SARS-CoV-2 infection among patients with systemic autoimmune diseases.
Identifieur interne : 000C64 ( Main/Exploration ); précédent : 000C63; suivant : 000C65SARS-CoV-2 infection among patients with systemic autoimmune diseases.
Auteurs : Giacomo Emmi [Italie] ; Alessandra Bettiol [Italie] ; Irene Mattioli [Italie] ; Elena Silvestri [Italie] ; Gerardo Di Scala [Italie] ; Maria Letizia Urban [Italie] ; Augusto Vaglio [Italie] ; Domenico Prisco [Italie]Source :
- Autoimmunity reviews [ 1873-0183 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Anticorps monoclonaux humanisés (usage thérapeutique), Antirhumatismaux (usage thérapeutique), Betacoronavirus (MeSH), Colchicine (usage thérapeutique), Femelle (MeSH), Hormones corticosurrénaliennes (usage thérapeutique), Humains (MeSH), Hydroxychloroquine (usage thérapeutique), Infections à coronavirus (complications), Italie (MeSH), Maladies auto-immunes (complications), Maladies auto-immunes (traitement médicamenteux), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (complications), Sujet âgé (MeSH), Études transversales (MeSH).
- MESH :
- traitement médicamenteux : Maladies auto-immunes.
- usage thérapeutique : Anticorps monoclonaux humanisés, Antirhumatismaux, Colchicine, Hormones corticosurrénaliennes, Hydroxychloroquine, Infections à coronavirus, Maladies auto-immunes, Pneumopathie virale.
- Adulte, Adulte d'âge moyen, Betacoronavirus, Femelle, Humains, Italie, Mâle, Pandémies, Sujet âgé, Études transversales.
- Wicri :
- geographic : Italie.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (therapeutic use), Adult (MeSH), Aged (MeSH), Antibodies, Monoclonal, Humanized (therapeutic use), Antirheumatic Agents (therapeutic use), Autoimmune Diseases (complications), Autoimmune Diseases (drug therapy), Betacoronavirus (MeSH), COVID-19 (MeSH), Colchicine (therapeutic use), Coronavirus Infections (complications), Cross-Sectional Studies (MeSH), Female (MeSH), Humans (MeSH), Hydroxychloroquine (therapeutic use), Italy (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), SARS-CoV-2 (MeSH).
- MESH :
- chemical , therapeutic use : Adrenal Cortex Hormones, Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Colchicine, Hydroxychloroquine.
- geographic : Italy.
- complications : Autoimmune Diseases, Coronavirus Infections, Pneumonia, Viral.
- drug therapy : Autoimmune Diseases.
- Adult, Aged, Betacoronavirus, COVID-19, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Pandemics, SARS-CoV-2.
Abstract
OBJECTIVES
This study aimed to evaluate the prevalence of clinically overt SARS-CoV-2 infection (COVID-19) among patients with systemic autoimmune diseases residing in Tuscany, and to compare it with that observed in the general Tuscan population.
METHODS
In this cross-sectional study, Tuscan outpatients with systemic autoimmune diseases followed at a tertiary referral centre were telephonically interviewed between April 1st-14th 2020 to collect demographic and clinical data, information on ongoing immunomodulating/immunosuppressive treatments, and on the presence of symptoms suspected of SARS-CoV-2 or of a confirmed infection.
RESULTS
458 patients were interviewed [74% female, median age 56 years (IQR 43-68)]; 56% of them were receiving corticosteroids, 44% traditional disease-modifying anti-rheumatic drugs (DMARDs), of whom 23% hydroxychloroquine, 5% colchicine, while 41% were on biologic DMARDs (of whom 9% on tocilizumab). Thirteen patients reported symptoms suggesting SARS-CoV-2 infection. Of them, 7 had undergone nasopharyngeal swab and only one was positive and developed severe SARS-CoV-2 complications. Within our cohort, the prevalence of SARS-CoV-2 infection was therefore 0.22% (0.01-1.21%), comparable to that observed in the general population of Tuscany [0.20% (0.20-0.21%), p = .597].
CONCLUSIONS
Patients with systemic autoimmune diseases do not seem to carry an increased risk of SARS- CoV-2 infection as compared to the general population.
