A retrospective analysis of the effect of the intervention of Arogya Kashayam in COVID-19 positive cases in Madhya Pradesh.
Identifieur interne : 001A65 ( Main/Corpus ); précédent : 001A64A retrospective analysis of the effect of the intervention of Arogya Kashayam in COVID-19 positive cases in Madhya Pradesh.
Auteurs : Umesh Shukla ; Sanjay Srivastava ; Pankaj Gupta ; Nitin UjjaliyaSource :
- Ayu [ 0974-8520 ]
Abstract
Introduction
Coronavirus disease (COVID-19) is a newly identified strain of corona virus that causes illness ranging from the clinical features similar to the common cold to a fatal condition due to severe respiratory failure. According to the WHO, there have been more than 26.3 million confirmed COVID-19 cases in more than 190 countries to date. In light of the outbreak, various treatment modalities have been considered, including traditional medicine, which has been widely used in the pandemic of severe acute respiratory syndrome (SARS) and H
Aim
To evaluate retrospectively, the effect of the intervention of AK-20 in COVID-19 positive cases as stand alone or in combination with hydroxychloroquine (HCQ) administered at CCC in Madhya Pradesh.
Materials and Methods
It is a retrospective study with 4432 COVID-19 reverse transcription-polymerase chain reaction (RTPCR) tested positive cases including 2750 males and 1682 females between 5 and 80 years of age. All the cases were intervened with AK-20 as stand alone or in combination with HCQ. Moreover, these patients were also given Zinc and Vitamin C simultaneously. The intervention of AK-20 was made through the district level government AYUSH machinery, and the related data were collected in specially designed case report form. The data were analyzed retrospectively, and outcomes included the RTPCR testing or asymptomatic discharge from the CCC as per the prevailing ICMR guidelines.
Results
The present study reveals that out of 4432 COVID-19 RTPCR-positive cases, 2817 (63.56%) received HCQ with AK-20 and 1615 cases (36.43%) received AK-20 as a stand alone treatment. Among the cases that received HCQ and AK-20, 2681 cases (94.17%) recovered completely in an average of 6.8 days and among those who were on standalone AK-20, 1502 cases (93.00%) recovered completely in the same average days. The Chi-square test showed that both the groups were equally effective (
Conclusion
The retrospective analysis showed that the treatment practices of AK-20 standalone or in combination with HCQ applied in COVID-19 positive cases at CCC in Madhya Pradesh were effective against SARS coronavirus 2 disease. A significant number of cases was tested negative or asymptomatically discharged from both the groups of interventions. Moreover, AK-20 alone has shown statistically equal results to that when used in combination with HCQ therapy.
DOI: 10.4103/ayu.ayu_365_20
PubMed: 33935437
PubMed Central: PMC8078609
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Khushilal Sharma Government Ayurveda College and Institute, Bhopal, Madhya Pradesh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Ujjaliya, Nitin" sort="Ujjaliya, Nitin" uniqKey="Ujjaliya N" first="Nitin" last="Ujjaliya">Nitin Ujjaliya</name><affiliation><nlm:affiliation>Department of Dravyaguna, Pt. Khushilal Sharma Government Ayurveda College and Institute, Bhopal, Madhya Pradesh, India.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019 Oct-Dec</date><idno type="RBID">pubmed:33935437</idno><idno type="pmid">33935437</idno><idno type="doi">10.4103/ayu.ayu_365_20</idno><idno type="pmc">PMC8078609</idno><idno type="wicri:Area/Main/Corpus">001A65</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001A65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A retrospective analysis of the effect of the intervention of <i>Arogya Kashayam</i> in COVID-19 positive cases in Madhya Pradesh.