Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.
Identifieur interne : 001864 ( Main/Corpus ); précédent : 001863; suivant : 001865Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.
Auteurs : Bernard La Scola ; Marion Le Bideau ; Julien Andreani ; Van Thuan Hoang ; Clio Grimaldier ; Philippe Colson ; Philippe Gautret ; Didier RaoultSource :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [ 1435-4373 ] ; 2020.
English descriptors
- KwdEn :
- Animals (MeSH), Betacoronavirus (isolation & purification), Betacoronavirus (physiology), COVID-19 (MeSH), Chlorocebus aethiops (MeSH), Coronavirus Infections (diagnosis), Coronavirus Infections (virology), France (MeSH), Humans (MeSH), Pandemics (MeSH), Patient Discharge (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (virology), RNA, Viral (analysis), Reverse Transcriptase Polymerase Chain Reaction (MeSH), SARS-CoV-2 (MeSH), Specimen Handling (standards), Vero Cells (MeSH), Viral Load (MeSH).
- MESH :
- chemical , analysis : RNA, Viral.
- geographic : France.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- isolation & purification : Betacoronavirus.
- physiology : Betacoronavirus.
- standards : Specimen Handling.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Animals, COVID-19, Chlorocebus aethiops, Humans, Pandemics, Patient Discharge, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Vero Cells, Viral Load.
Abstract
In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. It is of paramount importance to define when a treated patient can be considered as no longer contagious. Correlation between successful isolation of virus in cell culture and Ct value of quantitative RT-PCR targeting E gene suggests that patients with Ct above 33-34 using our RT-PCR system are not contagious and thus can be discharged from hospital care or strict confinement for non-hospitalized patients.
DOI: 10.1007/s10096-020-03913-9
PubMed: 32342252
PubMed Central: PMC7185831
Links to Exploration step
pubmed:32342252Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.</title><author><name sortKey="La Scola, Bernard" sort="La Scola, Bernard" uniqKey="La Scola B" first="Bernard" last="La Scola">Bernard La Scola</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France. bernard.la-scola@univ-amu.fr.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. bernard.la-scola@univ-amu.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Le Bideau, Marion" sort="Le Bideau, Marion" uniqKey="Le Bideau M" first="Marion" last="Le Bideau">Marion Le Bideau</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Andreani, Julien" sort="Andreani, Julien" uniqKey="Andreani J" first="Julien" last="Andreani">Julien Andreani</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hoang, Van Thuan" sort="Hoang, Van Thuan" uniqKey="Hoang V" first="Van Thuan" last="Hoang">Van Thuan Hoang</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam.</nlm:affiliation></affiliation></author><author><name sortKey="Grimaldier, Clio" sort="Grimaldier, Clio" uniqKey="Grimaldier C" first="Clio" last="Grimaldier">Clio Grimaldier</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Colson, Philippe" sort="Colson, Philippe" uniqKey="Colson P" first="Philippe" last="Colson">Philippe Colson</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gautret, Philippe" sort="Gautret, Philippe" uniqKey="Gautret P" first="Philippe" last="Gautret">Philippe Gautret</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France. didier.raoult@gmail.com.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. didier.raoult@gmail.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32342252</idno><idno type="pmid">32342252</idno><idno type="doi">10.1007/s10096-020-03913-9</idno><idno type="pmc">PMC7185831</idno><idno type="wicri:Area/Main/Corpus">001864</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001864</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.</title><author><name sortKey="La Scola, Bernard" sort="La Scola, Bernard" uniqKey="La Scola B" first="Bernard" last="La Scola">Bernard La Scola</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France. bernard.la-scola@univ-amu.fr.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. bernard.la-scola@univ-amu.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Le Bideau, Marion" sort="Le Bideau, Marion" uniqKey="Le Bideau M" first="Marion" last="Le Bideau">Marion Le Bideau</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Andreani, Julien" sort="Andreani, Julien" uniqKey="Andreani J" first="Julien" last="Andreani">Julien Andreani</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hoang, Van Thuan" sort="Hoang, Van Thuan" uniqKey="Hoang V" first="Van Thuan" last="Hoang">Van Thuan Hoang</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam.</nlm:affiliation></affiliation></author><author><name sortKey="Grimaldier, Clio" sort="Grimaldier, Clio" uniqKey="Grimaldier C" first="Clio" last="Grimaldier">Clio Grimaldier</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Colson, Philippe" sort="Colson, Philippe" uniqKey="Colson P" first="Philippe" last="Colson">Philippe Colson</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gautret, Philippe" sort="Gautret, Philippe" uniqKey="Gautret P" first="Philippe" last="Gautret">Philippe Gautret</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><affiliation><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France. didier.raoult@gmail.com.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. didier.raoult@gmail.