COVID-19 in solid organ transplant recipients: A single-center case series from Spain.
Identifieur interne : 001960 ( Main/Corpus ); précédent : 001959; suivant : 001961COVID-19 in solid organ transplant recipients: A single-center case series from Spain.
Auteurs : Mario Fernández-Ruiz ; Amado Andrés ; Carmelo Loinaz ; Juan F. Delgado ; Francisco L Pez-Medrano ; Rafael San Juan ; Esther González ; Natalia Polanco ; María D. Folgueira ; Antonio Lalueza ; Carlos Lumbreras ; José M. AguadoSource :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2020.
English descriptors
- KwdEn :
- Aged (MeSH), Antiviral Agents (administration & dosage), Betacoronavirus (MeSH), COVID-19 (MeSH), Coronavirus Infections (complications), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Drug Combinations (MeSH), Female (MeSH), Fever (MeSH), Humans (MeSH), Hydroxychloroquine (administration & dosage), Immunosuppressive Agents (administration & dosage), Immunosuppressive Agents (adverse effects), Interferon-beta (administration & dosage), Lopinavir (administration & dosage), Male (MeSH), Middle Aged (MeSH), Organ Transplantation (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), Radiography, Thoracic (MeSH), Retrospective Studies (MeSH), Ritonavir (administration & dosage), SARS-CoV-2 (MeSH), Spain (epidemiology), Transplant Recipients (MeSH).
- MESH :
- chemical , administration & dosage : Antiviral Agents, Hydroxychloroquine, Immunosuppressive Agents, Interferon-beta, Lopinavir, Ritonavir.
- chemical , adverse effects : Immunosuppressive Agents.
- geographic , epidemiology : Spain.
- complications : Coronavirus Infections, Pneumonia, Viral.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Aged, Betacoronavirus, COVID-19, Drug Combinations, Female, Fever, Humans, Male, Middle Aged, Organ Transplantation, Pandemics, Radiography, Thoracic, Retrospective Studies, SARS-CoV-2, Transplant Recipients.
Abstract
The clinical characteristics, management, and outcome of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after solid organ transplant (SOT) remain unknown. We report our preliminary experience with 18 SOT (kidney [44.4%], liver [33.3%], and heart [22.2%]) recipients diagnosed with COVID-19 by March 23, 2020 at a tertiary-care center at Madrid. Median age at diagnosis was 71.0 ± 12.8 years, and the median interval since transplantation was 9.3 years. Fever (83.3%) and radiographic abnormalities in form of unilateral or bilateral/multifocal consolidations (72.2%) were the most common presentations. Lopinavir/ritonavir (usually associated with hydroxychloroquine) was used in 50.0% of patients and had to be prematurely discontinued in 2 of them. Other antiviral regimens included hydroxychloroquine monotherapy (27.8%) and interferon-β (16.7%). As of April 4, the case-fatality rate was 27.8% (5/18). After a median follow-up of 18 days from symptom onset, 30.8% (4/13) of survivors developed progressive respiratory failure, 7.7% (1/13) showed stable clinical condition or improvement, and 61.5% (8/13) had been discharged home. C-reactive protein levels at various points were significantly higher among recipients who experienced unfavorable outcome. In conclusion, this frontline report suggests that SARS-CoV-2 infection has a severe course in SOT recipients.