</title><author><name sortKey="Shukla, Umesh" sort="Shukla, Umesh" uniqKey="Shukla U" first="Umesh" last="Shukla">Umesh Shukla</name><affiliation><nlm:affiliation>Principal and Head, Department of kaya Panchakarma, Madhya Pradesh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Srivastava, Sanjay" sort="Srivastava, Sanjay" uniqKey="Srivastava S" first="Sanjay" last="Srivastava">Sanjay Srivastava</name><affiliation><nlm:affiliation>Department of Rog Nidan and Vikriti Vigyan,Madhya Pradesh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Gupta, Pankaj" sort="Gupta, Pankaj" uniqKey="Gupta P" first="Pankaj" last="Gupta">Pankaj Gupta</name><affiliation><nlm:affiliation>Department of Rachana Sharira, Pt. Khushilal Sharma Government Ayurveda College and Institute, Bhopal, Madhya Pradesh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Ujjaliya, Nitin" sort="Ujjaliya, Nitin" uniqKey="Ujjaliya N" first="Nitin" last="Ujjaliya">Nitin Ujjaliya</name><affiliation><nlm:affiliation>Department of Dravyaguna, Pt. Khushilal Sharma Government Ayurveda College and Institute, Bhopal, Madhya Pradesh, India.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Ayu</title><idno type="ISSN">0974-8520</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Introduction</b></p><p>Coronavirus disease (COVID-19) is a newly identified strain of corona virus that causes illness ranging from the clinical features similar to the common cold to a fatal condition due to severe respiratory failure. According to the WHO, there have been more than 26.3 million confirmed COVID-19 cases in more than 190 countries to date. In light of the outbreak, various treatment modalities have been considered, including traditional medicine, which has been widely used in the pandemic of severe acute respiratory syndrome (SARS) and H</p></div><div type="abstract" xml:lang="en"><p><b>Aim</b></p><p>To evaluate retrospectively, the effect of the intervention of AK-20 in COVID-19 positive cases as stand alone or in combination with hydroxychloroquine (HCQ) administered at CCC in Madhya Pradesh.</p></div><div type="abstract" xml:lang="en"><p><b>Materials and Methods</b></p><p>It is a retrospective study with 4432 COVID-19 reverse transcription-polymerase chain reaction (RTPCR) tested positive cases including 2750 males and 1682 females between 5 and 80 years of age. All the cases were intervened with AK-20 as stand alone or in combination with HCQ. Moreover, these patients were also given Zinc and Vitamin C simultaneously. The intervention of AK-20 was made through the district level government AYUSH machinery, and the related data were collected in specially designed case report form. The data were analyzed retrospectively, and outcomes included the RTPCR testing or asymptomatic discharge from the CCC as per the prevailing ICMR guidelines.</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>The present study reveals that out of 4432 COVID-19 RTPCR-positive cases, 2817 (63.56%) received HCQ with AK-20 and 1615 cases (36.43%) received AK-20 as a stand alone treatment. Among the cases that received HCQ and AK-20, 2681 cases (94.17%) recovered completely in an average of 6.8 days and among those who were on standalone AK-20, 1502 cases (93.00%) recovered completely in the same average days. The Chi-square test showed that both the groups were equally effective (</p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>The retrospective analysis showed that the treatment practices of AK-20 standalone or in combination with HCQ applied in COVID-19 positive cases at CCC in Madhya Pradesh were effective against SARS coronavirus 2 disease. A significant number of cases was tested negative or asymptomatically discharged from both the groups of interventions. Moreover, AK-20 alone has shown statistically equal results to that when used in combination with HCQ therapy.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33935437</PMID><DateRevised><Year>2021</Year><Month>05</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0974-8520</ISSN><JournalIssue CitedMedium="Print"><Volume>40</Volume><Issue>4</Issue><PubDate><MedlineDate>2019 Oct-Dec</MedlineDate></PubDate></JournalIssue><Title>Ayu</Title><ISOAbbreviation>Ayu</ISOAbbreviation></Journal><ArticleTitle>A retrospective analysis of the effect of the intervention of <i>Arogya Kashayam</i> in COVID-19 positive cases in Madhya Pradesh.