Risk factors and frequency of COVID-19 among healthcare workers at a tertiary care centre in India: a case-control study.
Identifieur interne : 000191 ( Main/Curation ); précédent : 000190; suivant : 000192Risk factors and frequency of COVID-19 among healthcare workers at a tertiary care centre in India: a case-control study.
Auteurs : Nishanth Dev ; Ramesh Chand Meena ; D K Gupta ; Nitesh Gupta ; Jhuma SankarSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 1878-3503 ] ; 2021.
Abstract
BACKGROUND
There is a paucity of data on risk factors for infection among healthcare workers (HCWs) from India. Our objective was to evaluate the risk factors and frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among HCWs.
METHODS
We conducted this retrospective case-control study of 3100 HCWs between May and July 2020. HCWs positive for SARS-CoV-2 infection were the cases (n=506) and those negative for SARS-CoV-2 were the controls (n=253). Univariate analysis was followed by multivariate analysis of key demographic, clinical and infection control variables.
RESULTS
SARS-CoV-2 infection was found in 16.32% of HCWs. Nearly 45% of infected HCWs were asymptomatic. The proportions of sanitation workers (24% vs 8%; p<0.0001) and technicians (10% vs 4%; p=0.0002) were higher and that of doctors was lower among cases as compared with controls (23% vs 43%; p<0.0001). On univariate analysis, the type of HCW, smoking, lack of training, inadequate personal protective equipment (PPE) use and taking no or fewer doses of hydroxychloroquine (HCQ) were found to be significant. On multivariate analysis, the type of HCW (risk ratio [RR] 1.67 [95% confidence interval {CI} 1.34 to 2.08], p<0.0001), inappropriate PPE use (RR 0.63 [95% CI 0.44 to 0.89], p=0.01) and taking fewer doses of HCQ (RR 0.92 [95% CI 0.86 to 0.99], p=0.03) were significant.
CONCLUSIONS
The frequency of SARS-CoV-2 infection was 16% among HCWs. Being a sanitation worker, inappropriate PPE use and lack of HCQ prophylaxis predisposed HCWs to SARS-CoV-2 infection.
DOI: 10.1093/trstmh/trab047
PubMed: 33763687
PubMed Central: PMC8083760
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Nishanth Dev<affiliation><nlm:affiliation>Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Pulmonology and Critical Care, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Department of Pediatrics, All India Institute of Medical Sciences, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation>Le document en format XML
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D" first="D K" last="Gupta">D K Gupta</name><affiliation><nlm:affiliation>Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation></author><author><name sortKey="Gupta, Nitesh" sort="Gupta, Nitesh" uniqKey="Gupta N" first="Nitesh" last="Gupta">Nitesh Gupta</name><affiliation><nlm:affiliation>Department of Pulmonology and Critical Care, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation></author><author><name sortKey="Sankar, Jhuma" sort="Sankar, Jhuma" uniqKey="Sankar J" first="Jhuma" last="Sankar">Jhuma Sankar</name><affiliation><nlm:affiliation>Department of Pediatrics, All India Institute of Medical Sciences, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33763687</idno><idno type="pmid">33763687</idno><idno type="doi">10.1093/trstmh/trab047</idno><idno type="pmc">PMC8083760</idno><idno type="wicri:Area/Main/Corpus">000191</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000191</idno><idno type="wicri:Area/Main/Curation">000191</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000191</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Risk factors and frequency of COVID-19 among healthcare workers at a tertiary care centre in India: a case-control study.</title><author><name sortKey="Dev, Nishanth" sort="Dev, Nishanth" uniqKey="Dev N" first="Nishanth" last="Dev">Nishanth Dev</name><affiliation><nlm:affiliation>Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation></author><author><name sortKey="Meena, Ramesh Chand" sort="Meena, Ramesh Chand" uniqKey="Meena R" first="Ramesh Chand" last="Meena">Ramesh Chand Meena</name><affiliation><nlm:affiliation>Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation></author><author><name sortKey="Gupta, D K" sort="Gupta, D K" uniqKey="Gupta D" first="D K" last="Gupta">D K Gupta</name><affiliation><nlm:affiliation>Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation></author><author><name sortKey="Gupta, Nitesh" sort="Gupta, Nitesh" uniqKey="Gupta N" first="Nitesh" last="Gupta">Nitesh Gupta</name><affiliation><nlm:affiliation>Department of Pulmonology and Critical Care, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation></author><author><name sortKey="Sankar, Jhuma" sort="Sankar, Jhuma" uniqKey="Sankar J" first="Jhuma" last="Sankar">Jhuma Sankar</name><affiliation><nlm:affiliation>Department of Pediatrics, All India Institute of Medical Sciences, Delhi, India 110029.</nlm:affiliation><wicri:noCountry code="subField">India 110029</wicri:noCountry></affiliation></author></analytic><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><idno type="eISSN">1878-3503</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>There is a paucity of data on risk factors for infection among healthcare workers (HCWs) from India. Our objective was to evaluate the risk factors and frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among HCWs.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We conducted this retrospective case-control study of 3100 HCWs between May and July 2020. HCWs positive for SARS-CoV-2 infection were the cases (n=506) and those negative for SARS-CoV-2 were the controls (n=253). Univariate analysis was followed by multivariate analysis of key demographic, clinical and infection control variables.