Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.
Identifieur interne : 001A58 ( Main/Corpus ); précédent : 001A57; suivant : 001A59Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.
Auteurs : Jia Liu ; Ruiyuan Cao ; Mingyue Xu ; Xi Wang ; Huanyu Zhang ; Hengrui Hu ; Yufeng Li ; Zhihong Hu ; Wu Zhong ; Manli WangSource :
- Cell discovery [ 2056-5968 ] ; 2020.
DOI: 10.1038/s41421-020-0156-0
PubMed: 32194981
PubMed Central: PMC7078228
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of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>3University of the Chinese Academy of Sciences, 100049 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xi" sort="Wang, Xi" uniqKey="Wang X" first="Xi" last="Wang">Xi Wang</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Huanyu" sort="Zhang, Huanyu" uniqKey="Zhang H" first="Huanyu" last="Zhang">Huanyu Zhang</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>3University of the Chinese Academy of Sciences, 100049 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Hengrui" sort="Hu, Hengrui" uniqKey="Hu H" first="Hengrui" last="Hu">Hengrui Hu</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>3University of the Chinese Academy of Sciences, 100049 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yufeng" sort="Li, Yufeng" uniqKey="Li Y" first="Yufeng" last="Li">Yufeng Li</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>3University of the Chinese Academy of Sciences, 100049 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Zhihong" sort="Hu, Zhihong" uniqKey="Hu Z" first="Zhihong" last="Hu">Zhihong Hu</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Wu" sort="Zhong, Wu" uniqKey="Zhong W" first="Wu" last="Zhong">Wu Zhong</name><affiliation><nlm:affiliation>2National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, 100850 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Manli" sort="Wang, Manli" uniqKey="Wang M" first="Manli" last="Wang">Manli Wang</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32194981</idno><idno type="pmid">32194981</idno><idno type="doi">10.1038/s41421-020-0156-0</idno><idno type="pmc">PMC7078228</idno><idno type="wicri:Area/Main/Corpus">001A58</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001A58</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.</title><author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Ruiyuan" sort="Cao, Ruiyuan" uniqKey="Cao R" first="Ruiyuan" last="Cao">Ruiyuan Cao</name><affiliation><nlm:affiliation>2National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, 100850 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Mingyue" sort="Xu, Mingyue" uniqKey="Xu M" first="Mingyue" last="Xu">Mingyue Xu</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>3University of the Chinese Academy of Sciences, 100049 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xi" sort="Wang, Xi" uniqKey="Wang X" first="Xi" last="Wang">Xi Wang</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Huanyu" sort="Zhang, Huanyu" uniqKey="Zhang H" first="Huanyu" last="Zhang">Huanyu Zhang</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>3University of the Chinese Academy of Sciences, 100049 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Hengrui" sort="Hu, Hengrui" uniqKey="Hu H" first="Hengrui" last="Hu">Hengrui Hu</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>3University of the Chinese Academy of Sciences, 100049 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yufeng" sort="Li, Yufeng" uniqKey="Li Y" first="Yufeng" last="Li">Yufeng Li</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>3University of the Chinese Academy of Sciences, 100049 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Zhihong" sort="Hu, Zhihong" uniqKey="Hu Z" first="Zhihong" last="Hu">Zhihong Hu</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Wu" sort="Zhong, Wu" uniqKey="Zhong W" first="Wu" last="Zhong">Wu Zhong</name><affiliation><nlm:affiliation>2National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, 100850 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Manli" sort="Wang, Manli" uniqKey="Wang M" first="Manli" last="Wang">Manli Wang</name><affiliation><nlm:affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cell discovery</title><idno type="ISSN">2056-5968</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32194981</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2056-5968</ISSN><JournalIssue CitedMedium="Print"><Volume>6</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Cell discovery</Title><ISOAbbreviation>Cell Discov</ISOAbbreviation></Journal><ArticleTitle>Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.</ArticleTitle><Pagination><MedlinePgn>16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41421-020-0156-0</ELocationID><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Liu</LastName><ForeName>Jia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>1State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071 Wuhan, China.</Affiliation><Identifier Source="ISNI">0000000119573309</Identifier><Identifier Source="GRID">grid.9227.e</Identifier></AffiliationInfo></Author><Author ValidYN="Y" 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DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cell Discov</MedlineTA><NlmUniqueID>101661034</NlmUniqueID><ISSNLinking>2056-5968</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Eur Heart J Cardiovasc Pharmacother. 2020 Jul 1;6(4):256-257</RefSource><PMID Version="1">32347923</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Autophagy</Keyword><Keyword MajorTopicYN="N">Transcription</Keyword></KeywordList><CoiStatement>Conflict of interestThe authors declare that they have no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>04</Day></PubMedPubDate><PubMedPubDate 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