DOI: 10.1111/ajt.15929
PubMed: 32301155
Links to Exploration step
pubmed:32301155Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COVID-19 in solid organ transplant recipients: A single-center case series from Spain.</title><author><name sortKey="Fernandez Ruiz, Mario" sort="Fernandez Ruiz, Mario" uniqKey="Fernandez Ruiz M" first="Mario" last="Fernández-Ruiz">Mario Fernández-Ruiz</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Andres, Amado" sort="Andres, Amado" uniqKey="Andres A" first="Amado" last="Andrés">Amado Andrés</name><affiliation><nlm:affiliation>Department of Nephrology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Loinaz, Carmelo" sort="Loinaz, Carmelo" uniqKey="Loinaz C" first="Carmelo" last="Loinaz">Carmelo Loinaz</name><affiliation><nlm:affiliation>Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Delgado, Juan F" sort="Delgado, Juan F" uniqKey="Delgado J" first="Juan F" last="Delgado">Juan F. Delgado</name><affiliation><nlm:affiliation>Department of Cardiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Medrano, Francisco" sort="L Pez Medrano, Francisco" uniqKey="L Pez Medrano F" first="Francisco" last="L Pez-Medrano">Francisco L Pez-Medrano</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="San Juan, Rafael" sort="San Juan, Rafael" uniqKey="San Juan R" first="Rafael" last="San Juan">Rafael San Juan</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gonzalez, Esther" sort="Gonzalez, Esther" uniqKey="Gonzalez E" first="Esther" last="González">Esther González</name><affiliation><nlm:affiliation>Department of Nephrology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Polanco, Natalia" sort="Polanco, Natalia" uniqKey="Polanco N" first="Natalia" last="Polanco">Natalia Polanco</name><affiliation><nlm:affiliation>Department of Nephrology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Folgueira, Maria D" sort="Folgueira, Maria D" uniqKey="Folgueira M" first="María D" last="Folgueira">María D. Folgueira</name><affiliation><nlm:affiliation>Department of Microbiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lalueza, Antonio" sort="Lalueza, Antonio" uniqKey="Lalueza A" first="Antonio" last="Lalueza">Antonio Lalueza</name><affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lumbreras, Carlos" sort="Lumbreras, Carlos" uniqKey="Lumbreras C" first="Carlos" last="Lumbreras">Carlos Lumbreras</name><affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Aguado, Jose M" sort="Aguado, Jose M" uniqKey="Aguado J" first="José M" last="Aguado">José M. Aguado</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32301155</idno><idno type="pmid">32301155</idno><idno type="doi">10.1111/ajt.15929</idno><idno type="wicri:Area/Main/Corpus">001960</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001960</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19 in solid organ transplant recipients: A single-center case series from Spain.</title><author><name sortKey="Fernandez Ruiz, Mario" sort="Fernandez Ruiz, Mario" uniqKey="Fernandez Ruiz M" first="Mario" last="Fernández-Ruiz">Mario Fernández-Ruiz</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Andres, Amado" sort="Andres, Amado" uniqKey="Andres A" first="Amado" last="Andrés">Amado Andrés</name><affiliation><nlm:affiliation>Department of Nephrology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Loinaz, Carmelo" sort="Loinaz, Carmelo" uniqKey="Loinaz C" first="Carmelo" last="Loinaz">Carmelo Loinaz</name><affiliation><nlm:affiliation>Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Delgado, Juan F" sort="Delgado, Juan F" uniqKey="Delgado J" first="Juan F" last="Delgado">Juan F. Delgado</name><affiliation><nlm:affiliation>Department of Cardiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Medrano, Francisco" sort="L Pez Medrano, Francisco" uniqKey="L Pez Medrano F" first="Francisco" last="L Pez-Medrano">Francisco L Pez-Medrano</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="San Juan, Rafael" sort="San Juan, Rafael" uniqKey="San Juan R" first="Rafael" last="San Juan">Rafael San Juan</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gonzalez, Esther" sort="Gonzalez, Esther" uniqKey="Gonzalez E" first="Esther" last="González">Esther González</name><affiliation><nlm:affiliation>Department of Nephrology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Polanco, Natalia" sort="Polanco, Natalia" uniqKey="Polanco N" first="Natalia" last="Polanco">Natalia Polanco</name><affiliation><nlm:affiliation>Department of Nephrology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Folgueira, Maria D" sort="Folgueira, Maria D" uniqKey="Folgueira M" first="María D" last="Folgueira">María D. Folgueira</name><affiliation><nlm:affiliation>Department of Microbiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lalueza, Antonio" sort="Lalueza, Antonio" uniqKey="Lalueza A" first="Antonio" last="Lalueza">Antonio Lalueza</name><affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lumbreras, Carlos" sort="Lumbreras, Carlos" uniqKey="Lumbreras C" first="Carlos" last="Lumbreras">Carlos Lumbreras</name><affiliation><nlm:affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Aguado, Jose M" sort="Aguado, Jose M" uniqKey="Aguado J" first="José M" last="Aguado">José M. Aguado</name><affiliation><nlm:affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</nlm:affiliation></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Antiviral