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>SARS-CoV-2 infection was found in 16.32% of HCWs. Nearly 45% of infected HCWs were asymptomatic. The proportions of sanitation workers (24% vs 8%; p<0.0001) and technicians (10% vs 4%; p=0.0002) were higher and that of doctors was lower among cases as compared with controls (23% vs 43%; p<0.0001). On univariate analysis, the type of HCW, smoking, lack of training, inadequate personal protective equipment (PPE) use and taking no or fewer doses of hydroxychloroquine (HCQ) were found to be significant. On multivariate analysis, the type of HCW (risk ratio [RR] 1.67 [95% confidence interval {CI} 1.34 to 2.08], p<0.0001), inappropriate PPE use (RR 0.63 [95% CI 0.44 to 0.89], p=0.01) and taking fewer doses of HCQ (RR 0.92 [95% CI 0.86 to 0.99], p=0.03) were significant.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The frequency of SARS-CoV-2 infection was 16% among HCWs. Being a sanitation worker, inappropriate PPE use and lack of HCQ prophylaxis predisposed HCWs to SARS-CoV-2 infection.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">33763687</PMID><DateRevised><Year>2021</Year><Month>05</Month><Day>12</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1878-3503</ISSN><JournalIssue CitedMedium="Internet"><Volume>115</Volume><Issue>5</Issue><PubDate><Year>2021</Year><Month>05</Month><Day>08</Day></PubDate></JournalIssue><Title>Transactions of the Royal Society of Tropical Medicine and Hygiene</Title><ISOAbbreviation>Trans R Soc Trop Med Hyg</ISOAbbreviation></Journal><ArticleTitle>Risk factors and frequency of COVID-19 among healthcare workers at a tertiary care centre in India: a case-control study.</ArticleTitle><Pagination><MedlinePgn>551-556</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/trstmh/trab047</ELocationID><Abstract><AbstractText Label="BACKGROUND">There is a paucity of data on risk factors for infection among healthcare workers (HCWs) from India. Our objective was to evaluate the risk factors and frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among HCWs.</AbstractText><AbstractText Label="METHODS">We conducted this retrospective case-control study of 3100 HCWs between May and July 2020. HCWs positive for SARS-CoV-2 infection were the cases (n=506) and those negative for SARS-CoV-2 were the controls (n=253). Univariate analysis was followed by multivariate analysis of key demographic, clinical and infection control variables.</AbstractText><AbstractText Label="RESULTS">SARS-CoV-2 infection was found in 16.32% of HCWs. Nearly 45% of infected HCWs were asymptomatic. The proportions of sanitation workers (24% vs 8%; p<0.0001) and technicians (10% vs 4%; p=0.0002) were higher and that of doctors was lower among cases as compared with controls (23% vs 43%; p<0.0001). On univariate analysis, the type of HCW, smoking, lack of training, inadequate personal protective equipment (PPE) use and taking no or fewer doses of hydroxychloroquine (HCQ) were found to be significant. On multivariate analysis, the type of HCW (risk ratio [RR] 1.67 [95% confidence interval {CI} 1.34 to 2.08], p<0.0001), inappropriate PPE use (RR 0.63 [95% CI 0.44 to 0.89], p=0.01) and taking fewer doses of HCQ (RR 0.92 [95% CI 0.86 to 0.99], p=0.03) were significant.</AbstractText><AbstractText Label="CONCLUSIONS">The frequency of SARS-CoV-2 infection was 16% among HCWs. Being a sanitation worker, inappropriate PPE use and lack of HCQ prophylaxis predisposed HCWs to SARS-CoV-2 infection.</AbstractText><CopyrightInformation>© The Author(s) 2021. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dev</LastName><ForeName>Nishanth</ForeName><Initials>N</Initials><Identifier Source="ORCID">0000-0003-2486-6725</Identifier><AffiliationInfo><Affiliation>Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meena</LastName><ForeName>Ramesh Chand</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>D K</ForeName><Initials>DK</Initials><AffiliationInfo><Affiliation>Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>Nitesh</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pulmonology and Critical Care, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi, India 110029.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sankar</LastName><ForeName>Jhuma</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, All India Institute of Medical Sciences, Delhi, India 110029.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trans R Soc Trop Med Hyg</MedlineTA><NlmUniqueID>7506129</NlmUniqueID><ISSNLinking>0035-9203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">HCQ</Keyword><Keyword MajorTopicYN="Y">PPE</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2 infection</Keyword><Keyword MajorTopicYN="Y">healthcare worker</Keyword><Keyword MajorTopicYN="Y">hydroxychloroquine</Keyword><Keyword MajorTopicYN="Y">personal protective equipment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>11</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2021</Year><Month>02</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2021</Year><Month>03</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>3</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>3</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>36</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33763687</ArticleId><ArticleId IdType="pii">6186057</ArticleId><ArticleId IdType="doi">10.1093/trstmh/trab047</ArticleId><ArticleId IdType="pmc">PMC8083760</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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