</ArticleTitle><Pagination><MedlinePgn>209-215</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4103/ayu.ayu_365_20</ELocationID><Abstract><AbstractText Label="Introduction" NlmCategory="UNASSIGNED">Coronavirus disease (COVID-19) is a newly identified strain of corona virus that causes illness ranging from the clinical features similar to the common cold to a fatal condition due to severe respiratory failure. According to the WHO, there have been more than 26.3 million confirmed COVID-19 cases in more than 190 countries to date. In light of the outbreak, various treatment modalities have been considered, including traditional medicine, which has been widely used in the pandemic of severe acute respiratory syndrome (SARS) and H<sub>1</sub>N<sub>1</sub> influenza. Ayurveda contributes a measurable ratio in the world's traditional practices. As per the guideline of directorate of AYUSH, Government of Madhya Pradesh, cases of COVID-19 were intervened with <i>Arogya</i><i>Kashayam</i> (AK-20), a decoction prepared from the herbs at 88 COVID Care Centers (CCC) across the state.</AbstractText><AbstractText Label="Aim" NlmCategory="UNASSIGNED">To evaluate retrospectively, the effect of the intervention of AK-20 in COVID-19 positive cases as stand alone or in combination with hydroxychloroquine (HCQ) administered at CCC in Madhya Pradesh.</AbstractText><AbstractText Label="Materials and Methods" NlmCategory="UNASSIGNED">It is a retrospective study with 4432 COVID-19 reverse transcription-polymerase chain reaction (RTPCR) tested positive cases including 2750 males and 1682 females between 5 and 80 years of age. All the cases were intervened with AK-20 as stand alone or in combination with HCQ. Moreover, these patients were also given Zinc and Vitamin C simultaneously. The intervention of AK-20 was made through the district level government AYUSH machinery, and the related data were collected in specially designed case report form. The data were analyzed retrospectively, and outcomes included the RTPCR testing or asymptomatic discharge from the CCC as per the prevailing ICMR guidelines.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">The present study reveals that out of 4432 COVID-19 RTPCR-positive cases, 2817 (63.56%) received HCQ with AK-20 and 1615 cases (36.43%) received AK-20 as a stand alone treatment. Among the cases that received HCQ and AK-20, 2681 cases (94.17%) recovered completely in an average of 6.8 days and among those who were on standalone AK-20, 1502 cases (93.00%) recovered completely in the same average days. The Chi-square test showed that both the groups were equally effective (<i>P</i> < 0.01; <i>F</i> = 0.3764).</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">The retrospective analysis showed that the treatment practices of AK-20 standalone or in combination with HCQ applied in COVID-19 positive cases at CCC in Madhya Pradesh were effective against SARS coronavirus 2 disease. A significant number of cases was tested negative or asymptomatically discharged from both the groups of interventions. Moreover, AK-20 alone has shown statistically equal results to that when used in combination with HCQ therapy.</AbstractText><CopyrightInformation>Copyright: © 2021 AYU (An International Quarterly Journal of Research in Ayurveda).</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shukla</LastName><ForeName>Umesh</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Principal and Head, Department of kaya Panchakarma, Madhya Pradesh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Srivastava</LastName><ForeName>Sanjay</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Rog Nidan and Vikriti Vigyan,Madhya Pradesh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>Pankaj</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Rachana Sharira, Pt. Khushilal Sharma Government Ayurveda College and Institute, Bhopal, Madhya Pradesh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ujjaliya</LastName><ForeName>Nitin</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Dravyaguna, Pt. Khushilal Sharma Government Ayurveda College and Institute, Bhopal, Madhya Pradesh, India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>01</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>India</Country><MedlineTA>Ayu</MedlineTA><NlmUniqueID>7605807</NlmUniqueID><ISSNLinking>0974-8520</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antiviral drugs</Keyword><Keyword MajorTopicYN="N">Arogya Kashyam</Keyword><Keyword MajorTopicYN="N">corona virus</Keyword><Keyword MajorTopicYN="N">immunomodulation</Keyword><Keyword MajorTopicYN="N">severe acute respiratory syndrome</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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