Agents (administration & dosage)</term><term>Betacoronavirus (MeSH)</term><term>COVID-19 (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (therapy)</term><term>Drug Combinations (MeSH)</term><term>Female (MeSH)</term><term>Fever (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (administration & dosage)</term><term>Immunosuppressive Agents (administration & dosage)</term><term>Immunosuppressive Agents (adverse effects)</term><term>Interferon-beta (administration & dosage)</term><term>Lopinavir (administration & dosage)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Organ Transplantation (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (therapy)</term><term>Radiography, Thoracic (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Ritonavir (administration & dosage)</term><term>SARS-CoV-2 (MeSH)</term><term>Spain (epidemiology)</term><term>Transplant Recipients (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term><term>Hydroxychloroquine</term><term>Immunosuppressive Agents</term><term>Interferon-beta</term><term>Lopinavir</term><term>Ritonavir</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Betacoronavirus</term><term>COVID-19</term><term>Drug Combinations</term><term>Female</term><term>Fever</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Organ Transplantation</term><term>Pandemics</term><term>Radiography, Thoracic</term><term>Retrospective Studies</term><term>SARS-CoV-2</term><term>Transplant Recipients</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The clinical characteristics, management, and outcome of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after solid organ transplant (SOT) remain unknown. We report our preliminary experience with 18 SOT (kidney [44.4%], liver [33.3%], and heart [22.2%]) recipients diagnosed with COVID-19 by March 23, 2020 at a tertiary-care center at Madrid. Median age at diagnosis was 71.0 ± 12.8 years, and the median interval since transplantation was 9.3 years. Fever (83.3%) and radiographic abnormalities in form of unilateral or bilateral/multifocal consolidations (72.2%) were the most common presentations. Lopinavir/ritonavir (usually associated with hydroxychloroquine) was used in 50.0% of patients and had to be prematurely discontinued in 2 of them. Other antiviral regimens included hydroxychloroquine monotherapy (27.8%) and interferon-β (16.7%). As of April 4, the case-fatality rate was 27.8% (5/18). After a median follow-up of 18 days from symptom onset, 30.8% (4/13) of survivors developed progressive respiratory failure, 7.7% (1/13) showed stable clinical condition or improvement, and 61.5% (8/13) had been discharged home. C-reactive protein levels at various points were significantly higher among recipients who experienced unfavorable outcome. In conclusion, this frontline report suggests that SARS-CoV-2 infection has a severe course in SOT recipients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32301155</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>20</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>07</Month></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am J Transplant</ISOAbbreviation></Journal><ArticleTitle>COVID-19 in solid organ transplant recipients: A single-center case series from Spain.</ArticleTitle><Pagination><MedlinePgn>1849-1858</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.15929</ELocationID><Abstract><AbstractText>The clinical characteristics, management, and outcome of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after solid organ transplant (SOT) remain unknown. We report our preliminary experience with 18 SOT (kidney [44.4%], liver [33.3%], and heart [22.2%]) recipients diagnosed with COVID-19 by March 23, 2020 at a tertiary-care center at Madrid. Median age at diagnosis was 71.0 ± 12.8 years, and the median interval since transplantation was 9.3 years. Fever (83.3%) and radiographic abnormalities in form of unilateral or bilateral/multifocal consolidations (72.2%) were the most common presentations. Lopinavir/ritonavir (usually associated with hydroxychloroquine) was used in 50.0% of patients and had to be prematurely discontinued in 2 of them. Other antiviral regimens included hydroxychloroquine monotherapy (27.8%) and interferon-β (16.7%). As of April 4, the case-fatality rate was 27.8% (5/18). After a median follow-up of 18 days from symptom onset, 30.8% (4/13) of survivors developed progressive respiratory failure, 7.7% (1/13) showed stable clinical condition or improvement, and 61.5% (8/13) had been discharged home. C-reactive protein levels at various points were significantly higher among recipients who experienced unfavorable outcome. In conclusion, this frontline report suggests that SARS-CoV-2 infection has a severe course in SOT recipients.