COVID-19 in solid organ transplant recipients: A systematic review and meta-analysis of current literature.
Identifieur interne : 000683 ( Main/Exploration ); précédent : 000682; suivant : 000684COVID-19 in solid organ transplant recipients: A systematic review and meta-analysis of current literature.
Auteurs : Mohammed A. Raja [États-Unis] ; Maria A. Mendoza [États-Unis] ; Aasith Villavicencio [États-Unis] ; Shweta Anjan [États-Unis] ; John M. Reynolds [États-Unis] ; Veraprapas Kittipibul [États-Unis] ; Anmary Fernandez [États-Unis] ; Giselle Guerra [États-Unis] ; Jose F. Camargo [États-Unis] ; Jacques Simkins [États-Unis] ; Michele I. Morris [États-Unis] ; Lilian A. Abbo [États-Unis] ; Yoichiro Natori [États-Unis]Source :
- Transplantation reviews (Orlando, Fla.) [ 1557-9816 ] ; 2021.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- immunology : COVID-19.
- Humans, Immunocompromised Host, Immunosuppression, Pandemics, SARS-CoV-2, Transplant Recipients.
Abstract
Severe acute respiratory virus syndrome 2 (SARS-CoV-2) has led to a worldwide pandemic. Early studies in solid organ transplant (SOT) recipients suggested a wide variety of presentations, however, there remains a paucity of robust data in this population. We conducted a systematic review and meta-analysis of SOT recipients with SARS-CoV-2 infection from January 1st t October 9th, 2020. Pooled incidence of symptoms, treatments and outcomes were assessed. Two hundred and fifteen studies were included for systematic review and 60 for meta-analysis. We identified 2,772 unique SOT recipients including 1,500 kidney, 505 liver, 141 heart and 97 lung. Most common presenting symptoms were fever and cough in 70.2% and 63.8% respectively. Majority (81%) required hospital admission. Immunosuppressive medications, especially antimetabolites, were decreased in 76.2%. Hydroxychloroquine and interleukin six antagonists were administered in59.5% and 14.9% respectively, while only few patients received remdesivir and convalescent plasma. Intensive care unit admission was 29% from amongst hospitalized patients. Only few studies reported secondary infections. Overall mortality was 18.6%. Our analysis shows a high incidence of hospital admission in SOT recipients with SARS-CoV-2 infection. As management of SARS-CoV-2 continues to evolve, long-term outcomes among SOT recipients should be assessed in future studies.
DOI: 10.1016/j.trre.2020.100588
PubMed: 33246166
PubMed Central: PMC7666542
Affiliations:
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Raja</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mendoza, Maria A" sort="Mendoza, Maria A" uniqKey="Mendoza M" first="Maria A" last="Mendoza">Maria A. Mendoza</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Villavicencio, Aasith" sort="Villavicencio, Aasith" uniqKey="Villavicencio A" first="Aasith" last="Villavicencio">Aasith Villavicencio</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Anjan, Shweta" sort="Anjan, Shweta" uniqKey="Anjan S" first="Shweta" last="Anjan">Shweta Anjan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Reynolds, John M" sort="Reynolds, John M" uniqKey="Reynolds J" first="John M" last="Reynolds">John M. Reynolds</name><affiliation wicri:level="2"><nlm:affiliation>Department of Health Informatics, Calder Memorial Library, University of Miami Miller School of Medicine Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Informatics, Calder Memorial Library, University of Miami Miller School of Medicine Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Kittipibul, Veraprapas" sort="Kittipibul, Veraprapas" uniqKey="Kittipibul V" first="Veraprapas" last="Kittipibul">Veraprapas Kittipibul</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Fernandez, Anmary" sort="Fernandez, Anmary" uniqKey="Fernandez A" first="Anmary" last="Fernandez">Anmary Fernandez</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Guerra, Giselle" sort="Guerra, Giselle" uniqKey="Guerra G" first="Giselle" last="Guerra">Giselle Guerra</name><affiliation wicri:level="2"><nlm:affiliation>Miami Transplant Institute, Jackson Health System, Miami, FL, USA; Department of Medicine, Division of Nephrology, University of Miami Miller School of Medicine Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Miami Transplant Institute, Jackson Health System, Miami, FL, USA; Department of Medicine, Division of Nephrology, University of Miami Miller School of Medicine Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Camargo, Jose F" sort="Camargo, Jose F" uniqKey="Camargo J" first="Jose F" last="Camargo">Jose F. Camargo</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Simkins, Jacques" sort="Simkins, Jacques" uniqKey="Simkins J" first="Jacques" last="Simkins">Jacques Simkins</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Morris, Michele I" sort="Morris, Michele I" uniqKey="Morris M" first="Michele I" last="Morris">Michele I. Morris</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Abbo, Lilian A" sort="Abbo, Lilian A" uniqKey="Abbo L" first="Lilian A" last="Abbo">Lilian A. Abbo</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Natori, Yoichiro" sort="Natori, Yoichiro" uniqKey="Natori Y" first="Yoichiro" last="Natori">Yoichiro Natori</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL, USA. Electronic address: yxn138@med.miami.