Early experience with remdesivir in SARS-CoV-2 pneumonia.
Identifieur interne : 001674 ( Main/Curation ); précédent : 001673; suivant : 001675Early experience with remdesivir in SARS-CoV-2 pneumonia.
Auteurs : Emanuele Durante-Mangoni [Italie] ; Roberto Andini [Italie] ; Lorenzo Bertolino [Italie] ; Ferruccio Mele [Italie] ; Letizia Lucia Florio [Italie] ; Patrizia Murino [Italie] ; Antonio Corcione [Italie] ; Rosa Zampino [Italie]Source :
- Infection [ 1439-0973 ] ; 2020.
Descripteurs français
- KwdFr :
- AMP (administration et posologie), AMP (analogues et dérivés), AMP (effets indésirables), ARN viral (sang), Alanine (administration et posologie), Alanine (analogues et dérivés), Alanine (effets indésirables), Antiviraux (administration et posologie), Antiviraux (effets indésirables), Association médicamenteuse (MeSH), Betacoronavirus (effets des médicaments et des substances chimiques), Betacoronavirus (immunologie), Calendrier d'administration des médicaments (MeSH), Convalescence (MeSH), Darunavir (administration et posologie), Darunavir (effets indésirables), Défaillance multiviscérale (diagnostic), Défaillance multiviscérale (induit chimiquement), Défaillance multiviscérale (physiopathologie), Défaillance multiviscérale (virologie), Humains (MeSH), Hydroxychloroquine (administration et posologie), Hydroxychloroquine (effets indésirables), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Issue fatale (MeSH), Lopinavir (administration et posologie), Lopinavir (effets indésirables), Lésions hépatiques dues aux substances (diagnostic), Lésions hépatiques dues aux substances (physiopathologie), Lésions hépatiques dues aux substances (virologie), Lésions hépatiques dues aux substances (étiologie), Maladie grave (MeSH), Pandémies (MeSH), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (virologie), Ritonavir (administration et posologie), Ritonavir (effets indésirables), Torsades de pointes (diagnostic), Torsades de pointes (induit chimiquement), Torsades de pointes (physiopathologie), Torsades de pointes (virologie).
- MESH :
- administration et posologie : AMP, Alanine, Antiviraux, Darunavir, Hydroxychloroquine, Lopinavir, Ritonavir.
- analogues et dérivés : AMP, Alanine.
- diagnostic : Défaillance multiviscérale, Lésions hépatiques dues aux substances, Torsades de pointes.
- effets des médicaments et des substances chimiques : Betacoronavirus.
- effets indésirables : AMP, Alanine, Antiviraux, Darunavir, Hydroxychloroquine, Lopinavir, Ritonavir.
- immunologie : Betacoronavirus.
- induit chimiquement : Défaillance multiviscérale, Torsades de pointes.
- physiopathologie : Défaillance multiviscérale, Lésions hépatiques dues aux substances, Torsades de pointes.
- sang : ARN viral.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- virologie : Défaillance multiviscérale, Infections à coronavirus, Lésions hépatiques dues aux substances, Pneumopathie virale, Torsades de pointes.
- étiologie : Lésions hépatiques dues aux substances.
- Association médicamenteuse, Calendrier d'administration des médicaments, Convalescence, Humains, Issue fatale, Maladie grave, Pandémies.
English descriptors
- KwdEn :
- Adenosine Monophosphate (administration & dosage), Adenosine Monophosphate (adverse effects), Adenosine Monophosphate (analogs & derivatives), Alanine (administration & dosage), Alanine (adverse effects), Alanine (analogs & derivatives), Antiviral Agents (administration & dosage), Antiviral Agents (adverse effects), Betacoronavirus (drug effects), Betacoronavirus (immunology), COVID-19 (MeSH), Chemical and Drug Induced Liver Injury (diagnosis), Chemical and Drug Induced Liver Injury (etiology), Chemical and Drug Induced Liver Injury (physiopathology), Chemical and Drug Induced Liver Injury (virology), Convalescence (MeSH), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Critical Illness (MeSH), Darunavir (administration & dosage), Darunavir (adverse effects), Drug Administration Schedule (MeSH), Drug Combinations (MeSH), Fatal Outcome (MeSH), Humans (MeSH), Hydroxychloroquine (administration & dosage), Hydroxychloroquine (adverse effects), Lopinavir (administration & dosage), Lopinavir (adverse effects), Multiple Organ Failure (chemically induced), Multiple Organ Failure (diagnosis), Multiple Organ Failure (physiopathology), Multiple Organ Failure (virology), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (virology), RNA, Viral (blood), Ritonavir (administration & dosage), Ritonavir (adverse effects), SARS-CoV-2 (MeSH), Torsades de Pointes (chemically induced), Torsades de Pointes (diagnosis), Torsades de Pointes (physiopathology), Torsades de Pointes (virology).
