Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19).
Identifieur interne : 001813 ( Main/Corpus ); précédent : 001812; suivant : 001814Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19).
Auteurs : John R. Giudicessi ; Peter A. Noseworthy ; Paul A. Friedman ; Michael J. AckermanSource :
- Mayo Clinic proceedings [ 1942-5546 ] ; 2020.
English descriptors
- KwdEn :
- Anti-Infective Agents (administration & dosage), Anti-Infective Agents (adverse effects), Betacoronavirus (drug effects), Betacoronavirus (isolation & purification), COVID-19 (MeSH), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Death, Sudden, Cardiac (etiology), Death, Sudden, Cardiac (prevention & control), Drug Combinations (MeSH), Drug Monitoring (methods), Drug Repositioning (ethics), Drug Repositioning (methods), Electrocardiography (methods), Humans (MeSH), Hydroxychloroquine (administration & dosage), Hydroxychloroquine (adverse effects), Long QT Syndrome (chemically induced), Long QT Syndrome (mortality), Long QT Syndrome (therapy), Lopinavir (administration & dosage), Lopinavir (adverse effects), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (epidemiology), Risk Adjustment (methods), Ritonavir (administration & dosage), Ritonavir (adverse effects), SARS-CoV-2 (MeSH), Torsades de Pointes (chemically induced), Torsades de Pointes (mortality), Torsades de Pointes (therapy).
- MESH :
- chemical , administration & dosage : Anti-Infective Agents, Hydroxychloroquine, Lopinavir, Ritonavir.
- chemical , adverse effects : Anti-Infective Agents, Hydroxychloroquine, Lopinavir, Ritonavir.
- chemically induced : Long QT Syndrome, Torsades de Pointes.
- drug effects : Betacoronavirus.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- ethics : Drug Repositioning.
- etiology : Death, Sudden, Cardiac.
- isolation & purification : Betacoronavirus.
- methods : Drug Monitoring, Drug Repositioning, Electrocardiography, Risk Adjustment.
- mortality : Long QT Syndrome, Torsades de Pointes.
- prevention & control : Death, Sudden, Cardiac.
- therapy : Long QT Syndrome, Torsades de Pointes.
- COVID-19, Drug Combinations, Humans, Pandemics, SARS-CoV-2.
Abstract
As the coronavirus disease 19 (COVID-19) global pandemic rages across the globe, the race to prevent and treat this deadly disease has led to the "off-label" repurposing of drugs such as hydroxychloroquine and lopinavir/ritonavir, which have the potential for unwanted QT-interval prolongation and a risk of drug-induced sudden cardiac death. With the possibility that a considerable proportion of the world's population soon could receive COVID-19 pharmacotherapies with torsadogenic potential for therapy or postexposure prophylaxis, this document serves to help health care professionals mitigate the risk of drug-induced ventricular arrhythmias while minimizing risk of COVID-19 exposure to personnel and conserving the limited supply of personal protective equipment.
DOI: 10.1016/j.mayocp.2020.03.024
PubMed: 32359771
PubMed Central: PMC7141471
Links to Exploration step
pubmed:32359771Le document en format XML
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<term>Risk Adjustment (methods)</term>
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<term>Ritonavir (adverse effects)</term>
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<term>Torsades de Pointes</term>
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<term>Drug Combinations</term>
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<front><div type="abstract" xml:lang="en">As the coronavirus disease 19 (COVID-19) global pandemic rages across the globe, the race to prevent and treat this deadly disease has led to the "off-label" repurposing of drugs such as hydroxychloroquine and lopinavir/ritonavir, which have the potential for unwanted QT-interval prolongation and a risk of drug-induced sudden cardiac death. With the possibility that a considerable proportion of the world's population soon could receive COVID-19 pharmacotherapies with torsadogenic potential for therapy or postexposure prophylaxis, this document serves to help health care professionals mitigate the risk of drug-induced ventricular arrhythmias while minimizing risk of COVID-19 exposure to personnel and conserving the limited supply of personal protective equipment.</div>
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<Abstract><AbstractText>As the coronavirus disease 19 (COVID-19) global pandemic rages across the globe, the race to prevent and treat this deadly disease has led to the "off-label" repurposing of drugs such as hydroxychloroquine and lopinavir/ritonavir, which have the potential for unwanted QT-interval prolongation and a risk of drug-induced sudden cardiac death. With the possibility that a considerable proportion of the world's population soon could receive COVID-19 pharmacotherapies with torsadogenic potential for therapy or postexposure prophylaxis, this document serves to help health care professionals mitigate the risk of drug-induced ventricular arrhythmias while minimizing risk of COVID-19 exposure to personnel and conserving the limited supply of personal protective equipment.</AbstractText>
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