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><series><title level="j">Transplantation reviews (Orlando, Fla.)</title><idno type="eISSN">1557-9816</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>COVID-19 (immunology)</term><term>Humans (MeSH)</term><term>Immunocompromised Host (MeSH)</term><term>Immunosuppression (MeSH)</term><term>Pandemics (MeSH)</term><term>SARS-CoV-2 (MeSH)</term><term>Transplant Recipients (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains (MeSH)</term><term>Immunosuppression thérapeutique (MeSH)</term><term>Pandémies (MeSH)</term><term>Receveurs de transplantation (MeSH)</term><term>Sujet immunodéprimé (MeSH)</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>COVID-19</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Immunocompromised Host</term><term>Immunosuppression</term><term>Pandemics</term><term>SARS-CoV-2</term><term>Transplant Recipients</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Immunosuppression thérapeutique</term><term>Pandémies</term><term>Receveurs de transplantation</term><term>Sujet immunodéprimé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory virus syndrome 2 (SARS-CoV-2) has led to a worldwide pandemic. Early studies in solid organ transplant (SOT) recipients suggested a wide variety of presentations, however, there remains a paucity of robust data in this population. We conducted a systematic review and meta-analysis of SOT recipients with SARS-CoV-2 infection from January 1<sup>st</sup> t October 9<sup>th</sup>, 2020. Pooled incidence of symptoms, treatments and outcomes were assessed. Two hundred and fifteen studies were included for systematic review and 60 for meta-analysis. We identified 2,772 unique SOT recipients including 1,500 kidney, 505 liver, 141 heart and 97 lung. Most common presenting symptoms were fever and cough in 70.2% and 63.8% respectively. Majority (81%) required hospital admission. Immunosuppressive medications, especially antimetabolites, were decreased in 76.2%. Hydroxychloroquine and interleukin six antagonists were administered in59.5% and 14.9% respectively, while only few patients received remdesivir and convalescent plasma. Intensive care unit admission was 29% from amongst hospitalized patients. Only few studies reported secondary infections. Overall mortality was 18.6%. Our analysis shows a high incidence of hospital admission in SOT recipients with SARS-CoV-2 infection. As management of SARS-CoV-2 continues to evolve, long-term outcomes among SOT recipients should be assessed in future studies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33246166</PMID><DateCompleted><Year>2021</Year><Month>02</Month><Day>18</Day></DateCompleted><DateRevised><Year>2021</Year><Month>02</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-9816</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>1</Issue><PubDate><Year>2021</Year><Month>01</Month></PubDate></JournalIssue><Title>Transplantation reviews (Orlando, Fla.)</Title><ISOAbbreviation>Transplant Rev (Orlando)</ISOAbbreviation></Journal><ArticleTitle>COVID-19 in solid organ transplant recipients: A systematic review and meta-analysis of current literature.</ArticleTitle><Pagination><MedlinePgn>100588</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0955-470X(20)30061-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.trre.2020.100588</ELocationID><Abstract><AbstractText>Severe acute respiratory virus syndrome 2 (SARS-CoV-2) has led to a worldwide pandemic. Early studies in solid organ transplant (SOT) recipients suggested a wide variety of presentations, however, there remains a paucity of robust data in this population. We conducted a systematic review and meta-analysis of SOT recipients with SARS-CoV-2 infection from January 1<sup>st</sup> t October 9<sup>th</sup>, 2020. Pooled incidence of symptoms, treatments and outcomes were assessed. Two hundred and fifteen studies were included for systematic review and 60 for meta-analysis. We identified 2,772 unique SOT recipients including 1,500 kidney, 505 liver, 141 heart and 97 lung. Most common presenting symptoms were fever and cough in 70.2% and 63.8% respectively. Majority (81%) required hospital admission. Immunosuppressive medications, especially antimetabolites, were decreased in 76.2%. Hydroxychloroquine and interleukin six antagonists were administered in59.5% and 14.9% respectively, while only few patients received remdesivir and convalescent plasma. Intensive care unit admission was 29% from amongst hospitalized patients. Only few studies reported secondary infections. Overall mortality was 18.6%. Our analysis shows a high incidence of hospital admission in SOT recipients with SARS-CoV-2 infection. As management of SARS-CoV-2 continues to evolve, long-term outcomes among SOT recipients should be assessed in future studies.