- MESH :
- chemical , administration & dosage : Adenosine Monophosphate, Alanine, Antiviral Agents, Darunavir, Hydroxychloroquine, Lopinavir, Ritonavir.
- chemical , adverse effects : Adenosine Monophosphate, Alanine, Antiviral Agents, Darunavir, Hydroxychloroquine, Lopinavir, Ritonavir.
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine.
- chemical , blood : RNA, Viral.
- chemically induced : Multiple Organ Failure, Torsades de Pointes.
- diagnosis : Chemical and Drug Induced Liver Injury, Multiple Organ Failure, Torsades de Pointes.
- drug effects : Betacoronavirus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- etiology : Chemical and Drug Induced Liver Injury.
- immunology : Betacoronavirus.
- physiopathology : Chemical and Drug Induced Liver Injury, Multiple Organ Failure, Torsades de Pointes.
- virology : Chemical and Drug Induced Liver Injury, Coronavirus Infections, Multiple Organ Failure, Pneumonia, Viral, Torsades de Pointes.
- COVID-19, Convalescence, Critical Illness, Drug Administration Schedule, Drug Combinations, Fatal Outcome, Humans, Pandemics, SARS-CoV-2.
Abstract
At present, there is no definitive antiviral treatment for coronavirus disease 2019 (COVID-19). We describe our early experience with remdesivir in four critically ill COVID-19 patients. Patients received a 200 mg loading dose, followed by 100 mg daily intravenously for up to 10 days. All patients had been previously treated with other antivirals before remdesivir initiation. One patient experienced a torsade de pointes requiring cardiac resuscitation and one died due to multiple organ failure. Three patients showed biochemical signs of liver injury. Lymphocyte count increased in all patients soon after remdesivir initiation. Nasal swab SARS-CoV-2 RNA became negative in three of four patients after 3 days of therapy. We observed an in vivo virological effect of remdesivir in four critically ill, COVID-19 patients, coupled with a significant burden of adverse events. Although limited by the low number of subjects studied, our preliminary experience may be relevant for clinicians treating COVID-19.
DOI: 10.1007/s15010-020-01448-x
PubMed: 32418190
PubMed Central: PMC7229436
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pubmed:32418190Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Early experience with remdesivir in SARS-CoV-2 pneumonia.</title>
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<author><name sortKey="Florio, Letizia Lucia" sort="Florio, Letizia Lucia" uniqKey="Florio L" first="Letizia Lucia" last="Florio">Letizia Lucia Florio</name>
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<author><name sortKey="Murino, Patrizia" sort="Murino, Patrizia" uniqKey="Murino P" first="Patrizia" last="Murino">Patrizia Murino</name>
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<country xml:lang="fr">Italie</country>
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<author><name sortKey="Corcione, Antonio" sort="Corcione, Antonio" uniqKey="Corcione A" first="Antonio" last="Corcione">Antonio Corcione</name>
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<country xml:lang="fr">Italie</country>
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<author><name sortKey="Zampino, Rosa" sort="Zampino, Rosa" uniqKey="Zampino R" first="Rosa" last="Zampino">Rosa Zampino</name>
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<country xml:lang="fr">Italie</country>
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<series><title level="j">Infection</title>
<idno type="eISSN">1439-0973</idno>
<imprint><date when="2020" type="published">2020</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Monophosphate (administration & dosage)</term>
<term>Adenosine Monophosphate (adverse effects)</term>
<term>Adenosine Monophosphate (analogs & derivatives)</term>
<term>Alanine (administration & dosage)</term>
<term>Alanine (adverse effects)</term>
<term>Alanine (analogs & derivatives)</term>
<term>Antiviral Agents (administration & dosage)</term>
<term>Antiviral Agents (adverse effects)</term>
<term>Betacoronavirus (drug effects)</term>
<term>Betacoronavirus (immunology)</term>
<term>COVID-19 (MeSH)</term>
<term>Chemical and Drug Induced Liver Injury (diagnosis)</term>
<term>Chemical and Drug Induced Liver Injury (etiology)</term>
<term>Chemical and Drug Induced Liver Injury (physiopathology)</term>
<term>Chemical and Drug Induced Liver Injury (virology)</term>
<term>Convalescence (MeSH)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (virology)</term>
<term>Critical Illness (MeSH)</term>
<term>Darunavir (administration & dosage)</term>
<term>Darunavir (adverse effects)</term>
<term>Drug Administration Schedule (MeSH)</term>
<term>Drug Combinations (MeSH)</term>
<term>Fatal Outcome (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (administration & dosage)</term>
<term>Hydroxychloroquine (adverse effects)</term>
<term>Lopinavir (administration & dosage)</term>
<term>Lopinavir (adverse effects)</term>
<term>Multiple Organ Failure (chemically induced)</term>
<term>Multiple Organ Failure (diagnosis)</term>
<term>Multiple Organ Failure (physiopathology)</term>
<term>Multiple Organ Failure (virology)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (virology)</term>
<term>RNA, Viral (blood)</term>
<term>Ritonavir (administration & dosage)</term>
