Hydroxychloroquine Sulfate Related Hypoglycemia In A Non-Diabetic COVİD-19 Patient: A Case Report and Literature Review.
Identifieur interne : 000451 ( Main/Exploration ); précédent : 000450; suivant : 000452Hydroxychloroquine Sulfate Related Hypoglycemia In A Non-Diabetic COVİD-19 Patient: A Case Report and Literature Review.
Auteurs : Narimana Imanova Yaghji [Turquie] ; Elif Kilic Kan [Turquie] ; Songul Akcan [Turquie] ; Ramis Colak [Turquie] ; Aysegul Atmaca [Turquie]Source :
- Postgraduate medicine [ 1941-9260 ] ; 2021.
Abstract
Objective: Hypoglycemia is a serious adverse effect of hydroxychloroquine (HCQ) which is very rare in non-diabetic patients. This case report describes a non-diabetic patient without any other chronic diseases, who experienced mild hypoglycemia related to HCQ used for COVID-19 treatment.Methods: All etiologies causing hypoglycemia were investigated and a 72-hour fast test was performed.Results: A 34-year-old male patient was admitted to our hospital with a high fever, cough, and chest pain. The result of his COVID-19 PCR test was positive. He received HCQ for 10 days for the treatment of COVID-19 infection. He experienced fatigue, dizziness, severe headache, weakness and feeling of hunger after discontinuation of HCQ during his isolation at home. Before COVID-19 infection, he never experienced hypoglycemia symptoms. He did not have a history of chronic diseases, drug use, alcohol consumption, or smoking. A 72-hour fasting test was performed. He complained about headache and weakness during the 72-hour test period. The PG level was determined as 49 mg/dl during these symptoms. Concurrent insulin and C-peptide levels were <2 mU/mL and 0.553 ng/mL, respectively. ACTH, cortisol, growth hormones, liver and kidney function tests were normal. HbA1c level was 4.7% (28 mmol/mol) (Normal Range %4,5-5,7).Conclusion: Hypoglycemia may be observed as an adverse effect of HCQ used for COVID-19 infection even in patients without chronic diseases and comorbidities. We must be careful while using HCQ for these patients and must warn them about this effect. The warning about hypoglycemia effect of HCQ must be added to COVID-19 treatment guidelines.
DOI: 10.1080/00325481.2021.1889820
PubMed: 33583332
Affiliations:
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COVİD-19 Patient: A Case Report and Literature Review.</title><author><name sortKey="Imanova Yaghji, Narimana" sort="Imanova Yaghji, Narimana" uniqKey="Imanova Yaghji N" first="Narimana" last="Imanova Yaghji">Narimana Imanova Yaghji</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun</wicri:regionArea><wicri:noRegion>Samsun</wicri:noRegion></affiliation></author><author><name sortKey="Kan, Elif Kilic" sort="Kan, Elif Kilic" uniqKey="Kan E" first="Elif Kilic" last="Kan">Elif Kilic Kan</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun</wicri:regionArea><wicri:noRegion>Samsun</wicri:noRegion></affiliation></author><author><name sortKey="Akcan, Songul" sort="Akcan, Songul" uniqKey="Akcan S" first="Songul" last="Akcan">Songul Akcan</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun</wicri:regionArea><wicri:noRegion>Samsun</wicri:noRegion></affiliation></author><author><name sortKey="Colak, Ramis" sort="Colak, Ramis" uniqKey="Colak R" first="Ramis" last="Colak">Ramis Colak</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun</wicri:regionArea><wicri:noRegion>Samsun</wicri:noRegion></affiliation></author><author><name sortKey="Atmaca, Aysegul" sort="Atmaca, Aysegul" uniqKey="Atmaca A" first="Aysegul" last="Atmaca">Aysegul Atmaca</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun</wicri:regionArea><wicri:noRegion>Samsun</wicri:noRegion></affiliation></author></analytic><series><title level="j">Postgraduate medicine</title><idno type="eISSN">1941-9260</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><b>Objective</b>: Hypoglycemia is a serious adverse effect of hydroxychloroquine (HCQ) which is very rare in non-diabetic patients. This case report describes a non-diabetic patient without any other chronic diseases, who experienced mild hypoglycemia related to HCQ used for COVID-19 treatment.<b>Methods</b>: All etiologies causing hypoglycemia were investigated and a 72-hour fast test was performed.<b>Results</b>: A 34-year-old male patient was admitted to our hospital with a high fever, cough, and chest pain. The result of his COVID-19 PCR test was positive. He received HCQ for 10 days for the treatment of COVID-19 infection. He experienced fatigue, dizziness, severe headache, weakness and feeling of hunger after discontinuation of HCQ during his isolation at home. Before COVID-19 infection, he never experienced hypoglycemia symptoms. He did not have a history of chronic diseases, drug use, alcohol consumption, or smoking. A 72-hour fasting test was performed. He complained about headache and weakness during the 72-hour test period. The PG level was determined as 49 mg/dl during these symptoms. Concurrent insulin and C-peptide levels were <2 mU/mL and 0.553 ng/mL, respectively. ACTH, cortisol, growth hormones, liver and kidney function tests were normal. HbA1c level was 4.7% (28 mmol/mol) (Normal Range %4,5-5,7).