identification of the host (human) proteins interacting with SARS-CoV-2 viral proteins, with the aim of hampering these interactions that may cause severe COVID-19 symptoms. Sigma-1 and sigma-2 receptors surprisingly belong to the "druggable" host proteins found, with the pan-sigma receptor modulator PB28 displaying the most potent anti-SARS-CoV-2 activity in in vitro assays. Being 20-fold more active than hydroxychloroquine, without cardiac side effects, PB28 is a promising antiviral candidate worthy of further investigation. Our research group developed PB28 in 1996 and have thoroughly characterized its biological properties since then. Structure-affinity relationship (SAfiR) studies at the sigma receptor subtypes were also undertaken with PB28 as the lead compound. We herein report our knowledge of PB28 to share information that may help to gain insight into the antiviral action of this compound and sigma receptors, while providing structural hints that may speed up the translation into therapeutics of this class of ligands.</AbstractText>
<CopyrightInformation>Copyright © 2020 Abate, Niso, Abatematteo, Contino, Colabufo and Berardi.</CopyrightInformation>
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<ReferenceList><Reference><Citation>Glia. 2009 May;57(7):744-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19031439</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharmacol Exp Ther. 2001 Nov;299(2):620-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11602674</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2014 Nov 12;9(11):e111899</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25390692</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Handb Exp Pharmacol. 2017;244:81-108</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28275911</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Med Chem. 2015 Jan 7;89:606-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25462269</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ChemMedChem. 2009 Feb;4(2):188-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19140144</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2007 Oct;30(4):297-308</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17629679</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurotherapeutics. 2019 Apr;16(2):465-479</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30756361</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Med Chem. 2011 Oct;46(10):5154-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21899931</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Pharmacol Sci. 2019 Sep;40(9):636-654</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31387763</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Physiol Rep. 2019 Jul;7(12):e14147</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31222975</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Future Med Chem. 2018 Aug 1;10(16):1997-2018</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29966437</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem Lett. 2008 Mar 15;18(6):2183-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18178434</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2004 Apr 22;47(9):2308-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15084129</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Med Chem. 2016 Jan 27;108:577-585</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26717207</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pharmacol Res. 2019 Jun;144:315-330</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31048034</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Pharm. 2018 Feb 5;15(2):458-471</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29226684</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Ther. 2006 Jul;5(7):1807-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16891467</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Med Chem. 2018 Jan 20;144:359-371</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29287249</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2014 Apr 24;57(8):3314-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24697311</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Med Chem. 2011 Sep;46(9):4733-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21684636</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem. 2005 Jun 1;13(11):3623-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15862990</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ACS Med Chem Lett. 2020 Aug 14;11(10):2048-2050</Citation>
<ArticleIdList><ArticleId IdType="pubmed">33052254</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharmacol Exp Ther. 1976 Jun;197(3):517-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">945347</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2011 Jul 05;2:380</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21730960</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 1996 Jan 5;39(1):176-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8568804</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancers (Basel). 2020 Jan 21;12(2):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31973006</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Cancer. 2012 Feb 14;106(4):693-701</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22251921</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Cancer. 2017 Jan 13;17(1):51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28086830</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2009 Dec 10;52(23):7817-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19842660</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Pharmacol. 2015 Jul 5;758:16-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25843410</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Mol Genet. 2020 Mar 13;29(4):529-540</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31696229</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurobiol Dis. 2019 Sep;129:118-129</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31108174</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Cancer. 2000 Mar;82(6):1223-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10735510</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ChemMedChem. 2012 Oct;7(10):1847-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22890883</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2020 Aug 6;182(3):685-712.e19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32645325</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mini Rev Med Chem. 2005 Oct;5(10):927-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16250835</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2005 Dec 29;48(26):8237-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16366605</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem. 2008 Jan 1;16(1):362-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17936633</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):106-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15322732</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Pharmacol. 2019 Apr 24;10:419</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31068816</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chembiochem. 2015 May 4;16(7):1078-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25757101</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Exp Med Biol. 2017;964:79-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28315266</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Exp Med Biol. 2017;964:5-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28315261</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2006 Jul 13;49(14):4153-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16821775</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Neurol. 2011 Dec;70(6):913-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21842496</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Neurosci. 2019 Jul 23;13:761</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31396041</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Alzheimers Dement (N Y). 2019 Jan 23;5:20-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30723776</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Pharmacol. 2019 May 14;10:490</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31156430</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Dis. 2019 Mar 1;10(3):210</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30824685</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2014 Nov 12;9(11):e111898</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25390368</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Cancer. 2019 May 20;19(1):473</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31109310</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem. 2013 Apr 1;21(7):1865-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23415062</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurosci Lett. 2015 Mar 30;591:13-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25666889</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2011 Feb 24;54(4):1022-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21229979</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2013 Sep 26;56(18):7137-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23734634</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2020 Aug;56(2):106028</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32450198</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Alzheimers Dement. 2018 Jun;14(6):811-823</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29291374</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Pharmacol Sci. 2016 Apr;37(4):262-278</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26869505</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Future Med Chem. 2019 Oct;11(19):2547-2562</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31633399</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Exp Med Biol. 2017;964:85-107</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28315267</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pharmacol Res. 2017 Mar;117:67-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28007569</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Dis. 2020 Aug 19;11(8):656</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32814759</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cent Nerv Syst Agents Med Chem. 2009 Sep;9(3):205-19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20021355</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ChemMedChem. 2011 Jan 3;6(1):73-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21069657</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ChemMedChem. 2013 Dec;8(12):2026-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24106081</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Psychopharmacol. 2011 Jul;25(7):960-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21555330</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Naunyn Schmiedebergs Arch Pharmacol. 2003 Aug;368(2):106-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12879208</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ChemMedChem. 2010 Feb 1;5(2):268-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20077462</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cent Nerv Syst Agents Med Chem. 2009 Sep;9(3):246-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20021358</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2013 Jul 19;288(29):21448-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23760505</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2020 Jul;583(7816):459-468</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32353859</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Clin Cancer Res. 2012 May 02;31:41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22551149</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Calcium. 2006 Jul;40(1):23-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16687172</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharmacol Exp Ther. 2000 Mar;292(3):900-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10688603</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2011 Aug 25;54(16):5858-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21744858</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Surgery. 2012 Sep;152(3 Suppl 1):S152-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22763259</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7160-7165</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28559337</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Chem. 2007 Sep 20;50(19):4648-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17713896</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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