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Raja</LastName><ForeName>Mohammed A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mendoza</LastName><ForeName>Maria A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villavicencio</LastName><ForeName>Aasith</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anjan</LastName><ForeName>Shweta</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reynolds</LastName><ForeName>John M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Health Informatics, Calder Memorial Library, University of Miami Miller School of Medicine Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kittipibul</LastName><ForeName>Veraprapas</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez</LastName><ForeName>Anmary</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerra</LastName><ForeName>Giselle</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Miami Transplant Institute, Jackson Health System, Miami, FL, USA; Department of Medicine, Division of Nephrology, University of Miami Miller School of Medicine Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Camargo</LastName><ForeName>Jose F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simkins</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morris</LastName><ForeName>Michele I</ForeName><Initials>MI</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abbo</LastName><ForeName>Lilian A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Natori</LastName><ForeName>Yoichiro</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA; Miami Transplant Institute, Jackson Health System, Miami, FL, USA. Electronic address: yxn138@med.miami.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D000078182">Systematic Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>11</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Transplant Rev (Orlando)</MedlineTA><NlmUniqueID>8804364</NlmUniqueID><ISSNLinking>0955-470X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016867" MajorTopicYN="Y">Immunocompromised Host</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007165" MajorTopicYN="N">Immunosuppression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066027" MajorTopicYN="Y">Transplant Recipients</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Immunosuppression</Keyword><Keyword MajorTopicYN="Y">Meta-analysis</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword><Keyword MajorTopicYN="Y">Solid organ transplant</Keyword><Keyword MajorTopicYN="Y">Systematic review</Keyword></KeywordList><CoiStatement>Declaration of Competing Interest The authors of this manuscript declare no competing conflicts of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>10</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>11</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>11</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>2</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>11</Month><Day>27</Day><Hour>20</Hour><Minute>9</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33246166</ArticleId><ArticleId IdType="pii">S0955-470X(20)30061-6</ArticleId><ArticleId IdType="doi">10.1016/j.trre.2020.100588</ArticleId><ArticleId IdType="pmc">PMC7666542</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Raja, Mohammed A" sort="Raja, Mohammed A" uniqKey="Raja M" first="Mohammed A" last="Raja">Mohammed A. Raja</name></region><name sortKey="Abbo, Lilian A" sort="Abbo, Lilian A" uniqKey="Abbo L" first="Lilian A" last="Abbo">Lilian A. Abbo</name><name sortKey="Anjan, Shweta" sort="Anjan, Shweta" uniqKey="Anjan S" first="Shweta" last="Anjan">Shweta Anjan</name><name sortKey="Camargo, Jose F" sort="Camargo, Jose F" uniqKey="Camargo J" first="Jose F" last="Camargo">Jose F. Camargo</name><name sortKey="Fernandez, Anmary" sort="Fernandez, Anmary" uniqKey="Fernandez A" first="Anmary" last="Fernandez">Anmary Fernandez</name><name sortKey="Guerra, Giselle" sort="Guerra, Giselle" uniqKey="Guerra G" first="Giselle" last="Guerra">Giselle Guerra</name><name sortKey="Kittipibul, Veraprapas" sort="Kittipibul, Veraprapas" uniqKey="Kittipibul V" first="Veraprapas" last="Kittipibul">Veraprapas Kittipibul</name><name sortKey="Mendoza, Maria A" sort="Mendoza, Maria A" uniqKey="Mendoza M" first="Maria A" last="Mendoza">Maria A. Mendoza</name><name sortKey="Morris, Michele I" sort="Morris, Michele I" uniqKey="Morris M" first="Michele I" last="Morris">Michele I. Morris</name><name sortKey="Natori, Yoichiro" sort="Natori, Yoichiro" uniqKey="Natori Y" first="Yoichiro" last="Natori">Yoichiro Natori</name><name sortKey="Reynolds, John M" sort="Reynolds, John M" uniqKey="Reynolds J" first="John M" last="Reynolds">John M. Reynolds</name><name sortKey="Simkins, Jacques" sort="Simkins, Jacques" uniqKey="Simkins J" first="Jacques" last="Simkins">Jacques Simkins</name><name sortKey="Villavicencio, Aasith" sort="Villavicencio, Aasith" uniqKey="Villavicencio A" first="Aasith" last="Villavicencio">Aasith Villavicencio</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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