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</title><idno type="eISSN">1435-4373</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Betacoronavirus (isolation & purification)</term><term>Betacoronavirus (physiology)</term><term>COVID-19 (MeSH)</term><term>Chlorocebus aethiops (MeSH)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (virology)</term><term>France (MeSH)</term><term>Humans (MeSH)</term><term>Pandemics (MeSH)</term><term>Patient Discharge (MeSH)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (virology)</term><term>RNA, Viral (analysis)</term><term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term><term>SARS-CoV-2 (MeSH)</term><term>Specimen Handling (standards)</term><term>Vero Cells (MeSH)</term><term>Viral Load (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Specimen Handling</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>COVID-19</term><term>Chlorocebus aethiops</term><term>Humans</term><term>Pandemics</term><term>Patient Discharge</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS-CoV-2</term><term>Vero Cells</term><term>Viral Load</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. It is of paramount importance to define when a treated patient can be considered as no longer contagious. Correlation between successful isolation of virus in cell culture and Ct value of quantitative RT-PCR targeting E gene suggests that patients with Ct above 33-34 using our RT-PCR system are not contagious and thus can be discharged from hospital care or strict confinement for non-hospitalized patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32342252</PMID><DateCompleted><Year>2020</Year><Month>05</Month><Day>18</Day></DateCompleted><DateRevised><Year>2021</Year><Month>01</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1435-4373</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><Issue>6</Issue><PubDate><Year>2020</Year><Month>Jun</Month></PubDate></JournalIssue><Title>European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology</Title><ISOAbbreviation>Eur J Clin Microbiol Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.</ArticleTitle><Pagination><MedlinePgn>1059-1061</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10096-020-03913-9</ELocationID><Abstract><AbstractText>In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. It is of paramount importance to define when a treated patient can be considered as no longer contagious. Correlation between successful isolation of virus in cell culture and Ct value of quantitative RT-PCR targeting E gene suggests that patients with Ct above 33-34 using our RT-PCR system are not contagious and thus can be discharged from hospital care or strict confinement for non-hospitalized patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>La Scola</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-8006-7704</Identifier><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France. bernard.la-scola@univ-amu.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. bernard.la-scola@univ-amu.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Bideau</LastName><ForeName>Marion</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andreani</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoang</LastName><ForeName>Van Thuan</ForeName><Initials>VT</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grimaldier</LastName><ForeName>Clio</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colson</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gautret</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raoult</LastName><ForeName>Didier</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France. didier.raoult@gmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. didier.raoult@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Eur J Clin Microbiol Infect Dis</MedlineTA><NlmUniqueID>8804297</NlmUniqueID><ISSNLinking>0934-9723</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010351" MajorTopicYN="Y">Patient Discharge</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013048" MajorTopicYN="N">Specimen Handling</DescriptorName><QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="Y">Viral Load</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Co-culture</Keyword><Keyword MajorTopicYN="N">Correlation</Keyword><Keyword MajorTopicYN="N">Covid-19</Keyword><Keyword MajorTopicYN="N">RT-PCR</Keyword><Keyword MajorTopicYN="N">SARS-CoV2</Keyword><Keyword MajorTopicYN="N">Viral load</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>5</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32342252</ArticleId><ArticleId IdType="doi">10.1007/s10096-020-03913-9</ArticleId><ArticleId IdType="pii">10.1007/s10096-020-03913-9</ArticleId><ArticleId IdType="pmc">PMC7185831</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):793-798</Citation><ArticleIdList><ArticleId IdType="pubmed">32221523</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2020 Jul 28;71(15):732-739</Citation><ArticleIdList><ArticleId IdType="pubmed">32150618</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Mar 28;395(10229):1054-1062</Citation><ArticleIdList><ArticleId IdType="pubmed">32171076</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hosp Infect. 2020 Mar;104(3):246-251</Citation><ArticleIdList><ArticleId IdType="pubmed">32035997</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Mar 19;382(12):1177-1179</Citation><ArticleIdList><ArticleId IdType="pubmed">32074444</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2017 Aug 7;214(8):2303-2313</Citation><ArticleIdList><ArticleId IdType="pubmed">28694387</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2015 Nov 17;314(19):2034-2044</Citation><ArticleIdList><ArticleId IdType="pubmed">26575060</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2020 Jul;56(1):105949</Citation><ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Apr 7;323(13):1239-1242</Citation><ArticleIdList><ArticleId IdType="pubmed">32091533</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14408-14413</Citation><ArticleIdList><ArticleId IdType="pubmed">27911847</ArticleId></ArticleIdList></Reference><Reference><Citation>Travel Med Infect Dis. 2020 Jul - Aug;36:101632</Citation><ArticleIdList><ArticleId IdType="pubmed">32205269</ArticleId></ArticleIdList></Reference><Reference><Citation>ACS Infect Dis. 2015 Jul 10;1(7):317-26</Citation><ArticleIdList><ArticleId IdType="pubmed">27622822</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Antimicrob Agents. 2020 Mar;55(3):105924</Citation><ArticleIdList><ArticleId IdType="pubmed">32081636</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001864 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 001864 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidChloroV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= pubmed:32342252
|texte= Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:32342252" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a CovidChloroV1
| This area was generated with Dilib version V0.6.38. |  |