The controversial therapeutic journey of chloroquine and hydroxychloroquine in the battle against SARS-CoV-2: A comprehensive review.
Identifieur interne : 000094 ( Main/Exploration ); précédent : 000093; suivant : 000095The controversial therapeutic journey of chloroquine and hydroxychloroquine in the battle against SARS-CoV-2: A comprehensive review.
Auteurs : Subham Das [Inde] ; Anu Kunnath Ramachandran [Inde] ; Sumit Raosaheb Birangal [Inde] ; Saleem Akbar [Inde] ; Bahar Ahmed [Inde] ; Alex Joseph [Inde]Source :
- Medicine in drug discovery [ 2590-0986 ] ; 2021.
Abstract
Recently, the pandemic outbreak of a novel coronavirus, officially termed as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), indicated by a pulmonary infection in humans, has become one of the most significant challenges for public health. In the current fight against coronavirus disease-2019, the medical and health authorities across the world focused on quick diagnosis and isolation of patients; meanwhile, researchers worldwide are exploring the possibility of developing vaccines and novel therapeutic options to combat this deadly disease. Recently, based on various small clinical observations, uncontrolled case studies and previously reported antiviral activity against SARS-CoV-1 chloroquine (CQ) and hydroxychloroquine (HCQ) have attracted exceptional consideration as possible therapeutic agents against SARS-CoV-2. However, there are reports on little to no effect of CQ or HCQ against SARS-CoV-2, and many reports have raised concerns about their cardiac toxicity. Here, in this review, we examine the chemistry, molecular mechanism, and pharmacology, including the current scenario and future prospects of CQ or HCQ in the treatment of SARS-CoV-2.
DOI: 10.1016/j.medidd.2021.100085
PubMed: 33846702
PubMed Central: PMC8026171
Affiliations:
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xml:lang="en">Recently, the pandemic outbreak of a novel coronavirus, officially termed as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), indicated by a pulmonary infection in humans, has become one of the most significant challenges for public health. In the current fight against coronavirus disease-2019, the medical and health authorities across the world focused on quick diagnosis and isolation of patients; meanwhile, researchers worldwide are exploring the possibility of developing vaccines and novel therapeutic options to combat this deadly disease. Recently, based on various small clinical observations, uncontrolled case studies and previously reported antiviral activity against SARS-CoV-1 chloroquine (CQ) and hydroxychloroquine (HCQ) have attracted exceptional consideration as possible therapeutic agents against SARS-CoV-2. However, there are reports on little to no effect of CQ or HCQ against SARS-CoV-2, and many reports have raised concerns about their cardiac toxicity. Here, in this review, we examine the chemistry, molecular mechanism, and pharmacology, including the current scenario and future prospects of CQ or HCQ in the treatment of SARS-CoV-2.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33846702</PMID><DateRevised><Year>2021</Year><Month>04</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2590-0986</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><PubDate><Year>2021</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Medicine in drug discovery</Title><ISOAbbreviation>Med Drug Discov</ISOAbbreviation></Journal><ArticleTitle>The controversial therapeutic journey of chloroquine and hydroxychloroquine in the battle against SARS-CoV-2: A comprehensive review.</ArticleTitle><Pagination><MedlinePgn>100085</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.medidd.2021.100085</ELocationID><Abstract><AbstractText>Recently, the pandemic outbreak of a novel coronavirus, officially termed as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), indicated by a pulmonary infection in humans, has become one of the most significant challenges for public health. In the current fight against coronavirus disease-2019, the medical and health authorities across the world focused on quick diagnosis and isolation of patients; meanwhile, researchers worldwide are exploring the possibility of developing vaccines and novel therapeutic options to combat this deadly disease. Recently, based on various small clinical observations, uncontrolled case studies and previously reported antiviral activity against SARS-CoV-1 chloroquine (CQ) and hydroxychloroquine (HCQ) have attracted exceptional consideration as possible therapeutic agents against SARS-CoV-2. However, there are reports on little to no effect of CQ or HCQ against SARS-CoV-2, and many reports have raised concerns about their cardiac toxicity. Here, in this review, we examine the chemistry, molecular mechanism, and pharmacology, including the current scenario and future prospects of CQ or HCQ in the treatment of SARS-CoV-2.</AbstractText><CopyrightInformation>© 2021 The Authors.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Das</LastName><ForeName>Subham</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Manipal McGill Centre for Infectious Diseases, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramachandran</LastName><ForeName>Anu Kunnath</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Birangal</LastName><ForeName>Sumit Raosaheb</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akbar</LastName><ForeName>Saleem</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Bahar</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joseph</LastName><ForeName>Alex</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>03</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Med Drug Discov</MedlineTA><NlmUniqueID>101765689</NlmUniqueID><ISSNLinking>2590-0986</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Chloroquine</Keyword><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">Cytokine storm</Keyword><Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword></KeywordList><CoiStatement>The authors declare no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2021</Year><Month>01</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2021</Year><Month>02</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2021</Year><Month>02</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>29</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33846702</ArticleId><ArticleId IdType="doi">10.1016/j.medidd.2021.100085</ArticleId><ArticleId IdType="pii">S2590-0986(21)00006-3</ArticleId><ArticleId IdType="pmc">PMC8026171</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
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Birangal</name><name sortKey="Das, Subham" sort="Das, Subham" uniqKey="Das S" first="Subham" last="Das">Subham Das</name><name sortKey="Joseph, Alex" sort="Joseph, Alex" uniqKey="Joseph A" first="Alex" last="Joseph">Alex Joseph</name><name sortKey="Ramachandran, Anu Kunnath" sort="Ramachandran, Anu Kunnath" uniqKey="Ramachandran A" first="Anu Kunnath" last="Ramachandran">Anu Kunnath Ramachandran</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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