DOI: 10.1016/j.autrev.2020.102575
PubMed: 32376395
PubMed Central: PMC7200134
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Antibodies, Monoclonal, Humanized (therapeutic use)</term>
<term>Antirheumatic Agents (therapeutic use)</term>
<term>Autoimmune Diseases (complications)</term>
<term>Autoimmune Diseases (drug therapy)</term>
<term>Betacoronavirus (MeSH)</term>
<term>COVID-19 (MeSH)</term>
<term>Colchicine (therapeutic use)</term>
<term>Coronavirus Infections (complications)</term>
<term>Cross-Sectional Studies (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Italy (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>SARS-CoV-2 (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Anticorps monoclonaux humanisés (usage thérapeutique)</term>
<term>Antirhumatismaux (usage thérapeutique)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Colchicine (usage thérapeutique)</term>
<term>Femelle (MeSH)</term>
<term>Hormones corticosurrénaliennes (usage thérapeutique)</term>
<term>Humains (MeSH)</term>
<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Infections à coronavirus (complications)</term>
<term>Italie (MeSH)</term>
<term>Maladies auto-immunes (complications)</term>
<term>Maladies auto-immunes (traitement médicamenteux)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (complications)</term>
<term>Sujet âgé (MeSH)</term>
<term>Études transversales (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term>
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<term>Antirheumatic Agents</term>
<term>Colchicine</term>
<term>Hydroxychloroquine</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Autoimmune Diseases</term>
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Autoimmune Diseases</term>
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<term>Antirhumatismaux</term>
<term>Colchicine</term>
<term>Hormones corticosurrénaliennes</term>
<term>Hydroxychloroquine</term>
<term>Infections à coronavirus</term>
<term>Maladies auto-immunes</term>
<term>Pneumopathie virale</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Betacoronavirus</term>
<term>COVID-19</term>
<term>Cross-Sectional Studies</term>
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<term>Humans</term>
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<term>Femelle</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>This study aimed to evaluate the prevalence of clinically overt SARS-CoV-2 infection (COVID-19) among patients with systemic autoimmune diseases residing in Tuscany, and to compare it with that observed in the general Tuscan population.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>In this cross-sectional study, Tuscan outpatients with systemic autoimmune diseases followed at a tertiary referral centre were telephonically interviewed between April 1st-14th 2020 to collect demographic and clinical data, information on ongoing immunomodulating/immunosuppressive treatments, and on the presence of symptoms suspected of SARS-CoV-2 or of a confirmed infection.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>458 patients were interviewed [74% female, median age 56 years (IQR 43-68)]; 56% of them were receiving corticosteroids, 44% traditional disease-modifying anti-rheumatic drugs (DMARDs), of whom 23% hydroxychloroquine, 5% colchicine, while 41% were on biologic DMARDs (of whom 9% on tocilizumab). Thirteen patients reported symptoms suggesting SARS-CoV-2 infection. Of them, 7 had undergone nasopharyngeal swab and only one was positive and developed severe SARS-CoV-2 complications. Within our cohort, the prevalence of SARS-CoV-2 infection was therefore 0.22% (0.01-1.21%), comparable to that observed in the general population of Tuscany [0.20% (0.20-0.21%), p = .597].</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Patients with systemic autoimmune diseases do not seem to carry an increased risk of SARS- CoV-2 infection as compared to the general population.</p>
</div>
</front>
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<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">This study aimed to evaluate the prevalence of clinically overt SARS-CoV-2 infection (COVID-19) among patients with systemic autoimmune diseases residing in Tuscany, and to compare it with that observed in the general Tuscan population.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In this cross-sectional study, Tuscan outpatients with systemic autoimmune diseases followed at a tertiary referral centre were telephonically interviewed between April 1st-14th 2020 to collect demographic and clinical data, information on ongoing immunomodulating/immunosuppressive treatments, and on the presence of symptoms suspected of SARS-CoV-2 or of a confirmed infection.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">458 patients were interviewed [74% female, median age 56 years (IQR 43-68)]; 56% of them were receiving corticosteroids, 44% traditional disease-modifying anti-rheumatic drugs (DMARDs), of whom 23% hydroxychloroquine, 5% colchicine, while 41% were on biologic DMARDs (of whom 9% on tocilizumab). Thirteen patients reported symptoms suggesting SARS-CoV-2 infection. Of them, 7 had undergone nasopharyngeal swab and only one was positive and developed severe SARS-CoV-2 complications. Within our cohort, the prevalence of SARS-CoV-2 infection was therefore 0.22% (0.01-1.21%), comparable to that observed in the general population of Tuscany [0.20% (0.20-0.21%), p = .597].</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Patients with systemic autoimmune diseases do not seem to carry an increased risk of SARS- CoV-2 infection as compared to the general population.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Emmi</LastName>
<ForeName>Giacomo</ForeName>
<Initials>G</Initials>
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<ForeName>Alessandra</ForeName>
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<AffiliationInfo><Affiliation>Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Firenze, Italy. Electronic address: alessandra.bettiol@unifi.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mattioli</LastName>
<ForeName>Irene</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Experimental and Clinical Medicine, University of Firenze, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Silvestri</LastName>
<ForeName>Elena</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Experimental and Clinical Medicine, University of Firenze, Italy.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Di Scala</LastName>
<ForeName>Gerardo</ForeName>
<Initials>G</Initials>
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<Author ValidYN="Y"><LastName>Urban</LastName>
<ForeName>Maria Letizia</ForeName>
<Initials>ML</Initials>
<AffiliationInfo><Affiliation>Department of Experimental and Clinical Medicine, University of Firenze, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vaglio</LastName>
<ForeName>Augusto</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Firenze, Nephrology and Dialysis Unit, Meyer Children's Hospital, Firenze, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Prisco</LastName>
<ForeName>Domenico</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Experimental and Clinical Medicine, University of Firenze, Italy.</Affiliation>
</AffiliationInfo>
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<MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName>
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<Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword>
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<Keyword MajorTopicYN="N">Systemic autoimmune diseases</Keyword>
<Keyword MajorTopicYN="N">Tocilizumab</Keyword>
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<CoiStatement>Declaration of Competing Interest None declared.</CoiStatement>
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<affiliations><list><country><li>Italie</li>
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