<term>Ritonavir (adverse effects)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Torsades de Pointes (chemically induced)</term>
<term>Torsades de Pointes (diagnosis)</term>
<term>Torsades de Pointes (physiopathology)</term>
<term>Torsades de Pointes (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>AMP (administration et posologie)</term>
<term>AMP (analogues et dérivés)</term>
<term>AMP (effets indésirables)</term>
<term>ARN viral (sang)</term>
<term>Alanine (administration et posologie)</term>
<term>Alanine (analogues et dérivés)</term>
<term>Alanine (effets indésirables)</term>
<term>Antiviraux (administration et posologie)</term>
<term>Antiviraux (effets indésirables)</term>
<term>Association médicamenteuse (MeSH)</term>
<term>Betacoronavirus (effets des médicaments et des substances chimiques)</term>
<term>Betacoronavirus (immunologie)</term>
<term>Calendrier d'administration des médicaments (MeSH)</term>
<term>Convalescence (MeSH)</term>
<term>Darunavir (administration et posologie)</term>
<term>Darunavir (effets indésirables)</term>
<term>Défaillance multiviscérale (diagnostic)</term>
<term>Défaillance multiviscérale (induit chimiquement)</term>
<term>Défaillance multiviscérale (physiopathologie)</term>
<term>Défaillance multiviscérale (virologie)</term>
<term>Humains (MeSH)</term>
<term>Hydroxychloroquine (administration et posologie)</term>
<term>Hydroxychloroquine (effets indésirables)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Issue fatale (MeSH)</term>
<term>Lopinavir (administration et posologie)</term>
<term>Lopinavir (effets indésirables)</term>
<term>Lésions hépatiques dues aux substances (diagnostic)</term>
<term>Lésions hépatiques dues aux substances (physiopathologie)</term>
<term>Lésions hépatiques dues aux substances (virologie)</term>
<term>Lésions hépatiques dues aux substances (étiologie)</term>
<term>Maladie grave (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Ritonavir (administration et posologie)</term>
<term>Ritonavir (effets indésirables)</term>
<term>Torsades de pointes (diagnostic)</term>
<term>Torsades de pointes (induit chimiquement)</term>
<term>Torsades de pointes (physiopathologie)</term>
<term>Torsades de pointes (virologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adenosine Monophosphate</term>
<term>Alanine</term>
<term>Antiviral Agents</term>
<term>Darunavir</term>
<term>Hydroxychloroquine</term>
<term>Lopinavir</term>
<term>Ritonavir</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Adenosine Monophosphate</term>
<term>Alanine</term>
<term>Antiviral Agents</term>
<term>Darunavir</term>
<term>Hydroxychloroquine</term>
<term>Lopinavir</term>
<term>Ritonavir</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenosine Monophosphate</term>
<term>Alanine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>AMP</term>
<term>Alanine</term>
<term>Antiviraux</term>
<term>Darunavir</term>
<term>Hydroxychloroquine</term>
<term>Lopinavir</term>
<term>Ritonavir</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>AMP</term>
<term>Alanine</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Multiple Organ Failure</term>
<term>Torsades de Pointes</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Chemical and Drug Induced Liver Injury</term>
<term>Multiple Organ Failure</term>
<term>Torsades de Pointes</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Défaillance multiviscérale</term>
<term>Lésions hépatiques dues aux substances</term>
<term>Torsades de pointes</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Betacoronavirus</term>
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<term>Alanine</term>
<term>Antiviraux</term>
<term>Darunavir</term>
<term>Hydroxychloroquine</term>
<term>Lopinavir</term>
<term>Ritonavir</term>
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<keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Défaillance multiviscérale</term>
<term>Torsades de pointes</term>
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<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Défaillance multiviscérale</term>
<term>Lésions hépatiques dues aux substances</term>
<term>Torsades de pointes</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Chemical and Drug Induced Liver Injury</term>
<term>Multiple Organ Failure</term>
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<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
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<term>Infections à coronavirus</term>
<term>Lésions hépatiques dues aux substances</term>
<term>Pneumopathie virale</term>
<term>Torsades de pointes</term>
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<term>Coronavirus Infections</term>
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<term>Convalescence</term>
<term>Critical Illness</term>
<term>Drug Administration Schedule</term>
<term>Drug Combinations</term>
<term>Fatal Outcome</term>
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<term>Pandemics</term>
<term>SARS-CoV-2</term>
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<term>Calendrier d'administration des médicaments</term>