</AbstractText><CopyrightInformation>© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fernández-Ruiz</LastName><ForeName>Mario</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-0315-8001</Identifier><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrés</LastName><ForeName>Amado</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0003-0238-1364</Identifier><AffiliationInfo><Affiliation>Department of Nephrology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loinaz</LastName><ForeName>Carmelo</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of General Surgery, Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delgado</LastName><ForeName>Juan F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-Medrano</LastName><ForeName>Francisco</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0001-5333-7529</Identifier><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>San Juan</LastName><ForeName>Rafael</ForeName><Initials>R</Initials><Identifier Source="ORCID">0000-0003-3446-1991</Identifier><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>González</LastName><ForeName>Esther</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Nephrology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Polanco</LastName><ForeName>Natalia</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Nephrology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Folgueira</LastName><ForeName>María D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lalueza</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lumbreras</LastName><ForeName>Carlos</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aguado</LastName><ForeName>José M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Spanish Ministry of Science and Innovation</Agency><Country>International</Country></Grant><Grant><GrantID>13/00045</GrantID><Agency>Instituto de Salud Carlos III</Agency><Country>International</Country></Grant><Grant><GrantID>CP 18/00073</GrantID><Agency>Instituto de Salud Carlos III</Agency><Country>International</Country></Grant><Grant><GrantID>COV 20/00181</GrantID><Agency>Instituto de Salud Carlos III</Agency><Country>International</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C558899">lopinavir-ritonavir drug combination</NameOfSubstance></Chemical><Chemical><RegistryNumber>2494G1JF75</RegistryNumber><NameOfSubstance UI="D061466">Lopinavir</NameOfSubstance></Chemical><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>77238-31-4</RegistryNumber><NameOfSubstance UI="D016899">Interferon-beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>O3J8G9O825</RegistryNumber><NameOfSubstance UI="D019438">Ritonavir</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Am J Transplant. 2020 Sep;20(9):2630-2631</RefSource><PMID Version="1">32400965</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Am J Transplant. 2020 Sep;20(9):2628-2629</RefSource><PMID Version="1">32436646</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005334" MajorTopicYN="N">Fever</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016899" MajorTopicYN="N">Interferon-beta</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D061466" MajorTopicYN="N">Lopinavir</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016377" MajorTopicYN="Y">Organ Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013902" MajorTopicYN="N">Radiography, Thoracic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019438" MajorTopicYN="N">Ritonavir</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D066027" MajorTopicYN="Y">Transplant Recipients</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword><Keyword MajorTopicYN="Y">coronavirus</Keyword><Keyword MajorTopicYN="Y">outcome</Keyword><Keyword MajorTopicYN="Y">solid organ transplantation</Keyword><Keyword MajorTopicYN="Y">treatment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>04</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32301155</ArticleId><ArticleId IdType="doi">10.1111/ajt.15929</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>Zhu NA, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727-733.</Citation></Reference><Reference><Citation>Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395:565-574.</Citation></Reference><Reference><Citation>World Health Organization (WHO). Coronavirus disease 2019 (COVID-19). Situation Report 67. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200327-sitrep-67-covid-19.pdf?sfvrsn=b65f68eb_4. Accessed March 28, 2020.</Citation></Reference><Reference><Citation>Instituto de Salud Carlos III, Centro Nacional de Epidemiología. Informe sobre la situación de COVID-19 en España nº 16 (26 de marzo de 2020). https://www.isciii.es/QueHacemos/Servicios/VigilanciaSaludPublicaRENAVE/EnfermedadesTransmisibles/Documents/INFORMES/Informes%20COVID-19/Informe%20nº%2016.%20Situación%20de%20COVID-19%20en%20España%20a%2026%20marzo%20de%202020.pdf. Accessed March 28, 2020.</Citation></Reference><Reference><Citation>Michaels MG, La Hoz RM, Danziger-Isakov L, et al. Coronavirus disease 2019: implications of emerging infections for transplantation [published online ahead of print 2020]. Am J Transplant. https://doi.org/10.1111/ajt.15832.</Citation></Reference><Reference><Citation>Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497-506.</Citation></Reference><Reference><Citation>Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China[published online ahead of print 2020]. JAMA Intern Med. https://doi.org/10.1001/jamainternmed.2020.0994.</Citation></Reference><Reference><Citation>Young BE, Ong SWX, Kalimuddin S, et al. Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore [published online ahead of print 2020]. JAMA. https://doi.org/10.1001/jama.2020.3204.</Citation></Reference><Reference><Citation>Zhu L, Xu X, Ma K, et al. Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression [published online ahead of print 2020]. Am J Transplant. https://doi.org/10.1111/ajt.15869.</Citation></Reference><Reference><Citation>Guillen E, Pineiro GJ, Revuelta I, et al. Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation? [published online ahead of print 2020]. Am J Transplant. https://doi.org/10.1111/ajt.15874.</Citation></Reference><Reference><Citation>Manuel O, Lopez-Medrano F, Keiser L, et al. Influenza and other respiratory virus infections in solid organ transplant recipients. Clin Microbiol Infect. 2014;20(suppl 7):102-108.</Citation></Reference><Reference><Citation>Cordero E, Perez-Romero P, Moreno A, et al. Pandemic influenza A(H1N1) virus infection in solid organ transplant recipients: impact of viral and non-viral co-infection. Clin Microbiol Infect. 2012;18:67-73.</Citation></Reference><Reference><Citation>Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression [published online ahead of print 2020]. Lancet https://doi.org/10.1016/S0140-6736(20)30628-0.</Citation></Reference><Reference><Citation>Rice TW, Wheeler AP, Bernard GR, et al. Comparison of the SpO2/FiO2 ratio and the PaO2/FiO2 ratio in patients with acute lung injury or ARDS. Chest. 2007;132:410-417.</Citation></Reference><Reference><Citation>ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307:2526-2533.</Citation></Reference><Reference><Citation>Ministerio de Sanidad. Centro de Coordinación de Alertas y Emergencias Sanitarias. Documento técnico de manejo clínico de pacientes con enfermedad por el nuevo coronavirus (COVID-19) (versión 3 de Marzo de 2020). https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Protocolo_manejo_clinico_COVID-19.pdf. Accessed March 21, 2020.</Citation></Reference><Reference><Citation>Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 patients. AJR Am J Roentgenol. 2020:1-7. https://doi.org/10.2214/AJR.20.23034</Citation></Reference><Reference><Citation>Martinez MA. Compounds with therapeutic potential against novel respiratory 2019 coronavirus [published online ahead of print 2020]. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.00399-20.</Citation></Reference><Reference><Citation>Yao X, Ye F, Zhang M, et al. In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [published online ahead of print 2020]. Clin Infect Dis. https://doi.org/10.1093/cid/ciaa237.</Citation></Reference><Reference><Citation>Gautret P, Lagier JC, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial [published online ahead of print 2020]. Int J Antimicrob Agents. https://doi.org/10.1016/j.ijantimicag.2020.105949.</Citation></Reference><Reference><Citation>Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 [published online ahead of print 2020]. N Engl J Med. https://doi.org/10.1056/NEJMoa2001282.</Citation></Reference><Reference><Citation>Jain AB, Venkataramanan R, Eghtesad B, et al. Effect of coadministered lopinavir and ritonavir (Kaletra) on tacrolimus blood concentration in liver transplantation patients. Liver Transpl. 2003;9:954-960.</Citation></Reference><Reference><Citation>Gandolfini I, Delsante M, Fiaccadori E, et al. COVID-19 in kidney transplant recipients [published online ahead of print 2020]. Am J Transplant. https://doi.org/10.1111/ajt.15891.</Citation></Reference><Reference><Citation>Chen S, Yin Q, Shi H, et al. A familial cluster, including a kidney transplant recipient, of Coronavirus Disease 2019 (COVID-19) in Wuhan, China [published online ahead of print 2020]. Am J Transplant. https://doi.org/10.1111/ajt.15903.</Citation></Reference><Reference><Citation>Huang J, Lin H, Wu Y, et al. COVID-19 in post-transplantation patients - report of two cases [published online ahead of print 2020]. Am J Transplant. https://doi.org/10.1111/ajt.15896.</Citation></Reference><Reference><Citation>Bin L, Yangzhong W, Yuanyuan Z, Huibo S, Fanjun Z, Zhishui C. Successful treatment of severe COVID-19 pneumonia in a liver transplant recipient [published online ahead of print 2020]. Am J Transplant. https://doi.org/10.1111/ajt.15901.</Citation></Reference><Reference><Citation>Seminari E, Colaneri M, Sambo M, et al. Cov2 infection in a renal transplanted patients. A case report [published online ahead of print 2020]. Am J Transplant. https://doi.org/10.1111/ajt.15902.</Citation></Reference><Reference><Citation>Li F, Cai J, Dong N. First cases of COVID-19 in heart transplantation from China [published online ahead of print 2020]. J Heart Lung Transplant. https://doi.org/10.1016/j.healun.2020.03.006.</Citation></Reference><Reference><Citation>Antonio R, Silvia M. Immunosuppression drug-related and clinical manifestation of Coronavirus disease 2019: a therapeutical hypothesis [published online ahead of print 2020]. Am J Transplant. https://doi.org/10.1111/ajt.15905.</Citation></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001960 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001960 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidChloroV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:32301155
|texte= COVID-19 in solid organ transplant recipients: A single-center case series from Spain.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:32301155" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a CovidChloroV1
| This area was generated with Dilib version V0.6.38. |  |