<b>Conclusion</b>: Hypoglycemia may be observed as an adverse effect of HCQ used for COVID-19 infection even in patients without chronic diseases and comorbidities. We must be careful while using HCQ for these patients and must warn them about this effect. The warning about hypoglycemia effect of HCQ must be added to COVID-19 treatment guidelines.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33583332</PMID><DateRevised><Year>2021</Year><Month>05</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1941-9260</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2021</Year><Month>Feb</Month><Day>26</Day></PubDate></JournalIssue><Title>Postgraduate medicine</Title><ISOAbbreviation>Postgrad Med</ISOAbbreviation></Journal><ArticleTitle>Hydroxychloroquine Sulfate Related Hypoglycemia In A Non-Diabetic COVİD-19 Patient: A Case Report and Literature Review.</ArticleTitle><Pagination><MedlinePgn>1-4</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/00325481.2021.1889820</ELocationID><Abstract><AbstractText><b>Objective</b>: Hypoglycemia is a serious adverse effect of hydroxychloroquine (HCQ) which is very rare in non-diabetic patients. This case report describes a non-diabetic patient without any other chronic diseases, who experienced mild hypoglycemia related to HCQ used for COVID-19 treatment.<b>Methods</b>: All etiologies causing hypoglycemia were investigated and a 72-hour fast test was performed.<b>Results</b>: A 34-year-old male patient was admitted to our hospital with a high fever, cough, and chest pain. The result of his COVID-19 PCR test was positive. He received HCQ for 10 days for the treatment of COVID-19 infection. He experienced fatigue, dizziness, severe headache, weakness and feeling of hunger after discontinuation of HCQ during his isolation at home. Before COVID-19 infection, he never experienced hypoglycemia symptoms. He did not have a history of chronic diseases, drug use, alcohol consumption, or smoking. A 72-hour fasting test was performed. He complained about headache and weakness during the 72-hour test period. The PG level was determined as 49 mg/dl during these symptoms. Concurrent insulin and C-peptide levels were <2 mU/mL and 0.553 ng/mL, respectively. ACTH, cortisol, growth hormones, liver and kidney function tests were normal. HbA1c level was 4.7% (28 mmol/mol) (Normal Range %4,5-5,7).<b>Conclusion</b>: Hypoglycemia may be observed as an adverse effect of HCQ used for COVID-19 infection even in patients without chronic diseases and comorbidities. We must be careful while using HCQ for these patients and must warn them about this effect. The warning about hypoglycemia effect of HCQ must be added to COVID-19 treatment guidelines.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Imanova Yaghji</LastName><ForeName>Narimana</ForeName><Initials>N</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8842-901X</Identifier><AffiliationInfo><Affiliation>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kan</LastName><ForeName>Elif Kilic</ForeName><Initials>EK</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-9047-3121</Identifier><AffiliationInfo><Affiliation>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akcan</LastName><ForeName>Songul</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colak</LastName><ForeName>Ramis</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Atmaca</LastName><ForeName>Aysegul</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Ondokuz Mayıs University, Samsun, Turkey.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>02</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Postgrad Med</MedlineTA><NlmUniqueID>0401147</NlmUniqueID><ISSNLinking>0032-5481</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">hypoglycemia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>2</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>2</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>2</Month><Day>15</Day><Hour>5</Hour><Minute>34</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33583332</ArticleId><ArticleId IdType="doi">10.1080/00325481.2021.1889820</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Turquie</li></country></list><tree><country name="Turquie"><noRegion><name sortKey="Imanova Yaghji, Narimana" sort="Imanova Yaghji, Narimana" uniqKey="Imanova Yaghji N" first="Narimana" last="Imanova Yaghji">Narimana Imanova Yaghji</name></noRegion><name sortKey="Akcan, Songul" sort="Akcan, Songul" uniqKey="Akcan S" first="Songul" last="Akcan">Songul Akcan</name><name sortKey="Atmaca, Aysegul" sort="Atmaca, Aysegul" uniqKey="Atmaca A" first="Aysegul" last="Atmaca">Aysegul Atmaca</name><name sortKey="Colak, Ramis" sort="Colak, Ramis" uniqKey="Colak R" first="Ramis" last="Colak">Ramis Colak</name><name sortKey="Kan, Elif Kilic" sort="Kan, Elif Kilic" uniqKey="Kan E" first="Elif Kilic" last="Kan">Elif Kilic Kan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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