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<front><div type="abstract" xml:lang="en">At present, there is no definitive antiviral treatment for coronavirus disease 2019 (COVID-19). We describe our early experience with remdesivir in four critically ill COVID-19 patients. Patients received a 200 mg loading dose, followed by 100 mg daily intravenously for up to 10 days. All patients had been previously treated with other antivirals before remdesivir initiation. One patient experienced a torsade de pointes requiring cardiac resuscitation and one died due to multiple organ failure. Three patients showed biochemical signs of liver injury. Lymphocyte count increased in all patients soon after remdesivir initiation. Nasal swab SARS-CoV-2 RNA became negative in three of four patients after 3 days of therapy. We observed an in vivo virological effect of remdesivir in four critically ill, COVID-19 patients, coupled with a significant burden of adverse events. Although limited by the low number of subjects studied, our preliminary experience may be relevant for clinicians treating COVID-19.</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>01</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1439-0973</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>48</Volume>
<Issue>5</Issue>
<PubDate><Year>2020</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Infection</Title>
<ISOAbbreviation>Infection</ISOAbbreviation>
</Journal>
<ArticleTitle>Early experience with remdesivir in SARS-CoV-2 pneumonia.</ArticleTitle>
<Pagination><MedlinePgn>779-782</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s15010-020-01448-x</ELocationID>
<Abstract><AbstractText>At present, there is no definitive antiviral treatment for coronavirus disease 2019 (COVID-19). We describe our early experience with remdesivir in four critically ill COVID-19 patients. Patients received a 200 mg loading dose, followed by 100 mg daily intravenously for up to 10 days. All patients had been previously treated with other antivirals before remdesivir initiation. One patient experienced a torsade de pointes requiring cardiac resuscitation and one died due to multiple organ failure. Three patients showed biochemical signs of liver injury. Lymphocyte count increased in all patients soon after remdesivir initiation. Nasal swab SARS-CoV-2 RNA became negative in three of four patients after 3 days of therapy. We observed an in vivo virological effect of remdesivir in four critically ill, COVID-19 patients, coupled with a significant burden of adverse events. Although limited by the low number of subjects studied, our preliminary experience may be relevant for clinicians treating COVID-19.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Durante-Mangoni</LastName>
<ForeName>Emanuele</ForeName>
<Initials>E</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-5381-3537</Identifier>
<AffiliationInfo><Affiliation>Division of Internal Medicine, University of Campania 'L. Vanvitelli', Monaldi Hospital, Piazzale Ettore Ruggieri, 80131, Naples, Italy. emanuele.durante@unicampania.it.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Unit of Infectious and Transplant Medicine, AORN Ospedali dei Colli-Monaldi Hospital, Naples, Italy. emanuele.durante@unicampania.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Andini</LastName>
<ForeName>Roberto</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Unit of Infectious and Transplant Medicine, AORN Ospedali dei Colli-Monaldi Hospital, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bertolino</LastName>
<ForeName>Lorenzo</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Division of Internal Medicine, University of Campania 'L. Vanvitelli', Monaldi Hospital, Piazzale Ettore Ruggieri, 80131, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mele</LastName>
<ForeName>Ferruccio</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Division of Internal Medicine, University of Campania 'L. Vanvitelli', Monaldi Hospital, Piazzale Ettore Ruggieri, 80131, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Florio</LastName>
<ForeName>Letizia Lucia</ForeName>
<Initials>LL</Initials>
<AffiliationInfo><Affiliation>Division of Internal Medicine, University of Campania 'L. Vanvitelli', Monaldi Hospital, Piazzale Ettore Ruggieri, 80131, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Murino</LastName>
<ForeName>Patrizia</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, AORN Ospedali dei Colli-Monaldi Hospital, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Corcione</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, AORN Ospedali dei Colli-Monaldi Hospital, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zampino</LastName>
<ForeName>Rosa</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Division of Internal Medicine, University of Campania 'L. Vanvitelli', Monaldi Hospital, Piazzale Ettore Ruggieri, 80131, Naples, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Unit of Infectious and Transplant Medicine, AORN Ospedali dei Colli-Monaldi Hospital, Naples, Italy.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
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<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>05</Month>
<Day>16</Day>
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<MedlineTA>Infection</MedlineTA>
<NlmUniqueID>0365307</NlmUniqueID>
<ISSNLinking>0300-8126</ISSNLinking>
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</Chemical>
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<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
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